diff --git a/crates/egui/src/containers/combo_box.rs b/crates/egui/src/containers/combo_box.rs
index db5a9e3e8bd..b4c7bbca7d3 100644
--- a/crates/egui/src/containers/combo_box.rs
+++ b/crates/egui/src/containers/combo_box.rs
@@ -270,6 +270,16 @@ impl ComboBox {
         }
         response
     }
+
+    /// Check if the [`ComboBox`] with the given id has its popup menu currently opened.
+    pub fn is_open(ctx: &Context, id: Id) -> bool {
+        ctx.memory(|m| m.is_popup_open(Self::widget_to_popup_id(id)))
+    }
+
+    /// Convert a [`ComboBox`] id to the id used to store it's popup state.
+    fn widget_to_popup_id(widget_id: Id) -> Id {
+        widget_id.with("popup")
+    }
 }
 
 #[allow(clippy::too_many_arguments)]
@@ -282,7 +292,7 @@ fn combo_box_dyn<'c, R>(
     wrap_mode: Option<TextWrapMode>,
     (width, height): (Option<f32>, Option<f32>),
 ) -> InnerResponse<Option<R>> {
-    let popup_id = button_id.with("popup");
+    let popup_id = ComboBox::widget_to_popup_id(button_id);
 
     let is_popup_open = ui.memory(|m| m.is_popup_open(popup_id));
 
diff --git a/crates/egui/src/response.rs b/crates/egui/src/response.rs
index d980bd78eb6..264d53d5983 100644
--- a/crates/egui/src/response.rs
+++ b/crates/egui/src/response.rs
@@ -2,7 +2,8 @@ use std::{any::Any, sync::Arc};
 
 use crate::{
     emath::{Align, Pos2, Rect, Vec2},
-    menu, Context, CursorIcon, Id, LayerId, PointerButton, Sense, Ui, WidgetRect, WidgetText,
+    menu, ComboBox, Context, CursorIcon, Id, LayerId, PointerButton, Sense, Ui, WidgetRect,
+    WidgetText,
 };
 
 // ----------------------------------------------------------------------------
@@ -571,6 +572,10 @@ impl Response {
             return false;
         }
 
+        if ComboBox::is_open(&self.ctx, self.id) {
+            return false; // Don't cover the open ComboBox with a tooltip
+        }
+
         if self.enabled {
             if !self.hovered || !self.ctx.input(|i| i.pointer.has_pointer()) {
                 return false;