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Developed by Gavin Rhys Lloyd, Ralf Johannes Maria Weber.

+
+ +
+

Site built with pkgdown 2.0.7.

+
+ +
+ + + + + + + diff --git a/articles/data_analysis_omics_using_the_structtoolbox.html b/articles/data_analysis_omics_using_the_structtoolbox.html new file mode 100644 index 0000000..bc9c86f --- /dev/null +++ b/articles/data_analysis_omics_using_the_structtoolbox.html @@ -0,0 +1,2525 @@ + + + + + + + + +Data analysis of metabolomics and other omics datasets using the structToolbox • structToolbox + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

Data analysis of metabolomics and other omics datasets using the structToolbox

+

Gavin R +Lloyd

+
+ Phenome Centre Birmingham, University of Birmingham, +UK
+
+

Andris +Jankevics

+
+ Phenome Centre Birmingham, University of Birmingham, +UK
+
+

Ralf J +Weber

+
+ Phenome Centre Birmingham, University of Birmingham, +UK
+
+ + + Source: vignettes/data_analysis_omics_using_the_structtoolbox.Rmd +
data_analysis_omics_using_the_structtoolbox.Rmd
+
+ + +
+

Abstract

+

Data (pre-)processing and data analysis of Metabolomics and + other omics datasets using struct and structToolbox, including + univariate/multivariate statistics and machine learning + approaches.

+
+ +
+

Introduction +

+

The ‘structToolbox’ includes an extensive set of data +(pre-)processing and analysis tools for metabolomics and other omics, +with a strong emphasis on statistics and machine learning. The methods +and tools have been implemented using class-based templates available +via the struct (Statistics in R Using Class-based +Templates) package. The aim of this vignette is to introduce the reader +to basic and more advanced structToolbox-based operations and +implementations, such as the use of struct objects, +getting/setting methods/parameters, and building workflows for the +analysis of mass spectrometry (MS) and nuclear magnetic resonance +(NMR)-based Metabolomics and proteomics datasets. The workflows +demonstrated here include a wide range of methods and tools including +pre-processing such as filtering, normalisation and scaling, followed by +univariate and/or multivariate statistics, and machine learning +approaches.

+
+
+

Getting started +

+

The latest version of structToolbox compatible with your +current R version can be installed using BiocManager.

+
+# install BiocManager if not present
+if (!requireNamespace("BiocManager", quietly = TRUE))
+    install.packages("BiocManager")
+
+# install structToolbox and dependencies
+BiocManager::install("structToolbox")
+

A number of additional packages are needed for this vignette.

+
+## install additional bioc packages for vignette if needed
+#BiocManager::install(c('pmp', 'ropls', 'BiocFileCache'))
+
+## install additional CRAN packages if needed
+#install.packages(c('cowplot', 'openxlsx'))
+
+suppressPackageStartupMessages({
+    # Bioconductor packages
+    library(structToolbox)
+    library(pmp)
+    library(ropls)
+    library(BiocFileCache)
+  
+    # CRAN libraries
+    library(ggplot2)
+    library(gridExtra)
+    library(cowplot)
+    library(openxlsx)
+})
+
+
+# use the BiocFileCache
+bfc <- BiocFileCache(ask = FALSE)
+
+
+

Introduction to struct objects, including models, model +sequences, model charts and ontology. +

+
+

Introduction +

+

PCA (Principal Component Analysis) and PLS (Partial Least Squares) +are commonly applied methods for exploring and analysing multivariate +datasets. Here we use these two statistical methods to demonstrate the +different types of struct (STatistics in R Using Class +Templates) objects that are available as part of the +structToolbox and how these objects (i.e. class templates) +can be used to conduct unsupervised and supervised multivariate +statistical analysis.

+
+
+

Dataset +

+

For demonstration purposes we will use the “Iris” dataset. This +famous (Fisher’s or Anderson’s) dataset contains measurements of sepal +length and width and petal length and width, in centimeters, for 50 +flowers from each of 3 class of Iris. The class are Iris setosa, +versicolor, and virginica. See here (https://stat.ethz.ch/R-manual/R-devel/library/datasets/html/iris.html) +for more information.

+

Note: this vignette is also compatible with the Direct infusion mass +spectrometry metabolomics “benchmark” dataset described in Kirwan et +al., Sci Data 1, 140012 (2014) (https://doi.org/10.1038/sdata.2014.12).

+

Both datasets are available as part of the structToolbox package and +already prepared as a DatasetExperiment object.

+
+## Iris dataset (comment if using MTBLS79 benchmark data)
+D = iris_DatasetExperiment()
+D$sample_meta$class = D$sample_meta$Species
+
+## MTBLS (comment if using Iris data)
+# D = MTBLS79_DatasetExperiment(filtered=TRUE)
+# M = pqn_norm(qc_label='QC',factor_name='sample_type') + 
+#   knn_impute(neighbours=5) +
+#   glog_transform(qc_label='QC',factor_name='sample_type') +
+#   filter_smeta(mode='exclude',levels='QC',factor_name='sample_type')
+# M = model_apply(M,D)
+# D = predicted(M)
+
+# show info
+D
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          Fisher's Iris dataset
+## description:   This famous (Fisher's or Anderson's) iris data set gives the measurements in centimeters of
+##                  the variables sepal length and width and petal length and width,
+##                  respectively, for 50 flowers from each of 3 species of iris. The species are
+##                  Iris setosa, versicolor, and virginica.
+## data:          150 rows x 4 columns
+## sample_meta:   150 rows x 2 columns
+## variable_meta: 4 rows x 1 columns
+
+

DatasetExperiment objects +

+

The DatasetExperiment object is an extension of the +SummarizedExperiment class used by the Bioconductor +community. It contains three main parts:

+
    +
  1. +data A data frame containing the measured data for each +sample.
    2. +
  2. +sample_meta A data frame of additional information +related to the samples e.g. group labels.
    3. +
  3. +variable_meta A data frame of additional information +related to the variables (features) e.g. annotations
    4. +
+

Like all struct objects it also contains +name and description fields (called “slots” is +R language).

+

A key difference between DatasetExperiment and +SummarizedExperiment objects is that the data is +transposed. i.e. for DatasetExperiment objects the samples +are in rows and the features are in columns, while the opposite is true +for SummarizedExperiment objects.

+

All slots are accessible using dollar notation.

+
+# show some data
+head(D$data[,1:4])
+
##   Sepal.Length Sepal.Width Petal.Length Petal.Width
+## 1          5.1         3.5          1.4         0.2
+## 2          4.9         3.0          1.4         0.2
+## 3          4.7         3.2          1.3         0.2
+## 4          4.6         3.1          1.5         0.2
+## 5          5.0         3.6          1.4         0.2
+## 6          5.4         3.9          1.7         0.4
+
+
+
+

Using struct model objects +

+
+

Statistical models +

+

Before we can apply e.g. PCA we first need to create a PCA object. +This object contains all the inputs, outputs and methods needed to apply +PCA. We can set parameters such as the number of components when the PCA +model is created, but we can also use dollar notation to change/view it +later.

+
+P = PCA(number_components=15)
+P$number_components=5
+P$number_components
+
## [1] 5
+

The inputs for a model can be listed using +param_ids(object):

+ +
## [1] "number_components"
+

Or a summary of the object can be printed to the console:

+
+P
+
## A "PCA" object
+## --------------
+## name:          Principal Component Analysis (PCA)
+## description:   PCA is a multivariate data reduction technique. It summarises the data in a smaller number of
+##                  Principal Components that maximise variance.
+## input params:  number_components 
+## outputs:       scores, loadings, eigenvalues, ssx, correlation, that 
+## predicted:     that
+## seq_in:        data
+
+
+

Model sequences +

+

Unless you have good reason not to, it is usually sensible to mean +centre the columns of the data before PCA. Using the STRUCT +framework we can create a model sequence that will mean centre and then +apply PCA to the mean centred data.

+
+M = mean_centre() + PCA(number_components = 4)
+

In structToolbox mean centring and PCA are both model +objects, and joining them using “+” creates a model_sequence object. In +a model_sequence the outputs of the first object (mean centring) are +automatically passed to the inputs of the second object (PCA), which +allows you chain together modelling steps in order to build a +workflow.

+

The objects in the model_sequence can be accessed by indexing, and we +can combine this with dollar notation. For example, the PCA object is +the second object in our sequence and we can access the number of +components as follows:

+
+M[2]$number_components
+
## [1] 4
+
+
+

Training/testing models +

+

Model and model_sequence objects need to be trained using data in the +form of a DatasetExperiment object. For example, the PCA +model sequence we created (M) can be trained using the iris +DatasetExperiment object (‘D’).

+
+M = model_train(M,D)
+

This model sequence has now mean centred the original data and +calculated the PCA scores and loadings.

+

Model objects can be used to generate predictions for test datasets. +For the PCA model sequence this involves mean centring the test data +using the mean of training data, and the projecting the centred test +data onto the PCA model using the loadings. The outputs are all stored +in the model sequence and can be accessed using dollar notation. For +this example we will just use the training data again (sometimes called +autoprediction), which for PCA allows us to explore the training data in +more detail.

+
+M = model_predict(M,D)
+

Sometimes models don’t make use the training/test approach +e.g. univariate statsitics, filtering etc. For these models the +model_apply method can be used instead. For models that do +provide training/test methods, model_apply applies +autoprediction by default i.e. it is a short-cut for applying +model_train and model_predict to the same +data.

+
+M = model_apply(M,D)
+

The available outputs for an object can be listed and accessed like +input params, using dollar notation:

+
+output_ids(M[2])
+
## [1] "scores"      "loadings"    "eigenvalues" "ssx"         "correlation"
+## [6] "that"
+
+M[2]$scores
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          
+## description:   
+## data:          150 rows x 4 columns
+## sample_meta:   150 rows x 2 columns
+## variable_meta: 4 rows x 1 columns
+
+
+

Model charts +

+

The struct framework includes chart objects. Charts +associated with a model object can be listed.

+ +
## [1] "pca_biplot"           "pca_correlation_plot" "pca_dstat_plot"      
+## [4] "pca_loadings_plot"    "pca_scores_plot"      "pca_scree_plot"
+

Like model objects, chart objects need to be created before they can +be used. Here we will plot the PCA scores plot for our mean centred PCA +model.

+
+C = pca_scores_plot(factor_name='class') # colour by class
+chart_plot(C,M[2])
+

+

Note that indexing the PCA model is required because the +pca_scores_plot object requires a PCA object as input, not +a model_sequence.

+

If we make changes to the input parameters of the chart, +chart_plot must be called again to see the effects.

+
+# add petal width to meta data of pca scores
+M[2]$scores$sample_meta$example=D$data[,1]
+# update plot
+C$factor_name='example'
+chart_plot(C,M[2])
+

+

The chart_plot method returns a ggplot object so that +you can easily combine it with other plots using the +gridExtra or cowplot packages for example.

+
+# scores plot
+C1 = pca_scores_plot(factor_name='class') # colour by class
+g1 = chart_plot(C1,M[2])
+
+# scree plot
+C2 = pca_scree_plot()
+g2 = chart_plot(C2,M[2])
+
+# arange in grid
+grid.arrange(grobs=list(g1,g2),nrow=1)
+

+
+
+

Ontology +

+

Within the struct framework (and +structToolbox) an ontology slot is provided to +allow for standardardised definitions for objects and its inputs and +outputs using the Ontology Lookup Service (OLS).

+

For example, STATO is a general purpose STATistics Ontology (http://stato-ontology.org). From the webpage:

+
+

Its aim is to provide coverage for processes such as statistical +tests, their conditions of application, and information needed or +resulting from statistical methods, such as probability distributions, +variables, spread and variation metrics. STATO also covers aspects of +experimental design and description of plots and graphical +representations commonly used to provide visual cues of data +distribution or layout and to assist review of the results.

+
+

The ontology for an object can be set by assigning the ontology term +identifier to the ontology slot of any struct_class object +at design time. The ids can be listed using $ notation:

+
+# create an example PCA object
+P=PCA()
+
+# ontology for the PCA object
+P$ontology
+
## [1] "OBI:0200051"
+

The ontology method can be used obtain more detailed +ontology information. When cache = NULL the +struct package will automatically attempt to use the OLS +API (via the rols package) to obtain a name and description +for the provided identifiers. Here we used cached versions of the +ontology definitions provided in the structToolbox package +to prevent issues connecting to the OLS API when building the +package.

+
+ontology(P,cache = ontology_cache()) # set cache = NULL (default) for online use
+
## [[1]]
+## An object of class "ontology_list"
+## Slot "terms":
+## [[1]]
+## term id:       OBI:0200051
+## ontology:      obi
+## label:         principal components analysis dimensionality reduction
+## description:   A principal components analysis dimensionality reduction is a dimensionality reduction
+##                  achieved by applying principal components analysis and by keeping low-order principal
+##                  components and excluding higher-order ones.
+## iri:           http://purl.obolibrary.org/obo/OBI_0200051
+## 
+## 
+## 
+## [[2]]
+## An object of class "ontology_list"
+## Slot "terms":
+## [[1]]
+## term id:       STATO:0000555
+## ontology:      stato
+## label:         number of predictive components
+## description:   number of predictive components is a count used as input to the principle component analysis
+##                  (PCA)
+## iri:           http://purl.obolibrary.org/obo/STATO_0000555
+

Note that the ontology method returns definitions for +the object (PCA) and the inputs/outputs (number_of_components).

+
+
+
+

Validating supervised statistical models +

+

Validation is an important aspect of chemometric modelling. The +struct framework enables this kind of iterative model +testing through iterator objects.

+
+

Cross-validation +

+

Cross validation is a common technique for assessing the performance +of classification models. For this example we will use a Partial least +squares-discriminant analysis (PLS-DA) model. Data should be mean +centred prior to PLS, so we will build a model sequence first.

+
+M = mean_centre() + PLSDA(number_components=2,factor_name='class')
+M
+
## A model_seq object containing:
+## 
+## [1]
+## A "mean_centre" object
+## ----------------------
+## name:          Mean centre
+## description:   The mean sample is subtracted from all samples in the data matrix. The features in the centred
+##                  matrix all have zero mean.
+## input params:  mode 
+## outputs:       centred, mean_data, mean_sample_meta 
+## predicted:     centred
+## seq_in:        data
+## 
+## [2]
+## A "PLSDA" object
+## ----------------
+## name:          Partial least squares discriminant analysis
+## description:   PLS is a multivariate regression technique that extracts latent variables maximising
+##                  covariance between the input data and the response. The Discriminant Analysis
+##                  variant uses group labels in the response variable. For >2 groups a 1-vs-all
+##                  approach is used. Group membership can be predicted for test samples based on
+##                  a probability estimate of group membership, or the estimated y-value.
+## input params:  number_components, factor_name, pred_method 
+## outputs:       scores, loadings, yhat, design_matrix, y, reg_coeff, probability, vip, pls_model, pred, threshold, sr, sr_pvalue 
+## predicted:     pred
+## seq_in:        data
+

iterator objects like the k-fold cross-validation object +(kfold_xval) can be created just like any other +struct object. Parameters can be set at creation using the +equals sign, and accessed or changed later using dollar notation.

+
+# create object
+XCV = kfold_xval(folds=5,factor_name='class')
+
+# change the number of folds
+XCV$folds=10
+XCV$folds
+
## [1] 10
+

The model to be cross-validated can be set/accessed using the +models method.

+
+models(XCV)=M
+models(XCV)
+
## A model_seq object containing:
+## 
+## [1]
+## A "mean_centre" object
+## ----------------------
+## name:          Mean centre
+## description:   The mean sample is subtracted from all samples in the data matrix. The features in the centred
+##                  matrix all have zero mean.
+## input params:  mode 
+## outputs:       centred, mean_data, mean_sample_meta 
+## predicted:     centred
+## seq_in:        data
+## 
+## [2]
+## A "PLSDA" object
+## ----------------
+## name:          Partial least squares discriminant analysis
+## description:   PLS is a multivariate regression technique that extracts latent variables maximising
+##                  covariance between the input data and the response. The Discriminant Analysis
+##                  variant uses group labels in the response variable. For >2 groups a 1-vs-all
+##                  approach is used. Group membership can be predicted for test samples based on
+##                  a probability estimate of group membership, or the estimated y-value.
+## input params:  number_components, factor_name, pred_method 
+## outputs:       scores, loadings, yhat, design_matrix, y, reg_coeff, probability, vip, pls_model, pred, threshold, sr, sr_pvalue 
+## predicted:     pred
+## seq_in:        data
+

Alternatively, iterators can be combined with models using the +multiplication symbol was shorthand for the models +assignement method:

+
+# cross validation of a mean centred PLSDA model
+XCV = kfold_xval(
+        folds=5,
+        method='venetian',
+        factor_name='class') * 
+      (mean_centre() + PLSDA(factor_name='class'))
+

The run method can be used with any +iterator object. The iterator will then run the set model +or model sequence multiple times.

+

In this case we run cross-validation 5 times, splitting the data into +different training and test sets each time.

+

The run method also needs a metric to be +specified, which is another type of struct object. This +metric may be calculated once after all iterations, or after each +iteration, depending on the iterator type (resampling, permutation etc). +For cross-validation we will calculate “balanced accuracy” after all +iterations.

+
+XCV = run(XCV,D,balanced_accuracy())
+XCV$metric
+
##              metric mean sd
+## 1 balanced_accuracy 0.11 NA
+

Note The balanced_accuracy metric actually reports +1-accuracy, so a value of 0 indicates perfect performance. The standard +deviation “sd” is NA in this example because there is only one +permutation.

+

Like other struct objects, iterators can have chart +objects associated with them. The chart_names function will +list them for an object.

+ +
## [1] "kfoldxcv_grid"   "kfoldxcv_metric"
+

Charts for iterator objects can be plotted in the same +way as charts for any other object.

+
+C = kfoldxcv_grid(
+  factor_name='class',
+  level=levels(D$sample_meta$class)[2]) # first level
+chart_plot(C,XCV)
+

+

It is possible to combine multiple iterators by using the +multiplication symbol. This is equivalent to nesting one iterator inside +the other. For example, we can repeat our cross-validation multiple +times by permuting the sample order.

+
+# permute sample order 10 times and run cross-validation
+P = permute_sample_order(number_of_permutations = 10) * 
+    kfold_xval(folds=5,factor_name='class')*
+    (mean_centre() + PLSDA(factor_name='class',number_components=2))
+P = run(P,D,balanced_accuracy())
+P$metric
+
##              metric   mean          sd
+## 1 balanced_accuracy 0.1095 0.004972145
+
+
+
+
+

A typical workflow for processing and analysing mass +spectrometry-based metabolomics data. +

+
+

Introduction +

+

This vignette provides an overview of a structToolbox +workflow implemented to process (e.g. filter features, signal drift and +batch correction, normalise and missing value imputation) mass +spectrometry data. The workflow exists of methods that are part of the +Peak Matrix Processing (pmp) package, +including a range of additional filters that are described in Kirwan et +al., 2013, +2014.

+

Some packages are required for this vignette in addition +structToolbox:

+
+
+

Dataset +

+

For demonstration purposes we will process and analyse the MTBLS79 +dataset (‘Dataset 7:SFPM’ Kirwan et al., 2014. This dataset +represents a systematic evaluation of the reproducibility of a +multi-batch direct-infusion mass spectrometry (DIMS)-based metabolomics +study of cardiac tissue extracts. It comprises twenty biological samples +(cow vs. sheep) that were analysed repeatedly, in 8 batches across 7 +days, together with a concurrent set of quality control (QC) samples. +Data are presented from each step of the data processing workflow and +are available through MetaboLights (https://www.ebi.ac.uk/metabolights/MTBLS79).

+

The MTBLS79_DatasetExperiment object included in the +structToolbox package is a processed version of the MTBLS79 +dataset available in peak matrix processing (pmp) package. +This vignette describes step by step how the structToolbox +version was created from the pmp version (i.e. ‘Dataset +7:SFPM’ from the Scientific Data publication - https://doi.org/10.1038/sdata.2014.12).

+

The SummarizedExperiment object from the +pmp package needs to be converted to a +DatasetExperiment object for use with +structToolbox.

+
+# the pmp SE object
+SE = MTBLS79
+
+# convert to DE
+DE = as.DatasetExperiment(SE)
+DE$name = 'MTBLS79'
+DE$description = 'Converted from SE provided by the pmp package'
+
+# add a column indicating the order the samples were measured in
+DE$sample_meta$run_order = 1:nrow(DE)
+
+# add a column indicating if the sample is biological or a QC
+Type=as.character(DE$sample_meta$Class)
+Type[Type != 'QC'] = 'Sample'
+DE$sample_meta$Type = factor(Type)
+
+# add a column for plotting batches
+DE$sample_meta$batch_qc = DE$sample_meta$Batch
+DE$sample_meta$batch_qc[DE$sample_meta$Type=='QC']='QC'
+
+# convert to factors
+DE$sample_meta$Batch = factor(DE$sample_meta$Batch)
+DE$sample_meta$Type = factor(DE$sample_meta$Type)
+DE$sample_meta$Class = factor(DE$sample_meta$Class)
+DE$sample_meta$batch_qc = factor(DE$sample_meta$batch_qc)
+
+# print summary
+DE
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          MTBLS79
+## description:   Converted from SE provided by the pmp package
+## data:          172 rows x 2488 columns
+## sample_meta:   172 rows x 7 columns
+## variable_meta: 2488 rows x 0 columns
+

Full processing of the data set requires a number of steps. These +will be applied using a single struct model sequence +(model_seq).

