From 9fc8b0fb8722a473cdec692d9641d92d8ef724fd Mon Sep 17 00:00:00 2001
From: SC <github.com@genkisugi.net>
Date: Thu, 1 Feb 2024 09:20:02 -0800
Subject: [PATCH] automated commit

---
 models/R-HSA-2162123.ttl | 540 +++++++++++++++++++--------------------
 1 file changed, 270 insertions(+), 270 deletions(-)

diff --git a/models/R-HSA-2162123.ttl b/models/R-HSA-2162123.ttl
index cef0a61e9c17..e1ba3c873584 100644
--- a/models/R-HSA-2162123.ttl
+++ b/models/R-HSA-2162123.ttl
@@ -3488,10 +3488,10 @@
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-<http://model.geneontology.org/R-HSA-140355> <http://geneontology.org/lego/hint/layout/x> "731.7348542219781"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1304.1168444695556"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://model.geneontology.org/R-HSA-140355> <http://geneontology.org/lego/hint/layout/x> "234"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1170"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002333> <http://model.geneontology.org/R-HSA-428986_R-HSA-140355_controller> ;
-	<http://purl.org/pav/providedBy> "https://reactome.org" ;
+	<http://purl.org/pav/providedBy> "https://reactome.org" , "http://informatics.jax.org"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/BFO_0000050> <http://model.geneontology.org/R-HSA-2162123/R-HSA-2162123> ;
 	<http://purl.obolibrary.org/obo/BFO_0000066> <http://model.geneontology.org/reaction_R-HSA-140355_location_lociGO_0005788> ;
 	<http://purl.obolibrary.org/obo/RO_0002233> <http://model.geneontology.org/CHEBI_15379_R-HSA-140355> , <http://model.geneontology.org/CHEBI_32395_R-HSA-140355> ;
@@ -3503,7 +3503,7 @@
 	<http://www.w3.org/2004/02/skos/core#exactMatch> <http://www.reactome.org/biopax/84/48887#BiochemicalReaction11902> ;
 	<http://www.w3.org/2004/02/skos/core#note> "org.biopax.paxtools.model.level3.BiochemicalReaction" ;
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
-	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2024-02-01"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-140359> <http://geneontology.org/lego/hint/layout/x> "376.4894994440459"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "338.26041549209236"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -3623,10 +3623,10 @@
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-<http://model.geneontology.org/R-HSA-2161549> <http://geneontology.org/lego/hint/layout/x> "820.938235750466"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "775.9929271222816"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://model.geneontology.org/R-HSA-2161549> <http://geneontology.org/lego/hint/layout/x> "811"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "636"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002333> <http://model.geneontology.org/R-HSA-2142714_R-HSA-2161549_controller> ;
-	<http://purl.org/pav/providedBy> "https://reactome.org" ;
+	<http://purl.org/pav/providedBy> "https://reactome.org" , "http://informatics.jax.org"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/BFO_0000050> <http://model.geneontology.org/R-HSA-2162123/R-HSA-2162123> ;
 	<http://purl.obolibrary.org/obo/BFO_0000066> <http://model.geneontology.org/reaction_R-HSA-2161549_location_lociGO_0005829> ;
 	<http://purl.obolibrary.org/obo/RO_0002233> <http://model.geneontology.org/CHEBI_15378_R-HSA-2161549> , <http://model.geneontology.org/CHEBI_15554_R-HSA-2161549> , <http://model.geneontology.org/CHEBI_57783_R-HSA-2161549> ;
@@ -3637,7 +3637,7 @@
 	<http://www.w3.org/2004/02/skos/core#exactMatch> <http://www.reactome.org/biopax/84/48887#BiochemicalReaction11908> ;
 	<http://www.w3.org/2004/02/skos/core#note> "org.biopax.paxtools.model.level3.BiochemicalReaction" ;
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
-	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2024-02-01"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-2161563> <http://geneontology.org/lego/hint/layout/x> "1990.0169540017669"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "619.0245113070423"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -3696,10 +3696,10 @@
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
 	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://model.geneontology.org/R-HSA-2161613> <http://geneontology.org/lego/hint/layout/x> "710.9600222242874"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "998.1249039192958"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://model.geneontology.org/R-HSA-2161613> <http://geneontology.org/lego/hint/layout/x> "39"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1026"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002333> <http://model.geneontology.org/R-HSA-65976_R-HSA-2161613_controller> ;
-	<http://purl.org/pav/providedBy> "https://reactome.org" ;
+	<http://purl.org/pav/providedBy> "https://reactome.org" , "http://informatics.jax.org"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/BFO_0000050> <http://model.geneontology.org/R-HSA-2162123/R-HSA-2162123> ;
 	<http://purl.obolibrary.org/obo/BFO_0000066> <http://model.geneontology.org/reaction_R-HSA-2161613_location_lociGO_0005789> ;
 	<http://purl.obolibrary.org/obo/RO_0002233> <http://model.geneontology.org/CHEBI_15554_R-HSA-2161613> ;
@@ -3710,7 +3710,7 @@
 	<http://www.w3.org/2004/02/skos/core#exactMatch> <http://www.reactome.org/biopax/84/48887#BiochemicalReaction11931> ;
 	<http://www.w3.org/2004/02/skos/core#note> "org.biopax.paxtools.model.level3.BiochemicalReaction" ;
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
-	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2024-02-01"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-2161614> <http://geneontology.org/lego/hint/layout/x> "1948.1763947151733"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "-40.94737235526105"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -3743,10 +3743,10 @@
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
 	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://model.geneontology.org/R-HSA-2161620> <http://geneontology.org/lego/hint/layout/x> "1314.1584219055587"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "908.8402533351696"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://model.geneontology.org/R-HSA-2161620> <http://geneontology.org/lego/hint/layout/x> "1719"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "832"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002333> <http://model.geneontology.org/R-HSA-2142814_R-HSA-2161620_controller> ;
-	<http://purl.org/pav/providedBy> "https://reactome.org" ;
+	<http://purl.org/pav/providedBy> "https://reactome.org" , "http://informatics.jax.org"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/BFO_0000050> <http://model.geneontology.org/R-HSA-2162123/R-HSA-2162123> ;
 	<http://purl.obolibrary.org/obo/BFO_0000066> <http://model.geneontology.org/reaction_R-HSA-2161620_location_lociGO_0005789> ;
 	<http://purl.obolibrary.org/obo/RO_0002233> <http://model.geneontology.org/CHEBI_15554_R-HSA-2161620> ;
@@ -3758,7 +3758,7 @@
 	<http://www.w3.org/2004/02/skos/core#exactMatch> <http://www.reactome.org/biopax/84/48887#BiochemicalReaction11917> ;
 	<http://www.w3.org/2004/02/skos/core#note> "org.biopax.paxtools.model.level3.BiochemicalReaction" ;
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
-	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2024-02-01"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-2161651> <http://geneontology.org/lego/hint/layout/x> "151.02158473413616"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "-61.46563588176525"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -3907,10 +3907,10 @@
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
 	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://model.geneontology.org/R-HSA-2161732> <http://geneontology.org/lego/hint/layout/x> "1309.7328331009699"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1356.3774590235932"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://model.geneontology.org/R-HSA-2161732> <http://geneontology.org/lego/hint/layout/x> "1431"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1290"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002333> <http://model.geneontology.org/R-HSA-2161595_R-HSA-2161732_controller> ;
-	<http://purl.org/pav/providedBy> "https://reactome.org" ;
+	<http://purl.org/pav/providedBy> "https://reactome.org" , "http://informatics.jax.org"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/BFO_0000050> <http://model.geneontology.org/R-HSA-2162123/R-HSA-2162123> ;
 	<http://purl.obolibrary.org/obo/BFO_0000066> <http://model.geneontology.org/reaction_R-HSA-2161732_location_lociGO_0005788> ;
 	<http://purl.obolibrary.org/obo/RO_0002233> <http://model.geneontology.org/CHEBI_28728_R-HSA-2161732> , <http://model.geneontology.org/CHEBI_57540_R-HSA-2161732> ;
@@ -3921,7 +3921,7 @@
 	<http://www.w3.org/2004/02/skos/core#exactMatch> <http://www.reactome.org/biopax/84/48887#BiochemicalReaction11930> ;
 	<http://www.w3.org/2004/02/skos/core#note> "org.biopax.paxtools.model.level3.BiochemicalReaction" ;
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
-	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2024-02-01"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-2161733> <http://geneontology.org/lego/hint/layout/x> "1595.248908722016"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "634.9563257268792"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -3955,13 +3955,13 @@
 	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-2162123> <http://geneontology.org/lego/modelstate> "development"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/pav/providedBy> "https://reactome.org" ;
+	<http://purl.org/pav/providedBy> "https://reactome.org" , "http://informatics.jax.org"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<https://w3id.org/biolink/vocab/in_taxon> <http://purl.obolibrary.org/obo/NCBITaxon_9606> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://www.w3.org/2000/01/rdf-schema#comment> "For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl" , "http://www.reactome.org" , "Imported from Reactome: https://reactome.org/content/detail/R-HSA-2162123" ;
 	<http://purl.org/dc/elements/1.1/title> "Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - imported from: Reactome" ;
-	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
-	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2024-02-01"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-2162123/R-HSA-2162123> <http://geneontology.org/lego/hint/layout/x> "1180.2378251168434"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "-31.381973700094278"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -4108,9 +4108,9 @@
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-<http://model.geneontology.org/R-HSA-443894> <http://geneontology.org/lego/hint/layout/x> "1121.5885752884105"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1142.4997551168192"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/pav/providedBy> "https://reactome.org" ;
+<http://model.geneontology.org/R-HSA-443894> <http://geneontology.org/lego/hint/layout/x> "1059"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1355"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/pav/providedBy> "https://reactome.org" , "http://informatics.jax.org"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/BFO_0000050> <http://model.geneontology.org/R-HSA-2162123/R-HSA-2162123> ;
 	<http://purl.obolibrary.org/obo/BFO_0000066> <http://model.geneontology.org/reaction_R-HSA-443894_location_lociGO_0005788> ;
 	<http://purl.obolibrary.org/obo/RO_0002233> <http://model.geneontology.org/CHEBI_15377_R-HSA-443894> , <http://model.geneontology.org/CHEBI_15627_R-HSA-443894> ;
@@ -4122,7 +4122,7 @@
 	<http://www.w3.org/2004/02/skos/core#exactMatch> <http://www.reactome.org/biopax/84/48887#BiochemicalReaction11929> ;
 	<http://www.w3.org/2004/02/skos/core#note> "org.biopax.paxtools.model.level3.BiochemicalReaction" ;
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
-	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2024-02-01"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-561082_R-HSA-9749583_controller> <http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.geneontology.org/formats/oboInOwl#hasDbXref> "Reactome:R-HSA-561082" ;
@@ -4171,10 +4171,10 @@
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
 	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://model.geneontology.org/R-HSA-76500> <http://geneontology.org/lego/hint/layout/x> "987.1129437972189"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "944.6257021676615"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://model.geneontology.org/R-HSA-76500> <http://geneontology.org/lego/hint/layout/x> "702"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1350"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002333> <http://model.geneontology.org/R-HSA-65976_R-HSA-76500_controller> ;
-	<http://purl.org/pav/providedBy> "https://reactome.org" ;
+	<http://purl.org/pav/providedBy> "https://reactome.org" , "http://informatics.jax.org"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/BFO_0000050> <http://model.geneontology.org/R-HSA-2162123/R-HSA-2162123> ;
 	<http://purl.obolibrary.org/obo/BFO_0000066> <http://model.geneontology.org/reaction_R-HSA-76500_location_lociGO_0005789> ;
 	<http://purl.obolibrary.org/obo/RO_0002233> <http://model.geneontology.org/CHEBI_15554_R-HSA-76500> ;
@@ -4186,7 +4186,7 @@
 	<http://www.w3.org/2004/02/skos/core#exactMatch> <http://www.reactome.org/biopax/84/48887#BiochemicalReaction11928> ;
 	<http://www.w3.org/2004/02/skos/core#note> "org.biopax.paxtools.model.level3.BiochemicalReaction" ;
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" , "https://orcid.org/0000-0001-7476-6306" ;
-	<http://purl.org/dc/elements/1.1/date> "2024-01-04"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2024-02-01"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://model.geneontology.org/R-HSA-8856534_R-HSA-9645220_controller> <http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.geneontology.org/formats/oboInOwl#hasDbXref> "Reactome:R-HSA-8856534" ;
@@ -4585,7 +4585,7 @@
 
 <http://purl.org/dc/elements/1.1/source> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t308152 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_BFO_0000066_reaction_R-HSA-111883_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
+_:t2273036 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_BFO_0000066_reaction_R-HSA-111883_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-111883> ;
@@ -4595,7 +4595,7 @@ _:t308152 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308153 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_BFO_0000066_reaction_R-HSA-140355_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273037 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_BFO_0000066_reaction_R-HSA-140355_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140355> ;
@@ -4605,7 +4605,7 @@ _:t308153 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308154 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273038 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4615,7 +4615,7 @@ _:t308154 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308155 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_BFO_0000066_reaction_R-HSA-2161662_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273039 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_BFO_0000066_reaction_R-HSA-2161662_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4625,7 +4625,7 @@ _:t308155 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308156 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002233_CHEBI_57540_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002233_CHEBI_57540_R-HSA-2161662_Reactome_R-HSA-2162123> ;
