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<title>notes and thoughts on "On protein synthesis" | filfil's readings</title>
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<h1>notes and thoughts on "On protein synthesis"</h1>
<div class="contact">
<p>email: filfilflavor (at} proton (dot} me</p>
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<p>Please feel free to contact me! (I sincerely mean it.) Especially if you have a potential opportunity for me.</p>
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<hr>
<p>"On protein synthesis"</p>
<p>Francis H. C. Crick</p>
<p><i>The Biological Replication of Macromolecules</i>, Symposia of the Society for Experimental Biology, 12 (1958), 138-63. Reprinted paper, unmarked.</p>
<p>26 pages / 15 page PDF</p>
<p><a href="https://wellcomecollection.org/works/z3d5fnyg">https://wellcomecollection.org/works/z3d5fnyg</a></p>
<hr>
<p>interesting quotes:</p>
<p>"I shall also argue that the main function of the genetic material is to control (not necessarily directly) the synthesis of proteins. There is little direct evidence to support this, but to my mind the psychological drive behind this hypothesis is at the moment independent of such evidence." (138)</p>
<p>"It is widely believed (though not by everyone) that the nucleic acids are in some way responsible for the control of protein synthesis, either directly or indirectly. The actual evidence for this is rather meagre." (144)</p>
<p>"My own thinking (and that of many of my colleagues) is based on two general principles, which I call the Sequence Hypothesis and the Central Dogma. The direct evidence for both of them is negligible, but I have found them to be of great help in getting to grips with these very complex problems." (152)</p>
<p>"This aspect of protein synthesis appeals mainly to those with a background in the more sophisticated sciences. Most biochemists, in spite of being rather fascinated by the problem, dislike arguments of this kind. It seems to them unfair to construct theories without adequate experimental facts. Cosmologists, on the other hand, appear to lack such inhibitions." (158)</p>
<p>"This gap between theory and experiment is a great stimulus to the imagination." (161)</p>
<hr>
<p>I. INTRODUCTION (138-139)</p>
<p>The importance of proteins</p>
<p>II. THE PROBLEM (139-144)</p>
<p>Elementary facts about proteins</p>
<p>The nature of protein synthesis</p><p>The essence of the problem</p>
<p>III. RECENT EXPERIMENTAL WORK (144-152)</p>
<p>The role of the nucleic acids</p>
<p>The site of protein synthesis</p>
<p>Microsomal particles and protein synthesis</p>
<p>Activating enzymes</p>
<p><i>In vitro</i> incorporation</p>
<p>RNA turnover and protein synthesis</p>
<p>Summary of experimental work</p>
<p>IV. IDEAS ABOUT PROTEIN SYNTHESIS (152-160)</p>
<p>General principles</p>
<p>The Sequence Hypothesis</p>
<p>The Central Dogma</p>
<p>Some ideas on cytoplasmic protein synthesis</p>
<p>The adaptor hypothesis</p>
<p>The soluble RNA</p>
<p>Subsequent steps</p>
<p>Two types of RNA</p>
<p>The coding problem</p>
<p>V. CONCLUSIONS (160-161)</p>
<p>REFERENCES (161-163)</p>
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