+
+
+

Signal drift and batch correction +

+

A batch correction algorithm is applied to reduce intra- and inter- +batch variations in the dataset. Quality Control-Robust Spline +Correction (QC-RSC) is provided in the pmp package, and it +has been wrapped into a structToolbox object called +sb_corr.

+
+M = # batch correction
+    sb_corr(
+      order_col='run_order',
+      batch_col='Batch', 
+      qc_col='Type', 
+      qc_label='QC',
+      spar_lim = c(0.6,0.8) 
+    )
+
+M = model_apply(M,DE)
+

The figure below shows a plot of a feature vs run order, before and +after the correction. The fitted spline for each batch is shown in grey. +It can be seen that the correction has removed instrument drift within +and between batches.

+
+C = feature_profile(
+      run_order='run_order',
+      qc_label='QC',
+      qc_column='Type',
+      colour_by='batch_qc',
+      feature_to_plot='200.03196',
+      plot_sd=FALSE
+  )
+
+# plot and modify using ggplot2 
+chart_plot(C,M,DE)+ylab('Peak area')+ggtitle('Before')
+

+
+chart_plot(C,predicted(M))+ylab('Peak area')+ggtitle('After')
+

+

An additional step is added to the published workflow to remove any +feature not corrected by QCRCMS. This can occur if there are not enough +measured QC values within a batch. QCRMS in the +pmp package currently returns NA for all samples in the +feature where this occurs. Features where this occurs will be +excluded.

+
+M2 = filter_na_count(
+      threshold=3,
+      factor_name='Batch'
+    )
+M2 = model_apply(M2,predicted(M))
+
+# calculate number of features removed
+nc = ncol(DE) - ncol(predicted(M2))
+
+cat(paste0('Number of features removed: ', nc))
+
## Number of features removed: 425
+

The output of this step is the output of +MTBLS79_DatasetExperiment(filtered=FALSE).

+
+
+

Feature filtering +

+

In the journal article three spectral cleaning steps are applied. In +the first filter a Kruskal-Wallis test is used to identify features not +reliably detected in the QC samples (p < 0.0001) of all batches. We +follow the same parameters as the original article and do not use +multiple test correction (mtc = 'none').

+
+M3 = kw_rank_sum(
+      alpha=0.0001,
+      mtc='none',
+      factor_names='Batch',
+      predicted='significant'
+    ) +
+    filter_by_name(
+      mode='exclude',
+      dimension = 'variable',
+      seq_in = 'names', 
+      names='seq_fcn', # this is a placeholder and will be replaced by seq_fcn
+      seq_fcn=function(x){return(x[,1])}
+    )
+M3 = model_apply(M3, predicted(M2))
+
+nc = ncol(predicted(M2)) - ncol(predicted(M3))
+cat(paste0('Number of features removed: ', nc))
+
## Number of features removed: 262
+

To make use of univariate tests such as kw_rank_sum as a +filter some advanced features of struct are needed. Slots +predicted, and seq_in are used to ensure the +correct output of the univariate test is connected to the correct input +of a feature filter using filter_by_name. Another slot +seq_fcn is used to extract the relevant column of the +predicted output so that it is compatible with the +seq_in input. A placeholder is used for the “names” +parameter (names = 'place_holder') as this input will be +replaced by the output from seq_fcn.

+

The second filter is a Wilcoxon Signed-Rank test. It is used to +identify features that are not representative of the average of the +biological samples (p < 1e-14). Again we make use of +seq_in and seq_fcn.

+
+M4 = wilcox_test(
+      alpha=1e-14,
+      factor_names='Type', 
+      mtc='none', 
+      predicted = 'significant'
+    ) +
+    filter_by_name(
+      mode='exclude',
+      dimension='variable',
+      seq_in='names', 
+      names='place_holder',
+      seq_fcn=function(x){return(x$significant)}
+    )
+M4 = model_apply(M4, predicted(M3))
+
+nc = ncol(predicted(M3)) - ncol(predicted(M4))
+cat(paste0('Number of features removed: ', nc))
+
## Number of features removed: 169
+

Finally, an RSD filter is used to remove features with high +analytical variation (QC RSD > 20 removed)

+
+M5 = rsd_filter(
+     rsd_threshold=20,
+     factor_name='Type'
+)
+M5 = model_apply(M5,predicted(M4))
+
+nc = ncol(predicted(M4)) - ncol(predicted(M5))
+cat(paste0('Number of features removed: ', nc))
+
## Number of features removed: 53
+

The output of this filter is the output of +MTBLS79_DatasetExperiment(filtered=TRUE).

+
+
+

Normalisation, missing value imputation and scaling +

+

We will apply a number of common pre-processing steps to the filtered +peak matrix that are identical to steps applied in are described in +Kirwan et al. 2013, +2014.

+
    +
  • Probabilistic Quotient Normalisation (PQN)
    • +
  • k-nearest neighbours imputation (k = 5)
    • +
  • Generalised log transform (glog)
    • +
+

These steps prepare the data for multivariate analysis by accounting +for sample concentration differences, imputing missing values and +scaling the data.

+
+# peak matrix processing
+M6 = pqn_norm(qc_label='QC',factor_name='Type') + 
+     knn_impute(neighbours=5) +
+     glog_transform(qc_label='QC',factor_name='Type')
+M6 = model_apply(M6,predicted(M5))
+
+
+

Exploratory Analysis +

+

Principal Component Analysis (PCA) can be used to visualise +high-dimensional data. It is an unsupervised method that maximises +variance in a reduced number of latent variables, or principal +components.

+
+# PCA
+M7  = mean_centre() + PCA(number_components = 2)
+
+# apply model sequence to data
+M7 = model_apply(M7,predicted(M6))
+
+# plot pca scores
+C = pca_scores_plot(factor_name=c('Sample_Rep','Class'),ellipse='none')
+chart_plot(C,M7[2]) + coord_fixed() +guides(colour=FALSE)
+
## Warning: The `<scale>` argument of `guides()` cannot be `FALSE`. Use "none" instead as
+## of ggplot2 3.3.4.
+## This warning is displayed once every 8 hours.
+## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
+## generated.
+

+

This plot is very similar to Figure 3b of the original publication link. +Sample replicates are represented by colours and samples groups (C = cow +and S = Sheep) by different shapes.

+

Plotting the scores and colouring by Batch indicates that the +signal/batch correction was effective as all batches are +overlapping.

+
+# chart object
+C = pca_scores_plot(factor_name=c('Batch'),ellipse='none')
+# plot
+chart_plot(C,M7[2]) + coord_fixed()
+

+
+
+
+

Partial Least Squares (PLS) analysis of a untargeted LC-MS-based +clinical metabolomics dataset. +

+
+

Introduction +

+

The aim of this vignette is to demonstrate how to 1) apply and +validate Partial Least Squares (PLS) analysis using the structToolbox, +2) reproduce statistical analysis in Thevenot +et al. (2015) and 3. compare different implementations of PLS.

+
+
+

Dataset +

+

The objective of the original study was to: > …study the influence +of age, body mass index (bmi), and gender on metabolite concentrations +in urine, by analysing 183 samples from a cohort of adults with liquid +chromatography coupled to high-resolution mass spectrometry.

+

Thevenot +et al. (2015)

+

The “Sacurine” dataset needs to be converted to a +DatasetExperiment object. The ropls +package provides the data as a list containing a +dataMatrix, sampleMetadata and +variableMetadata.

+
+data('sacurine',package = 'ropls')
+# the 'sacurine' list should now be available
+
+# move the annotations to a new column and rename the features by index to avoid issues
+# later when data.frames get transposed and names get checked/changed
+sacurine$variableMetadata$annotation=rownames(sacurine$variableMetadata)
+rownames(sacurine$variableMetadata)=1:nrow(sacurine$variableMetadata)
+colnames(sacurine$dataMatrix)=1:ncol(sacurine$dataMatrix)
+
+# create DatasetExperiment
+DE = DatasetExperiment(data = data.frame(sacurine$dataMatrix),
+                       sample_meta = sacurine$sampleMetadata,
+                       variable_meta = sacurine$variableMetadata,
+                       name = 'Sacurine data',
+                       description = 'See ropls package documentation for details')
+
+# print summary
+DE
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          Sacurine data
+## description:   See ropls package documentation for details
+## data:          183 rows x 109 columns
+## sample_meta:   183 rows x 3 columns
+## variable_meta: 109 rows x 4 columns
+
+
+

Data preprocessing +

+

The Sacurine dataset used within this vignette has already been +pre-processed:

+
+

After signal drift and batch effect correction of intensities, each +urine profile was normalized to the osmolality of the sample. Finally, +the data were log10 transformed.

+
+
+
+

Exploratory data analysis +

+

Since the data has already been processed the data can be visualised +using Principal Component Analysis (PCA) without further pre-processing. +The ropls package automatically applies unit variance +scaling (autoscaling) by default. The same approach is applied here.

+
+# prepare model sequence
+M = autoscale() + PCA(number_components = 5)
+# apply model sequence to dataset
+M = model_apply(M,DE)
+
+# pca scores plots
+g=list()
+for (k in colnames(DE$sample_meta)) {
+    C = pca_scores_plot(factor_name = k)
+    g[[k]] = chart_plot(C,M[2])
+}
+# plot using cowplot
+plot_grid(plotlist=g, nrow=1, align='vh', labels=c('A','B','C'))
+

+

The third plot coloured by gender (C) is identical to Figure 2 of the +ropls +package vignette. The structToolbox package provides a +range of PCA-related diagnostic plots, including D-statistic, scree, and +loadings plots. These plots can be used to further explore the variance +of the data.

+
+C = pca_scree_plot()
+g1 = chart_plot(C,M[2])
+
+C = pca_loadings_plot()
+g2 = chart_plot(C,M[2])
+
+C = pca_dstat_plot(alpha=0.95)
+g3 = chart_plot(C,M[2])
+
+p1=plot_grid(plotlist = list(g1,g2),align='h',nrow=1,axis='b')
+p2=plot_grid(plotlist = list(g3),nrow=1)
+plot_grid(p1,p2,nrow=2)
+

+
+
+

Partial Least Squares (PLS) analysis +

+

The ropls package uses its own implementation of the +(O)PLS algorithms. structToolbox uses the pls +package, so it is interesting to compare the outputs from both +approaches. For simplicity only the scores plots are compared.

+
+# prepare model sequence
+M = autoscale() + PLSDA(factor_name='gender')
+M = model_apply(M,DE)
+
+C = pls_scores_plot(factor_name = 'gender')
+chart_plot(C,M[2])
+

+

The plot is similar to fig.3 of the ropls +vignette. Differences are due to inverted LV axes, a common occurrence +with the NIPALS algorithm (used by both structToolbox and +ropls) which depends on how the algorithm is +initialised.

+

To compare the R2 values for the model in structToolbox we have to +use a regression model, instead of a discriminant model. For this we +convert the gender factor to a numeric variable before applying the +model.

+
+# convert gender to numeric
+DE$sample_meta$gender=as.numeric(DE$sample_meta$gender)
+
+# models sequence
+M = autoscale(mode='both') + PLSR(factor_name='gender',number_components=3)
+M = model_apply(M,DE)
+
+# some diagnostic charts
+C = plsr_cook_dist()
+g1 = chart_plot(C,M[2])
+
+C = plsr_prediction_plot()
+g2 = chart_plot(C,M[2])
+
+C = plsr_qq_plot()
+g3 = chart_plot(C,M[2])
+
+C = plsr_residual_hist()
+g4 = chart_plot(C,M[2])
+
+plot_grid(plotlist = list(g1,g2,g3,g4), nrow=2,align='vh')
+

+

The ropls package automatically applies cross-validation +to asses the performance of the PLSDA model. In +structToolbox this is applied separately to give more +control over the approach used if desired. The default cross-validation +used by the ropls package is 7-fold cross-validation and we +replicate that here.

+
+# model sequence
+M = kfold_xval(folds=7, factor_name='gender') * 
+    (autoscale(mode='both') + PLSR(factor_name='gender'))
+M = run(M,DE,r_squared())
+

Training set R2: 0.6975706 0.6798415 0.646671 0.6532914 0.7109769 +0.670777 0.6935344

+

Test set Q2: 0.5460723

+

The validity of the model can further be assessed using permutation +testing. For this we will return to a discriminant model.

+
+# reset gender to original factor
+DE$sample_meta$gender=sacurine$sampleMetadata$gender
+# model sequence
+M = permutation_test(number_of_permutations = 10, factor_name='gender') *
+    kfold_xval(folds=7,factor_name='gender') *
+    (autoscale() + PLSDA(factor_name='gender',number_components = 3))
+M = run(M,DE,balanced_accuracy())
+
+C = permutation_test_plot(style='boxplot')
+chart_plot(C,M)+ylab('1 - balanced accuracy')
+

+

The permuted models have a balanced accuracy of around 50%, which is +to be expected for a dataset with two groups. The unpermuted models have +a balanced accuracy of around 90% and is therefore much better than +might be expected to occur by chance.

+
+
+
+

Univariate and multivariate statistical analysis of a NMR-based +clinical metabolomics dataset. +

+
+

Introduction +

+

The purpose of this vignette is to demonstrate the different +functionalities and methods that are available as part of the +structToolbox and reproduce the data analysis reported in Mendez +et al., (2020) and Chan et al., +(2016).

+
+
+

Dataset +

+

The 1H-NMR dataset used and described in Mendez +et al., (2020) and in this vignette contains processed spectra of +urine samples obtained from gastric cancer and healthy patients Chan et al., +(2016). The experimental raw data is available through Metabolomics +Workbench (PR000699) and +the processed version is available from here +as an Excel data file.

+

As a first step we need to reorganise and convert the Excel data file +into a DatasetExperiment object. Using the openxlsx package +the file can be read directly into an R data.frame and then +manipulated as required.

+
+url = 'https://github.com/CIMCB/MetabWorkflowTutorial/raw/master/GastricCancer_NMR.xlsx'
+
+# read in file directly from github...
+# X=read.xlsx(url)
+
+# ...or use BiocFileCache
+path = bfcrpath(bfc,url)
+
## adding rname 'https://github.com/CIMCB/MetabWorkflowTutorial/raw/master/GastricCancer_NMR.xlsx'
+
+X = read.xlsx(path)
+
+# sample meta data
+SM=X[,1:4]
+rownames(SM)=SM$SampleID
+# convert to factors
+SM$SampleType=factor(SM$SampleType)
+SM$Class=factor(SM$Class)
+# keep a numeric version of class for regression
+SM$Class_num = as.numeric(SM$Class)
+
+## data matrix
+# remove meta data
+X[,1:4]=NULL
+rownames(X)=SM$SampleID
+
+# feature meta data
+VM=data.frame(idx=1:ncol(X))
+rownames(VM)=colnames(X)
+
+# prepare DatasetExperiment
+DE = DatasetExperiment(
+    data=X,
+    sample_meta=SM,
+    variable_meta=VM,
+    description='1H-NMR urinary metabolomic profiling for diagnosis of gastric cancer',
+    name='Gastric cancer (NMR)')
+
+DE
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          Gastric cancer (NMR)
+## description:   1H-NMR urinary metabolomic profiling for diagnosis of gastric cancer
+## data:          140 rows x 149 columns
+## sample_meta:   140 rows x 5 columns
+## variable_meta: 149 rows x 1 columns
+
+
+

Data pre-processing and quality assessment +

+

It is good practice to remove any features that may be of low +quality, and to assess the quality of the data in general. In the +Tutorial features with QC-RSD > 20% and where more than 10% of the +features are missing are retained.

+
+# prepare model sequence
+M = rsd_filter(rsd_threshold=20,qc_label='QC',factor_name='Class') +
+    mv_feature_filter(threshold = 10,method='across',factor_name='Class')
+
+# apply model
+M = model_apply(M,DE)
+
+# get the model output
+filtered = predicted(M)
+
+# summary of filtered data
+filtered
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          Gastric cancer (NMR)
+## description:   1H-NMR urinary metabolomic profiling for diagnosis of gastric cancer
+## data:          140 rows x 53 columns
+## sample_meta:   140 rows x 5 columns
+## variable_meta: 53 rows x 1 columns
+

Note there is an additional feature vs the the processing reported by +Mendez et. al. because the filters here use >= or <= instead of +> and <.

+

After suitable scaling and transformation PCA can be used to assess +data quality. It is expected that the biological variance (samples) will +be larger than the technical variance (QCs). In the workflow that we are +reproducing (link) +the following steps were applied:

+
    +
  • log10 transform
    • +
  • autoscaling (scaled to unit variance)
    • +
  • knn imputation (3 neighbours)
    • +
+

The transformed and scaled matrix in then used as input to PCA. Using +struct we can chain all of these steps into a single model +sequence.

+
+# prepare the model sequence
+M = log_transform(base = 10) +
+    autoscale() + 
+    knn_impute(neighbours = 3) +
+    PCA(number_components = 10)
+
+# apply model sequence to data
+M = model_apply(M,filtered)
+
+# get the transformed, scaled and imputed matrix
+TSI = predicted(M[3])
+
+# scores plot
+C = pca_scores_plot(factor_name = 'SampleType')
+g1 = chart_plot(C,M[4])
+
+# loadings plot
+C = pca_loadings_plot()
+g2 = chart_plot(C,M[4])
+
+plot_grid(g1,g2,align='hv',nrow=1,axis='tblr')
+

+
+
+

Univariate statistics +

+

structToolbox provides a number of objects for ttest, +counting numbers of features etc. For brevity only the ttest is +calculated for comparison with the workflow we are following (link). +The QC samples need to be excluded, and the data reduced to only the GC +and HE groups.

+
+# prepare model
+TT = filter_smeta(mode='include',factor_name='Class',levels=c('GC','HE')) +  
+     ttest(alpha=0.05,mtc='fdr',factor_names='Class')
+
+# apply model
+TT = model_apply(TT,filtered)
+
+# keep the data filtered by group for later
+filtered = predicted(TT[1])
+
+# convert to data frame
+out=as_data_frame(TT[2])
+
+# show first few features
+head(out)
+
##     t_statistic   t_p_value t_significant estimate.mean.GC estimate.mean.HE
+## M4   -3.5392652 0.008421042          TRUE         26.47778         51.73947
+## M5    1.4296604 0.410396437         FALSE        265.11860        169.91500
+## M7    2.7456506 0.051494976         FALSE        118.52558         53.98718
+## M8   -2.1294198 0.178392032         FALSE         54.39535         79.26750
+## M11   0.5106536 0.776939682         FALSE        201.34390        171.27949
+## M14  -1.4786810 0.403091881         FALSE         61.53171         83.90250
+##         lower      upper
+## M4  -39.56162 -10.961769
+## M5  -38.04747 228.454679
+## M7   17.60818 111.468619
+## M8  -48.20069  -1.543611
+## M11 -87.30604 147.434869
+## M14 -52.57754   7.835950
+
+
+

Multivariate statistics and machine learning +

+
+

Training and Test sets +

+

Splitting data into training and test sets is an important aspect of +machine learning. In structToolbox this is implemented +using the split_data object for random subsampling across +the whole dataset, and stratified_split for splitting based +on group sizes, which is the approach used by Mendez et al.

+
+# prepare model
+M = stratified_split(p_train=0.75,factor_name='Class')
+# apply to filtered data
+M = model_apply(M,filtered)
+# get data from object
+train = M$training
+train
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          Gastric cancer (NMR)
+##                (Training set)
+## description:   • 1H-NMR urinary metabolomic profiling for diagnosis of gastric cancer
+##                • A subset of the data has been selected as a training set
+## data:          62 rows x 53 columns
+## sample_meta:   62 rows x 5 columns
+## variable_meta: 53 rows x 1 columns
+
+cat('\n')
+
+test = M$testing
+test
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          Gastric cancer (NMR)
+##                (Testing set)
+## description:   • 1H-NMR urinary metabolomic profiling for diagnosis of gastric cancer
+##                • A subset of the data has been selected as a test set
+## data:          21 rows x 53 columns
+## sample_meta:   21 rows x 5 columns
+## variable_meta: 53 rows x 1 columns
+
+
+

Optimal number of PLS components +

+

In Mendez et al a k-fold cross-validation is used to determine the +optimal number of PLS components. 100 bootstrap iterations are used to +generate confidence intervals. In strucToolbox these are +implemented using “iterator” objects, that can be combined with model +objects. R2 is used as the metric for optimisation, so the +PLSR model in structToolbox will be used. For speed only 10 +bootstrap iterations are used here.