+_:t2273040 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002233_CHEBI_57540_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002233_CHEBI_57540_R-HSA-2161662_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4635,7 +4635,7 @@ _:t308156 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308157 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002233_R-ALL-2161661_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002233_R-ALL-2161661_R-HSA-2161662_Reactome_R-HSA-2162123> ;
+_:t2273041 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002233_R-ALL-2161661_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002233_R-ALL-2161661_R-HSA-2161662_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4645,7 +4645,7 @@ _:t308157 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308158 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_CHEBI_15378_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_CHEBI_15378_R-HSA-2161662_Reactome_R-HSA-2162123> ;
+_:t2273042 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_CHEBI_15378_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_CHEBI_15378_R-HSA-2161662_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4655,7 +4655,7 @@ _:t308158 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308159 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_CHEBI_57945_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_CHEBI_57945_R-HSA-2161662_Reactome_R-HSA-2162123> ;
+_:t2273043 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_CHEBI_57945_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_CHEBI_57945_R-HSA-2161662_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4665,7 +4665,7 @@ _:t308159 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308160 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_R-ALL-2161597_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_R-ALL-2161597_R-HSA-2161662_Reactome_R-HSA-2162123> ;
+_:t2273044 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_R-ALL-2161597_R-HSA-2161662_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002234_R-ALL-2161597_R-HSA-2161662_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4675,7 +4675,7 @@ _:t308160 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308161 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002333_R-HSA-2142778_R-HSA-2161662_controller_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002333_R-HSA-2142778_R-HSA-2161662_controller_Reactome_R-HSA-2162123> ;
+_:t2273045 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002333_R-HSA-2142778_R-HSA-2161662_controller_Reactome_R-HSA-2161662> , <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002333_R-HSA-2142778_R-HSA-2161662_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4685,7 +4685,7 @@ _:t308161 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308162 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002413_R-HSA-2161692_Reactome_R-HSA-2162123> ;
+_:t2273046 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161662_RO_0002413_R-HSA-2161692_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161662> ;
@@ -4696,7 +4696,7 @@ _:t308162 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308163 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273047 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161666> ;
@@ -4706,7 +4706,7 @@ _:t308163 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308164 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002233_CHEBI_15379_R-HSA-140355_Reactome_R-HSA-140355> , <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002233_CHEBI_15379_R-HSA-140355_Reactome_R-HSA-2162123> ;
+_:t2273048 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002233_CHEBI_15379_R-HSA-140355_Reactome_R-HSA-140355> , <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002233_CHEBI_15379_R-HSA-140355_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140355> ;
@@ -4716,7 +4716,7 @@ _:t308164 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308165 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_BFO_0000066_reaction_R-HSA-2161666_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273049 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_BFO_0000066_reaction_R-HSA-2161666_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161666> ;
@@ -4726,7 +4726,7 @@ _:t308165 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308166 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002233_CHEBI_27820_R-HSA-2161666_Reactome_R-HSA-2161666> , <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002233_CHEBI_27820_R-HSA-2161666_Reactome_R-HSA-2162123> ;
+_:t2273050 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002233_CHEBI_27820_R-HSA-2161666_Reactome_R-HSA-2161666> , <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002233_CHEBI_27820_R-HSA-2161666_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161666> ;
@@ -4736,7 +4736,7 @@ _:t308166 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308167 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002234_CHEBI_27555_R-HSA-2161666_Reactome_R-HSA-2161666> , <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002234_CHEBI_27555_R-HSA-2161666_Reactome_R-HSA-2162123> ;
+_:t2273051 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002234_CHEBI_27555_R-HSA-2161666_Reactome_R-HSA-2161666> , <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002234_CHEBI_27555_R-HSA-2161666_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161666> ;
@@ -4746,7 +4746,7 @@ _:t308167 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308168 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002411_R-HSA-2161668_Reactome_R-HSA-2162123> ;
+_:t2273052 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002411_R-HSA-2161668_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161666> ;
@@ -4756,7 +4756,7 @@ _:t308168 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308169 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002413_R-HSA-2161735_Reactome_R-HSA-2162123> ;
+_:t2273053 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161666_RO_0002413_R-HSA-2161735_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161666> ;
@@ -4767,7 +4767,7 @@ _:t308169 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308170 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273054 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161668> ;
@@ -4777,7 +4777,7 @@ _:t308170 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308171 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_BFO_0000066_reaction_R-HSA-2161668_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273055 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_BFO_0000066_reaction_R-HSA-2161668_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161668> ;
@@ -4787,7 +4787,7 @@ _:t308171 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308172 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002233_CHEBI_27820_R-HSA-2161668_Reactome_R-HSA-2161668> , <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002233_CHEBI_27820_R-HSA-2161668_Reactome_R-HSA-2162123> ;
+_:t2273056 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002233_CHEBI_27820_R-HSA-2161668_Reactome_R-HSA-2161668> , <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002233_CHEBI_27820_R-HSA-2161668_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161668> ;
@@ -4797,7 +4797,7 @@ _:t308172 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308173 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002234_CHEBI_15377_R-HSA-2161668_Reactome_R-HSA-2161668> , <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002234_CHEBI_15377_R-HSA-2161668_Reactome_R-HSA-2162123> ;
+_:t2273057 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002234_CHEBI_15377_R-HSA-2161668_Reactome_R-HSA-2161668> , <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002234_CHEBI_15377_R-HSA-2161668_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161668> ;
@@ -4807,7 +4807,7 @@ _:t308173 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308174 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002234_CHEBI_63975_R-HSA-2161668_Reactome_R-HSA-2161668> , <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002234_CHEBI_63975_R-HSA-2161668_Reactome_R-HSA-2162123> ;
+_:t2273058 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002234_CHEBI_63975_R-HSA-2161668_Reactome_R-HSA-2161668> , <http://model.geneontology.org/ev_w_id_R-HSA-2161668_RO_0002234_CHEBI_63975_R-HSA-2161668_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161668> ;
@@ -4817,7 +4817,7 @@ _:t308174 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308175 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002233_CHEBI_32395_R-HSA-140355_Reactome_R-HSA-140355> , <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002233_CHEBI_32395_R-HSA-140355_Reactome_R-HSA-2162123> ;
+_:t2273059 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002233_CHEBI_32395_R-HSA-140355_Reactome_R-HSA-140355> , <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002233_CHEBI_32395_R-HSA-140355_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140355> ;
@@ -4827,7 +4827,7 @@ _:t308175 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308176 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273060 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161673> ;
@@ -4837,7 +4837,7 @@ _:t308176 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308177 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_BFO_0000066_reaction_R-HSA-2161673_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273061 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_BFO_0000066_reaction_R-HSA-2161673_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161673> ;
@@ -4847,7 +4847,7 @@ _:t308177 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308178 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002233_CHEBI_15555_R-HSA-2161673_Reactome_R-HSA-2161673> , <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002233_CHEBI_15555_R-HSA-2161673_Reactome_R-HSA-2162123> ;
+_:t2273062 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002233_CHEBI_15555_R-HSA-2161673_Reactome_R-HSA-2161673> , <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002233_CHEBI_15555_R-HSA-2161673_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161673> ;
@@ -4857,7 +4857,7 @@ _:t308178 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308179 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002234_CHEBI_15377_R-HSA-2161673_Reactome_R-HSA-2161673> , <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002234_CHEBI_15377_R-HSA-2161673_Reactome_R-HSA-2162123> ;
+_:t2273063 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002234_CHEBI_15377_R-HSA-2161673_Reactome_R-HSA-2161673> , <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002234_CHEBI_15377_R-HSA-2161673_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161673> ;
@@ -4867,7 +4867,7 @@ _:t308179 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308180 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002234_CHEBI_63999_R-HSA-2161673_Reactome_R-HSA-2161673> , <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002234_CHEBI_63999_R-HSA-2161673_Reactome_R-HSA-2162123> ;
+_:t2273064 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002234_CHEBI_63999_R-HSA-2161673_Reactome_R-HSA-2161673> , <http://model.geneontology.org/ev_w_id_R-HSA-2161673_RO_0002234_CHEBI_63999_R-HSA-2161673_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161673> ;
@@ -4877,7 +4877,7 @@ _:t308180 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308181 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273065 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161692> ;
@@ -4887,7 +4887,7 @@ _:t308181 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308182 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_BFO_0000066_reaction_R-HSA-2161692_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273066 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_BFO_0000066_reaction_R-HSA-2161692_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161692> ;
@@ -4897,7 +4897,7 @@ _:t308182 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308183 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_CHEBI_15378_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_CHEBI_15378_R-HSA-2161692_Reactome_R-HSA-2162123> ;
+_:t2273067 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_CHEBI_15378_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_CHEBI_15378_R-HSA-2161692_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161692> ;
@@ -4907,7 +4907,7 @@ _:t308183 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308184 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_CHEBI_57783_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_CHEBI_57783_R-HSA-2161692_Reactome_R-HSA-2162123> ;
+_:t2273068 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_CHEBI_57783_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_CHEBI_57783_R-HSA-2161692_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161692> ;
@@ -4917,7 +4917,7 @@ _:t308184 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308185 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_R-ALL-2161650_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_R-ALL-2161650_R-HSA-2161692_Reactome_R-HSA-2162123> ;
+_:t2273069 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_R-ALL-2161650_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002233_R-ALL-2161650_R-HSA-2161692_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161692> ;
@@ -4927,7 +4927,7 @@ _:t308185 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308186 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002234_CHEBI_27647_R-HSA-140355_Reactome_R-HSA-140355> , <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002234_CHEBI_27647_R-HSA-140355_Reactome_R-HSA-2162123> ;
+_:t2273070 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002234_CHEBI_27647_R-HSA-140355_Reactome_R-HSA-140355> , <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002234_CHEBI_27647_R-HSA-140355_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140355> ;
@@ -4937,7 +4937,7 @@ _:t308186 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308187 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002234_CHEBI_58349_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002234_CHEBI_58349_R-HSA-2161692_Reactome_R-HSA-2162123> ;
+_:t2273071 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002234_CHEBI_58349_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002234_CHEBI_58349_R-HSA-2161692_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161692> ;
@@ -4947,7 +4947,7 @@ _:t308187 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308188 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002234_R-ALL-2161684_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002234_R-ALL-2161684_R-HSA-2161692_Reactome_R-HSA-2162123> ;
