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<!DOCTYPE html>
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<title>S24LiRBCFolate - Streamline</title>
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<div class="s24-li-rbc-folate-content">
<div class="s24-li-rbc-folate-nav-bar">
<img
alt="Rectangle1I145"
src="public/external/rectangle1i145-k1uq-200h.png"
class="s24-li-rbc-folate-rectangle1"
/>
<div class="s24-li-rbc-folate-group1">
<img
alt="Ellipse1I145"
src="public/Streamline/logo_1-600w.png"
class="s24-li-rbc-folate-ellipse1"
/>
<span class="s24-li-rbc-folate-text">The Rivers Streamline</span>
</div>
<div class="s24-li-rbc-folate-group3">
<a href="index.html" class="s24-li-rbc-folate-text01">Home</a>
<span class="s24-li-rbc-folate-text02">About</span>
<a
href="https://www.instagram.com/rivers.streamline/"
target="_blank"
rel="noreferrer noopener"
class="s24-li-rbc-folate-text03"
>
<span>Instagram</span>
<br />
<br />
</a>
</div>
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<div class="s24-li-rbc-folate-content1">
<div class="s24-li-rbc-folate-main-content">
<div class="s24-li-rbc-folate-content2">
<div class="s24-li-rbc-folate-oarticle">
<div class="s24-li-rbc-folate-blog-info">
<div class="s24-li-rbc-folate-heading">
<span class="s24-li-rbc-folate-text07">
RBC Folate’s Effect on Cardiovascular Disease
</span>
</div>
<div class="s24-li-rbc-folate-short-info">
<div class="s24-li-rbc-folate-aauthor">
<img
alt="joyce"
src="public/external/imagei2101-pano-200h.png"
class="s24-li-rbc-folate-image"
/>
<span class="s24-li-rbc-folate-text08">
<span>Zimon Li '26</span>
<br />
</span>
</div>
<span class="s24-li-rbc-folate-text11">Spring 2024</span>
</div>
</div>
<img
alt="Image2101"
src="https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcS6zkZ9w_5W6qDKPreF4roYxWz7X8e9T6Ms9vjclo79Aw&s"
loading="lazy"
class="s24-li-rbc-folate-image1"
/>
<div class="s24-li-rbc-folate-para"></div>
<div class="s24-li-rbc-folate-para1">
<span class="s24-li-rbc-folate-text12">
<span></span>
<span class="ArticlequoteRegular">
Cardiovascular disease is one of the world’s top
killers, responsible for around 30% of deaths around the
globe. Understanding what you can do to protect your
heart, as it affects one of the body’s most vital
organs, is essential for a long and happy life.
</span>
</span>
<span class="s24-li-rbc-folate-text15">
<span class="AMainArticleText">
Cardiovascular disease is one of the world’s top
killers, responsible for around 30% of deaths around the
globe. Understanding what you can do to protect your
heart, as it affects one of the body’s most vital
organs, is essential for a long and happy life.
</span>
<br class="s24-li-rbc-folate-text17" />
<br class="AMainArticleText" />
<span class="AMainArticleText">
Cardiovascular disease is the leading cause of death in
many minority groups such as the Hispanic, African
American, and Native American communities.With less
access to healthy food and pharmaceutical places many
minority groups are the victims of vitamin deficiencies
like hypovitaminosis D and calcium deficiency due to
lactose intolerance, which also leads to other vitamins
being deficient. Jim Crow laws and the Housing Act of
1934 contributed to an increased mortality rate by
impeding access to education, proper healthcare, and
proper food. These minority neighborhoods would also be
exposed to pollution with an increased risk for
cardiovascular disease.
</span>
<br class="s24-li-rbc-folate-text20" />
<br class="AMainArticleText" />
<span class="AMainArticleText">
Barriers to treatments or access to healthy foods also
form when it comes to language and immigration which are
the leading causes of unemployment. In addition, stress
is prominent in the majority of service industry jobs
which leads to increased amounts of those with diabetes
and obesity. These are both significant risk factors for
cardiovascular disease.
</span>
<br class="s24-li-rbc-folate-text23" />
<br class="AMainArticleText" />
<span class="AMainArticleText">
Folate is a vitamin that breaks down in your bloodstream
and helps control your homocysteine levels. Homocysteine
controls the contractile strength of your blood vessels.
By consuming more folate your homocysteine levels lower
which means that your blood vessels relax and decrease
the risk of high blood pressure.