+
+# scale/transform training data
+M = log_transform(base = 10) +
+    autoscale() + 
+    knn_impute(neighbours = 3,by='samples')
+
+# apply model
+M = model_apply(M,train)
+
+# get scaled/transformed training data
+train_st = predicted(M)
+
+# prepare model sequence
+MS = grid_search_1d(
+        param_to_optimise = 'number_components',
+        search_values = as.numeric(c(1:6)),
+        model_index = 2,
+        factor_name = 'Class_num',
+        max_min = 'max') *
+     permute_sample_order(
+        number_of_permutations = 10) *
+     kfold_xval(
+        folds = 5,
+        factor_name = 'Class_num') * 
+     (mean_centre(mode='sample_meta')+
+      PLSR(factor_name='Class_num'))
+
+# run the validation
+MS = struct::run(MS,train_st,r_squared())
+
+#
+C = gs_line()
+chart_plot(C,MS)
+

+

The chart plotted shows Q2, which is comparable with Figure 13 of Mendez +et al . Two components were selected by Mendez et al, so we will use +that here.

+
+
+

PLS model evalutation +

+

To evaluate the model for discriminant analysis in structToolbox the +PLSDA model is appropriate.

+
+# prepare the discriminant model
+P = PLSDA(number_components = 2, factor_name='Class')
+
+# apply the model
+P = model_apply(P,train_st)
+
+# charts
+C = plsda_predicted_plot(factor_name='Class',style='boxplot')
+g1 = chart_plot(C,P)
+
+C = plsda_predicted_plot(factor_name='Class',style='density')
+g2 = chart_plot(C,P)+xlim(c(-2,2))
+
+C = plsda_roc_plot(factor_name='Class')
+g3 = chart_plot(C,P)
+
+plot_grid(g1,g2,g3,align='vh',axis='tblr',nrow=1, labels=c('A','B','C'))
+

+
+# AUC for comparison with Mendez et al
+MET = calculate(AUC(),P$y$Class,P$yhat[,1])
+MET
+
## A "AUC" object
+## --------------
+## name:          Area under ROC curve
+## description:   The area under the ROC curve of a classifier is estimated using the trapezoid method.
+## value:         0.9739583
+

Note that the default cutoff in A and B of the figure above for the +PLS models in structToolbox is 0, because groups are +encoded as +/-1. This has no impact on the overall performance of the +model.

+
+
+

Permutation test +

+

A permutation test can be used to assess how likely the observed +result is to have occurred by chance. In structToolbox +permutation_test is an iterator object that can be combined +with other iterators and models.

+
+# model sequence
+MS = permutation_test(number_of_permutations = 20,factor_name = 'Class_num') * 
+     kfold_xval(folds = 5,factor_name = 'Class_num') *
+     (mean_centre(mode='sample_meta') + PLSR(factor_name='Class_num', number_components = 2))
+
+# run iterator
+MS = struct::run(MS,train_st,r_squared())
+
+# chart
+C = permutation_test_plot(style = 'density') 
+chart_plot(C,MS) + xlim(c(-1,1)) + xlab('R Squared')
+

+

This plot is comparable to the bottom half of Figure 17 in Mendez +et. al.. The unpermuted (true) Q2 values are consistently better +than the permuted (null) models. i.e. the model is reliable.

+
+
+

PLS projection plots +

+

PLS can also be used to visualise the model and interpret the latent +variables.

+
+# prepare the discriminant model
+P = PLSDA(number_components = 2, factor_name='Class')
+
+# apply the model
+P = model_apply(P,train_st)
+
+C = pls_scores_plot(components=c(1,2),factor_name = 'Class')
+chart_plot(C,P)
+

+
+
+

PLS feature importance +

+

Regression coefficients and VIP scores can be used to estimate the +importance of individual features to the PLS model. In Mendez et al +bootstrapping is used to estimate the confidence intervals, but for +brevity here we will skip this.

+
+# prepare chart
+C = pls_vip_plot(ycol = 'HE')
+g1 = chart_plot(C,P)
+
+C = pls_regcoeff_plot(ycol='HE')
+g2 = chart_plot(C,P)
+
+plot_grid(g1,g2,align='hv',axis='tblr',nrow=2)
+

+
+
+
+
+

Classification of Metabolomics Data using Support Vector +Machines. +

+
+

Introduction +

+

The aim of this vignette is to illustrate how to apply SVM analysis +for Classifying Metabolomics data.

+

Support vector Machines (SVM) are a commonly used method in Machine +Learning. For classification tasks they are used to generate a boundary +between groups of samples in the training set. As well as generating +linear boundaries, SVM can be extended to exploit the use of kernels and +generate complex non-linear boundaries between groups if required.

+

For the structToolbox package, SVM functionality +provided by the e1071 package +has been incorporated into a model object. A chart object +(svm_plot_2d) is also available to plot SVM boundaries for +data with two variables.

+
+
+

Dataset +

+

The 1H-NMR dataset used and described in Mendez +et al., (2020) and in this vignette contains processed spectra of +urine samples obtained from gastric cancer and healthy patients Chan et al., +(2016). The raw experimental data is available through Metabolomics +Workbench (PR000699) and +the processed version is available from here +as an Excel data file.

+

For simplicity we will use a pre-processed version of the 1H-NMR +“Gastric cancer” dataset using the structToolbox package. +Details in regards to pre-processing are reported in the +“NMR_clinical_metabolomics” vignette of the `r Biocpkg(“structToolbox”) +package.

+
+# summary of DatasetExperiment object
+DE
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          
+## description:   
+## data:          140 rows x 53 columns
+## sample_meta:   140 rows x 5 columns
+## variable_meta: 53 rows x 1 columns
+

For the purposes of illustrating the effect of SVM parameters on the +boundary between groups, we reduce the data to include only the GC and +HE groups and apply PLS to reduce the data to two components. We then +treat the PLS scores as as a two group dataset with only two +features.

+
+# model sequence and pls model (NB data already centred)
+MS = filter_smeta(mode = 'include', levels = c('GC','HE'), factor_name = 'Class') +
+     PLSDA(factor_name = 'Class',number_components = 2)
+
+# apply PLS model
+MS = model_apply(MS,DE)
+
+# plot the data
+C = pls_scores_plot(factor_name = 'Class')
+chart_plot(C,MS[2])
+

+
+# new DatasetExperiment object from the PLS scores
+DE2 = DatasetExperiment(
+  data = MS[2]$scores$data, 
+  sample_meta = predicted(MS[1])$sample_meta,
+  variable_meta = data.frame('LV'=c(1,2),row.names = colnames(MS[2]$scores)),
+  name = 'Illustrativate SVM dataset',
+  description = 'Generated by applying PLS to the processed Gastric cancer (NMR) dataset'
+)
+
+DE2
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          Illustrativate SVM dataset
+## description:   Generated by applying PLS to the processed Gastric cancer (NMR) dataset
+## data:          83 rows x 2 columns
+## sample_meta:   83 rows x 5 columns
+## variable_meta: 2 rows x 1 columns
+
+
+

Basic SVM model +

+

The simplest SVM model uses a linear kernel. In +structToolbox the SVM model can be used to +train and apply SVM models. A svm_plot_2d chart object is +provided for visualisation of boundaries in two dimensions.

+
+# SVM model
+M = SVM(
+  factor_name = 'Class',
+  kernel = 'linear'
+)
+
+# apply model
+M = model_apply(M,DE2)
+
+# plot boundary
+C = svm_plot_2d(factor_name = 'Class')
+chart_plot(C,M, DE2)
+

+

The SVM boundary is plotted in black, the margins in grey and support +vectors are indicated by grey circles.

+
+
+

SVM cost function +

+

The SVM cost function applies a penalty to samples on the wrong side +of the margins. A high penalty results in a narrow margin and tries to +force more samples to be on the correct side of the boundary. A low +penalty makes for a wider margin and is less strict about samples being +misclassified. The optimal cost to use is data dependent.

+
+# low cost
+M$cost=0.01
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g1=chart_plot(C,M,DE2)
+
+# medium cost
+M$cost=0.05
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g2=chart_plot(C,M,DE2)
+
+# high cost
+M$cost=100
+M=model_apply(M,DE2)
+
+C=svm_plot_2d(factor_name='Species')
+g3=chart_plot(C,M,DE2)
+
+# plot
+prow <- plot_grid(
+  g1 + theme(legend.position="none"),
+  g2 + theme(legend.position="none"),
+  g3 + theme(legend.position="none"),
+  align = 'vh',
+  labels = c("Low cost", "Medium cost", "High cost"),
+  hjust = -1,
+  nrow = 2
+)
+
+legend <- get_legend(
+  # create some space to the left of the legend
+  g1 + guides(color = guide_legend(nrow = 1)) +
+  theme(legend.position = "bottom")
+)
+
+plot_grid(prow, legend, ncol=1, rel_heights = c(1, .1))
+

+
+
+

Kernel functions +

+

A number of different kernels can be used with support vector +machines. For the structToolbox wrapper ‘linear’, +‘polynomial’,‘radial’ and ‘sigmoid’ kernels can be specified. Using +kernels allows the boundary to be more flexible, but often require +additional parameters to be specified. The best kernel to use will vary +depending on the dataset, but a common choice is the radial kernel as it +allows high flexibility with a single parameter.

+
+# set a fixed cost for this comparison
+M$cost=1
+
+# linear kernel
+M$kernel='linear'
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g1=chart_plot(C,M,DE2)
+
+# polynomial kernel
+M$kernel='polynomial'
+M$gamma=1
+M$coef0=0
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g2=chart_plot(C,M,DE2)
+
+# rbf kernel
+M$kernel='radial'
+M$gamma=1
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g3=chart_plot(C,M,DE2)
+
+# sigmoid kernel
+M$kernel='sigmoid'
+M$gamma=1
+M$coef0=0
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g4=chart_plot(C,M,DE2)
+
+# plot
+prow <- plot_grid(
+  g1 + theme(legend.position="none"),
+  g2 + theme(legend.position="none"),
+  g3 + theme(legend.position="none"),
+  g4 + theme(legend.position="none"),
+  align = 'vh',
+  labels = c("Linear", "Polynomial", "Radial","Sigmoid"),
+  hjust = -1,
+  nrow = 2
+)
+legend <- get_legend(
+  # create some space to the left of the legend
+  g1 + guides(color = guide_legend(nrow = 1)) +
+    theme(legend.position = "bottom")
+)
+plot_grid(prow, legend, ncol = 1, rel_heights = c(1, .1))
+

+

The parameters of a kernel can be used to control the complexity of +the boundary. Here I show how the radial kernel parameter “gamma” can be +used to change the complexity of the boundary. In combination with the +cost parameter (which I keep constant here) this allows for highly +flexible boundary models.

+
+# rbf kernel and cost
+M$kernel = 'radial'
+M$cost = 1
+
+# low gamma
+M$gamma=0.01
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g1=chart_plot(C,M,DE2)
+
+# medium gamma
+M$gamma=0.1
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g2=chart_plot(C,M,DE2)
+
+# high gamma
+M$gamma=1
+M=model_apply(M,DE2)
+C=svm_plot_2d(factor_name='Species')
+g3=chart_plot(C,M,DE2)
+
+# plot
+prow <- plot_grid(
+ g1 + theme(legend.position="none"),
+ g2 + theme(legend.position="none"),
+ g3 + theme(legend.position="none"),
+ align = 'vh',
+ labels = c("Low gamma", "Medium gamma", "High gamma"),
+ hjust = -1,
+ nrow = 2
+)
+legend <- get_legend(
+  # create some space to the left of the legend
+  g1 + guides(color = guide_legend(nrow = 1)) +
+  theme(legend.position = "bottom")
+)
+plot_grid(prow, legend, ncol = 1, rel_heights = c(1, .1))
+

+

Note that best practice would be to select the optimal kernel +parameter(s) in combination with the cost parameter (e.g. by 2d grid +search) so that the best combination of both is identified.

+
+
+
+

Exploratory data analysis of LC-MS-based proteomics and metabolomics +datasets (STATegra project) +

+
+

Introduction +

+

The aim of this vignette is to conduct data preprocessing and +exploratory analysis of data from the STATegra project (https://www.nature.com/articles/s41597-019-0202-7). For +demonstration purposes we will focus on the Proteomics and Metabolomics +datasets that are publicly available as part of the STATegra multi-omics +dataset.

+
+

…the STATegra multi-omics dataset combines measurements from up to 10 +different omics technologies applied to the same biological system, +namely the well-studied mouse pre-B-cell differentiation. STATegra +includes high-throughput measurements of chromatin structure, gene +expression, proteomics and metabolomics, and it is complemented with +single-cell data. Gomez-Cabrero +et al

+
+

STATegra includes high-throughput measurements of chromatin +structure, gene expression, proteomics and metabolomics, and it is +complemented with single-cell data.

+
+
+

LC-MS-based proteomics dataset +

+

The LC-MS-based proteomics dataset from the STATegra multi-omics +dataset (see Introduction) can be found on github and must +be extracted from the zip file prior to data analysis.

+
+# path to zip
+zipfile = "https://raw.github.com/STATegraData/STATegraData/master/Script_STATegra_Proteomics.zip"
+
+## retrieve from BiocFileCache
+path = bfcrpath(bfc,zipfile)
+temp = bfccache(bfc)
+
+## ... or download to temp location
+# path = tempfile()
+# temp = tempdir()
+# download.file(zipfile,path)
+
+# unzip
+unzip(path, files = "Proteomics_01_uniprot_canonical_normalized.txt", exdir=temp)
+# read samples
+all_data <-  read.delim(file.path(temp,"Proteomics_01_uniprot_canonical_normalized.txt"), as.is = TRUE, header = TRUE, sep = "\t")
+

The imported data needs to be converted to +DatasetExperiment format for use with +structToolbox.

+
+# extract data matrix
+data = all_data[1:2527,51:86]
+# shorten sample names
+colnames(data) = lapply(colnames(data), function (x) substr(x, 27, nchar(x)))
+# replace 0 with NA
+data[data == 0] <- NA
+# transpose
+data=as.data.frame(t(data))
+
+# prepare sample meta
+SM = lapply(rownames(data),function(x) {
+  s=strsplit(x,'_')[[1]] # split at underscore
+  out=data.frame(
+    'treatment' = s[[1]],
+    'time' = substr(s[[2]],1,nchar(s[[2]])-1) ,    
+    'batch' = substr(s[[3]],6,nchar(s[[3]])),
+    'condition' = substr(x,1,6) # interaction between treatment and time
+  )
+  return(out)
+})
+SM = do.call(rbind,SM)
+rownames(SM)=rownames(data)
+# convert to factors
+SM$treatment=factor(SM$treatment)
+SM$time=ordered(SM$time,c("0","2","6","12","18","24"))
+SM$batch=ordered(SM$batch,c(1,3,4,5,6,7))
+SM$condition=factor(SM$condition)
+
+# variable meta data
+VM = all_data[1:2527,c(1,6,7)]
+rownames(VM)=colnames(data)
+
+# prepare DatasetExperiment
+DS = DatasetExperiment(
+  data = data, 
+  sample_meta = SM, 
+  variable_meta = VM, 
+  name = 'STATegra Proteomics',
+  description = 'downloaded from: https://github.com/STATegraData/STATegraData/'
+)
+DS
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          STATegra Proteomics
+## description:   downloaded from: https://github.com/STATegraData/STATegraData/
+## data:          36 rows x 2527 columns
+## sample_meta:   36 rows x 4 columns
+## variable_meta: 2527 rows x 3 columns
+

A number of Reporter genes were included in the study. We plot two of +them here to illustrate some trends in the data.

+
+# find id of reporters
+Ldha = which(DS$variable_meta$Gene.names=='Ldha')
+Hk2 = which(DS$variable_meta$Gene.names=='Hk2')
+
+# chart object
+C = feature_boxplot(feature_to_plot=Ldha,factor_name='time',label_outliers=FALSE)
+g1=chart_plot(C,DS)+ggtitle('Ldha')+ylab('expression')
+C = feature_boxplot(feature_to_plot=Hk2,factor_name='time',label_outliers=FALSE)
+g2=chart_plot(C,DS)+ggtitle('Hk2')+ylab('expression')
+
+plot_grid(g1,g2,nrow=1,align='vh',axis='tblr')
+

+
+

Data transformation +

+

The data is log2 transformed, then scaled such that the mean of the +medians is equal for all conditions. These steps are available in +structToolbox using log_transform and +mean_of_medians objects.

+
+# prepare model sequence
+M = log_transform(
+  base=2) + 
+  mean_of_medians(
+    factor_name = 'condition')
+# apply model sequence
+M = model_apply(M,DS) 
+
+# get transformed data
+DST = predicted(M)
+

The Reporter genes are plotted again for comparison.

+
+# chart object
+C = feature_boxplot(feature_to_plot=Ldha,factor_name='time',label_outliers=FALSE)
+g1=chart_plot(C,DST)+ggtitle('Ldha')+ylab('log2(expression)')
+C = feature_boxplot(feature_to_plot=Hk2,factor_name='time',label_outliers=FALSE)
+g2=chart_plot(C,DST)+ggtitle('Hk2')+ylab('log2(expression)')
+
+plot_grid(g1,g2,nrow=1,align='vh',axis='tblr')
+

+
+
+

Missing value filtering +

+

Missing value filtering involves removing any feature (gene) where +there are at least 3 missing values per group in at least 11 +samples.

+

This specific filter is not in structToolbox at this +time, but can be achieved by combining filter_na_count and +filter_by_name objects.

+

Specifically, the default output of filter_na_count is +changed to return a matrix of NA counts per class. This output is then +connected to the ‘names’ input of filter_by_names and +converted to TRUE/FALSE using the ‘seq_fcn’ input.

+

The ‘seq_fcn’ function processes the NA counts before they +are used as inputs for filter_by_names. When data is passed +along the model sequence it passes unchanged through the +filter_na_count object becuase the default output has been +changed, so the filter_na_count and +filter_by_name objects are working together as a single +filter.

+
+# build model sequence
+M2 = filter_na_count(
+  threshold=2,
+  factor_name='condition', 
+  predicted='na_count') +    # override the default output
+  filter_by_name(
+    mode='exclude',
+    dimension='variable',
+    names='place_holder',
+    seq_in='names',
+    seq_fcn=function(x) {      # convert NA count pre group to true/false
+      x=x>2                  # more the two missing per group
+      x=rowSums(x)>10        # in more than 10 groups
+      return(x)
+    }
+  )
+# apply to transformed data
+M2 = model_apply(M2,DST)
+
+# get the filtered data
+DSTF = predicted(M2)
+
+
+

Missing value imputation +

+

STATegra uses two imputation methods that are not available as +struct objects, so we create temporary +STATegra_impute objects to do this using some functions +from the struct package.

+

The first imputation method imputes missing values for any treatment +where values are missing for all samples using a “random value below +discovery”. We create a new struct object using +set_struct_obj in the global environment, and a +“method_apply” method that implements the imputation.

+
+# create new imputation object
+set_struct_obj(
+  class_name = 'STATegra_impute1',
+  struct_obj = 'model',
+  params=c(factor_sd='character',factor_name='character'),
+  outputs=c(imputed='DatasetExperiment'),
+  prototype = list(
+    name = 'STATegra imputation 1',
+    description = 'If missing values are present for all one group then they are replaced with min/2 + "random value below discovery".',
+    predicted = 'imputed'
+  ) 
+)
+
+# create method_apply for imputation method 1
+set_obj_method(
+  class_name='STATegra_impute1',
+  method_name='model_apply',
+  definition=function(M,D) {
+    
+    # for each feature count NA within each level
+    na = apply(D$data,2,function(x){
+      tapply(x,D$sample_meta[[M$factor_name]],function(y){
+        sum(is.na(y))
+      })
+    })
+    # count number of samples in each group
+    count=summary(D$sample_meta[[M$factor_name]])
+    # standard deviation of features within levels of factor_sd
+    sd = apply(D$data,2,function(x) {tapply(x,D$sample_meta[[M$factor_sd]],sd,na.rm=TRUE)})
+    sd = median(sd,na.rm=TRUE)
+    
+    # impute or not
+    check=na == matrix(count,nrow=2,ncol=ncol(D)) # all missing in one class
+    
+    # impute matrix
+    mi = D$data
+    for (j in 1:nrow(mi)) {
+      # index of group for this sample
+      g = which(levels(D$sample_meta[[M$factor_name]])==D$sample_meta[[M$factor_name]][j])
+      iv=rnorm(ncol(D),min(D$data[j,],na.rm=TRUE)/2,sd)
+      mi[j,is.na(mi[j,]) & check[g,]] = iv[is.na(mi[j,]) & check[g,]]
+    }
+    D$data = mi
+    M$imputed=D
+    return(M)
+  }
+)
+

The second imputation method replacing missing values in any +condition with exactly 1 missing value with the mean of the values for +that condition. Again we create a new struct object and corresponding +method for the the new object to implement the filter.