+_:t2273072 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002234_R-ALL-2161684_R-HSA-2161692_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002234_R-ALL-2161684_R-HSA-2161692_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161692> ;
@@ -4957,7 +4957,7 @@ _:t308188 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308189 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002333_R-HSA-8940670_R-HSA-2161692_controller_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002333_R-HSA-8940670_R-HSA-2161692_controller_Reactome_R-HSA-2162123> ;
+_:t2273073 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002333_R-HSA-8940670_R-HSA-2161692_controller_Reactome_R-HSA-2161692> , <http://model.geneontology.org/ev_w_id_R-HSA-2161692_RO_0002333_R-HSA-8940670_R-HSA-2161692_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161692> ;
@@ -4967,7 +4967,7 @@ _:t308189 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308190 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273074 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161701> ;
@@ -4977,7 +4977,7 @@ _:t308190 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308191 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_BFO_0000066_reaction_R-HSA-2161701_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273075 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_BFO_0000066_reaction_R-HSA-2161701_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161701> ;
@@ -4987,7 +4987,7 @@ _:t308191 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308192 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002233_CHEBI_15554_R-HSA-2161701_Reactome_R-HSA-2161701> , <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002233_CHEBI_15554_R-HSA-2161701_Reactome_R-HSA-2162123> ;
+_:t2273076 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002233_CHEBI_15554_R-HSA-2161701_Reactome_R-HSA-2161701> , <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002233_CHEBI_15554_R-HSA-2161701_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161701> ;
@@ -4997,7 +4997,7 @@ _:t308192 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308193 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002234_CHEBI_15555_R-HSA-2161701_Reactome_R-HSA-2161701> , <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002234_CHEBI_15555_R-HSA-2161701_Reactome_R-HSA-2162123> ;
+_:t2273077 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002234_CHEBI_15555_R-HSA-2161701_Reactome_R-HSA-2161701> , <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002234_CHEBI_15555_R-HSA-2161701_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161701> ;
@@ -5007,7 +5007,7 @@ _:t308193 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308194 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002333_R-HSA-2142683_R-HSA-2161701_controller_Reactome_R-HSA-2161701> , <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002333_R-HSA-2142683_R-HSA-2161701_controller_Reactome_R-HSA-2162123> ;
+_:t2273078 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002333_R-HSA-2142683_R-HSA-2161701_controller_Reactome_R-HSA-2161701> , <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002333_R-HSA-2142683_R-HSA-2161701_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161701> ;
@@ -5017,7 +5017,7 @@ _:t308194 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308195 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002411_R-HSA-2161662_Reactome_R-HSA-2162123> ;
+_:t2273079 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002411_R-HSA-2161662_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161701> ;
@@ -5027,7 +5027,7 @@ _:t308195 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308196 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002413_R-HSA-2161614_Reactome_R-HSA-2162123> ;
+_:t2273080 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161701_RO_0002413_R-HSA-2161614_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161701> ;
@@ -5038,7 +5038,7 @@ _:t308196 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308197 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002333_R-HSA-428986_R-HSA-140355_controller_Reactome_R-HSA-140355> , <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002333_R-HSA-428986_R-HSA-140355_controller_Reactome_R-HSA-2162123> ;
+_:t2273081 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002333_R-HSA-428986_R-HSA-140355_controller_Reactome_R-HSA-140355> , <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002333_R-HSA-428986_R-HSA-140355_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140355> ;
@@ -5048,7 +5048,7 @@ _:t308197 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308198 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273082 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161732> ;
@@ -5058,7 +5058,7 @@ _:t308198 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308199 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_BFO_0000066_reaction_R-HSA-2161732_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273083 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_BFO_0000066_reaction_R-HSA-2161732_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161732> ;
@@ -5068,7 +5068,7 @@ _:t308199 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308200 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002233_CHEBI_28728_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002233_CHEBI_28728_R-HSA-2161732_Reactome_R-HSA-2162123> ;
+_:t2273084 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002233_CHEBI_28728_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002233_CHEBI_28728_R-HSA-2161732_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161732> ;
@@ -5078,7 +5078,7 @@ _:t308200 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308201 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002233_CHEBI_57540_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002233_CHEBI_57540_R-HSA-2161732_Reactome_R-HSA-2162123> ;
+_:t2273085 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002233_CHEBI_57540_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002233_CHEBI_57540_R-HSA-2161732_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161732> ;
@@ -5088,7 +5088,7 @@ _:t308201 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308202 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_15378_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_15378_R-HSA-2161732_Reactome_R-HSA-2162123> ;
+_:t2273086 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_15378_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_15378_R-HSA-2161732_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161732> ;
@@ -5098,7 +5098,7 @@ _:t308202 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308203 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_28667_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_28667_R-HSA-2161732_Reactome_R-HSA-2162123> ;
+_:t2273087 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_28667_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_28667_R-HSA-2161732_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161732> ;
@@ -5108,7 +5108,7 @@ _:t308203 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308204 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_57945_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_57945_R-HSA-2161732_Reactome_R-HSA-2162123> ;
+_:t2273088 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_57945_R-HSA-2161732_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002234_CHEBI_57945_R-HSA-2161732_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161732> ;
@@ -5118,7 +5118,7 @@ _:t308204 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308205 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002333_R-HSA-2161595_R-HSA-2161732_controller_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002333_R-HSA-2161595_R-HSA-2161732_controller_Reactome_R-HSA-2162123> ;
+_:t2273089 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002333_R-HSA-2161595_R-HSA-2161732_controller_Reactome_R-HSA-2161732> , <http://model.geneontology.org/ev_w_id_R-HSA-2161732_RO_0002333_R-HSA-2161595_R-HSA-2161732_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161732> ;
@@ -5128,7 +5128,7 @@ _:t308205 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308206 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273090 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161733> ;
@@ -5138,7 +5138,7 @@ _:t308206 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308207 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_BFO_0000066_reaction_R-HSA-2161733_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273091 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_BFO_0000066_reaction_R-HSA-2161733_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161733> ;
@@ -5148,7 +5148,7 @@ _:t308207 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308208 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002413_R-HSA-140359_Reactome_R-HSA-2162123> ;
+_:t2273092 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_RO_0002413_R-HSA-140359_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140355> ;
@@ -5159,7 +5159,7 @@ _:t308208 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308209 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002233_CHEBI_15555_R-HSA-2161733_Reactome_R-HSA-2161733> , <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002233_CHEBI_15555_R-HSA-2161733_Reactome_R-HSA-2162123> ;
+_:t2273093 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002233_CHEBI_15555_R-HSA-2161733_Reactome_R-HSA-2161733> , <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002233_CHEBI_15555_R-HSA-2161733_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161733> ;
@@ -5169,7 +5169,7 @@ _:t308209 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308210 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002234_CHEBI_15377_R-HSA-2161733_Reactome_R-HSA-2161733> , <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002234_CHEBI_15377_R-HSA-2161733_Reactome_R-HSA-2162123> ;
+_:t2273094 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002234_CHEBI_15377_R-HSA-2161733_Reactome_R-HSA-2161733> , <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002234_CHEBI_15377_R-HSA-2161733_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161733> ;
@@ -5179,7 +5179,7 @@ _:t308210 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308211 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002234_CHEBI_27485_R-HSA-2161733_Reactome_R-HSA-2161733> , <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002234_CHEBI_27485_R-HSA-2161733_Reactome_R-HSA-2162123> ;
+_:t2273095 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002234_CHEBI_27485_R-HSA-2161733_Reactome_R-HSA-2161733> , <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002234_CHEBI_27485_R-HSA-2161733_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161733> ;
@@ -5189,7 +5189,7 @@ _:t308211 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308212 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002413_R-HSA-2161563_Reactome_R-HSA-2162123> ;
+_:t2273096 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161733_RO_0002413_R-HSA-2161563_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161733> ;
@@ -5200,7 +5200,7 @@ _:t308212 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308213 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161735_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273097 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161735_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161735> ;
@@ -5210,7 +5210,7 @@ _:t308213 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308214 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161735_BFO_0000066_reaction_R-HSA-2161735_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273098 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161735_BFO_0000066_reaction_R-HSA-2161735_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161735> ;
@@ -5220,7 +5220,7 @@ _:t308214 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308215 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161735_RO_0002233_CHEBI_27555_R-HSA-2161735_Reactome_R-HSA-2161735> , <http://model.geneontology.org/ev_w_id_R-HSA-2161735_RO_0002233_CHEBI_27555_R-HSA-2161735_Reactome_R-HSA-2162123> ;
+_:t2273099 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161735_RO_0002233_CHEBI_27555_R-HSA-2161735_Reactome_R-HSA-2161735> , <http://model.geneontology.org/ev_w_id_R-HSA-2161735_RO_0002233_CHEBI_27555_R-HSA-2161735_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161735> ;
@@ -5230,7 +5230,7 @@ _:t308215 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308216 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161735_RO_0002234_CHEBI_28099_R-HSA-2161735_Reactome_R-HSA-2161735> , <http://model.geneontology.org/ev_w_id_R-HSA-2161735_RO_0002234_CHEBI_28099_R-HSA-2161735_Reactome_R-HSA-2162123> ;
+_:t2273100 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161735_RO_0002234_CHEBI_28099_R-HSA-2161735_Reactome_R-HSA-2161735> , <http://model.geneontology.org/ev_w_id_R-HSA-2161735_RO_0002234_CHEBI_28099_R-HSA-2161735_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161735> ;
@@ -5240,7 +5240,7 @@ _:t308216 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308217 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273101 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2299725> ;
@@ -5250,7 +5250,7 @@ _:t308217 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308218 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-2299725_Reactome_R-HSA-2162123> ;
+_:t2273102 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002338_start_loc_http://purl.obolibrary.org/obo/GO_0005829_R-HSA-2299725_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002338> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2299725> ;
@@ -5260,7 +5260,7 @@ _:t308218 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308219 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273103 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -5270,7 +5270,7 @@ _:t308219 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308220 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0005788_R-HSA-2299725_Reactome_R-HSA-2162123> ;
+_:t2273104 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002339_end_loc_http://purl.obolibrary.org/obo/GO_0005788_R-HSA-2299725_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002339> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2299725> ;
@@ -5280,7 +5280,7 @@ _:t308220 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308221 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002411_R-HSA-2161549_Reactome_R-HSA-2162123> ;
+_:t2273105 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002411_R-HSA-2161549_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2299725> ;
@@ -5290,7 +5290,7 @@ _:t308221 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308222 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002411_R-HSA-2161612_Reactome_R-HSA-2162123> ;
+_:t2273106 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002411_R-HSA-2161612_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2299725> ;
@@ -5300,7 +5300,7 @@ _:t308222 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308223 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002411_R-HSA-2161660_Reactome_R-HSA-2162123> ;
+_:t2273107 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002411_R-HSA-2161660_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2299725> ;
