diff --git a/pkg/cmd/roachtest/spec/machine_type.go b/pkg/cmd/roachtest/spec/machine_type.go
index 9078d659f349..16510d334eed 100644
--- a/pkg/cmd/roachtest/spec/machine_type.go
+++ b/pkg/cmd/roachtest/spec/machine_type.go
@@ -214,6 +214,7 @@ func SelectGCEMachineType(cpus int, mem MemPerCPU, arch vm.CPUArch) (string, vm.
 // N.B. cpus is expected to be an even number; validation is deferred to a specific cloud provider.
 //
 // See ExampleSelectAzureMachineType for an exhaustive list of selected machine types.
+// TODO: Add Ebsv5 machine type to leverage NVMe
 func SelectAzureMachineType(cpus int, mem MemPerCPU, arch vm.CPUArch) (string, vm.CPUArch, error) {
 	series := "Ddsv5" // 4 GB RAM per CPU
 	selectedArch := vm.ArchAMD64
diff --git a/pkg/roachprod/vm/azure/azure.go b/pkg/roachprod/vm/azure/azure.go
index d1dd4753fb5a..ebb5a615e53e 100644
--- a/pkg/roachprod/vm/azure/azure.go
+++ b/pkg/roachprod/vm/azure/azure.go
@@ -746,7 +746,11 @@ func (p *Provider) createVM(
 		OSInitializedFile:    vm.OSInitializedFile,
 		StartupLogs:          vm.StartupLogs,
 	}
-	if !opts.SSDOpts.UseLocalSSD {
+	useNVMe := MachineSupportsNVMe(providerOpts.MachineType)
+	if useNVMe {
+		startupArgs.DiskControllerNVMe = true
+	}
+	if !opts.SSDOpts.UseLocalSSD && !useNVMe {
 		// We define lun42 explicitly in the data disk request below.
 		lun := 42
 		startupArgs.AttachedDiskLun = &lun
@@ -864,6 +868,10 @@ func (p *Provider) createVM(
 			},
 		},
 	}
+	if useNVMe {
+		machine.VirtualMachineProperties.StorageProfile.DiskControllerType = compute.NVMe
+	}
+
 	if !opts.SSDOpts.UseLocalSSD {
 		caching := compute.CachingTypesNone
 
@@ -1690,3 +1698,25 @@ func MachineFamilyVersionFromMachineType(machineType string) int {
 	}
 	return -1
 }
+
+// MachineSupportsNVMe Azure supports Nvme for E series v5 machine family.
+// OS disk and network disk support nvme. Local storage do not support nvme.
+func MachineSupportsNVMe(machineType string) bool {
+	version := MachineFamilyVersionFromMachineType(machineType)
+	if version == 5 {
+		matches := azureMachineTypes.FindStringSubmatch(machineType)
+		if len(matches) >= 4 {
+			family, features := matches[1], matches[3]
+			// additive features of azure vm are represented by lower case letter
+			// b = Block Storage performance
+			// d = diskful (that is, a local temp disk is present);
+			// s = Premium Storage capable, including possible use of Ultra SSD
+			// https://learn.microsoft.com/en-us/azure/virtual-machines/vm-naming-conventions
+			// example of supported machine types Standard_E2bds_v5, Standard_E2bs_v5
+			if family == "Standard_E" && (features == "bs" || features == "bds") {
+				return true
+			}
+		}
+	}
+	return false
+}
diff --git a/pkg/roachprod/vm/azure/utils.go b/pkg/roachprod/vm/azure/utils.go
index 1147139cbc53..45cbbea85f24 100644
--- a/pkg/roachprod/vm/azure/utils.go
+++ b/pkg/roachprod/vm/azure/utils.go
@@ -27,6 +27,7 @@ type azureStartupArgs struct {
 	DisksInitializedFile string // File to touch when disks are initialized.
 	OSInitializedFile    string // File to touch when OS is initialized.
 	StartupLogs          string // File to redirect startup script output logs.
+	DiskControllerNVMe   bool   // Interface data disk via NVMe
 }
 
 const azureStartupTemplate = `#!/bin/bash
@@ -42,12 +43,13 @@ exec &> >(tee -a {{ .StartupLogs }})
 echo "startup script starting: $(date -u)"
 mount_opts="defaults"
 
-{{if .AttachedDiskLun}}
+devices=()
+{{if .DiskControllerNVMe}}
+# Setup nvme network storage, need to remove nvme OS disk from the device list.
+devices=($(realpath -qe /dev/disk/by-id/nvme-* | grep -v "nvme0n1" | sort -u))
+{{else if .AttachedDiskLun}}
 # Setup network attached storage
 devices=("/dev/disk/azure/scsi1/lun{{.AttachedDiskLun}}")
-{{else}}
-# Setup local storage.
-devices=($(realpath -qe /dev/disk/by-id/nvme-* | sort -u))
 {{end}}
 
 if (( ${#devices[@]} == 0 ));