+
+# create new imputation object
+set_struct_obj(
+  class_name = 'STATegra_impute2',
+  struct_obj = 'model',
+  params=c(factor_name='character'),
+  outputs=c(imputed='DatasetExperiment'),
+  prototype = list(
+    name = 'STATegra imputation 2',
+    description = 'For those conditions with only 1 NA impute with the mean of the condition.',
+    predicted = 'imputed'
+  ) 
+)
+
+# create method_apply for imputation method 2
+set_obj_method(
+  class_name='STATegra_impute2',
+  method_name='model_apply',
+  definition=function(M,D) {
+    # levels in condition
+    L = levels(D$sample_meta[[M$factor_name]])
+    
+    # for each feature count NA within each level
+    na = apply(D$data,2,function(x){
+      tapply(x,D$sample_meta[[M$factor_name]],function(y){
+        sum(is.na(y))
+      })
+    })
+    
+    # standard deviation of features within levels of factor_sd
+    sd = apply(D$data,2,function(x) {tapply(x,D$sample_meta[[M$factor_name]],sd,na.rm=TRUE)})
+    sd = median(sd,na.rm=TRUE)
+    
+    # impute or not
+    check=na == 1 # only one missing for a condition
+    
+    # index of samples for each condition
+    IDX = list()
+    for (k in L) {
+      IDX[[k]]=which(D$sample_meta[[M$factor_name]]==k)
+    }
+    
+    ## impute
+    # for each feature
+    for (k in 1:ncol(D)) {
+      # for each condition
+      for (j in 1:length(L)) {
+        # if passes test
+        if (check[j,k]) {
+          # mean of samples in group
+          m = mean(D$data[IDX[[j]],k],na.rm=TRUE)
+          # imputed value
+          im = rnorm(1,m,sd)
+          # replace NA with imputed
+          D$data[is.na(D$data[,k]) & D$sample_meta[[M$factor_name]]==L[j],k]=im
+        }
+      }
+    }
+    M$imputed=D
+    return(M)
+  }
+)
+

The new STATegra imputation objects can now be used in model +sequences like any other struct object. A final filter is +added to remove any feature that has missing values after +imputation.

+
+# model sequence
+M3 = STATegra_impute1(factor_name='treatment',factor_sd='condition') +
+     STATegra_impute2(factor_name = 'condition') + 
+     filter_na_count(threshold = 3, factor_name='condition')
+# apply model
+M3 = model_apply(M3,DSTF)
+# get imputed data
+DSTFI = predicted(M3)
+DSTFI
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          STATegra Proteomics
+## description:   downloaded from: https://github.com/STATegraData/STATegraData/
+## data:          36 rows x 864 columns
+## sample_meta:   36 rows x 4 columns
+## variable_meta: 864 rows x 3 columns
+
+
+

Exploratory analysis +

+

It is often useful to visualise the distribution of values across +samples to verify that the transformations/normalisation/filtering etc +have been effective.

+

+

The values are no longer skewed and show an approximately normal +distribution. The boxplots are comparable in width with very few +outliers indicated, so the transformations etc have had an overall +positive effect.

+

PCA is used to provide a graphical representation of the data. For +comparison with the outputs from STATegra a filter is included to reduce +the data to include only the treated samples (IKA)

+
+# model sequence
+P = filter_smeta(mode='include',factor_name='treatment',levels='IKA') +
+    mean_centre() + 
+    PCA(number_components = 2)
+# apply model
+P = model_apply(P,DSTFI)
+
+# scores plots coloured by factors
+g = list()
+for (k in c('batch','time')) {
+  C = pca_scores_plot(factor_name=k,ellipse='none')
+  g[[k]]=chart_plot(C,P[3])
+}
+
+plot_grid(plotlist = g,nrow=1)
+

+

There does not appear to be a strong batch effect. PC1 is dominated +by time point “24” and some potentially outlying points from time points +“2” and “0”.

+
+
+
+

LC-MS-based metabolomics dataset +

+

The LC-MS-based metabolomics dataset from the STATegra multi-omics +dataset (see Introduction) can be found on github and must +be extracted from zip file prior to data analysis.

+
+# path to zip
+zipfile = "https://raw.github.com/STATegraData/STATegraData/master/Script_STATegra_Metabolomics.zip"
+
+## retrieve from BiocFileCache
+path = bfcrpath(bfc,zipfile)
+temp = bfccache(bfc)
+
+## ... or download to temp location
+# path = tempfile()
+# temp = tempdir()
+# download.file(zipfile,path)
+
+# unzip
+unzip(zipfile=path, files = "LC_MS_raw_data.xlsx", exdir=temp)
+
+# read samples
+data <- as.data.frame(read.xlsx(file.path(temp,"LC_MS_raw_data.xlsx"),sheet = 'Data'))
+

The imported data needs to be converted to +DatasetExperiment format for use with +structToolbox.

+
+# extract sample meta data
+SM = data[ ,1:8]
+
+# add coloumn for sample type (QC, blank etc)
+blanks=c(1,2,33,34,65,66)
+QCs=c(3,4,11,18,25,32,35,36,43,50,57,64)
+SM$sample_type='Sample'
+SM$sample_type[blanks]='Blank'
+SM$sample_type[QCs]='QC'
+
+# put qc/blank labels in all factors for plotting later
+SM$biol.batch[SM$sample_type!='Sample']=SM$sample_type[SM$sample_type!='Sample']
+SM$time.point[SM$sample_type!='Sample']=SM$sample_type[SM$sample_type!='Sample']
+SM$condition[SM$sample_type!='Sample']=SM$sample_type[SM$sample_type!='Sample']
+
+# convert to factors
+SM$biol.batch=ordered(SM$biol.batch,c('9','10','11','12','QC','Blank'))
+SM$time.point=ordered(SM$time.point,c('0h','2h','6h','12h','18h','24h','QC','Blank'))
+SM$condition=factor(SM$condition)
+SM$sample_type=factor(SM$sample_type)
+
+# variable meta data
+VM = data.frame('annotation'=colnames(data)[9:ncol(data)])
+
+# raw data
+X = data[,9:ncol(data)]
+# convert 0 to NA
+X[X==0]=NA
+# force to numeric; any non-numerics will become NA
+X=data.frame(lapply(X,as.numeric),check.names = FALSE)
+
+# make sure row/col names match
+rownames(X)=data$label
+rownames(SM)=data$label
+rownames(VM)=colnames(X)
+
+
+# create DatasetExperiment object
+DE = DatasetExperiment(
+  data = X, 
+  sample_meta = SM, 
+  variable_meta = VM, 
+  name = 'STATegra Metabolomics LCMS',
+  description = 'https://www.nature.com/articles/s41597-019-0202-7'
+)
+
+DE
+
## A "DatasetExperiment" object
+## ----------------------------
+## name:          STATegra Metabolomics LCMS
+## description:   https://www.nature.com/articles/s41597-019-0202-7
+## data:          66 rows x 152 columns
+## sample_meta:   66 rows x 9 columns
+## variable_meta: 152 rows x 1 columns
+
+

Data preprocessing +

+

In the STATegra project the LCMS data was combined with GCMS data and +multiblock analysis was conducted. Here only the LCMS will be explored, +so the data will be processed differently in comparison to Gomez-Cabrero +et al. Some basic processing steps will be applied in order to +generate a valid PCA plot from the biological and QC samples.

+
+# prepare model sequence
+MS = filter_smeta(mode = 'include', levels='QC', factor_name = 'sample_type') +
+     knn_impute(neighbours=5) +
+     vec_norm() + 
+     log_transform(base = 10) 
+
+# apply model sequence
+MS = model_apply(MS, DE)
+
## Warning in knnimp(x, k, maxmiss = rowmax, maxp = maxp): 3 rows with more than 50 % entries missing;
+##  mean imputation used for these rows
+
+
+

Exploratory analysis +

+

First we will use PCA to look at the QC samples in order to make an +assessment of the data quality.

+
+# pca model sequence
+M =  mean_centre() +
+     PCA(number_components = 3)
+
+# apply model
+M = model_apply(M,predicted(MS))
+
+
+# PCA scores plot
+C = pca_scores_plot(factor_name = 'sample_type',label_factor = 'order',points_to_label = 'all')
+# plot
+chart_plot(C,M[2])
+

+

The QC labelled “36” is clearly very different to the other QCs. In +STATegra this QC was removed, so we will exclude it here as well. This +corresponds to QC H1. STATegra also excluded QC samples measured +immediately after a blank, which we will also do here.

+
+# prepare model sequence
+MS = filter_smeta(
+      mode = 'include', 
+      levels='QC', 
+      factor_name = 'sample_type') +
+  
+     filter_by_name(
+      mode = 'exclude', 
+      dimension='sample',
+      names = c('1358BZU_0001QC_H1','1358BZU_0001QC_A1','1358BZU_0001QC_G1')) +
+  
+     knn_impute(
+      neighbours=5) +
+  
+     vec_norm() + 
+  
+     log_transform(
+       base = 10) + 
+  
+     mean_centre() +
+  
+     PCA(
+       number_components = 3)
+
+# apply model sequence
+MS = model_apply(MS, DE)
+
## Warning in knnimp(x, k, maxmiss = rowmax, maxp = maxp): 4 rows with more than 50 % entries missing;
+##  mean imputation used for these rows
+
+# PCA scores plot
+C = pca_scores_plot(factor_name = 'sample_type',label_factor = 'order',points_to_label = 'all')
+# plot
+chart_plot(C,MS[7])
+

+

Now we will plot the QC samples in context with the samples. There +are several possible approaches, and we will apply the approach of +applying PCA to the full dataset including the QCs. We will exclude the +blanks as it is likely that they will dominate the plot if not removed. +All samples from batch 12 were excluded from STATegra and we will +replicate that here.

+
+# prepare model sequence
+MS = filter_smeta(
+      mode = 'exclude', 
+      levels='Blank', 
+      factor_name = 'sample_type') +
+  
+     filter_smeta(
+      mode = 'exclude', 
+      levels='12', 
+      factor_name = 'biol.batch') +
+  
+     filter_by_name(
+      mode = 'exclude', 
+      dimension='sample',
+      names = c('1358BZU_0001QC_H1',
+                '1358BZU_0001QC_A1',
+                '1358BZU_0001QC_G1')) +
+  
+     knn_impute(
+      neighbours=5) +
+  
+     vec_norm() + 
+  
+     log_transform(
+       base = 10) + 
+  
+     mean_centre() +
+  
+     PCA(
+       number_components = 3)
+
+# apply model sequence
+MS = model_apply(MS, DE)
+
## Warning in knnimp(x, k, maxmiss = rowmax, maxp = maxp): 2 rows with more than 50 % entries missing;
+##  mean imputation used for these rows
+
+# PCA scores plots
+C = pca_scores_plot(factor_name = 'sample_type')
+# plot
+chart_plot(C,MS[8])
+

+The QCs appear to representative of the samples, but there are strong +clusters in the data, including the QC samples which have no biological +variation. There is likely to be a number of ‘low quality’ features that +should be excluded, so we will do that now, and use more sophisticated +normalisation (PQN) and scaling methods (glog).

+
+MS =  filter_smeta(
+       mode = 'exclude', 
+       levels = '12', 
+       factor_name = 'biol.batch') +
+  
+      filter_by_name(
+       mode = 'exclude', 
+       dimension='sample',
+       names = c('1358BZU_0001QC_H1',
+                 '1358BZU_0001QC_A1',
+                 '1358BZU_0001QC_G1')) +
+
+      blank_filter(
+       fold_change = 20,
+       qc_label = 'QC',
+       factor_name = 'sample_type') +
+
+      filter_smeta(
+       mode='exclude',
+       levels='Blank',
+       factor_name='sample_type') +
+  
+      mv_feature_filter(
+       threshold = 80, 
+       qc_label = 'QC', 
+       factor_name = 'sample_type', 
+       method = 'QC') +
+     
+      mv_feature_filter(
+        threshold = 50, 
+        factor_name = 'sample_type', 
+        method='across') +
+  
+     rsd_filter(
+       rsd_threshold=20, 
+       qc_label='QC',
+       factor_name='sample_type') +
+  
+     mv_sample_filter(
+       mv_threshold = 50) +
+     
+     pqn_norm(
+       qc_label='QC',
+       factor_name='sample_type') +
+     
+     knn_impute(
+       neighbours=5, 
+       by='samples') +
+     
+     glog_transform(
+       qc_label = 'QC',
+       factor_name = 'sample_type') +
+     
+     mean_centre() + 
+     
+     PCA(
+       number_components = 10)
+
+# apply model sequence
+MS = model_apply(MS, DE)
+
+
+# PCA plots using different factors
+g=list()
+for (k in c('order','biol.batch','time.point','condition')) {
+  C = pca_scores_plot(factor_name = k,ellipse='none')
+  # plot
+  g[[k]]=chart_plot(C,MS[length(MS)])
+}
+
+plot_grid(plotlist = g,align='vh',axis='tblr',nrow=2,labels=c('A','B','C','D'))
+

+

We can see now that the QCs are tightly clustered. This indicates +that the biological variance of the remaining high quality features is +much greater than the technical variance represented by the QCs.

+

There does not appear to be a trend by measurement order (A), which +is an important indicator that instrument drift throughout the run is +not a large source of variation in this dataset.

+

There does not appear to be strong clustering related to biological +batch (B).

+

There does not appear to be a strong trend with time (C) but this is +likely to be a more subtle variation and might be masked by other +sources of variance at this stage.

+

There is some clustering related to condition (D) but with +overlap.

+

To further explore any trends with time, we will split the data by +the condition factor and only explore the Ikaros group. Removing the +condition factor variation will potentially make it easier to spot any +more subtle trends. We will extract the glog transformed matrix from the +previous model sequence and continue from there.

+
+# get the glog scaled data
+GL = predicted(MS[11])
+
+# extract the Ikaros group and apply PCA
+IK = filter_smeta(
+      mode='include',
+      factor_name='condition',
+      levels='Ikaros') +
+     mean_centre() + 
+     PCA(number_components = 5)
+
+# apply the model sequence to glog transformed data
+IK = model_apply(IK,GL)
+
+# plot the PCA scores
+C = pca_scores_plot(factor_name='time.point',ellipse = 'sample')
+g1=chart_plot(C,IK[3])
+g2=g1 + scale_color_viridis_d() # add continuous scale colouring
+
+plot_grid(g1,g2,nrow=2,align='vh',axis = 'tblr',labels=c('A','B'))
+

+

Colouring by groups (A) makes the time point trend difficult to see, +but by adding a ggplot continuous colour scale “viridis” +(B) the trend with time along PC1 becomes much clearer.

+
+
+
+
+

Session Info +

+ +
## R version 4.3.1 (2023-06-16)
+## Platform: x86_64-pc-linux-gnu (64-bit)
+## Running under: Ubuntu 22.04.3 LTS
+## 
+## Matrix products: default
+## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+## 
+## locale:
+##  [1] LC_CTYPE=C.UTF-8       LC_NUMERIC=C           LC_TIME=C.UTF-8       
+##  [4] LC_COLLATE=C.UTF-8     LC_MONETARY=C.UTF-8    LC_MESSAGES=C.UTF-8   
+##  [7] LC_PAPER=C.UTF-8       LC_NAME=C              LC_ADDRESS=C          
+## [10] LC_TELEPHONE=C         LC_MEASUREMENT=C.UTF-8 LC_IDENTIFICATION=C   
+## 
+## time zone: UTC
+## tzcode source: system (glibc)
+## 
+## attached base packages:
+## [1] stats     graphics  grDevices utils     datasets  methods   base     
+## 
+## other attached packages:
+##  [1] openxlsx_4.2.5.2     cowplot_1.1.1        gridExtra_2.3       
+##  [4] ggplot2_3.4.4        BiocFileCache_2.8.0  dbplyr_2.3.4        
+##  [7] ropls_1.32.0         pmp_1.12.0           structToolbox_1.13.5
+## [10] struct_1.12.0        BiocStyle_2.28.1    
+## 
+## loaded via a namespace (and not attached):
+##   [1] DBI_1.1.3                   bitops_1.0-7               
+##   [3] MultiDataSet_1.28.0         rlang_1.1.1                
+##   [5] magrittr_2.0.3              e1071_1.7-13               
+##   [7] matrixStats_1.0.0           compiler_4.3.1             
+##   [9] RSQLite_2.3.1               systemfonts_1.0.5          
+##  [11] vctrs_0.6.4                 reshape2_1.4.4             
+##  [13] stringr_1.5.0               pkgconfig_2.0.3            
+##  [15] crayon_1.5.2                fastmap_1.1.1              
+##  [17] XVector_0.40.0              labeling_0.4.3             
+##  [19] utf8_1.2.3                  rmarkdown_2.25             
+##  [21] itertools_0.1-3             ragg_1.2.6                 
+##  [23] bit_4.0.5                   purrr_1.0.2                
+##  [25] xfun_0.40                   MultiAssayExperiment_1.26.0
+##  [27] randomForest_4.7-1.1        zlibbioc_1.46.0            
+##  [29] cachem_1.0.8                GenomeInfoDb_1.36.4        
+##  [31] jsonlite_1.8.7              progress_1.2.2             
+##  [33] blob_1.2.4                  DelayedArray_0.26.7        
+##  [35] prettyunits_1.2.0           parallel_4.3.1             
+##  [37] rols_2.28.0                 R6_2.5.1                   
+##  [39] bslib_0.5.1                 stringi_1.7.12             
+##  [41] limma_3.56.2                GenomicRanges_1.52.1       
+##  [43] jquerylib_0.1.4             Rcpp_1.0.11                
+##  [45] bookdown_0.35               SummarizedExperiment_1.30.2
+##  [47] iterators_1.0.14            knitr_1.44                 
+##  [49] IRanges_2.34.1              Matrix_1.6-1.1             
+##  [51] tidyselect_1.2.0            abind_1.4-5                
+##  [53] yaml_2.3.7                  codetools_0.2-19           
+##  [55] curl_5.1.0                  doRNG_1.8.6                
+##  [57] lattice_0.21-8              tibble_3.2.1               
+##  [59] plyr_1.8.9                  withr_2.5.1                
+##  [61] Biobase_2.60.0              evaluate_0.22              
+##  [63] ontologyIndex_2.11          desc_1.4.2                 
+##  [65] isoband_0.2.7               proxy_0.4-27               
+##  [67] zip_2.3.0                   filelock_1.0.2             
+##  [69] pillar_1.9.0                BiocManager_1.30.22        
+##  [71] MatrixGenerics_1.12.3       rngtools_1.5.2             
+##  [73] foreach_1.5.2               stats4_4.3.1               
+##  [75] generics_0.1.3              rprojroot_2.0.3            
+##  [77] sp_2.1-0                    RCurl_1.98-1.12            
+##  [79] hms_1.1.3                   S4Vectors_0.38.2           
+##  [81] munsell_0.5.0               scales_1.2.1               
+##  [83] calibrate_1.7.7             class_7.3-22               
+##  [85] glue_1.6.2                  tools_4.3.1                
+##  [87] fs_1.6.3                    grid_4.3.1                 
+##  [89] impute_1.74.1               missForest_1.5             
+##  [91] colorspace_2.1-0            GenomeInfoDbData_1.2.10    
+##  [93] cli_3.6.1                   textshaping_0.3.7          
+##  [95] fansi_1.0.5                 viridisLite_0.4.2          
+##  [97] ggthemes_4.2.4              S4Arrays_1.0.6             
+##  [99] dplyr_1.1.3                 pls_2.8-2                  
+## [101] pcaMethods_1.92.0           gtable_0.3.4               
+## [103] sass_0.4.7                  digest_0.6.33              
+## [105] BiocGenerics_0.46.0         farver_2.1.1               
+## [107] memoise_2.0.1               htmltools_0.5.6.1          
+## [109] pkgdown_2.0.7               lifecycle_1.0.3            
+## [111] httr_1.4.7                  qqman_0.1.9                
+## [113] bit64_4.0.5                 MASS_7.3-60
+
+
+
+ + + +
+

+

Developed by Gavin Rhys Lloyd, Ralf Johannes Maria Weber.

+
+ +
+

+

Site built with pkgdown 2.0.7.

+
+ +
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    +
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    Articles

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    +

    All vignettes

    +

    + +
    Data analysis of metabolomics and other omics datasets using the structToolbox
    +
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    + + +
    +

    Developed by Gavin Rhys Lloyd, Ralf Johannes Maria Weber.

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    Site built with pkgdown 2.0.7.