@@ -5310,7 +5310,7 @@ _:t308223 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308224 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002411_R-HSA-265295_Reactome_R-HSA-2162123> ;
+_:t2273108 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0002411_R-HSA-265295_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2299725> ;
@@ -5320,7 +5320,7 @@ _:t308224 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308225 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0004009_transported_CHEBI_15554_R-HSA-2299725_Reactome_R-HSA-2162123> ;
+_:t2273109 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2299725_RO_0004009_transported_CHEBI_15554_R-HSA-2299725_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004009> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2299725> ;
@@ -5330,7 +5330,7 @@ _:t308225 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308226 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273110 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5340,7 +5340,7 @@ _:t308226 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308227 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_BFO_0000066_reaction_R-HSA-2309773_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273111 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_BFO_0000066_reaction_R-HSA-2309773_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5350,7 +5350,7 @@ _:t308227 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308228 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_10545_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_10545_R-HSA-2309773_Reactome_R-HSA-2309773> ;
+_:t2273112 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_10545_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_10545_R-HSA-2309773_Reactome_R-HSA-2309773> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5360,7 +5360,7 @@ _:t308228 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308229 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_15378_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_15378_R-HSA-2309773_Reactome_R-HSA-2309773> ;
+_:t2273113 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_15378_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_15378_R-HSA-2309773_Reactome_R-HSA-2309773> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5370,7 +5370,7 @@ _:t308229 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308230 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_BFO_0000066_reaction_R-HSA-140359_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273114 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_BFO_0000066_reaction_R-HSA-140359_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -5380,7 +5380,7 @@ _:t308230 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308231 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_27647_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_27647_R-HSA-2309773_Reactome_R-HSA-2309773> ;
+_:t2273115 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_27647_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002233_CHEBI_27647_R-HSA-2309773_Reactome_R-HSA-2309773> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5390,7 +5390,7 @@ _:t308231 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308232 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002234_CHEBI_15377_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002234_CHEBI_15377_R-HSA-2309773_Reactome_R-HSA-2309773> ;
+_:t2273116 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002234_CHEBI_15377_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002234_CHEBI_15377_R-HSA-2309773_Reactome_R-HSA-2309773> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5400,7 +5400,7 @@ _:t308232 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308233 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002234_CHEBI_15554_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002234_CHEBI_15554_R-HSA-2309773_Reactome_R-HSA-2309773> ;
+_:t2273117 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002234_CHEBI_15554_R-HSA-2309773_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002234_CHEBI_15554_R-HSA-2309773_Reactome_R-HSA-2309773> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5410,7 +5410,7 @@ _:t308233 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308234 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002333_R-HSA-140491_R-HSA-2309773_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002333_R-HSA-140491_R-HSA-2309773_controller_Reactome_R-HSA-2309773> ;
+_:t2273118 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002333_R-HSA-140491_R-HSA-2309773_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002333_R-HSA-140491_R-HSA-2309773_controller_Reactome_R-HSA-2309773> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5420,7 +5420,7 @@ _:t308234 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308235 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002411_R-HSA-2299725_Reactome_R-HSA-2162123> ;
+_:t2273119 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002411_R-HSA-2299725_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5430,7 +5430,7 @@ _:t308235 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308236 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002413_R-HSA-2161613_Reactome_R-HSA-2162123> ;
+_:t2273120 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002413_R-HSA-2161613_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5441,7 +5441,7 @@ _:t308236 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308237 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002413_R-HSA-2161620_Reactome_R-HSA-2162123> ;
+_:t2273121 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002413_R-HSA-2161620_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5452,7 +5452,7 @@ _:t308237 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308238 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002413_R-HSA-76496_Reactome_R-HSA-2162123> ;
+_:t2273122 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002413_R-HSA-76496_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5463,7 +5463,7 @@ _:t308238 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308239 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002413_R-HSA-76500_Reactome_R-HSA-2162123> ;
+_:t2273123 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0002413_R-HSA-76500_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5474,7 +5474,7 @@ _:t308239 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308240 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0012001_CHEBI_16797_R-HSA-2309773_controller_Reactome_R-HSA-2162123> ;
+_:t2273124 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309773_RO_0012001_CHEBI_16797_R-HSA-2309773_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0012001> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309773> ;
@@ -5484,7 +5484,7 @@ _:t308240 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308241 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_10545_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_10545_R-HSA-140359_Reactome_R-HSA-2162123> ;
+_:t2273125 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_10545_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_10545_R-HSA-140359_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -5494,7 +5494,7 @@ _:t308241 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308242 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273126 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309787> ;
@@ -5504,7 +5504,7 @@ _:t308242 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308243 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_BFO_0000066_reaction_R-HSA-2309787_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273127 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_BFO_0000066_reaction_R-HSA-2309787_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309787> ;
@@ -5514,7 +5514,7 @@ _:t308243 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308244 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002233_CHEBI_15379_R-HSA-2309787_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002233_CHEBI_15379_R-HSA-2309787_Reactome_R-HSA-2309787> ;
+_:t2273128 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002233_CHEBI_15379_R-HSA-2309787_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002233_CHEBI_15379_R-HSA-2309787_Reactome_R-HSA-2309787> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309787> ;
@@ -5524,7 +5524,7 @@ _:t308244 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308245 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002233_CHEBI_32395_R-HSA-2309787_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002233_CHEBI_32395_R-HSA-2309787_Reactome_R-HSA-2309787> ;
+_:t2273129 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002233_CHEBI_32395_R-HSA-2309787_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002233_CHEBI_32395_R-HSA-2309787_Reactome_R-HSA-2309787> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309787> ;
@@ -5534,7 +5534,7 @@ _:t308245 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308246 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002234_CHEBI_27647_R-HSA-2309787_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002234_CHEBI_27647_R-HSA-2309787_Reactome_R-HSA-2309787> ;
+_:t2273130 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002234_CHEBI_27647_R-HSA-2309787_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002234_CHEBI_27647_R-HSA-2309787_Reactome_R-HSA-2309787> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309787> ;
@@ -5544,7 +5544,7 @@ _:t308246 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308247 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002333_R-HSA-140491_R-HSA-2309787_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002333_R-HSA-140491_R-HSA-2309787_controller_Reactome_R-HSA-2309787> ;
+_:t2273131 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002333_R-HSA-140491_R-HSA-2309787_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002333_R-HSA-140491_R-HSA-2309787_controller_Reactome_R-HSA-2309787> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309787> ;
@@ -5554,7 +5554,7 @@ _:t308247 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308248 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002413_R-HSA-2309773_Reactome_R-HSA-2162123> ;
+_:t2273132 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2309787_RO_0002413_R-HSA-2309773_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2309787> ;
@@ -5565,7 +5565,7 @@ _:t308248 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308249 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273133 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314678> ;
@@ -5575,7 +5575,7 @@ _:t308249 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308250 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002233_CHEBI_13719_R-HSA-2314678_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002233_CHEBI_13719_R-HSA-2314678_Reactome_R-HSA-2314678> ;
+_:t2273134 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002233_CHEBI_13719_R-HSA-2314678_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002233_CHEBI_13719_R-HSA-2314678_Reactome_R-HSA-2314678> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314678> ;
@@ -5585,7 +5585,7 @@ _:t308250 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308251 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002233_R-HSA-428986_R-HSA-2314678_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002233_R-HSA-428986_R-HSA-2314678_Reactome_R-HSA-2314678> ;
+_:t2273135 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002233_R-HSA-428986_R-HSA-2314678_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002233_R-HSA-428986_R-HSA-2314678_Reactome_R-HSA-2314678> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314678> ;
@@ -5595,7 +5595,7 @@ _:t308251 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308252 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_15378_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_15378_R-HSA-140359_Reactome_R-HSA-2162123> ;
+_:t2273136 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_15378_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_15378_R-HSA-140359_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -5605,7 +5605,7 @@ _:t308252 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308253 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002234_CHEBI_30762_R-HSA-2314678_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002234_CHEBI_30762_R-HSA-2314678_Reactome_R-HSA-2314678> ;
+_:t2273137 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002234_CHEBI_30762_R-HSA-2314678_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002234_CHEBI_30762_R-HSA-2314678_Reactome_R-HSA-2314678> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314678> ;
@@ -5615,7 +5615,7 @@ _:t308253 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308254 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002234_R-HSA-2314695_R-HSA-2314678_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002234_R-HSA-2314695_R-HSA-2314678_Reactome_R-HSA-2314678> ;
+_:t2273138 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002234_R-HSA-2314695_R-HSA-2314678_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314678_RO_0002234_R-HSA-2314695_R-HSA-2314678_Reactome_R-HSA-2314678> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314678> ;
@@ -5625,7 +5625,7 @@ _:t308254 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308255 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273139 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314686> ;
@@ -5635,7 +5635,7 @@ _:t308255 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308256 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002233_CHEBI_13719_R-HSA-2314686_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002233_CHEBI_13719_R-HSA-2314686_Reactome_R-HSA-2314686> ;
+_:t2273140 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002233_CHEBI_13719_R-HSA-2314686_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002233_CHEBI_13719_R-HSA-2314686_Reactome_R-HSA-2314686> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314686> ;
@@ -5645,7 +5645,7 @@ _:t308256 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308257 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002233_R-HSA-140491_R-HSA-2314686_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002233_R-HSA-140491_R-HSA-2314686_Reactome_R-HSA-2314686> ;
+_:t2273141 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002233_R-HSA-140491_R-HSA-2314686_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002233_R-HSA-140491_R-HSA-2314686_Reactome_R-HSA-2314686> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314686> ;
@@ -5655,7 +5655,7 @@ _:t308257 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308258 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002234_CHEBI_30762_R-HSA-2314686_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002234_CHEBI_30762_R-HSA-2314686_Reactome_R-HSA-2314686> ;
+_:t2273142 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002234_CHEBI_30762_R-HSA-2314686_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002234_CHEBI_30762_R-HSA-2314686_Reactome_R-HSA-2314686> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314686> ;
