diff --git a/shapes/go-cam-shapes.shex b/shapes/go-cam-shapes.shex
index 47201c5..0737686 100644
--- a/shapes/go-cam-shapes.shex
+++ b/shapes/go-cam-shapes.shex
@@ -193,6 +193,8 @@ PREFIX results_in_remodeling_of: <http://purl.obolibrary.org/obo/RO_0002591>
   part_of: @<BiologicalProcess> *;
   has_input: ( @<ChemicalEntity> OR @<AnatomicalEntity> OR @<ProteinContainingComplex> OR @<Organism> ) *;
   has_output: ( @<ChemicalEntity> OR @<AnatomicalEntity> OR @<ProteinContainingComplex> ) *;
+  has_primary_input: @<ChemicalEntity> *;
+  has_primary_output: @<ChemicalEntity> *;
   occurs_in: @<AnatomicalEntity> {0,1};
   transports_or_maintains_localization_of: ( @<InformationBiomacromolecule> OR @<ProteinContainingComplex> ) *;
   has_target_end_location: @<AnatomicalEntity> {0,1};