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    + + + + + + + diff --git a/authors.html b/authors.html new file mode 100644 index 0000000..3f752a4 --- /dev/null +++ b/authors.html @@ -0,0 +1,97 @@ + +Authors and Citation • structToolbox + Skip to contents + + +
    +
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    Authors and Citation

    +
    + +
    +

    Authors

    + +
    • +

      Gavin Rhys Lloyd. Author, maintainer. +

      +
      • +
    • +

      Ralf Johannes Maria Weber. Author. +

      +
      • +
    + +
    +

    Citation

    +

    Source: inst/CITATION

    + +

    Lloyd, G., Jankevics, A., and Weber, R. 2020. struct: an R/Bioconductor-based framework for standardized metabolomics data analysis and beyond. Bioinformatics, 36(22-23), p.5551-5552.

    + 
    @Article{,
+  title = {struct: an R/Bioconductor-based framework for standardized metabolomics data analysis and beyond},
+  author = {Gavin Rhys Lloyd and Andris Jankevics and Ralf Johannes Maria Weber},
+  journal = {Bioinformatics},
+  year = {2020},
+  volume = {36},
+  number = {22-23},
+  pages = {5551-5552},
+  url = {https://doi.org/10.1093/bioinformatics/btaa1031},
+}
    +
    +
    + + +
    +

    Developed by Gavin Rhys Lloyd, Ralf Johannes Maria Weber.

    +
    + +
    +

    Site built with pkgdown 2.0.7.