@@ -5665,7 +5665,7 @@ _:t308258 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308259 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002234_R-HSA-2314687_R-HSA-2314686_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002234_R-HSA-2314687_R-HSA-2314686_Reactome_R-HSA-2314686> ;
+_:t2273143 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002234_R-HSA-2314687_R-HSA-2314686_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-2314686_RO_0002234_R-HSA-2314687_R-HSA-2314686_Reactome_R-HSA-2314686> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2314686> ;
@@ -5675,7 +5675,7 @@ _:t308259 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308260 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273144 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-265295> ;
@@ -5685,7 +5685,7 @@ _:t308260 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308261 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_BFO_0000066_reaction_R-HSA-265295_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273145 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_BFO_0000066_reaction_R-HSA-265295_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-265295> ;
@@ -5695,7 +5695,7 @@ _:t308261 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308262 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002233_CHEBI_15554_R-HSA-265295_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002233_CHEBI_15554_R-HSA-265295_Reactome_R-HSA-265295> ;
+_:t2273146 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002233_CHEBI_15554_R-HSA-265295_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002233_CHEBI_15554_R-HSA-265295_Reactome_R-HSA-265295> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-265295> ;
@@ -5705,7 +5705,7 @@ _:t308262 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308263 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002233_CHEBI_15377_R-HSA-111883_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002233_CHEBI_15377_R-HSA-111883_Reactome_R-HSA-111995> ;
+_:t2273147 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002233_CHEBI_15377_R-HSA-111883_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002233_CHEBI_15377_R-HSA-111883_Reactome_R-HSA-111995> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-111883> ;
@@ -5715,7 +5715,7 @@ _:t308263 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308264 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_27647_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_27647_R-HSA-140359_Reactome_R-HSA-2162123> ;
+_:t2273148 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_27647_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002233_CHEBI_27647_R-HSA-140359_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -5725,7 +5725,7 @@ _:t308264 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308265 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002234_CHEBI_15551_R-HSA-265295_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002234_CHEBI_15551_R-HSA-265295_Reactome_R-HSA-265295> ;
+_:t2273149 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002234_CHEBI_15551_R-HSA-265295_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002234_CHEBI_15551_R-HSA-265295_Reactome_R-HSA-265295> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-265295> ;
@@ -5735,7 +5735,7 @@ _:t308265 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308266 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002333_R-HSA-8864254_R-HSA-265295_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002333_R-HSA-8864254_R-HSA-265295_controller_Reactome_R-HSA-265295> ;
+_:t2273150 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002333_R-HSA-8864254_R-HSA-265295_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-265295_RO_0002333_R-HSA-8864254_R-HSA-265295_controller_Reactome_R-HSA-265295> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-265295> ;
@@ -5745,7 +5745,7 @@ _:t308266 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308267 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273151 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-443894> ;
@@ -5755,7 +5755,7 @@ _:t308267 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308268 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_BFO_0000066_reaction_R-HSA-443894_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273152 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_BFO_0000066_reaction_R-HSA-443894_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-443894> ;
@@ -5765,7 +5765,7 @@ _:t308268 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308269 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002233_CHEBI_15377_R-HSA-443894_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002233_CHEBI_15377_R-HSA-443894_Reactome_R-HSA-443894> ;
+_:t2273153 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002233_CHEBI_15377_R-HSA-443894_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002233_CHEBI_15377_R-HSA-443894_Reactome_R-HSA-443894> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-443894> ;
@@ -5775,7 +5775,7 @@ _:t308269 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308270 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002233_CHEBI_15627_R-HSA-443894_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002233_CHEBI_15627_R-HSA-443894_Reactome_R-HSA-443894> ;
+_:t2273154 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002233_CHEBI_15627_R-HSA-443894_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002233_CHEBI_15627_R-HSA-443894_Reactome_R-HSA-443894> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-443894> ;
@@ -5785,7 +5785,7 @@ _:t308270 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308271 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002234_CHEBI_28728_R-HSA-443894_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002234_CHEBI_28728_R-HSA-443894_Reactome_R-HSA-443894> ;
+_:t2273155 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002234_CHEBI_28728_R-HSA-443894_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002234_CHEBI_28728_R-HSA-443894_Reactome_R-HSA-443894> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-443894> ;
@@ -5795,7 +5795,7 @@ _:t308271 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308272 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002413_R-HSA-2161732_Reactome_R-HSA-2162123> ;
+_:t2273156 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-443894_RO_0002413_R-HSA-2161732_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-443894> ;
@@ -5806,7 +5806,7 @@ _:t308272 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308273 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273157 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76496> ;
@@ -5816,7 +5816,7 @@ _:t308273 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308274 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_BFO_0000066_reaction_R-HSA-76496_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
+_:t2273158 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_BFO_0000066_reaction_R-HSA-76496_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76496> ;
@@ -5826,7 +5826,7 @@ _:t308274 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308275 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002234_CHEBI_15377_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002234_CHEBI_15377_R-HSA-140359_Reactome_R-HSA-2162123> ;
+_:t2273159 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002234_CHEBI_15377_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002234_CHEBI_15377_R-HSA-140359_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -5836,7 +5836,7 @@ _:t308275 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308276 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002233_CHEBI_15554_R-HSA-76496_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002233_CHEBI_15554_R-HSA-76496_Reactome_R-HSA-76496> ;
+_:t2273160 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002233_CHEBI_15554_R-HSA-76496_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002233_CHEBI_15554_R-HSA-76496_Reactome_R-HSA-76496> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76496> ;
@@ -5846,7 +5846,7 @@ _:t308276 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308277 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002234_CHEBI_15552_R-HSA-76496_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002234_CHEBI_15552_R-HSA-76496_Reactome_R-HSA-76496> ;
+_:t2273161 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002234_CHEBI_15552_R-HSA-76496_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002234_CHEBI_15552_R-HSA-76496_Reactome_R-HSA-76496> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76496> ;
@@ -5856,7 +5856,7 @@ _:t308277 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308278 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002333_R-HSA-3222410_R-HSA-76496_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002333_R-HSA-3222410_R-HSA-76496_controller_Reactome_R-HSA-76496> ;
+_:t2273162 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002333_R-HSA-3222410_R-HSA-76496_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002333_R-HSA-3222410_R-HSA-76496_controller_Reactome_R-HSA-76496> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76496> ;
@@ -5866,7 +5866,7 @@ _:t308278 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308279 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002413_R-HSA-2161619_Reactome_R-HSA-2162123> ;
+_:t2273163 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76496_RO_0002413_R-HSA-2161619_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76496> ;
@@ -5877,7 +5877,7 @@ _:t308279 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308280 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273164 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76500> ;
@@ -5887,7 +5887,7 @@ _:t308280 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308281 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_BFO_0000066_reaction_R-HSA-76500_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
+_:t2273165 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_BFO_0000066_reaction_R-HSA-76500_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76500> ;
@@ -5897,7 +5897,7 @@ _:t308281 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308282 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002233_CHEBI_15554_R-HSA-76500_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002233_CHEBI_15554_R-HSA-76500_Reactome_R-HSA-76500> ;
+_:t2273166 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002233_CHEBI_15554_R-HSA-76500_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002233_CHEBI_15554_R-HSA-76500_Reactome_R-HSA-76500> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76500> ;
@@ -5907,7 +5907,7 @@ _:t308282 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308283 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002234_CHEBI_15627_R-HSA-76500_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002234_CHEBI_15627_R-HSA-76500_Reactome_R-HSA-76500> ;
+_:t2273167 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002234_CHEBI_15627_R-HSA-76500_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002234_CHEBI_15627_R-HSA-76500_Reactome_R-HSA-76500> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76500> ;
@@ -5917,7 +5917,7 @@ _:t308283 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308284 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002333_R-HSA-65976_R-HSA-76500_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002333_R-HSA-65976_R-HSA-76500_controller_Reactome_R-HSA-76500> ;
+_:t2273168 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002333_R-HSA-65976_R-HSA-76500_controller_Reactome_R-HSA-2162123> , <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002333_R-HSA-65976_R-HSA-76500_controller_Reactome_R-HSA-76500> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76500> ;
@@ -5927,7 +5927,7 @@ _:t308284 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308285 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002413_R-HSA-443894_Reactome_R-HSA-2162123> ;
+_:t2273169 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-76500_RO_0002413_R-HSA-443894_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-76500> ;
@@ -5938,7 +5938,7 @@ _:t308285 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308286 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002234_CHEBI_15554_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002234_CHEBI_15554_R-HSA-140359_Reactome_R-HSA-2162123> ;
+_:t2273170 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002234_CHEBI_15554_R-HSA-140359_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002234_CHEBI_15554_R-HSA-140359_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -5948,7 +5948,7 @@ _:t308286 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308287 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_BFO_0000066_reaction_R-HSA-9645220_location_lociGO_0005886_Reactome_R-HSA-2162123> ;
+_:t2273171 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_BFO_0000066_reaction_R-HSA-9645220_location_lociGO_0005886_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9645220> ;
@@ -5958,7 +5958,7 @@ _:t308287 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308288 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002233_CHEBI_15378_R-HSA-9645220_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002233_CHEBI_15378_R-HSA-9645220_Reactome_R-HSA-9645220> ;
+_:t2273172 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002233_CHEBI_15378_R-HSA-9645220_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002233_CHEBI_15378_R-HSA-9645220_Reactome_R-HSA-9645220> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9645220> ;
@@ -5968,7 +5968,7 @@ _:t308288 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308289 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002233_R-ALL-433683_R-HSA-9645220_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002233_R-ALL-433683_R-HSA-9645220_Reactome_R-HSA-9645220> ;
+_:t2273173 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002233_R-ALL-433683_R-HSA-9645220_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002233_R-ALL-433683_R-HSA-9645220_Reactome_R-HSA-9645220> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9645220> ;
@@ -5978,7 +5978,7 @@ _:t308289 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308290 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002234_CHEBI_15378_R-HSA-9645220_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002234_CHEBI_15378_R-HSA-9645220_Reactome_R-HSA-9645220> ;
+_:t2273174 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002234_CHEBI_15378_R-HSA-9645220_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002234_CHEBI_15378_R-HSA-9645220_Reactome_R-HSA-9645220> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9645220> ;
@@ -5988,7 +5988,7 @@ _:t308290 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308291 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002234_R-ALL-433686_R-HSA-9645220_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002234_R-ALL-433686_R-HSA-9645220_Reactome_R-HSA-9645220> ;
+_:t2273175 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002234_R-ALL-433686_R-HSA-9645220_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002234_R-ALL-433686_R-HSA-9645220_Reactome_R-HSA-9645220> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9645220> ;