</span>
<br class="s24-li-rbc-folate-text26" />
<br />
</span>
</div>
<img
alt="Image2101"
src="https://static.vecteezy.com/system/resources/previews/004/935/458/non_2x/blood-sample-tube-for-rbc-folate-test-to-measures-the-amount-of-folate-in-the-blood-folic-acid-red-blood-cell-folate-concentration-is-considered-the-most-reliable-indicator-of-folate-status-photo.jpg"
loading="lazy"
class="s24-li-rbc-folate-image2"
/>
<span class="s24-li-rbc-folate-text28">
<span class="AMainArticleText">
Aging has a detrimental effect on the heart and arterial
system, leading to an increase in a variety of
cardiovascular diseases (atherosclerosis, hypertension,
myocardial infarction, and stroke). Aging of the blood
vessels results in increased arterial thickening and
stiffness and dysfunctional endothelium (walls of the
arteries). These changes result in increased systolic
pressure (pressure during the contraction of the heart)
and present major risk factors for the development of
cardiovascular diseases such as atherosclerosis,
hypertension and stroke, and atrial fibrillation.
</span>
<br class="s24-li-rbc-folate-text30" />
<br class="AMainArticleText" />
<span class="AMainArticleText">
However, some of these vitamins B12, B9, and B6 are
protective factors in cardiovascular health. Among the
elderly, vitamin B12 deficiency occurs in about 20% of the
population; more than 60% are due to food-cobalamin
malabsorption syndrome. Increased plasma homocysteine
levels due to a lack of folate levels in the bloodstream
have been recognized as an important risk factor for CVD.
Studies demonstrated that a supplement consisting of 5 mg
folic acid and 250 μg vitamin B12 lowered fasting plasma
homocysteine levels by 32% after 12 weeks in patients with
coronary artery disease. Few studies have been conducted
that connect protective factors of B12 and B9 to
cardiovascular disease in the NHANES data set. Connections
between vitamin usage and ethnicities or socioeconomic
status and other demographic factors have been minimally
studied. The purpose of this study is to connect vitamin
usage to cardiovascular disease and how socioeconomic
status, ethnicity, or other demographic factors come into
play.
</span>
<br class="AMainArticleText" />
</span>
<div class="s24-li-rbc-folate-quote">
<span class="s24-li-rbc-folate-text34">
<span class="ArticlequoteRegular">
Folate is a vitamin that breaks down in your bloodstream
and helps control your homocysteine levels.
</span>
<span class="ArticlequoteRegular"></span>
<span class="ArticlequoteRegular"></span>
</span>
</div>
<div class="s24-li-rbc-folate-para2">
<span class="s24-li-rbc-folate-text38">
<span class="AMainArticleText"></span>
<span class="AMainArticleText">
This study aims to explore red blood cell (RBC) folate
levels as an indicator of cardiovascular disease in
multiple demographics of people. Data from the
prospective cohort study of the National Health and
Nutrition Examination Survey (2017-2020) was analyzed.
The association of coronary heart disease (CHD) risk
with RBC folate was estimated using logistic regression,
adjusting for multiple variables such as age, race, sex,
poverty income ratio, smoking status, BMI, and access to
health insurance. A total of 3271 patients with RBC
folate data that fit the data parameters were included.
There was a significant trend between increased RBC
folate levels and decreased risk of CHD disease (p
<0.035). Compared with the lowest quartile of RBC
folate, the multivariable-adjusted odds ratios and 95%
confidence intervals for CHD were 0.68 (95% CI 0.28 -
1.67) for the second quartile, 0.47 (0.16 – 1.37) for
the third quartile, and 0.27 (95% CI 0.09 - 0.85) for
the highest (fourth) quartile. In conclusion, higher
levels of RBC folate are associated with a decreased
risk of CHD in this cohort.
</span>
<br />
<br />
<span>Click to see data from the study</span>
<a
href="https://docs.google.com/document/d/1-BT4SOudIZX6L6tX6Yo5_Qg3EM6F3tRbZRrGMB0bVgE/edit?usp=sharing"
target="_blank"
rel="noreferrer noopener"
class="s24-li-rbc-folate-link"
>
here.
</a>
<br />
<span></span>
</span>
<img
alt="Image2101"
src="https://jcp.bmj.com/content/jclinpath/56/4/313/F1.large.jpg"
class="s24-li-rbc-folate-image3"
/>
</div>
</div>
<div class="s24-li-rbc-folate-oconclusion">
<div class="s24-li-rbc-folate-para3">
<span class="s24-li-rbc-folate-text46">Sources:</span>
<span class="s24-li-rbc-folate-link1">
<span>
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-01977-8#:~:text=Deficiency%20of%20either%20of%20these,3%2C4%2C5%5D.
</span>
<br />
<br />
<span>
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366686/
</span>
<br />
<br />
<span>
https://www.mountsinai.org/health-library/supplement/vitamin-b9-folic-acid#:~:text=B%20complex%20vitamins%2C%20especially%20vitamins,B%20vitamins%20from%20healt
</span>
<br />
<span>hy%20foods.</span>
<br />
<span></span>
<br class="s24-li-rbc-folate-text58" />
<span>
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896895/
</span>
<span></span>
</span>
</div>
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<span class="s24-li-rbc-folate-text77">About</span>
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<span class="s24-li-rbc-folate-text79">
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