    +
    + +
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J,Z="x"===y?gt:bt,tt="x"===y?mt:_t,et=A[w],it="y"===w?"height":"width",nt=et+m[Z],st=et-m[tt],ot=-1!==[gt,bt].indexOf(_),rt=null!=(J=null==x?void 0:x[w])?J:0,at=ot?nt:et-E[it]-T[it]-rt+O.altAxis,lt=ot?et+E[it]+T[it]-rt-O.altAxis:st,ct=f&&ot?function(t,e,i){var n=ae(t,e,i);return n>i?i:n}(at,et,lt):ae(f?at:nt,et,f?lt:st);A[w]=ct,k[w]=ct-et}e.modifiersData[n]=k}},requiresIfExists:["offset"]};function $e(t,e,i){void 0===i&&(i=!1);var n,s,o=zt(e),r=zt(e)&&function(t){var e=t.getBoundingClientRect(),i=Xt(e.width)/t.offsetWidth||1,n=Xt(e.height)/t.offsetHeight||1;return 1!==i||1!==n}(e),a=ie(e),l=Gt(t,r,i),c={scrollLeft:0,scrollTop:0},h={x:0,y:0};return(o||!o&&!i)&&(("body"!==Wt(e)||Ee(a))&&(c=(n=e)!==Bt(n)&&zt(n)?{scrollLeft:(s=n).scrollLeft,scrollTop:s.scrollTop}:we(n)),zt(e)?((h=Gt(e,!0)).x+=e.clientLeft,h.y+=e.clientTop):a&&(h.x=Ae(a))),{x:l.left+c.scrollLeft-h.x,y:l.top+c.scrollTop-h.y,width:l.width,height:l.height}}function We(t){var e=new Map,i=new Set,n=[];function s(t){i.add(t.name),[].concat(t.requires||[],t.requiresIfExists||[]).forEach((function(t){if(!i.has(t)){var n=e.get(t);n&&s(n)}})),n.push(t)}return t.forEach((function(t){e.set(t.name,t)})),t.forEach((function(t){i.has(t.name)||s(t)})),n}var Be={placement:"bottom",modifiers:[],strategy:"absolute"};function Fe(){for(var t=arguments.length,e=new Array(t),i=0;iNumber.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_getPopperConfig(){const t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return(this._inNavbar||"static"===this._config.display)&&(B.setDataAttribute(this._menu,"popper","static"),t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,..."function"==typeof this._config.popperConfig?this._config.popperConfig(t):this._config.popperConfig}}_selectMenuItem({key:t,target:e}){const i=Q.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter((t=>a(t)));i.length&&b(i,e,t===Ye,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(2===t.button||"keyup"===t.type&&"Tab"!==t.key)return;const e=Q.find(ti);for(const i of e){const e=hi.getInstance(i);if(!e||!1===e._config.autoClose)continue;const n=t.composedPath(),s=n.includes(e._menu);if(n.includes(e._element)||"inside"===e._config.autoClose&&!s||"outside"===e._config.autoClose&&s)continue;if(e._menu.contains(t.target)&&("keyup"===t.type&&"Tab"===t.key||/input|select|option|textarea|form/i.test(t.target.tagName)))continue;const o={relatedTarget:e._element};"click"===t.type&&(o.clickEvent=t),e._completeHide(o)}}static dataApiKeydownHandler(t){const e=/input|textarea/i.test(t.target.tagName),i="Escape"===t.key,n=[Xe,Ye].includes(t.key);if(!n&&!i)return;if(e&&!i)return;t.preventDefault();const s=this.matches(Ze)?this:Q.prev(this,Ze)[0]||Q.next(this,Ze)[0]||Q.findOne(Ze,t.delegateTarget.parentNode),o=hi.getOrCreateInstance(s);if(n)return t.stopPropagation(),o.show(),void o._selectMenuItem(t);o._isShown()&&(t.stopPropagation(),o.hide(),s.focus())}}P.on(document,Ge,Ze,hi.dataApiKeydownHandler),P.on(document,Ge,ei,hi.dataApiKeydownHandler),P.on(document,Ue,hi.clearMenus),P.on(document,"keyup.bs.dropdown.data-api",hi.clearMenus),P.on(document,Ue,Ze,(function(t){t.preventDefault(),hi.getOrCreateInstance(this).toggle()})),g(hi);const di=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",ui=".sticky-top",fi="padding-right",pi="margin-right";class gi{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,fi,(e=>e+t)),this._setElementAttributes(di,fi,(e=>e+t)),this._setElementAttributes(ui,pi,(e=>e-t))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,fi),this._resetElementAttributes(di,fi),this._resetElementAttributes(ui,pi)}isOverflowing(){return this.getWidth()>0}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t).getPropertyValue(e);t.style.setProperty(e,`${i(Number.parseFloat(s))}px`)}))}_saveInitialAttribute(t,e){const i=t.style.getPropertyValue(e);i&&B.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=B.getDataAttribute(t,e);null!==i?(B.removeDataAttribute(t,e),t.style.setProperty(e,i)):t.style.removeProperty(e)}))}_applyManipulationCallback(t,e){if(o(t))e(t);else for(const i of Q.find(t,this._element))e(i)}}const mi="show",_i="mousedown.bs.backdrop",bi={className:"modal-backdrop",clickCallback:null,isAnimated:!1,isVisible:!0,rootElement:"body"},vi={className:"string",clickCallback:"(function|null)",isAnimated:"boolean",isVisible:"boolean",rootElement:"(element|string)"};class yi extends F{constructor(t){super(),this._config=this._getConfig(t),this._isAppended=!1,this._element=null}static get Default(){return bi}static get DefaultType(){return vi}static get NAME(){return"backdrop"}show(t){if(!this._config.isVisible)return void m(t);this._append();const e=this._getElement();this._config.isAnimated&&d(e),e.classList.add(mi),this._emulateAnimation((()=>{m(t)}))}hide(t){this._config.isVisible?(this._getElement().classList.remove(mi),this._emulateAnimation((()=>{this.dispose(),m(t)}))):m(t)}dispose(){this._isAppended&&(P.off(this._element,_i),this._element.remove(),this._isAppended=!1)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_configAfterMerge(t){return t.rootElement=r(t.rootElement),t}_append(){if(this._isAppended)return;const t=this._getElement();this._config.rootElement.append(t),P.on(t,_i,(()=>{m(this._config.clickCallback)})),this._isAppended=!0}_emulateAnimation(t){_(t,this._getElement(),this._config.isAnimated)}}const wi=".bs.focustrap",Ai="backward",Ei={autofocus:!0,trapElement:null},Ti={autofocus:"boolean",trapElement:"element"};class Ci extends F{constructor(t){super(),this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}static get Default(){return Ei}static get DefaultType(){return Ti}static get NAME(){return"focustrap"}activate(){this._isActive||(this._config.autofocus&&this._config.trapElement.focus(),P.off(document,wi),P.on(document,"focusin.bs.focustrap",(t=>this._handleFocusin(t))),P.on(document,"keydown.tab.bs.focustrap",(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,P.off(document,wi))}_handleFocusin(t){const{trapElement:e}=this._config;if(t.target===document||t.target===e||e.contains(t.target))return;const i=Q.focusableChildren(e);0===i.length?e.focus():this._lastTabNavDirection===Ai?i[i.length-1].focus():i[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?Ai:"forward")}}const Oi="hidden.bs.modal",xi="show.bs.modal",ki="modal-open",Li="show",Di="modal-static",Si={backdrop:!0,focus:!0,keyboard:!0},Ii={backdrop:"(boolean|string)",focus:"boolean",keyboard:"boolean"};class Ni extends z{constructor(t,e){super(t,e),this._dialog=Q.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._isTransitioning=!1,this._scrollBar=new gi,this._addEventListeners()}static get Default(){return Si}static get DefaultType(){return Ii}static get NAME(){return"modal"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||P.trigger(this._element,xi,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isTransitioning=!0,this._scrollBar.hide(),document.body.classList.add(ki),this._adjustDialog(),this._backdrop.show((()=>this._showElement(t))))}hide(){this._isShown&&!this._isTransitioning&&(P.trigger(this._element,"hide.bs.modal").defaultPrevented||(this._isShown=!1,this._isTransitioning=!0,this._focustrap.deactivate(),this._element.classList.remove(Li),this._queueCallback((()=>this._hideModal()),this._element,this._isAnimated())))}dispose(){for(const t of[window,this._dialog])P.off(t,".bs.modal");this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new yi({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new Ci({trapElement:this._element})}_showElement(t){document.body.contains(this._element)||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0;const e=Q.findOne(".modal-body",this._dialog);e&&(e.scrollTop=0),d(this._element),this._element.classList.add(Li),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,P.trigger(this._element,"shown.bs.modal",{relatedTarget:t})}),this._dialog,this._isAnimated())}_addEventListeners(){P.on(this._element,"keydown.dismiss.bs.modal",(t=>{if("Escape"===t.key)return this._config.keyboard?(t.preventDefault(),void this.hide()):void this._triggerBackdropTransition()})),P.on(window,"resize.bs.modal",(()=>{this._isShown&&!this._isTransitioning&&this._adjustDialog()})),P.on(this._element,"mousedown.dismiss.bs.modal",(t=>{P.one(this._element,"click.dismiss.bs.modal",(e=>{this._element===t.target&&this._element===e.target&&("static"!==this._config.backdrop?this._config.backdrop&&this.hide():this._triggerBackdropTransition())}))}))}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(ki),this._resetAdjustments(),this._scrollBar.reset(),P.trigger(this._element,Oi)}))}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(P.trigger(this._element,"hidePrevented.bs.modal").defaultPrevented)return;const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._element.style.overflowY;"hidden"===e||this._element.classList.contains(Di)||(t||(this._element.style.overflowY="hidden"),this._element.classList.add(Di),this._queueCallback((()=>{this._element.classList.remove(Di),this._queueCallback((()=>{this._element.style.overflowY=e}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;if(i&&!t){const t=p()?"paddingLeft":"paddingRight";this._element.style[t]=`${e}px`}if(!i&&t){const t=p()?"paddingRight":"paddingLeft";this._element.style[t]=`${e}px`}}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=Ni.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}P.on(document,"click.bs.modal.data-api",'[data-bs-toggle="modal"]',(function(t){const e=n(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),P.one(e,xi,(t=>{t.defaultPrevented||P.one(e,Oi,(()=>{a(this)&&this.focus()}))}));const i=Q.findOne(".modal.show");i&&Ni.getInstance(i).hide(),Ni.getOrCreateInstance(e).toggle(this)})),q(Ni),g(Ni);const Pi="show",ji="showing",Mi="hiding",Hi=".offcanvas.show",$i="hidePrevented.bs.offcanvas",Wi="hidden.bs.offcanvas",Bi={backdrop:!0,keyboard:!0,scroll:!1},Fi={backdrop:"(boolean|string)",keyboard:"boolean",scroll:"boolean"};class zi extends z{constructor(t,e){super(t,e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get Default(){return Bi}static get DefaultType(){return Fi}static get NAME(){return"offcanvas"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||P.trigger(this._element,"show.bs.offcanvas",{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._backdrop.show(),this._config.scroll||(new gi).hide(),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add(ji),this._queueCallback((()=>{this._config.scroll&&!this._config.backdrop||this._focustrap.activate(),this._element.classList.add(Pi),this._element.classList.remove(ji),P.trigger(this._element,"shown.bs.offcanvas",{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(P.trigger(this._element,"hide.bs.offcanvas").defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.add(Mi),this._backdrop.hide(),this._queueCallback((()=>{this._element.classList.remove(Pi,Mi),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._config.scroll||(new gi).reset(),P.trigger(this._element,Wi)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_initializeBackDrop(){const t=Boolean(this._config.backdrop);return new yi({className:"offcanvas-backdrop",isVisible:t,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:t?()=>{"static"!==this._config.backdrop?this.hide():P.trigger(this._element,$i)}:null})}_initializeFocusTrap(){return new Ci({trapElement:this._element})}_addEventListeners(){P.on(this._element,"keydown.dismiss.bs.offcanvas",(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():P.trigger(this._element,$i))}))}static jQueryInterface(t){return this.each((function(){const e=zi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}P.on(document,"click.bs.offcanvas.data-api",'[data-bs-toggle="offcanvas"]',(function(t){const e=n(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),l(this))return;P.one(e,Wi,(()=>{a(this)&&this.focus()}));const i=Q.findOne(Hi);i&&i!==e&&zi.getInstance(i).hide(),zi.getOrCreateInstance(e).toggle(this)})),P.on(window,"load.bs.offcanvas.data-api",(()=>{for(const t of Q.find(Hi))zi.getOrCreateInstance(t).show()})),P.on(window,"resize.bs.offcanvas",(()=>{for(const t of Q.find("[aria-modal][class*=show][class*=offcanvas-]"))"fixed"!==getComputedStyle(t).position&&zi.getOrCreateInstance(t).hide()})),q(zi),g(zi);const qi=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Ri=/^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i,Vi=/^data:(?:image\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\/(?:mpeg|mp4|ogg|webm)|audio\/(?:mp3|oga|ogg|opus));base64,[\d+/a-z]+=*$/i,Ki=(t,e)=>{const i=t.nodeName.toLowerCase();return e.includes(i)?!qi.has(i)||Boolean(Ri.test(t.nodeValue)||Vi.test(t.nodeValue)):e.filter((t=>t instanceof RegExp)).some((t=>t.test(i)))},Qi={"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},Xi={allowList:Qi,content:{},extraClass:"",html:!1,sanitize:!0,sanitizeFn:null,template:"
    "},Yi={allowList:"object",content:"object",extraClass:"(string|function)",html:"boolean",sanitize:"boolean",sanitizeFn:"(null|function)",template:"string"},Ui={entry:"(string|element|function|null)",selector:"(string|element)"};class Gi extends F{constructor(t){super(),this._config=this._getConfig(t)}static get Default(){return Xi}static get DefaultType(){return Yi}static get NAME(){return"TemplateFactory"}getContent(){return Object.values(this._config.content).map((t=>this._resolvePossibleFunction(t))).filter(Boolean)}hasContent(){return this.getContent().length>0}changeContent(t){return this._checkContent(t),this._config.content={...this._config.content,...t},this}toHtml(){const t=document.createElement("div");t.innerHTML=this._maybeSanitize(this._config.template);for(const[e,i]of Object.entries(this._config.content))this._setContent(t,i,e);const e=t.children[0],i=this._resolvePossibleFunction(this._config.extraClass);return i&&e.classList.add(...i.split(" ")),e}_typeCheckConfig(t){super._typeCheckConfig(t),this._checkContent(t.content)}_checkContent(t){for(const[e,i]of Object.entries(t))super._typeCheckConfig({selector:e,entry:i},Ui)}_setContent(t,e,i){const n=Q.findOne(i,t);n&&((e=this._resolvePossibleFunction(e))?o(e)?this._putElementInTemplate(r(e),n):this._config.html?n.innerHTML=this._maybeSanitize(e):n.textContent=e:n.remove())}_maybeSanitize(t){return this._config.sanitize?function(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(const t of s){const i=t.nodeName.toLowerCase();if(!Object.keys(e).includes(i)){t.remove();continue}const n=[].concat(...t.attributes),s=[].concat(e["*"]||[],e[i]||[]);for(const e of n)Ki(e,s)||t.removeAttribute(e.nodeName)}return n.body.innerHTML}(t,this._config.allowList,this._config.sanitizeFn):t}_resolvePossibleFunction(t){return"function"==typeof t?t(this):t}_putElementInTemplate(t,e){if(this._config.html)return e.innerHTML="",void e.append(t);e.textContent=t.textContent}}const Ji=new Set(["sanitize","allowList","sanitizeFn"]),Zi="fade",tn="show",en=".modal",nn="hide.bs.modal",sn="hover",on="focus",rn={AUTO:"auto",TOP:"top",RIGHT:p()?"left":"right",BOTTOM:"bottom",LEFT:p()?"right":"left"},an={allowList:Qi,animation:!0,boundary:"clippingParents",container:!1,customClass:"",delay:0,fallbackPlacements:["top","right","bottom","left"],html:!1,offset:[0,0],placement:"top",popperConfig:null,sanitize:!0,sanitizeFn:null,selector:!1,template:'',title:"",trigger:"hover 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object[0] : object\n }\n\n if (typeof object === 'string' && object.length > 0) {\n return document.querySelector(object)\n }\n\n return null\n}\n\nconst isVisible = element => {\n if (!isElement(element) || element.getClientRects().length === 0) {\n return false\n }\n\n const elementIsVisible = getComputedStyle(element).getPropertyValue('visibility') === 'visible'\n // Handle `details` element as its content may falsie appear visible when it is closed\n const closedDetails = element.closest('details:not([open])')\n\n if (!closedDetails) {\n return elementIsVisible\n }\n\n if (closedDetails !== element) {\n const summary = element.closest('summary')\n if (summary && summary.parentNode !== closedDetails) {\n return false\n }\n\n if (summary === null) {\n return false\n }\n }\n\n return elementIsVisible\n}\n\nconst isDisabled = element => {\n if (!element || element.nodeType !== Node.ELEMENT_NODE) {\n return true\n }\n\n if (element.classList.contains('disabled')) {\n return true\n }\n\n if (typeof element.disabled !== 'undefined') {\n return element.disabled\n }\n\n return element.hasAttribute('disabled') && element.getAttribute('disabled') !== 'false'\n}\n\nconst findShadowRoot = element => {\n if (!document.documentElement.attachShadow) {\n return null\n }\n\n // Can find the shadow root otherwise it'll return the document\n if (typeof element.getRootNode === 'function') {\n const root = element.getRootNode()\n return root instanceof ShadowRoot ? root : null\n }\n\n if (element instanceof ShadowRoot) {\n return element\n }\n\n // when we don't find a shadow root\n if (!element.parentNode) {\n return null\n }\n\n return findShadowRoot(element.parentNode)\n}\n\nconst noop = () => {}\n\n/**\n * Trick to restart an element's animation\n *\n * @param {HTMLElement} element\n * @return void\n *\n * @see https://www.charistheo.io/blog/2021/02/restart-a-css-animation-with-javascript/#restarting-a-css-animation\n */\nconst reflow = element => {\n element.offsetHeight // eslint-disable-line no-unused-expressions\n}\n\nconst getjQuery = () => {\n if (window.jQuery && !document.body.hasAttribute('data-bs-no-jquery')) {\n return window.jQuery\n }\n\n return null\n}\n\nconst DOMContentLoadedCallbacks = []\n\nconst onDOMContentLoaded = callback => {\n if (document.readyState === 'loading') {\n // add listener on the first call when the document is in loading state\n if (!DOMContentLoadedCallbacks.length) {\n document.addEventListener('DOMContentLoaded', () => {\n for (const callback of DOMContentLoadedCallbacks) {\n callback()\n }\n })\n }\n\n DOMContentLoadedCallbacks.push(callback)\n } else {\n callback()\n }\n}\n\nconst isRTL = () => document.documentElement.dir === 'rtl'\n\nconst defineJQueryPlugin = plugin => {\n onDOMContentLoaded(() => {\n const $ = getjQuery()\n /* istanbul ignore if */\n if ($) {\n const name = plugin.NAME\n const JQUERY_NO_CONFLICT = $.fn[name]\n $.fn[name] = plugin.jQueryInterface\n $.fn[name].Constructor = plugin\n $.fn[name].noConflict = () => {\n $.fn[name] = JQUERY_NO_CONFLICT\n return plugin.jQueryInterface\n }\n }\n })\n}\n\nconst execute = callback => {\n if (typeof callback === 'function') {\n callback()\n }\n}\n\nconst executeAfterTransition = (callback, transitionElement, waitForTransition = true) => {\n if (!waitForTransition) {\n execute(callback)\n return\n }\n\n const durationPadding = 5\n const emulatedDuration = getTransitionDurationFromElement(transitionElement) + durationPadding\n\n let called = false\n\n const handler = ({ target }) => {\n if (target !== transitionElement) {\n return\n }\n\n called = true\n transitionElement.removeEventListener(TRANSITION_END, handler)\n execute(callback)\n }\n\n transitionElement.addEventListener(TRANSITION_END, handler)\n setTimeout(() => {\n if (!called) {\n triggerTransitionEnd(transitionElement)\n }\n }, emulatedDuration)\n}\n\n/**\n * Return the previous/next element of a list.\n *\n * @param {array} list The list of elements\n * @param activeElement The active element\n * @param shouldGetNext Choose to get next or previous element\n * @param isCycleAllowed\n * @return {Element|elem} The proper element\n */\nconst getNextActiveElement = (list, activeElement, shouldGetNext, isCycleAllowed) => {\n const listLength = list.length\n let index = list.indexOf(activeElement)\n\n // if the element does not exist in the list return an element\n // depending on the direction and if cycle is allowed\n if (index === -1) {\n return !shouldGetNext && isCycleAllowed ? list[listLength - 1] : list[0]\n }\n\n index += shouldGetNext ? 1 : -1\n\n if (isCycleAllowed) {\n index = (index + listLength) % listLength\n }\n\n return list[Math.max(0, Math.min(index, listLength - 1))]\n}\n\nexport {\n defineJQueryPlugin,\n execute,\n executeAfterTransition,\n findShadowRoot,\n getElement,\n getElementFromSelector,\n getjQuery,\n getNextActiveElement,\n getSelectorFromElement,\n getTransitionDurationFromElement,\n getUID,\n isDisabled,\n isElement,\n isRTL,\n isVisible,\n noop,\n onDOMContentLoaded,\n reflow,\n triggerTransitionEnd,\n toType\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): dom/event-handler.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { getjQuery } from '../util/index'\n\n/**\n * Constants\n */\n\nconst namespaceRegex = /[^.]*(?=\\..*)\\.|.*/\nconst stripNameRegex = /\\..*/\nconst stripUidRegex = /::\\d+$/\nconst eventRegistry = {} // Events storage\nlet uidEvent = 1\nconst customEvents = {\n mouseenter: 'mouseover',\n mouseleave: 'mouseout'\n}\n\nconst nativeEvents = new Set([\n 'click',\n 'dblclick',\n 'mouseup',\n 'mousedown',\n 'contextmenu',\n 'mousewheel',\n 'DOMMouseScroll',\n 'mouseover',\n 'mouseout',\n 'mousemove',\n 'selectstart',\n 'selectend',\n 'keydown',\n 'keypress',\n 'keyup',\n 'orientationchange',\n 'touchstart',\n 'touchmove',\n 'touchend',\n 'touchcancel',\n 'pointerdown',\n 'pointermove',\n 'pointerup',\n 'pointerleave',\n 'pointercancel',\n 'gesturestart',\n 'gesturechange',\n 'gestureend',\n 'focus',\n 'blur',\n 'change',\n 'reset',\n 'select',\n 'submit',\n 'focusin',\n 'focusout',\n 'load',\n 'unload',\n 'beforeunload',\n 'resize',\n 'move',\n 'DOMContentLoaded',\n 'readystatechange',\n 'error',\n 'abort',\n 'scroll'\n])\n\n/**\n * Private methods\n */\n\nfunction makeEventUid(element, uid) {\n return (uid && `${uid}::${uidEvent++}`) || element.uidEvent || uidEvent++\n}\n\nfunction getElementEvents(element) {\n const uid = makeEventUid(element)\n\n element.uidEvent = uid\n eventRegistry[uid] = eventRegistry[uid] || {}\n\n return eventRegistry[uid]\n}\n\nfunction bootstrapHandler(element, fn) {\n return function handler(event) {\n hydrateObj(event, { delegateTarget: element })\n\n if (handler.oneOff) {\n EventHandler.off(element, event.type, fn)\n }\n\n return fn.apply(element, [event])\n }\n}\n\nfunction bootstrapDelegationHandler(element, selector, fn) {\n return function handler(event) {\n const domElements = element.querySelectorAll(selector)\n\n for (let { target } = event; target && target !== this; target = target.parentNode) {\n for (const domElement of domElements) {\n if (domElement !== target) {\n continue\n }\n\n hydrateObj(event, { delegateTarget: target })\n\n if (handler.oneOff) {\n EventHandler.off(element, event.type, selector, fn)\n }\n\n return fn.apply(target, [event])\n }\n }\n }\n}\n\nfunction findHandler(events, callable, delegationSelector = null) {\n return Object.values(events)\n .find(event => event.callable === callable && event.delegationSelector === delegationSelector)\n}\n\nfunction normalizeParameters(originalTypeEvent, handler, delegationFunction) {\n const isDelegated = typeof handler === 'string'\n // todo: tooltip passes `false` instead of selector, so we need to check\n const callable = isDelegated ? delegationFunction : (handler || delegationFunction)\n let typeEvent = getTypeEvent(originalTypeEvent)\n\n if (!nativeEvents.has(typeEvent)) {\n typeEvent = originalTypeEvent\n }\n\n return [isDelegated, callable, typeEvent]\n}\n\nfunction addHandler(element, originalTypeEvent, handler, delegationFunction, oneOff) {\n if (typeof originalTypeEvent !== 'string' || !element) {\n return\n }\n\n let [isDelegated, callable, typeEvent] = normalizeParameters(originalTypeEvent, handler, delegationFunction)\n\n // in case of mouseenter or mouseleave wrap the handler within a function that checks for its DOM position\n // this prevents the handler from being dispatched the same way as mouseover or mouseout does\n if (originalTypeEvent in customEvents) {\n const wrapFunction = fn => {\n return function (event) {\n if (!event.relatedTarget || (event.relatedTarget !== event.delegateTarget && !event.delegateTarget.contains(event.relatedTarget))) {\n return fn.call(this, event)\n }\n }\n }\n\n callable = wrapFunction(callable)\n }\n\n const events = getElementEvents(element)\n const handlers = events[typeEvent] || (events[typeEvent] = {})\n const previousFunction = findHandler(handlers, callable, isDelegated ? handler : null)\n\n if (previousFunction) {\n previousFunction.oneOff = previousFunction.oneOff && oneOff\n\n return\n }\n\n const uid = makeEventUid(callable, originalTypeEvent.replace(namespaceRegex, ''))\n const fn = isDelegated ?\n bootstrapDelegationHandler(element, handler, callable) :\n bootstrapHandler(element, callable)\n\n fn.delegationSelector = isDelegated ? handler : null\n fn.callable = callable\n fn.oneOff = oneOff\n fn.uidEvent = uid\n handlers[uid] = fn\n\n element.addEventListener(typeEvent, fn, isDelegated)\n}\n\nfunction removeHandler(element, events, typeEvent, handler, delegationSelector) {\n const fn = findHandler(events[typeEvent], handler, delegationSelector)\n\n if (!fn) {\n return\n }\n\n element.removeEventListener(typeEvent, fn, Boolean(delegationSelector))\n delete events[typeEvent][fn.uidEvent]\n}\n\nfunction removeNamespacedHandlers(element, events, typeEvent, namespace) {\n const storeElementEvent = events[typeEvent] || {}\n\n for (const handlerKey of Object.keys(storeElementEvent)) {\n if (handlerKey.includes(namespace)) {\n const event = storeElementEvent[handlerKey]\n removeHandler(element, events, typeEvent, event.callable, event.delegationSelector)\n }\n }\n}\n\nfunction getTypeEvent(event) {\n // allow to get the native events from namespaced events ('click.bs.button' --> 'click')\n event = event.replace(stripNameRegex, '')\n return customEvents[event] || event\n}\n\nconst EventHandler = {\n on(element, event, handler, delegationFunction) {\n addHandler(element, event, handler, delegationFunction, false)\n },\n\n one(element, event, handler, delegationFunction) {\n addHandler(element, event, handler, delegationFunction, true)\n },\n\n off(element, originalTypeEvent, handler, delegationFunction) {\n if (typeof originalTypeEvent !== 'string' || !element) {\n return\n }\n\n const [isDelegated, callable, typeEvent] = normalizeParameters(originalTypeEvent, handler, delegationFunction)\n const inNamespace = typeEvent !== originalTypeEvent\n const events = getElementEvents(element)\n const storeElementEvent = events[typeEvent] || {}\n const isNamespace = originalTypeEvent.startsWith('.')