@@ -5998,7 +5998,7 @@ _:t308291 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308292 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002333_R-HSA-8856534_R-HSA-9645220_controller_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002333_R-HSA-8856534_R-HSA-9645220_controller_Reactome_R-HSA-9645220> ;
+_:t2273176 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002333_R-HSA-8856534_R-HSA-9645220_controller_Reactome_R-HSA-433692> , <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002333_R-HSA-8856534_R-HSA-9645220_controller_Reactome_R-HSA-9645220> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9645220> ;
@@ -6008,7 +6008,7 @@ _:t308292 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308293 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002411_R-HSA-2314678_Reactome_R-HSA-2162123> ;
+_:t2273177 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002411_R-HSA-2314678_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9645220> ;
@@ -6018,7 +6018,7 @@ _:t308293 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308294 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002411_R-HSA-2314686_Reactome_R-HSA-2162123> ;
+_:t2273178 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9645220_RO_0002411_R-HSA-2314686_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9645220> ;
@@ -6028,7 +6028,7 @@ _:t308294 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308295 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_BFO_0000066_reaction_R-HSA-9749583_location_lociGO_0005886_Reactome_R-HSA-2162123> ;
+_:t2273179 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_BFO_0000066_reaction_R-HSA-9749583_location_lociGO_0005886_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749583> ;
@@ -6038,7 +6038,7 @@ _:t308295 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308296 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002233_R-ALL-9749786_R-HSA-9749583_Reactome_R-HSA-9749583> , <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002233_R-ALL-9749786_R-HSA-9749583_Reactome_R-HSA-9749641> ;
+_:t2273180 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002233_R-ALL-9749786_R-HSA-9749583_Reactome_R-HSA-9749583> , <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002233_R-ALL-9749786_R-HSA-9749583_Reactome_R-HSA-9749641> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749583> ;
@@ -6048,7 +6048,7 @@ _:t308296 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308297 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002333_R-HSA-428986_R-HSA-140359_controller_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002333_R-HSA-428986_R-HSA-140359_controller_Reactome_R-HSA-2162123> ;
+_:t2273181 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002333_R-HSA-428986_R-HSA-140359_controller_Reactome_R-HSA-140359> , <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002333_R-HSA-428986_R-HSA-140359_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -6058,7 +6058,7 @@ _:t308297 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308298 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002234_R-ALL-9749576_R-HSA-9749583_Reactome_R-HSA-9749583> , <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002234_R-ALL-9749576_R-HSA-9749583_Reactome_R-HSA-9749641> ;
+_:t2273182 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002234_R-ALL-9749576_R-HSA-9749583_Reactome_R-HSA-9749583> , <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002234_R-ALL-9749576_R-HSA-9749583_Reactome_R-HSA-9749641> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749583> ;
@@ -6068,7 +6068,7 @@ _:t308298 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308299 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002333_R-HSA-561082_R-HSA-9749583_controller_Reactome_R-HSA-9749583> , <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002333_R-HSA-561082_R-HSA-9749583_controller_Reactome_R-HSA-9749641> ;
+_:t2273183 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002333_R-HSA-561082_R-HSA-9749583_controller_Reactome_R-HSA-9749583> , <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002333_R-HSA-561082_R-HSA-9749583_controller_Reactome_R-HSA-9749641> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749583> ;
@@ -6078,7 +6078,7 @@ _:t308299 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308300 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002411_R-HSA-2314678_Reactome_R-HSA-2162123> ;
+_:t2273184 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002411_R-HSA-2314678_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749583> ;
@@ -6088,7 +6088,7 @@ _:t308300 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308301 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002411_R-HSA-2314686_Reactome_R-HSA-2162123> ;
+_:t2273185 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749583_RO_0002411_R-HSA-2314686_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749583> ;
@@ -6098,7 +6098,7 @@ _:t308301 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308302 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_BFO_0000066_reaction_R-HSA-9749607_location_lociGO_0005886_Reactome_R-HSA-2162123> ;
+_:t2273186 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_BFO_0000066_reaction_R-HSA-9749607_location_lociGO_0005886_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749607> ;
@@ -6108,7 +6108,7 @@ _:t308302 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308303 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002233_CHEBI_13719_R-HSA-9749607_Reactome_R-HSA-9749607> , <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002233_CHEBI_13719_R-HSA-9749607_Reactome_R-HSA-9749641> ;
+_:t2273187 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002233_CHEBI_13719_R-HSA-9749607_Reactome_R-HSA-9749607> , <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002233_CHEBI_13719_R-HSA-9749607_Reactome_R-HSA-9749641> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749607> ;
@@ -6118,7 +6118,7 @@ _:t308303 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308304 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002234_CHEBI_13719_R-HSA-9749607_Reactome_R-HSA-9749607> , <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002234_CHEBI_13719_R-HSA-9749607_Reactome_R-HSA-9749641> ;
+_:t2273188 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002234_CHEBI_13719_R-HSA-9749607_Reactome_R-HSA-9749607> , <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002234_CHEBI_13719_R-HSA-9749607_Reactome_R-HSA-9749641> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749607> ;
@@ -6128,7 +6128,7 @@ _:t308304 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308305 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002333_R-HSA-9749603_R-HSA-9749607_controller_Reactome_R-HSA-9749607> , <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002333_R-HSA-9749603_R-HSA-9749607_controller_Reactome_R-HSA-9749641> ;
+_:t2273189 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002333_R-HSA-9749603_R-HSA-9749607_controller_Reactome_R-HSA-9749607> , <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002333_R-HSA-9749603_R-HSA-9749607_controller_Reactome_R-HSA-9749641> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749607> ;
@@ -6138,7 +6138,7 @@ _:t308305 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308306 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002411_R-HSA-2314678_Reactome_R-HSA-2162123> ;
+_:t2273190 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002411_R-HSA-2314678_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749607> ;
@@ -6148,7 +6148,7 @@ _:t308306 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308307 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002411_R-HSA-2314686_Reactome_R-HSA-2162123> ;
+_:t2273191 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-9749607_RO_0002411_R-HSA-2314686_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-9749607> ;
@@ -6158,7 +6158,7 @@ _:t308307 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308308 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002411_R-HSA-2299725_Reactome_R-HSA-2162123> ;
+_:t2273192 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002411_R-HSA-2299725_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -6168,7 +6168,7 @@ _:t308308 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308309 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002413_R-HSA-2161613_Reactome_R-HSA-2162123> ;
+_:t2273193 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002413_R-HSA-2161613_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -6179,7 +6179,7 @@ _:t308309 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308310 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002413_R-HSA-2161620_Reactome_R-HSA-2162123> ;
+_:t2273194 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002413_R-HSA-2161620_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -6190,7 +6190,7 @@ _:t308310 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308311 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002413_R-HSA-76496_Reactome_R-HSA-2162123> ;
+_:t2273195 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002413_R-HSA-76496_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -6201,7 +6201,7 @@ _:t308311 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308312 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002413_R-HSA-76500_Reactome_R-HSA-2162123> ;
+_:t2273196 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140359_RO_0002413_R-HSA-76500_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140359> ;
@@ -6212,7 +6212,7 @@ _:t308312 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308313 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273197 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161549> ;
@@ -6222,7 +6222,7 @@ _:t308313 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308314 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002233_CHEBI_57643_R-HSA-111883_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002233_CHEBI_57643_R-HSA-111883_Reactome_R-HSA-111995> ;
+_:t2273198 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002233_CHEBI_57643_R-HSA-111883_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002233_CHEBI_57643_R-HSA-111883_Reactome_R-HSA-111995> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-111883> ;
@@ -6232,7 +6232,7 @@ _:t308314 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308315 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_BFO_0000066_reaction_R-HSA-2161549_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273199 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_BFO_0000066_reaction_R-HSA-2161549_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161549> ;
@@ -6242,7 +6242,7 @@ _:t308315 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308316 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_15378_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_15378_R-HSA-2161549_Reactome_R-HSA-2162123> ;
+_:t2273200 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_15378_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_15378_R-HSA-2161549_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161549> ;
@@ -6252,7 +6252,7 @@ _:t308316 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308317 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_15554_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_15554_R-HSA-2161549_Reactome_R-HSA-2162123> ;
+_:t2273201 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_15554_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_15554_R-HSA-2161549_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161549> ;
@@ -6262,7 +6262,7 @@ _:t308317 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308318 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_57783_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_57783_R-HSA-2161549_Reactome_R-HSA-2162123> ;
+_:t2273202 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_57783_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002233_CHEBI_57783_R-HSA-2161549_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161549> ;
@@ -6272,7 +6272,7 @@ _:t308318 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308319 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002234_CHEBI_15553_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002234_CHEBI_15553_R-HSA-2161549_Reactome_R-HSA-2162123> ;
+_:t2273203 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002234_CHEBI_15553_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002234_CHEBI_15553_R-HSA-2161549_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161549> ;
@@ -6282,7 +6282,7 @@ _:t308319 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308320 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002234_CHEBI_58349_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002234_CHEBI_58349_R-HSA-2161549_Reactome_R-HSA-2162123> ;
+_:t2273204 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002234_CHEBI_58349_R-HSA-2161549_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002234_CHEBI_58349_R-HSA-2161549_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161549> ;
@@ -6292,7 +6292,7 @@ _:t308320 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308321 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002333_R-HSA-2142714_R-HSA-2161549_controller_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002333_R-HSA-2142714_R-HSA-2161549_controller_Reactome_R-HSA-2162123> ;
+_:t2273205 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002333_R-HSA-2142714_R-HSA-2161549_controller_Reactome_R-HSA-2161549> , <http://model.geneontology.org/ev_w_id_R-HSA-2161549_RO_0002333_R-HSA-2142714_R-HSA-2161549_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161549> ;
@@ -6302,7 +6302,7 @@ _:t308321 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308322 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273206 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161563> ;
@@ -6312,7 +6312,7 @@ _:t308322 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308323 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_BFO_0000066_reaction_R-HSA-2161563_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273207 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_BFO_0000066_reaction_R-HSA-2161563_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161563> ;
@@ -6322,7 +6322,7 @@ _:t308323 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308324 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002233_CHEBI_27485_R-HSA-2161563_Reactome_R-HSA-2161563> , <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002233_CHEBI_27485_R-HSA-2161563_Reactome_R-HSA-2162123> ;
+_:t2273208 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002233_CHEBI_27485_R-HSA-2161563_Reactome_R-HSA-2161563> , <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002233_CHEBI_27485_R-HSA-2161563_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161563> ;
@@ -6332,7 +6332,7 @@ _:t308324 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308325 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002234_CHEBI_17504_R-HSA-111883_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002234_CHEBI_17504_R-HSA-111883_Reactome_R-HSA-111995> ;
+_:t2273209 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002234_CHEBI_17504_R-HSA-111883_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002234_CHEBI_17504_R-HSA-111883_Reactome_R-HSA-111995> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-111883> ;
