chapter_02.md

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default		true	switchboard.png	Chapter 2	Through The Intramolecular Grapevine: Cellular Decision Making Via Allosteric Transcription factors	title title_url external_url description Summary false Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its input-output response. This chapter presents a general theory of allosteric transcriptional regulation using the Monod-Wyman-Changeux model. We rigorously test this model using the ubiquitous simple repression motif in bacteria by first predicting the behavior of strains that span a large range of repressor copy numbers and DNA binding strengths and then constructing and measuring their response.	prev next content url Chapter I chapter_01 content url Chapter III chapter_03	chapter_02	section_01_header section_02_abstract section_03_introduction section_04_model section_05_results section_06_discussion section_07_methods

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