\n\n if (typeof callable !== 'undefined') {\n // Simplest case: handler is passed, remove that listener ONLY.\n if (!Object.keys(storeElementEvent).length) {\n return\n }\n\n removeHandler(element, events, typeEvent, callable, isDelegated ? handler : null)\n return\n }\n\n if (isNamespace) {\n for (const elementEvent of Object.keys(events)) {\n removeNamespacedHandlers(element, events, elementEvent, originalTypeEvent.slice(1))\n }\n }\n\n for (const keyHandlers of Object.keys(storeElementEvent)) {\n const handlerKey = keyHandlers.replace(stripUidRegex, '')\n\n if (!inNamespace || originalTypeEvent.includes(handlerKey)) {\n const event = storeElementEvent[keyHandlers]\n removeHandler(element, events, typeEvent, event.callable, event.delegationSelector)\n }\n }\n },\n\n trigger(element, event, args) {\n if (typeof event !== 'string' || !element) {\n return null\n }\n\n const $ = getjQuery()\n const typeEvent = getTypeEvent(event)\n const inNamespace = event !== typeEvent\n\n let jQueryEvent = null\n let bubbles = true\n let nativeDispatch = true\n let defaultPrevented = false\n\n if (inNamespace && $) {\n jQueryEvent = $.Event(event, args)\n\n $(element).trigger(jQueryEvent)\n bubbles = !jQueryEvent.isPropagationStopped()\n nativeDispatch = !jQueryEvent.isImmediatePropagationStopped()\n defaultPrevented = jQueryEvent.isDefaultPrevented()\n }\n\n let evt = new Event(event, { bubbles, cancelable: true })\n evt = hydrateObj(evt, args)\n\n if (defaultPrevented) {\n evt.preventDefault()\n }\n\n if (nativeDispatch) {\n element.dispatchEvent(evt)\n }\n\n if (evt.defaultPrevented && jQueryEvent) {\n jQueryEvent.preventDefault()\n }\n\n return evt\n }\n}\n\nfunction hydrateObj(obj, meta) {\n for (const [key, value] of Object.entries(meta || {})) {\n try {\n obj[key] = value\n } catch {\n Object.defineProperty(obj, key, {\n configurable: true,\n get() {\n return value\n }\n })\n }\n }\n\n return obj\n}\n\nexport default EventHandler\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): dom/data.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\n/**\n * Constants\n */\n\nconst elementMap = new Map()\n\nexport default {\n set(element, key, instance) {\n if (!elementMap.has(element)) {\n elementMap.set(element, new Map())\n }\n\n const instanceMap = elementMap.get(element)\n\n // make it clear we only want one instance per element\n // can be removed later when multiple key/instances are fine to be used\n if (!instanceMap.has(key) && instanceMap.size !== 0) {\n // eslint-disable-next-line no-console\n console.error(`Bootstrap doesn't allow more than one instance per element. Bound instance: ${Array.from(instanceMap.keys())[0]}.`)\n return\n }\n\n instanceMap.set(key, instance)\n },\n\n get(element, key) {\n if (elementMap.has(element)) {\n return elementMap.get(element).get(key) || null\n }\n\n return null\n },\n\n remove(element, key) {\n if (!elementMap.has(element)) {\n return\n }\n\n const instanceMap = elementMap.get(element)\n\n instanceMap.delete(key)\n\n // free up element references if there are no instances left for an element\n if (instanceMap.size === 0) {\n elementMap.delete(element)\n }\n }\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): dom/manipulator.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nfunction normalizeData(value) {\n if (value === 'true') {\n return true\n }\n\n if (value === 'false') {\n return false\n }\n\n if (value === Number(value).toString()) {\n return Number(value)\n }\n\n if (value === '' || value === 'null') {\n return null\n }\n\n if (typeof value !== 'string') {\n return value\n }\n\n try {\n return JSON.parse(decodeURIComponent(value))\n } catch {\n return value\n }\n}\n\nfunction normalizeDataKey(key) {\n return key.replace(/[A-Z]/g, chr => `-${chr.toLowerCase()}`)\n}\n\nconst Manipulator = {\n setDataAttribute(element, key, value) {\n element.setAttribute(`data-bs-${normalizeDataKey(key)}`, value)\n },\n\n removeDataAttribute(element, key) {\n element.removeAttribute(`data-bs-${normalizeDataKey(key)}`)\n },\n\n getDataAttributes(element) {\n if (!element) {\n return {}\n }\n\n const attributes = {}\n const bsKeys = Object.keys(element.dataset).filter(key => key.startsWith('bs') && !key.startsWith('bsConfig'))\n\n for (const key of bsKeys) {\n let pureKey = key.replace(/^bs/, '')\n pureKey = pureKey.charAt(0).toLowerCase() + pureKey.slice(1, pureKey.length)\n attributes[pureKey] = normalizeData(element.dataset[key])\n }\n\n return attributes\n },\n\n getDataAttribute(element, key) {\n return normalizeData(element.getAttribute(`data-bs-${normalizeDataKey(key)}`))\n }\n}\n\nexport default Manipulator\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): util/config.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { isElement, toType } from './index'\nimport Manipulator from '../dom/manipulator'\n\n/**\n * Class definition\n */\n\nclass Config {\n // Getters\n static get Default() {\n return {}\n }\n\n static get DefaultType() {\n return {}\n }\n\n static get NAME() {\n throw new Error('You have to implement the static method \"NAME\", for each component!')\n }\n\n _getConfig(config) {\n config = this._mergeConfigObj(config)\n config = this._configAfterMerge(config)\n this._typeCheckConfig(config)\n return config\n }\n\n _configAfterMerge(config) {\n return config\n }\n\n _mergeConfigObj(config, element) {\n const jsonConfig = isElement(element) ? Manipulator.getDataAttribute(element, 'config') : {} // try to parse\n\n return {\n ...this.constructor.Default,\n ...(typeof jsonConfig === 'object' ? jsonConfig : {}),\n ...(isElement(element) ? Manipulator.getDataAttributes(element) : {}),\n ...(typeof config === 'object' ? config : {})\n }\n }\n\n _typeCheckConfig(config, configTypes = this.constructor.DefaultType) {\n for (const property of Object.keys(configTypes)) {\n const expectedTypes = configTypes[property]\n const value = config[property]\n const valueType = isElement(value) ? 'element' : toType(value)\n\n if (!new RegExp(expectedTypes).test(valueType)) {\n throw new TypeError(\n `${this.constructor.NAME.toUpperCase()}: Option \"${property}\" provided type \"${valueType}\" but expected type \"${expectedTypes}\".`\n )\n }\n }\n }\n}\n\nexport default Config\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): base-component.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Data from './dom/data'\nimport { executeAfterTransition, getElement } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Config from './util/config'\n\n/**\n * Constants\n */\n\nconst VERSION = '5.2.2'\n\n/**\n * Class definition\n */\n\nclass BaseComponent extends Config {\n constructor(element, config) {\n super()\n\n element = getElement(element)\n if (!element) {\n return\n }\n\n this._element = element\n this._config = this._getConfig(config)\n\n Data.set(this._element, this.constructor.DATA_KEY, this)\n }\n\n // Public\n dispose() {\n Data.remove(this._element, this.constructor.DATA_KEY)\n EventHandler.off(this._element, this.constructor.EVENT_KEY)\n\n for (const propertyName of Object.getOwnPropertyNames(this)) {\n this[propertyName] = null\n }\n }\n\n _queueCallback(callback, element, isAnimated = true) {\n executeAfterTransition(callback, element, isAnimated)\n }\n\n _getConfig(config) {\n config = this._mergeConfigObj(config, this._element)\n config = this._configAfterMerge(config)\n this._typeCheckConfig(config)\n return config\n }\n\n // Static\n static getInstance(element) {\n return Data.get(getElement(element), this.DATA_KEY)\n }\n\n static getOrCreateInstance(element, config = {}) {\n return this.getInstance(element) || new this(element, typeof config === 'object' ? config : null)\n }\n\n static get VERSION() {\n return VERSION\n }\n\n static get DATA_KEY() {\n return `bs.${this.NAME}`\n }\n\n static get EVENT_KEY() {\n return `.${this.DATA_KEY}`\n }\n\n static eventName(name) {\n return `${name}${this.EVENT_KEY}`\n }\n}\n\nexport default BaseComponent\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): util/component-functions.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport { getElementFromSelector, isDisabled } from './index'\n\nconst enableDismissTrigger = (component, method = 'hide') => {\n const clickEvent = `click.dismiss${component.EVENT_KEY}`\n const name = component.NAME\n\n EventHandler.on(document, clickEvent, `[data-bs-dismiss=\"${name}\"]`, function (event) {\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n if (isDisabled(this)) {\n return\n }\n\n const target = getElementFromSelector(this) || this.closest(`.${name}`)\n const instance = component.getOrCreateInstance(target)\n\n // Method argument is left, for Alert and only, as it doesn't implement the 'hide' method\n instance[method]()\n })\n}\n\nexport {\n enableDismissTrigger\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): alert.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * Constants\n */\n\nconst NAME = 'alert'\nconst DATA_KEY = 'bs.alert'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_CLOSE = `close${EVENT_KEY}`\nconst EVENT_CLOSED = `closed${EVENT_KEY}`\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\n/**\n * Class definition\n */\n\nclass Alert extends BaseComponent {\n // Getters\n static get NAME() {\n return NAME\n }\n\n // Public\n close() {\n const closeEvent = EventHandler.trigger(this._element, EVENT_CLOSE)\n\n if (closeEvent.defaultPrevented) {\n return\n }\n\n this._element.classList.remove(CLASS_NAME_SHOW)\n\n const isAnimated = this._element.classList.contains(CLASS_NAME_FADE)\n this._queueCallback(() => this._destroyElement(), this._element, isAnimated)\n }\n\n // Private\n _destroyElement() {\n this._element.remove()\n EventHandler.trigger(this._element, EVENT_CLOSED)\n this.dispose()\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Alert.getOrCreateInstance(this)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](this)\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nenableDismissTrigger(Alert, 'close')\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Alert)\n\nexport default Alert\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): button.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\n\n/**\n * Constants\n */\n\nconst NAME = 'button'\nconst DATA_KEY = 'bs.button'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst CLASS_NAME_ACTIVE = 'active'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"button\"]'\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\n/**\n * Class definition\n */\n\nclass Button extends BaseComponent {\n // Getters\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle() {\n // Toggle class and sync the `aria-pressed` attribute with the return value of the `.toggle()` method\n this._element.setAttribute('aria-pressed', this._element.classList.toggle(CLASS_NAME_ACTIVE))\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Button.getOrCreateInstance(this)\n\n if (config === 'toggle') {\n data[config]()\n }\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, event => {\n event.preventDefault()\n\n const button = event.target.closest(SELECTOR_DATA_TOGGLE)\n const data = Button.getOrCreateInstance(button)\n\n data.toggle()\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Button)\n\nexport default Button\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): dom/selector-engine.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { isDisabled, isVisible } from '../util/index'\n\n/**\n * Constants\n */\n\nconst SelectorEngine = {\n find(selector, element = document.documentElement) {\n return [].concat(...Element.prototype.querySelectorAll.call(element, selector))\n },\n\n findOne(selector, element = document.documentElement) {\n return Element.prototype.querySelector.call(element, selector)\n },\n\n children(element, selector) {\n return [].concat(...element.children).filter(child => child.matches(selector))\n },\n\n parents(element, selector) {\n const parents = []\n let ancestor = element.parentNode.closest(selector)\n\n while (ancestor) {\n parents.push(ancestor)\n ancestor = ancestor.parentNode.closest(selector)\n }\n\n return parents\n },\n\n prev(element, selector) {\n let previous = element.previousElementSibling\n\n while (previous) {\n if (previous.matches(selector)) {\n return [previous]\n }\n\n previous = previous.previousElementSibling\n }\n\n return []\n },\n // TODO: this is now unused; remove later along with prev()\n next(element, selector) {\n let next = element.nextElementSibling\n\n while (next) {\n if (next.matches(selector)) {\n return [next]\n }\n\n next = next.nextElementSibling\n }\n\n return []\n },\n\n focusableChildren(element) {\n const focusables = [\n 'a',\n 'button',\n 'input',\n 'textarea',\n 'select',\n 'details',\n '[tabindex]',\n '[contenteditable=\"true\"]'\n ].map(selector => `${selector}:not([tabindex^=\"-\"])`).join(',')\n\n return this.find(focusables, element).filter(el => !isDisabled(el) && isVisible(el))\n }\n}\n\nexport default SelectorEngine\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): util/swipe.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Config from './config'\nimport EventHandler from '../dom/event-handler'\nimport { execute } from './index'\n\n/**\n * Constants\n */\n\nconst NAME = 'swipe'\nconst EVENT_KEY = '.bs.swipe'\nconst EVENT_TOUCHSTART = `touchstart${EVENT_KEY}`\nconst EVENT_TOUCHMOVE = `touchmove${EVENT_KEY}`\nconst EVENT_TOUCHEND = `touchend${EVENT_KEY}`\nconst EVENT_POINTERDOWN = `pointerdown${EVENT_KEY}`\nconst EVENT_POINTERUP = `pointerup${EVENT_KEY}`\nconst POINTER_TYPE_TOUCH = 'touch'\nconst POINTER_TYPE_PEN = 'pen'\nconst CLASS_NAME_POINTER_EVENT = 'pointer-event'\nconst SWIPE_THRESHOLD = 40\n\nconst Default = {\n endCallback: null,\n leftCallback: null,\n rightCallback: null\n}\n\nconst DefaultType = {\n endCallback: '(function|null)',\n leftCallback: '(function|null)',\n rightCallback: '(function|null)'\n}\n\n/**\n * Class definition\n */\n\nclass Swipe extends Config {\n constructor(element, config) {\n super()\n this._element = element\n\n if (!element || !Swipe.isSupported()) {\n return\n }\n\n this._config = this._getConfig(config)\n this._deltaX = 0\n this._supportPointerEvents = Boolean(window.PointerEvent)\n this._initEvents()\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n dispose() {\n EventHandler.off(this._element, EVENT_KEY)\n }\n\n // Private\n _start(event) {\n if (!this._supportPointerEvents) {\n this._deltaX = event.touches[0].clientX\n\n return\n }\n\n if (this._eventIsPointerPenTouch(event)) {\n this._deltaX = event.clientX\n }\n }\n\n _end(event) {\n if (this._eventIsPointerPenTouch(event)) {\n this._deltaX = event.clientX - this._deltaX\n }\n\n this._handleSwipe()\n execute(this._config.endCallback)\n }\n\n _move(event) {\n this._deltaX = event.touches && event.touches.length > 1 ?\n 0 :\n event.touches[0].clientX - this._deltaX\n }\n\n _handleSwipe() {\n const absDeltaX = Math.abs(this._deltaX)\n\n if (absDeltaX <= SWIPE_THRESHOLD) {\n return\n }\n\n const direction = absDeltaX / this._deltaX\n\n this._deltaX = 0\n\n if (!direction) {\n return\n }\n\n execute(direction > 0 ? this._config.rightCallback : this._config.leftCallback)\n }\n\n _initEvents() {\n if (this._supportPointerEvents) {\n EventHandler.on(this._element, EVENT_POINTERDOWN, event => this._start(event))\n EventHandler.on(this._element, EVENT_POINTERUP, event => this._end(event))\n\n this._element.classList.add(CLASS_NAME_POINTER_EVENT)\n } else {\n EventHandler.on(this._element, EVENT_TOUCHSTART, event => this._start(event))\n EventHandler.on(this._element, EVENT_TOUCHMOVE, event => this._move(event))\n EventHandler.on(this._element, EVENT_TOUCHEND, event => this._end(event))\n }\n }\n\n _eventIsPointerPenTouch(event) {\n return this._supportPointerEvents && (event.pointerType === POINTER_TYPE_PEN || event.pointerType === POINTER_TYPE_TOUCH)\n }\n\n // Static\n static isSupported() {\n return 'ontouchstart' in document.documentElement || navigator.maxTouchPoints > 0\n }\n}\n\nexport default Swipe\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): carousel.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n defineJQueryPlugin,\n getElementFromSelector,\n getNextActiveElement,\n isRTL,\n isVisible,\n reflow,\n triggerTransitionEnd\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport Swipe from './util/swipe'\nimport BaseComponent from './base-component'\n\n/**\n * Constants\n */\n\nconst NAME = 'carousel'\nconst DATA_KEY = 'bs.carousel'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ARROW_LEFT_KEY = 'ArrowLeft'\nconst ARROW_RIGHT_KEY = 'ArrowRight'\nconst TOUCHEVENT_COMPAT_WAIT = 500 // Time for mouse compat events to fire after touch\n\nconst ORDER_NEXT = 'next'\nconst ORDER_PREV = 'prev'\nconst DIRECTION_LEFT = 'left'\nconst DIRECTION_RIGHT = 'right'\n\nconst EVENT_SLIDE = `slide${EVENT_KEY}`\nconst EVENT_SLID = `slid${EVENT_KEY}`\nconst EVENT_KEYDOWN = `keydown${EVENT_KEY}`\nconst EVENT_MOUSEENTER = `mouseenter${EVENT_KEY}`\nconst EVENT_MOUSELEAVE = `mouseleave${EVENT_KEY}`\nconst EVENT_DRAG_START = `dragstart${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_CAROUSEL = 'carousel'\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_SLIDE = 'slide'\nconst CLASS_NAME_END = 'carousel-item-end'\nconst CLASS_NAME_START = 'carousel-item-start'\nconst CLASS_NAME_NEXT = 'carousel-item-next'\nconst CLASS_NAME_PREV = 'carousel-item-prev'\n\nconst SELECTOR_ACTIVE = '.active'\nconst SELECTOR_ITEM = '.carousel-item'\nconst SELECTOR_ACTIVE_ITEM = SELECTOR_ACTIVE + SELECTOR_ITEM\nconst SELECTOR_ITEM_IMG = '.carousel-item img'\nconst SELECTOR_INDICATORS = '.carousel-indicators'\nconst SELECTOR_DATA_SLIDE = '[data-bs-slide], [data-bs-slide-to]'\nconst SELECTOR_DATA_RIDE = '[data-bs-ride=\"carousel\"]'\n\nconst KEY_TO_DIRECTION = {\n [ARROW_LEFT_KEY]: DIRECTION_RIGHT,\n [ARROW_RIGHT_KEY]: DIRECTION_LEFT\n}\n\nconst Default = {\n interval: 5000,\n keyboard: true,\n pause: 'hover',\n ride: false,\n touch: true,\n wrap: true\n}\n\nconst DefaultType = {\n interval: '(number|boolean)', // TODO:v6 remove boolean support\n keyboard: 'boolean',\n pause: '(string|boolean)',\n ride: '(boolean|string)',\n touch: 'boolean',\n wrap: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Carousel extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._interval = null\n this._activeElement = null\n this._isSliding = false\n this.touchTimeout = null\n this._swipeHelper = null\n\n this._indicatorsElement = SelectorEngine.findOne(SELECTOR_INDICATORS, this._element)\n this._addEventListeners()\n\n if (this._config.ride === CLASS_NAME_CAROUSEL) {\n this.cycle()\n }\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n next() {\n this._slide(ORDER_NEXT)\n }\n\n nextWhenVisible() {\n // FIXME TODO use `document.visibilityState`\n // Don't call next when the page isn't visible\n // or the carousel or its parent isn't visible\n if (!document.hidden && isVisible(this._element)) {\n this.next()\n }\n }\n\n prev() {\n this._slide(ORDER_PREV)\n }\n\n pause() {\n if (this._isSliding) {\n triggerTransitionEnd(this._element)\n }\n\n this._clearInterval()\n }\n\n cycle() {\n this._clearInterval()\n this._updateInterval()\n\n this._interval = setInterval(() => this.nextWhenVisible(), this._config.interval)\n }\n\n _maybeEnableCycle() {\n if (!this._config.ride) {\n return\n }\n\n if (this._isSliding) {\n EventHandler.one(this._element, EVENT_SLID, () => this.cycle())\n return\n }\n\n this.cycle()\n }\n\n to(index) {\n const items = this._getItems()\n if (index > items.length - 1 || index < 0) {\n return\n }\n\n if (this._isSliding) {\n EventHandler.one(this._element, EVENT_SLID, () => this.to(index))\n return\n }\n\n const activeIndex = this._getItemIndex(this._getActive())\n if (activeIndex === index) {\n return\n }\n\n const order = index > activeIndex ? ORDER_NEXT : ORDER_PREV\n\n this._slide(order, items[index])\n }\n\n dispose() {\n if (this._swipeHelper) {\n this._swipeHelper.dispose()\n }\n\n super.dispose()\n }\n\n // Private\n _configAfterMerge(config) {\n config.defaultInterval = config.interval\n return config\n }\n\n _addEventListeners() {\n if (this._config.keyboard) {\n EventHandler.on(this._element, EVENT_KEYDOWN, event => this._keydown(event))\n }\n\n if (this._config.pause === 'hover') {\n EventHandler.on(this._element, EVENT_MOUSEENTER, () => this.pause())\n EventHandler.on(this._element, EVENT_MOUSELEAVE, () => this._maybeEnableCycle())\n }\n\n if (this._config.touch && Swipe.isSupported()) {\n this._addTouchEventListeners()\n }\n }\n\n _addTouchEventListeners() {\n for (const img of SelectorEngine.find(SELECTOR_ITEM_IMG, this._element)) {\n EventHandler.on(img, EVENT_DRAG_START, event => event.preventDefault())\n }\n\n const endCallBack = () => {\n if (this._config.pause !== 'hover') {\n return\n }\n\n // If it's a touch-enabled device, mouseenter/leave are fired as\n // part of the mouse compatibility events on first tap - the carousel\n // would stop cycling until user tapped out of it;\n // here, we listen for touchend, explicitly pause the carousel\n // (as if it's the second time we tap on it, mouseenter compat event\n // is NOT fired) and after a timeout (to allow for mouse compatibility\n // events to fire) we explicitly restart cycling\n\n this.pause()\n if (this.touchTimeout) {\n clearTimeout(this.touchTimeout)\n }\n\n this.touchTimeout = setTimeout(() => this._maybeEnableCycle(), TOUCHEVENT_COMPAT_WAIT + this._config.interval)\n }\n\n const swipeConfig = {\n leftCallback: () => this._slide(this._directionToOrder(DIRECTION_LEFT)),\n rightCallback: () => this._slide(this._directionToOrder(DIRECTION_RIGHT)),\n endCallback: endCallBack\n }\n\n this._swipeHelper = new Swipe(this._element, swipeConfig)\n }\n\n _keydown(event) {\n if (/input|textarea/i.test(event.target.tagName)) {\n return\n }\n\n const direction = KEY_TO_DIRECTION[event.key]\n if (direction) {\n event.preventDefault()\n this._slide(this._directionToOrder(direction))\n }\n }\n\n _getItemIndex(element) {\n return this._getItems().indexOf(element)\n }\n\n _setActiveIndicatorElement(index) {\n if (!this._indicatorsElement) {\n return\n }\n\n const activeIndicator = SelectorEngine.findOne(SELECTOR_ACTIVE, this._indicatorsElement)\n\n activeIndicator.classList.remove(CLASS_NAME_ACTIVE)\n activeIndicator.removeAttribute('aria-current')\n\n const newActiveIndicator = SelectorEngine.findOne(`[data-bs-slide-to=\"${index}\"]`, this._indicatorsElement)\n\n if (newActiveIndicator) {\n newActiveIndicator.classList.add(CLASS_NAME_ACTIVE)\n newActiveIndicator.setAttribute('aria-current', 'true')\n }\n }\n\n _updateInterval() {\n const element = this._activeElement || this._getActive()\n\n if (!element) {\n return\n }\n\n const elementInterval = Number.parseInt(element.getAttribute('data-bs-interval'), 10)\n\n this._config.interval = elementInterval || this._config.defaultInterval\n }\n\n _slide(order, element = null) {\n if (this._isSliding) {\n return\n }\n\n const activeElement = this._getActive()\n const isNext = order === ORDER_NEXT\n const nextElement = element || getNextActiveElement(this._getItems(), activeElement, isNext, this._config.wrap)\n\n if (nextElement === activeElement) {\n return\n }\n\n const nextElementIndex = this._getItemIndex(nextElement)\n\n const triggerEvent = eventName => {\n return EventHandler.trigger(this._element, eventName, {\n relatedTarget: nextElement,\n direction: this._orderToDirection(order),\n from: this._getItemIndex(activeElement),\n to: nextElementIndex\n })\n }\n\n const slideEvent = triggerEvent(EVENT_SLIDE)\n\n if (slideEvent.defaultPrevented) {\n return\n }\n\n if (!activeElement || !nextElement) {\n // Some weirdness is happening, so we bail\n // todo: change tests that use empty divs to avoid this check\n return\n }\n\n const isCycling = Boolean(this._interval)\n this.pause()\n\n this._isSliding = true\n\n this._setActiveIndicatorElement(nextElementIndex)\n this._activeElement = nextElement\n\n const directionalClassName = isNext ? CLASS_NAME_START : CLASS_NAME_END\n const orderClassName = isNext ? CLASS_NAME_NEXT : CLASS_NAME_PREV\n\n nextElement.classList.add(orderClassName)\n\n reflow(nextElement)\n\n activeElement.classList.add(directionalClassName)\n nextElement.classList.add(directionalClassName)\n\n const completeCallBack = () => {\n nextElement.classList.remove(directionalClassName, orderClassName)\n nextElement.classList.add(CLASS_NAME_ACTIVE)\n\n activeElement.classList.remove(CLASS_NAME_ACTIVE, orderClassName, directionalClassName)\n\n this._isSliding = false\n\n triggerEvent(EVENT_SLID)\n }\n\n this._queueCallback(completeCallBack, activeElement, this._isAnimated())\n\n if (isCycling) {\n this.cycle()\n }\n }\n\n _isAnimated() {\n return this._element.classList.contains(CLASS_NAME_SLIDE)\n }\n\n _getActive() {\n return SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n }\n\n _getItems() {\n return SelectorEngine.find(SELECTOR_ITEM, this._element)\n }\n\n _clearInterval() {\n if (this._interval) {\n clearInterval(this._interval)\n this._interval = null\n }\n }\n\n _directionToOrder(direction) {\n if (isRTL()) {\n return direction === DIRECTION_LEFT ? ORDER_PREV : ORDER_NEXT\n }\n\n return direction === DIRECTION_LEFT ? ORDER_NEXT : ORDER_PREV\n }\n\n _orderToDirection(order) {\n if (isRTL()) {\n return order === ORDER_PREV ? DIRECTION_LEFT : DIRECTION_RIGHT\n }\n\n return order === ORDER_PREV ? DIRECTION_RIGHT : DIRECTION_LEFT\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Carousel.getOrCreateInstance(this, config)\n\n if (typeof config === 'number') {\n data.to(config)\n return\n }\n\n if (typeof config === 'string') {\n if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n }\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_SLIDE, function (event) {\n const target = getElementFromSelector(this)\n\n if (!target || !target.classList.contains(CLASS_NAME_CAROUSEL)) {\n return\n }\n\n event.preventDefault()\n\n const carousel = Carousel.getOrCreateInstance(target)\n const slideIndex = this.getAttribute('data-bs-slide-to')\n\n if (slideIndex) {\n carousel.to(slideIndex)\n carousel._maybeEnableCycle()\n return\n }\n\n if (Manipulator.getDataAttribute(this, 'slide') === 'next') {\n carousel.next()\n carousel._maybeEnableCycle()\n return\n }\n\n carousel.prev()\n carousel._maybeEnableCycle()\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n const carousels = SelectorEngine.find(SELECTOR_DATA_RIDE)\n\n for (const carousel of carousels) {\n Carousel.getOrCreateInstance(carousel)\n }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Carousel)\n\nexport default Carousel\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): collapse.