@@ -6342,7 +6342,7 @@ _:t308325 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308326 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002234_CHEBI_28130_R-HSA-2161563_Reactome_R-HSA-2161563> , <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002234_CHEBI_28130_R-HSA-2161563_Reactome_R-HSA-2162123> ;
+_:t2273210 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002234_CHEBI_28130_R-HSA-2161563_Reactome_R-HSA-2161563> , <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002234_CHEBI_28130_R-HSA-2161563_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161563> ;
@@ -6352,7 +6352,7 @@ _:t308326 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308327 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002413_R-HSA-2161588_Reactome_R-HSA-2162123> ;
+_:t2273211 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161563_RO_0002413_R-HSA-2161588_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161563> ;
@@ -6363,7 +6363,7 @@ _:t308327 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308328 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273212 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161588> ;
@@ -6373,7 +6373,7 @@ _:t308328 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308329 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_BFO_0000066_reaction_R-HSA-2161588_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273213 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_BFO_0000066_reaction_R-HSA-2161588_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161588> ;
@@ -6383,7 +6383,7 @@ _:t308329 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308330 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002233_CHEBI_28130_R-HSA-2161588_Reactome_R-HSA-2161588> , <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002233_CHEBI_28130_R-HSA-2161588_Reactome_R-HSA-2162123> ;
+_:t2273214 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002233_CHEBI_28130_R-HSA-2161588_Reactome_R-HSA-2161588> , <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002233_CHEBI_28130_R-HSA-2161588_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161588> ;
@@ -6393,7 +6393,7 @@ _:t308330 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308331 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002234_CHEBI_15377_R-HSA-2161588_Reactome_R-HSA-2161588> , <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002234_CHEBI_15377_R-HSA-2161588_Reactome_R-HSA-2162123> ;
+_:t2273215 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002234_CHEBI_15377_R-HSA-2161588_Reactome_R-HSA-2161588> , <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002234_CHEBI_15377_R-HSA-2161588_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161588> ;
@@ -6403,7 +6403,7 @@ _:t308331 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308332 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002234_CHEBI_34159_R-HSA-2161588_Reactome_R-HSA-2161588> , <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002234_CHEBI_34159_R-HSA-2161588_Reactome_R-HSA-2162123> ;
+_:t2273216 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002234_CHEBI_34159_R-HSA-2161588_Reactome_R-HSA-2161588> , <http://model.geneontology.org/ev_w_id_R-HSA-2161588_RO_0002234_CHEBI_34159_R-HSA-2161588_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161588> ;
@@ -6413,7 +6413,7 @@ _:t308332 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308333 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273217 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161612> ;
@@ -6423,7 +6423,7 @@ _:t308333 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308334 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_BFO_0000066_reaction_R-HSA-2161612_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273218 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_BFO_0000066_reaction_R-HSA-2161612_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161612> ;
@@ -6433,7 +6433,7 @@ _:t308334 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308335 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002233_CHEBI_15554_R-HSA-2161612_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002233_CHEBI_15554_R-HSA-2161612_Reactome_R-HSA-2162123> ;
+_:t2273219 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002233_CHEBI_15554_R-HSA-2161612_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002233_CHEBI_15554_R-HSA-2161612_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161612> ;
@@ -6443,7 +6443,7 @@ _:t308335 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308336 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002234_CHEBI_32395_R-HSA-111883_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002234_CHEBI_32395_R-HSA-111883_Reactome_R-HSA-111995> ;
+_:t2273220 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002234_CHEBI_32395_R-HSA-111883_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002234_CHEBI_32395_R-HSA-111883_Reactome_R-HSA-111995> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-111883> ;
@@ -6453,7 +6453,7 @@ _:t308336 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308337 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002233_CHEBI_15967_R-HSA-2161612_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002233_CHEBI_15967_R-HSA-2161612_Reactome_R-HSA-2162123> ;
+_:t2273221 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002233_CHEBI_15967_R-HSA-2161612_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002233_CHEBI_15967_R-HSA-2161612_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161612> ;
@@ -6463,7 +6463,7 @@ _:t308337 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308338 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002234_CHEBI_15553_R-HSA-2161612_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002234_CHEBI_15553_R-HSA-2161612_Reactome_R-HSA-2162123> ;
+_:t2273222 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002234_CHEBI_15553_R-HSA-2161612_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002234_CHEBI_15553_R-HSA-2161612_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161612> ;
@@ -6473,7 +6473,7 @@ _:t308338 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308339 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002234_CHEBI_18191_R-HSA-2161612_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002234_CHEBI_18191_R-HSA-2161612_Reactome_R-HSA-2162123> ;
+_:t2273223 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002234_CHEBI_18191_R-HSA-2161612_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002234_CHEBI_18191_R-HSA-2161612_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161612> ;
@@ -6483,7 +6483,7 @@ _:t308339 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308340 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002333_R-HSA-2142703_R-HSA-2161612_controller_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002333_R-HSA-2142703_R-HSA-2161612_controller_Reactome_R-HSA-2162123> ;
+_:t2273224 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002333_R-HSA-2142703_R-HSA-2161612_controller_Reactome_R-HSA-2161612> , <http://model.geneontology.org/ev_w_id_R-HSA-2161612_RO_0002333_R-HSA-2142703_R-HSA-2161612_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161612> ;
@@ -6493,7 +6493,7 @@ _:t308340 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308341 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273225 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161613> ;
@@ -6503,7 +6503,7 @@ _:t308341 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308342 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_BFO_0000066_reaction_R-HSA-2161613_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
+_:t2273226 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_BFO_0000066_reaction_R-HSA-2161613_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161613> ;
@@ -6513,7 +6513,7 @@ _:t308342 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308343 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002233_CHEBI_15554_R-HSA-2161613_Reactome_R-HSA-2161613> , <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002233_CHEBI_15554_R-HSA-2161613_Reactome_R-HSA-2162123> ;
+_:t2273227 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002233_CHEBI_15554_R-HSA-2161613_Reactome_R-HSA-2161613> , <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002233_CHEBI_15554_R-HSA-2161613_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161613> ;
@@ -6523,7 +6523,7 @@ _:t308343 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308344 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002234_CHEBI_566274_R-HSA-2161613_Reactome_R-HSA-2161613> , <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002234_CHEBI_566274_R-HSA-2161613_Reactome_R-HSA-2162123> ;
+_:t2273228 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002234_CHEBI_566274_R-HSA-2161613_Reactome_R-HSA-2161613> , <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002234_CHEBI_566274_R-HSA-2161613_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161613> ;
@@ -6533,7 +6533,7 @@ _:t308344 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308345 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002234_CHEBI_63977_R-HSA-2161613_Reactome_R-HSA-2161613> , <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002234_CHEBI_63977_R-HSA-2161613_Reactome_R-HSA-2162123> ;
+_:t2273229 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002234_CHEBI_63977_R-HSA-2161613_Reactome_R-HSA-2161613> , <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002234_CHEBI_63977_R-HSA-2161613_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161613> ;
@@ -6543,7 +6543,7 @@ _:t308345 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308346 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002333_R-HSA-65976_R-HSA-2161613_controller_Reactome_R-HSA-2161613> , <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002333_R-HSA-65976_R-HSA-2161613_controller_Reactome_R-HSA-2162123> ;
+_:t2273230 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002333_R-HSA-65976_R-HSA-2161613_controller_Reactome_R-HSA-2161613> , <http://model.geneontology.org/ev_w_id_R-HSA-2161613_RO_0002333_R-HSA-65976_R-HSA-2161613_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161613> ;
@@ -6553,7 +6553,7 @@ _:t308346 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308347 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002333_R-HSA-111860_R-HSA-111883_controller_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002333_R-HSA-111860_R-HSA-111883_controller_Reactome_R-HSA-111995> ;
+_:t2273231 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002333_R-HSA-111860_R-HSA-111883_controller_Reactome_R-HSA-111883> , <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002333_R-HSA-111860_R-HSA-111883_controller_Reactome_R-HSA-111995> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-111883> ;
@@ -6563,7 +6563,7 @@ _:t308347 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308348 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273232 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161614> ;
@@ -6573,7 +6573,7 @@ _:t308348 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308349 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_BFO_0000066_reaction_R-HSA-2161614_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273233 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_BFO_0000066_reaction_R-HSA-2161614_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161614> ;
@@ -6583,7 +6583,7 @@ _:t308349 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308350 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_15378_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_15378_R-HSA-2161614_Reactome_R-HSA-2162123> ;
+_:t2273234 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_15378_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_15378_R-HSA-2161614_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161614> ;
@@ -6593,7 +6593,7 @@ _:t308350 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308351 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_15555_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_15555_R-HSA-2161614_Reactome_R-HSA-2162123> ;
+_:t2273235 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_15555_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_15555_R-HSA-2161614_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161614> ;
@@ -6603,7 +6603,7 @@ _:t308351 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308352 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_57783_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_57783_R-HSA-2161614_Reactome_R-HSA-2162123> ;
+_:t2273236 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_57783_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002233_CHEBI_57783_R-HSA-2161614_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161614> ;
@@ -6613,7 +6613,7 @@ _:t308352 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308353 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002234_CHEBI_27595_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002234_CHEBI_27595_R-HSA-2161614_Reactome_R-HSA-2162123> ;
+_:t2273237 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002234_CHEBI_27595_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002234_CHEBI_27595_R-HSA-2161614_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161614> ;
@@ -6623,7 +6623,7 @@ _:t308353 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308354 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002234_CHEBI_58349_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002234_CHEBI_58349_R-HSA-2161614_Reactome_R-HSA-2162123> ;
+_:t2273238 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002234_CHEBI_58349_R-HSA-2161614_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002234_CHEBI_58349_R-HSA-2161614_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161614> ;
@@ -6633,7 +6633,7 @@ _:t308354 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308355 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002333_R-HSA-2142714_R-HSA-2161614_controller_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002333_R-HSA-2142714_R-HSA-2161614_controller_Reactome_R-HSA-2162123> ;
+_:t2273239 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002333_R-HSA-2142714_R-HSA-2161614_controller_Reactome_R-HSA-2161614> , <http://model.geneontology.org/ev_w_id_R-HSA-2161614_RO_0002333_R-HSA-2142714_R-HSA-2161614_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161614> ;
@@ -6643,7 +6643,7 @@ _:t308355 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308356 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273240 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161619> ;
@@ -6653,7 +6653,7 @@ _:t308356 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308357 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_BFO_0000066_reaction_R-HSA-2161619_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
+_:t2273241 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_BFO_0000066_reaction_R-HSA-2161619_location_lociGO_0005788_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161619> ;
@@ -6663,7 +6663,7 @@ _:t308357 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308358 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002411_R-HSA-140355_Reactome_R-HSA-2162123> ;
+_:t2273242 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002411_R-HSA-140355_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-111883> ;
@@ -6673,7 +6673,7 @@ _:t308358 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308359 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002233_CHEBI_15377_R-HSA-2161619_Reactome_R-HSA-2161619> , <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002233_CHEBI_15377_R-HSA-2161619_Reactome_R-HSA-2162123> ;
+_:t2273243 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002233_CHEBI_15377_R-HSA-2161619_Reactome_R-HSA-2161619> , <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002233_CHEBI_15377_R-HSA-2161619_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161619> ;
@@ -6683,7 +6683,7 @@ _:t308359 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308360 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002233_CHEBI_15552_R-HSA-2161619_Reactome_R-HSA-2161619> , <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002233_CHEBI_15552_R-HSA-2161619_Reactome_R-HSA-2162123> ;
+_:t2273244 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002233_CHEBI_15552_R-HSA-2161619_Reactome_R-HSA-2161619> , <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002233_CHEBI_15552_R-HSA-2161619_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161619> ;
@@ -6693,7 +6693,7 @@ _:t308360 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308361 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002234_CHEBI_28158_R-HSA-2161619_Reactome_R-HSA-2161619> , <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002234_CHEBI_28158_R-HSA-2161619_Reactome_R-HSA-2162123> ;
+_:t2273245 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002234_CHEBI_28158_R-HSA-2161619_Reactome_R-HSA-2161619> , <http://model.geneontology.org/ev_w_id_R-HSA-2161619_RO_0002234_CHEBI_28158_R-HSA-2161619_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161619> ;
@@ -6703,7 +6703,7 @@ _:t308361 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308362 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273246 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161620> ;
@@ -6713,7 +6713,7 @@ _:t308362 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308363 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_BFO_0000066_reaction_R-HSA-2161620_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
+_:t2273247 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_BFO_0000066_reaction_R-HSA-2161620_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161620> ;
@@ -6723,7 +6723,7 @@ _:t308363 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308364 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002233_CHEBI_15554_R-HSA-2161620_Reactome_R-HSA-2161620> , <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002233_CHEBI_15554_R-HSA-2161620_Reactome_R-HSA-2162123> ;
+_:t2273248 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002233_CHEBI_15554_R-HSA-2161620_Reactome_R-HSA-2161620> , <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002233_CHEBI_15554_R-HSA-2161620_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161620> ;
@@ -6733,7 +6733,7 @@ _:t308364 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308365 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002234_CHEBI_15555_R-HSA-2161620_Reactome_R-HSA-2161620> , <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002234_CHEBI_15555_R-HSA-2161620_Reactome_R-HSA-2162123> ;
+_:t2273249 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002234_CHEBI_15555_R-HSA-2161620_Reactome_R-HSA-2161620> , <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002234_CHEBI_15555_R-HSA-2161620_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161620> ;
@@ -6743,7 +6743,7 @@ _:t308365 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308366 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002333_R-HSA-2142814_R-HSA-2161620_controller_Reactome_R-HSA-2161620> , <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002333_R-HSA-2142814_R-HSA-2161620_controller_Reactome_R-HSA-2162123> ;
+_:t2273250 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002333_R-HSA-2142814_R-HSA-2161620_controller_Reactome_R-HSA-2161620> , <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002333_R-HSA-2142814_R-HSA-2161620_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161620> ;
@@ -6753,7 +6753,7 @@ _:t308366 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308367 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002413_R-HSA-2161673_Reactome_R-HSA-2162123> ;
+_:t2273251 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002413_R-HSA-2161673_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161620> ;
@@ -6764,7 +6764,7 @@ _:t308367 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308368 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002413_R-HSA-2161733_Reactome_R-HSA-2162123> ;
+_:t2273252 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161620_RO_0002413_R-HSA-2161733_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161620> ;
@@ -6775,7 +6775,7 @@ _:t308368 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308369 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002411_R-HSA-2309787_Reactome_R-HSA-2162123> ;
+_:t2273253 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-111883_RO_0002411_R-HSA-2309787_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-111883> ;
@@ -6785,7 +6785,7 @@ _:t308369 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308370 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273254 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161651> ;
@@ -6795,7 +6795,7 @@ _:t308370 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308371 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_BFO_0000066_reaction_R-HSA-2161651_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273255 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_BFO_0000066_reaction_R-HSA-2161651_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161651> ;
@@ -6805,7 +6805,7 @@ _:t308371 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308372 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_15378_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_15378_R-HSA-2161651_Reactome_R-HSA-2162123> ;
+_:t2273256 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_15378_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_15378_R-HSA-2161651_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161651> ;
@@ -6815,7 +6815,7 @@ _:t308372 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308373 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_15551_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_15551_R-HSA-2161651_Reactome_R-HSA-2162123> ;
+_:t2273257 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_15551_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_15551_R-HSA-2161651_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161651> ;
@@ -6825,7 +6825,7 @@ _:t308373 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308374 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_57783_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_57783_R-HSA-2161651_Reactome_R-HSA-2162123> ;
+_:t2273258 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_57783_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002233_CHEBI_57783_R-HSA-2161651_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161651> ;
@@ -6835,7 +6835,7 @@ _:t308374 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308375 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002234_CHEBI_15553_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002234_CHEBI_15553_R-HSA-2161651_Reactome_R-HSA-2162123> ;
+_:t2273259 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002234_CHEBI_15553_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002234_CHEBI_15553_R-HSA-2161651_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161651> ;
@@ -6845,7 +6845,7 @@ _:t308375 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308376 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002234_CHEBI_58349_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002234_CHEBI_58349_R-HSA-2161651_Reactome_R-HSA-2162123> ;
+_:t2273260 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002234_CHEBI_58349_R-HSA-2161651_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002234_CHEBI_58349_R-HSA-2161651_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161651> ;
@@ -6855,7 +6855,7 @@ _:t308376 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308377 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002333_R-HSA-2142784_R-HSA-2161651_controller_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002333_R-HSA-2142784_R-HSA-2161651_controller_Reactome_R-HSA-2162123> ;
+_:t2273261 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002333_R-HSA-2142784_R-HSA-2161651_controller_Reactome_R-HSA-2161651> , <http://model.geneontology.org/ev_w_id_R-HSA-2161651_RO_0002333_R-HSA-2142784_R-HSA-2161651_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161651> ;
@@ -6865,7 +6865,7 @@ _:t308377 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308378 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273262 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161659> ;
@@ -6875,7 +6875,7 @@ _:t308378 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308379 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_BFO_0000066_reaction_R-HSA-2161659_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
+_:t2273263 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_BFO_0000066_reaction_R-HSA-2161659_location_lociGO_0005829_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161659> ;
@@ -6885,7 +6885,7 @@ _:t308379 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308380 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273264 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-140355_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-140355> ;
@@ -6895,7 +6895,7 @@ _:t308380 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308381 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002233_CHEBI_15551_R-HSA-2161659_Reactome_R-HSA-2161659> , <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002233_CHEBI_15551_R-HSA-2161659_Reactome_R-HSA-2162123> ;
+_:t2273265 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002233_CHEBI_15551_R-HSA-2161659_Reactome_R-HSA-2161659> , <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002233_CHEBI_15551_R-HSA-2161659_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161659> ;
@@ -6905,7 +6905,7 @@ _:t308381 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308382 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002234_CHEBI_15377_R-HSA-2161659_Reactome_R-HSA-2161659> , <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002234_CHEBI_15377_R-HSA-2161659_Reactome_R-HSA-2162123> ;
+_:t2273266 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002234_CHEBI_15377_R-HSA-2161659_Reactome_R-HSA-2161659> , <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002234_CHEBI_15377_R-HSA-2161659_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161659> ;
@@ -6915,7 +6915,7 @@ _:t308382 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308383 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002234_CHEBI_27820_R-HSA-2161659_Reactome_R-HSA-2161659> , <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002234_CHEBI_27820_R-HSA-2161659_Reactome_R-HSA-2162123> ;
+_:t2273267 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002234_CHEBI_27820_R-HSA-2161659_Reactome_R-HSA-2161659> , <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002234_CHEBI_27820_R-HSA-2161659_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161659> ;
@@ -6925,7 +6925,7 @@ _:t308383 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308384 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002413_R-HSA-2161666_Reactome_R-HSA-2162123> ;
+_:t2273268 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161659_RO_0002413_R-HSA-2161666_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161659> ;
@@ -6936,7 +6936,7 @@ _:t308384 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308385 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
+_:t2273269 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_BFO_0000050_R-HSA-2162123/R-HSA-2162123_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000050> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161660> ;
@@ -6946,7 +6946,7 @@ _:t308385 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308386 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_BFO_0000066_reaction_R-HSA-2161660_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
+_:t2273270 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_BFO_0000066_reaction_R-HSA-2161660_location_lociGO_0005789_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161660> ;
@@ -6956,7 +6956,7 @@ _:t308386 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308387 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002233_CHEBI_15554_R-HSA-2161660_Reactome_R-HSA-2161660> , <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002233_CHEBI_15554_R-HSA-2161660_Reactome_R-HSA-2162123> ;
+_:t2273271 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002233_CHEBI_15554_R-HSA-2161660_Reactome_R-HSA-2161660> , <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002233_CHEBI_15554_R-HSA-2161660_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161660> ;
@@ -6966,7 +6966,7 @@ _:t308387 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308388 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002234_CHEBI_15551_R-HSA-2161660_Reactome_R-HSA-2161660> , <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002234_CHEBI_15551_R-HSA-2161660_Reactome_R-HSA-2162123> ;
+_:t2273272 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002234_CHEBI_15551_R-HSA-2161660_Reactome_R-HSA-2161660> , <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002234_CHEBI_15551_R-HSA-2161660_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161660> ;
@@ -6976,7 +6976,7 @@ _:t308388 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308389 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002333_R-HSA-2142686_R-HSA-2161660_controller_Reactome_R-HSA-2161660> , <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002333_R-HSA-2142686_R-HSA-2161660_controller_Reactome_R-HSA-2162123> ;
+_:t2273273 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002333_R-HSA-2142686_R-HSA-2161660_controller_Reactome_R-HSA-2161660> , <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002333_R-HSA-2142686_R-HSA-2161660_controller_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002333> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161660> ;
@@ -6986,7 +6986,7 @@ _:t308389 <http://geneontology.org/lego/evidence> <http://model.geneontology.org
 	<http://purl.org/dc/elements/1.1/contributor> "GOC:reactome_curators" ;
 	<http://purl.org/dc/elements/1.1/date> "2023-06-21" .
 
-_:t308390 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002413_R-HSA-2161659_Reactome_R-HSA-2162123> ;
+_:t2273274 <http://geneontology.org/lego/evidence> <http://model.geneontology.org/ev_w_id_R-HSA-2161660_RO_0002413_R-HSA-2161659_Reactome_R-HSA-2162123> ;
 	<http://purl.org/pav/providedBy> "https://reactome.org" ;
 	<http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002413> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://model.geneontology.org/R-HSA-2161660> ;