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n defineJQueryPlugin,\n getElement,\n getElementFromSelector,\n getSelectorFromElement,\n reflow\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * Constants\n */\n\nconst NAME = 'collapse'\nconst DATA_KEY = 'bs.collapse'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_COLLAPSE = 'collapse'\nconst CLASS_NAME_COLLAPSING = 'collapsing'\nconst CLASS_NAME_COLLAPSED = 'collapsed'\nconst CLASS_NAME_DEEPER_CHILDREN = `:scope .${CLASS_NAME_COLLAPSE} .${CLASS_NAME_COLLAPSE}`\nconst CLASS_NAME_HORIZONTAL = 'collapse-horizontal'\n\nconst WIDTH = 'width'\nconst HEIGHT = 'height'\n\nconst SELECTOR_ACTIVES = '.collapse.show, .collapse.collapsing'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"collapse\"]'\n\nconst Default = {\n parent: null,\n toggle: true\n}\n\nconst DefaultType = {\n parent: '(null|element)',\n toggle: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Collapse extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._isTransitioning = false\n this._triggerArray = []\n\n const toggleList = SelectorEngine.find(SELECTOR_DATA_TOGGLE)\n\n for (const elem of toggleList) {\n const selector = getSelectorFromElement(elem)\n const filterElement = SelectorEngine.find(selector)\n .filter(foundElement => foundElement === this._element)\n\n if (selector !== null && filterElement.length) {\n this._triggerArray.push(elem)\n }\n }\n\n this._initializeChildren()\n\n if (!this._config.parent) {\n this._addAriaAndCollapsedClass(this._triggerArray, this._isShown())\n }\n\n if (this._config.toggle) {\n this.toggle()\n }\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle() {\n if (this._isShown()) {\n this.hide()\n } else {\n this.show()\n }\n }\n\n show() {\n if (this._isTransitioning || this._isShown()) {\n return\n }\n\n let activeChildren = []\n\n // find active children\n if (this._config.parent) {\n activeChildren = this._getFirstLevelChildren(SELECTOR_ACTIVES)\n .filter(element => element !== this._element)\n .map(element => Collapse.getOrCreateInstance(element, { toggle: false }))\n }\n\n if (activeChildren.length && activeChildren[0]._isTransitioning) {\n return\n }\n\n const startEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n if (startEvent.defaultPrevented) {\n return\n }\n\n for (const activeInstance of activeChildren) {\n activeInstance.hide()\n }\n\n const dimension = this._getDimension()\n\n this._element.classList.remove(CLASS_NAME_COLLAPSE)\n this._element.classList.add(CLASS_NAME_COLLAPSING)\n\n this._element.style[dimension] = 0\n\n this._addAriaAndCollapsedClass(this._triggerArray, true)\n this._isTransitioning = true\n\n const complete = () => {\n this._isTransitioning = false\n\n this._element.classList.remove(CLASS_NAME_COLLAPSING)\n this._element.classList.add(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n this._element.style[dimension] = ''\n\n EventHandler.trigger(this._element, EVENT_SHOWN)\n }\n\n const capitalizedDimension = dimension[0].toUpperCase() + dimension.slice(1)\n const scrollSize = `scroll${capitalizedDimension}`\n\n this._queueCallback(complete, this._element, true)\n this._element.style[dimension] = `${this._element[scrollSize]}px`\n }\n\n hide() {\n if (this._isTransitioning || !this._isShown()) {\n return\n }\n\n const startEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n if (startEvent.defaultPrevented) {\n return\n }\n\n const dimension = this._getDimension()\n\n this._element.style[dimension] = `${this._element.getBoundingClientRect()[dimension]}px`\n\n reflow(this._element)\n\n this._element.classList.add(CLASS_NAME_COLLAPSING)\n this._element.classList.remove(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n for (const trigger of this._triggerArray) {\n const element = getElementFromSelector(trigger)\n\n if (element && !this._isShown(element)) {\n this._addAriaAndCollapsedClass([trigger], false)\n }\n }\n\n this._isTransitioning = true\n\n const complete = () => {\n this._isTransitioning = false\n this._element.classList.remove(CLASS_NAME_COLLAPSING)\n this._element.classList.add(CLASS_NAME_COLLAPSE)\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n }\n\n this._element.style[dimension] = ''\n\n this._queueCallback(complete, this._element, true)\n }\n\n _isShown(element = this._element) {\n return element.classList.contains(CLASS_NAME_SHOW)\n }\n\n // Private\n _configAfterMerge(config) {\n config.toggle = Boolean(config.toggle) // Coerce string values\n config.parent = getElement(config.parent)\n return config\n }\n\n _getDimension() {\n return this._element.classList.contains(CLASS_NAME_HORIZONTAL) ? WIDTH : HEIGHT\n }\n\n _initializeChildren() {\n if (!this._config.parent) {\n return\n }\n\n const children = this._getFirstLevelChildren(SELECTOR_DATA_TOGGLE)\n\n for (const element of children) {\n const selected = getElementFromSelector(element)\n\n if (selected) {\n this._addAriaAndCollapsedClass([element], this._isShown(selected))\n }\n }\n }\n\n _getFirstLevelChildren(selector) {\n const children = SelectorEngine.find(CLASS_NAME_DEEPER_CHILDREN, this._config.parent)\n // remove children if greater depth\n return SelectorEngine.find(selector, this._config.parent).filter(element => !children.includes(element))\n }\n\n _addAriaAndCollapsedClass(triggerArray, isOpen) {\n if (!triggerArray.length) {\n return\n }\n\n for (const element of triggerArray) {\n element.classList.toggle(CLASS_NAME_COLLAPSED, !isOpen)\n element.setAttribute('aria-expanded', isOpen)\n }\n }\n\n // Static\n static jQueryInterface(config) {\n const _config = {}\n if (typeof config === 'string' && /show|hide/.test(config)) {\n _config.toggle = false\n }\n\n return this.each(function () {\n const data = Collapse.getOrCreateInstance(this, _config)\n\n if (typeof config === 'string') {\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n }\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n // preventDefault only for elements (which change the URL) not inside the collapsible element\n if (event.target.tagName === 'A' || (event.delegateTarget && event.delegateTarget.tagName === 'A')) {\n event.preventDefault()\n }\n\n const selector = getSelectorFromElement(this)\n const selectorElements = SelectorEngine.find(selector)\n\n for (const element of selectorElements) {\n Collapse.getOrCreateInstance(element, { toggle: false }).toggle()\n }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Collapse)\n\nexport default Collapse\n","export var top = 'top';\nexport var bottom = 'bottom';\nexport var right = 'right';\nexport var left = 'left';\nexport var auto = 'auto';\nexport var basePlacements = [top, bottom, right, left];\nexport var start = 'start';\nexport var end = 'end';\nexport var clippingParents = 'clippingParents';\nexport var viewport = 'viewport';\nexport var popper = 'popper';\nexport var reference = 'reference';\nexport var variationPlacements = /*#__PURE__*/basePlacements.reduce(function (acc, placement) {\n return acc.concat([placement + \"-\" + start, placement + \"-\" + end]);\n}, []);\nexport var placements = /*#__PURE__*/[].concat(basePlacements, [auto]).reduce(function (acc, placement) {\n return acc.concat([placement, placement + \"-\" + start, placement + \"-\" + end]);\n}, []); // modifiers that need to read the DOM\n\nexport var beforeRead = 'beforeRead';\nexport var read = 'read';\nexport var afterRead = 'afterRead'; // pure-logic modifiers\n\nexport var beforeMain = 'beforeMain';\nexport var main = 'main';\nexport var afterMain = 'afterMain'; // modifier with the purpose to write to the DOM (or write into a framework state)\n\nexport var beforeWrite = 'beforeWrite';\nexport var write = 'write';\nexport var afterWrite = 'afterWrite';\nexport var modifierPhases = [beforeRead, read, afterRead, beforeMain, main, afterMain, beforeWrite, write, afterWrite];","export default function getNodeName(element) {\n return element ? (element.nodeName || '').toLowerCase() : null;\n}","export default function getWindow(node) {\n if (node == null) {\n return window;\n }\n\n if (node.toString() !== '[object Window]') {\n var ownerDocument = node.ownerDocument;\n return ownerDocument ? ownerDocument.defaultView || window : window;\n }\n\n return node;\n}","import getWindow from \"./getWindow.js\";\n\nfunction isElement(node) {\n var OwnElement = getWindow(node).Element;\n return node instanceof OwnElement || node instanceof Element;\n}\n\nfunction isHTMLElement(node) {\n var OwnElement = getWindow(node).HTMLElement;\n return node instanceof OwnElement || node instanceof HTMLElement;\n}\n\nfunction isShadowRoot(node) {\n // IE 11 has no ShadowRoot\n if (typeof ShadowRoot === 'undefined') {\n return false;\n }\n\n var OwnElement = getWindow(node).ShadowRoot;\n return node instanceof OwnElement || node instanceof ShadowRoot;\n}\n\nexport { isElement, isHTMLElement, isShadowRoot };","import getNodeName from \"../dom-utils/getNodeName.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // This modifier takes the styles prepared by the `computeStyles` modifier\n// and applies them to the HTMLElements such as popper and arrow\n\nfunction applyStyles(_ref) {\n var state = _ref.state;\n Object.keys(state.elements).forEach(function (name) {\n var style = state.styles[name] || {};\n var attributes = state.attributes[name] || {};\n var element = state.elements[name]; // arrow is optional + virtual elements\n\n if (!isHTMLElement(element) || !getNodeName(element)) {\n return;\n } // Flow doesn't support to extend this property, but it's the most\n // effective way to apply styles to an HTMLElement\n // $FlowFixMe[cannot-write]\n\n\n Object.assign(element.style, style);\n Object.keys(attributes).forEach(function (name) {\n var value = attributes[name];\n\n if (value === false) {\n element.removeAttribute(name);\n } else {\n element.setAttribute(name, value === true ? '' : value);\n }\n });\n });\n}\n\nfunction effect(_ref2) {\n var state = _ref2.state;\n var initialStyles = {\n popper: {\n position: state.options.strategy,\n left: '0',\n top: '0',\n margin: '0'\n },\n arrow: {\n position: 'absolute'\n },\n reference: {}\n };\n Object.assign(state.elements.popper.style, initialStyles.popper);\n state.styles = initialStyles;\n\n if (state.elements.arrow) {\n Object.assign(state.elements.arrow.style, initialStyles.arrow);\n }\n\n return function () {\n Object.keys(state.elements).forEach(function (name) {\n var element = state.elements[name];\n var attributes = state.attributes[name] || {};\n var styleProperties = Object.keys(state.styles.hasOwnProperty(name) ? state.styles[name] : initialStyles[name]); // Set all values to an empty string to unset them\n\n var style = styleProperties.reduce(function (style, property) {\n style[property] = '';\n return style;\n }, {}); // arrow is optional + virtual elements\n\n if (!isHTMLElement(element) || !getNodeName(element)) {\n return;\n }\n\n Object.assign(element.style, style);\n Object.keys(attributes).forEach(function (attribute) {\n element.removeAttribute(attribute);\n });\n });\n };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'applyStyles',\n enabled: true,\n phase: 'write',\n fn: applyStyles,\n effect: effect,\n requires: ['computeStyles']\n};","import { auto } from \"../enums.js\";\nexport default function getBasePlacement(placement) {\n return placement.split('-')[0];\n}","export var max = Math.max;\nexport var min = Math.min;\nexport var round = Math.round;","export default function getUAString() {\n var uaData = navigator.userAgentData;\n\n if (uaData != null && uaData.brands) {\n return uaData.brands.map(function (item) {\n return item.brand + \"/\" + item.version;\n }).join(' ');\n }\n\n return navigator.userAgent;\n}","import getUAString from \"../utils/userAgent.js\";\nexport default function isLayoutViewport() {\n return !/^((?!chrome|android).)*safari/i.test(getUAString());\n}","import { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport { round } from \"../utils/math.js\";\nimport getWindow from \"./getWindow.js\";\nimport isLayoutViewport from \"./isLayoutViewport.js\";\nexport default function getBoundingClientRect(element, includeScale, isFixedStrategy) {\n if (includeScale === void 0) {\n includeScale = false;\n }\n\n if (isFixedStrategy === void 0) {\n isFixedStrategy = false;\n }\n\n var clientRect = element.getBoundingClientRect();\n var scaleX = 1;\n var scaleY = 1;\n\n if (includeScale && isHTMLElement(element)) {\n scaleX = element.offsetWidth > 0 ? round(clientRect.width) / element.offsetWidth || 1 : 1;\n scaleY = element.offsetHeight > 0 ? round(clientRect.height) / element.offsetHeight || 1 : 1;\n }\n\n var _ref = isElement(element) ? getWindow(element) : window,\n visualViewport = _ref.visualViewport;\n\n var addVisualOffsets = !isLayoutViewport() && isFixedStrategy;\n var x = (clientRect.left + (addVisualOffsets && visualViewport ? visualViewport.offsetLeft : 0)) / scaleX;\n var y = (clientRect.top + (addVisualOffsets && visualViewport ? visualViewport.offsetTop : 0)) / scaleY;\n var width = clientRect.width / scaleX;\n var height = clientRect.height / scaleY;\n return {\n width: width,\n height: height,\n top: y,\n right: x + width,\n bottom: y + height,\n left: x,\n x: x,\n y: y\n };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\"; // Returns the layout rect of an element relative to its offsetParent. Layout\n// means it doesn't take into account transforms.\n\nexport default function getLayoutRect(element) {\n var clientRect = getBoundingClientRect(element); // Use the clientRect sizes if it's not been transformed.\n // Fixes https://github.com/popperjs/popper-core/issues/1223\n\n var width = element.offsetWidth;\n var height = element.offsetHeight;\n\n if (Math.abs(clientRect.width - width) <= 1) {\n width = clientRect.width;\n }\n\n if (Math.abs(clientRect.height - height) <= 1) {\n height = clientRect.height;\n }\n\n return {\n x: element.offsetLeft,\n y: element.offsetTop,\n width: width,\n height: height\n };\n}","import { isShadowRoot } from \"./instanceOf.js\";\nexport default function contains(parent, child) {\n var rootNode = child.getRootNode && child.getRootNode(); // First, attempt with faster native method\n\n if (parent.contains(child)) {\n return true;\n } // then fallback to custom implementation with Shadow DOM support\n else if (rootNode && isShadowRoot(rootNode)) {\n var next = child;\n\n do {\n if (next && parent.isSameNode(next)) {\n return true;\n } // $FlowFixMe[prop-missing]: need a better way to handle this...\n\n\n next = next.parentNode || next.host;\n } while (next);\n } // Give up, the result is false\n\n\n return false;\n}","import getWindow from \"./getWindow.js\";\nexport default function getComputedStyle(element) {\n return getWindow(element).getComputedStyle(element);\n}","import getNodeName from \"./getNodeName.js\";\nexport default function isTableElement(element) {\n return ['table', 'td', 'th'].indexOf(getNodeName(element)) >= 0;\n}","import { isElement } from \"./instanceOf.js\";\nexport default function getDocumentElement(element) {\n // $FlowFixMe[incompatible-return]: assume body is always available\n return ((isElement(element) ? element.ownerDocument : // $FlowFixMe[prop-missing]\n element.document) || window.document).documentElement;\n}","import getNodeName from \"./getNodeName.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport { isShadowRoot } from \"./instanceOf.js\";\nexport default function getParentNode(element) {\n if (getNodeName(element) === 'html') {\n return element;\n }\n\n return (// this is a quicker (but less type safe) way to save quite some bytes from the bundle\n // $FlowFixMe[incompatible-return]\n // $FlowFixMe[prop-missing]\n element.assignedSlot || // step into the shadow DOM of the parent of a slotted node\n element.parentNode || ( // DOM Element detected\n isShadowRoot(element) ? element.host : null) || // ShadowRoot detected\n // $FlowFixMe[incompatible-call]: HTMLElement is a Node\n getDocumentElement(element) // fallback\n\n );\n}","import getWindow from \"./getWindow.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isHTMLElement, isShadowRoot } from \"./instanceOf.js\";\nimport isTableElement from \"./isTableElement.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getUAString from \"../utils/userAgent.js\";\n\nfunction getTrueOffsetParent(element) {\n if (!isHTMLElement(element) || // https://github.com/popperjs/popper-core/issues/837\n getComputedStyle(element).position === 'fixed') {\n return null;\n }\n\n return element.offsetParent;\n} // `.offsetParent` reports `null` for fixed elements, while absolute elements\n// return the containing block\n\n\nfunction getContainingBlock(element) {\n var isFirefox = /firefox/i.test(getUAString());\n var isIE = /Trident/i.test(getUAString());\n\n if (isIE && isHTMLElement(element)) {\n // In IE 9, 10 and 11 fixed elements containing block is always established by the viewport\n var elementCss = getComputedStyle(element);\n\n if (elementCss.position === 'fixed') {\n return null;\n }\n }\n\n var currentNode = getParentNode(element);\n\n if (isShadowRoot(currentNode)) {\n currentNode = currentNode.host;\n }\n\n while (isHTMLElement(currentNode) && ['html', 'body'].indexOf(getNodeName(currentNode)) < 0) {\n var css = getComputedStyle(currentNode); // This is non-exhaustive but covers the most common CSS properties that\n // create a containing block.\n // https://developer.mozilla.org/en-US/docs/Web/CSS/Containing_block#identifying_the_containing_block\n\n if (css.transform !== 'none' || css.perspective !== 'none' || css.contain === 'paint' || ['transform', 'perspective'].indexOf(css.willChange) !== -1 || isFirefox && css.willChange === 'filter' || isFirefox && css.filter && css.filter !== 'none') {\n return currentNode;\n } else {\n currentNode = currentNode.parentNode;\n }\n }\n\n return null;\n} // Gets the closest ancestor positioned element. Handles some edge cases,\n// such as table ancestors and cross browser bugs.\n\n\nexport default function getOffsetParent(element) {\n var window = getWindow(element);\n var offsetParent = getTrueOffsetParent(element);\n\n while (offsetParent && isTableElement(offsetParent) && getComputedStyle(offsetParent).position === 'static') {\n offsetParent = getTrueOffsetParent(offsetParent);\n }\n\n if (offsetParent && (getNodeName(offsetParent) === 'html' || getNodeName(offsetParent) === 'body' && getComputedStyle(offsetParent).position === 'static')) {\n return window;\n }\n\n return offsetParent || getContainingBlock(element) || window;\n}","export default function getMainAxisFromPlacement(placement) {\n return ['top', 'bottom'].indexOf(placement) >= 0 ? 'x' : 'y';\n}","import { max as mathMax, min as mathMin } from \"./math.js\";\nexport function within(min, value, max) {\n return mathMax(min, mathMin(value, max));\n}\nexport function withinMaxClamp(min, value, max) {\n var v = within(min, value, max);\n return v > max ? max : v;\n}","import getFreshSideObject from \"./getFreshSideObject.js\";\nexport default function mergePaddingObject(paddingObject) {\n return Object.assign({}, getFreshSideObject(), paddingObject);\n}","export default function getFreshSideObject() {\n return {\n top: 0,\n right: 0,\n bottom: 0,\n left: 0\n };\n}","export default function expandToHashMap(value, keys) {\n return keys.reduce(function (hashMap, key) {\n hashMap[key] = value;\n return hashMap;\n }, {});\n}","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport contains from \"../dom-utils/contains.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport { within } from \"../utils/within.js\";\nimport mergePaddingObject from \"../utils/mergePaddingObject.js\";\nimport expandToHashMap from \"../utils/expandToHashMap.js\";\nimport { left, right, basePlacements, top, bottom } from \"../enums.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar toPaddingObject = function toPaddingObject(padding, state) {\n padding = typeof padding === 'function' ? padding(Object.assign({}, state.rects, {\n placement: state.placement\n })) : padding;\n return mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n};\n\nfunction arrow(_ref) {\n var _state$modifiersData$;\n\n var state = _ref.state,\n name = _ref.name,\n options = _ref.options;\n var arrowElement = state.elements.arrow;\n var popperOffsets = state.modifiersData.popperOffsets;\n var basePlacement = getBasePlacement(state.placement);\n var axis = getMainAxisFromPlacement(basePlacement);\n var isVertical = [left, right].indexOf(basePlacement) >= 0;\n var len = isVertical ? 'height' : 'width';\n\n if (!arrowElement || !popperOffsets) {\n return;\n }\n\n var paddingObject = toPaddingObject(options.padding, state);\n var arrowRect = getLayoutRect(arrowElement);\n var minProp = axis === 'y' ? top : left;\n var maxProp = axis === 'y' ? bottom : right;\n var endDiff = state.rects.reference[len] + state.rects.reference[axis] - popperOffsets[axis] - state.rects.popper[len];\n var startDiff = popperOffsets[axis] - state.rects.reference[axis];\n var arrowOffsetParent = getOffsetParent(arrowElement);\n var clientSize = arrowOffsetParent ? axis === 'y' ? arrowOffsetParent.clientHeight || 0 : arrowOffsetParent.clientWidth || 0 : 0;\n var centerToReference = endDiff / 2 - startDiff / 2; // Make sure the arrow doesn't overflow the popper if the center point is\n // outside of the popper bounds\n\n var min = paddingObject[minProp];\n var max = clientSize - arrowRect[len] - paddingObject[maxProp];\n var center = clientSize / 2 - arrowRect[len] / 2 + centerToReference;\n var offset = within(min, center, max); // Prevents breaking syntax highlighting...\n\n var axisProp = axis;\n state.modifiersData[name] = (_state$modifiersData$ = {}, _state$modifiersData$[axisProp] = offset, _state$modifiersData$.centerOffset = offset - center, _state$modifiersData$);\n}\n\nfunction effect(_ref2) {\n var state = _ref2.state,\n options = _ref2.options;\n var _options$element = options.element,\n arrowElement = _options$element === void 0 ? '[data-popper-arrow]' : _options$element;\n\n if (arrowElement == null) {\n return;\n } // CSS selector\n\n\n if (typeof arrowElement === 'string') {\n arrowElement = state.elements.popper.querySelector(arrowElement);\n\n if (!arrowElement) {\n return;\n }\n }\n\n if (process.env.NODE_ENV !== \"production\") {\n if (!isHTMLElement(arrowElement)) {\n console.error(['Popper: \"arrow\" element must be an HTMLElement (not an SVGElement).', 'To use an SVG arrow, wrap it in an HTMLElement that will be used as', 'the arrow.'].join(' '));\n }\n }\n\n if (!contains(state.elements.popper, arrowElement)) {\n if (process.env.NODE_ENV !== \"production\") {\n console.error(['Popper: \"arrow\" modifier\\'s `element` must be a child of the popper', 'element.'].join(' '));\n }\n\n return;\n }\n\n state.elements.arrow = arrowElement;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'arrow',\n enabled: true,\n phase: 'main',\n fn: arrow,\n effect: effect,\n requires: ['popperOffsets'],\n requiresIfExists: ['preventOverflow']\n};","export default function getVariation(placement) {\n return placement.split('-')[1];\n}","import { top, left, right, bottom, end } from \"../enums.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getWindow from \"../dom-utils/getWindow.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getComputedStyle from \"../dom-utils/getComputedStyle.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport { round } from \"../utils/math.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar unsetSides = {\n top: 'auto',\n right: 'auto',\n bottom: 'auto',\n left: 'auto'\n}; // Round the offsets to the nearest suitable subpixel based on the DPR.\n// Zooming can change the DPR, but it seems to report a value that will\n// cleanly divide the values into the appropriate subpixels.\n\nfunction roundOffsetsByDPR(_ref) {\n var x = _ref.x,\n y = _ref.y;\n var win = window;\n var dpr = win.devicePixelRatio || 1;\n return {\n x: round(x * dpr) / dpr || 0,\n y: round(y * dpr) / dpr || 0\n };\n}\n\nexport function mapToStyles(_ref2) {\n var _Object$assign2;\n\n var popper = _ref2.popper,\n popperRect = _ref2.popperRect,\n placement = _ref2.placement,\n variation = _ref2.variation,\n offsets = _ref2.offsets,\n position = _ref2.position,\n gpuAcceleration = _ref2.gpuAcceleration,\n adaptive = _ref2.adaptive,\n roundOffsets = _ref2.roundOffsets,\n isFixed = _ref2.isFixed;\n var _offsets$x = offsets.x,\n x = _offsets$x === void 0 ? 0 : _offsets$x,\n _offsets$y = offsets.y,\n y = _offsets$y === void 0 ? 0 : _offsets$y;\n\n var _ref3 = typeof roundOffsets === 'function' ? roundOffsets({\n x: x,\n y: y\n }) : {\n x: x,\n y: y\n };\n\n x = _ref3.x;\n y = _ref3.y;\n var hasX = offsets.hasOwnProperty('x');\n var hasY = offsets.hasOwnProperty('y');\n var sideX = left;\n var sideY = top;\n var win = window;\n\n if (adaptive) {\n var offsetParent = getOffsetParent(popper);\n var heightProp = 'clientHeight';\n var widthProp = 'clientWidth';\n\n if (offsetParent === getWindow(popper)) {\n offsetParent = getDocumentElement(popper);\n\n if (getComputedStyle(offsetParent).position !== 'static' && position === 'absolute') {\n heightProp = 'scrollHeight';\n widthProp = 'scrollWidth';\n }\n } // $FlowFixMe[incompatible-cast]: force type refinement, we compare offsetParent with window above, but Flow doesn't detect it\n\n\n offsetParent = offsetParent;\n\n if (placement === top || (placement === left || placement === right) && variation === end) {\n sideY = bottom;\n var offsetY = isFixed && offsetParent === win && win.visualViewport ? win.visualViewport.height : // $FlowFixMe[prop-missing]\n offsetParent[heightProp];\n y -= offsetY - popperRect.height;\n y *= gpuAcceleration ? 1 : -1;\n }\n\n if (placement === left || (placement === top || placement === bottom) && variation === end) {\n sideX = right;\n var offsetX = isFixed && offsetParent === win && win.visualViewport ? win.visualViewport.width : // $FlowFixMe[prop-missing]\n offsetParent[widthProp];\n x -= offsetX - popperRect.width;\n x *= gpuAcceleration ? 1 : -1;\n }\n }\n\n var commonStyles = Object.assign({\n position: position\n }, adaptive && unsetSides);\n\n var _ref4 = roundOffsets === true ? roundOffsetsByDPR({\n x: x,\n y: y\n }) : {\n x: x,\n y: y\n };\n\n x = _ref4.x;\n y = _ref4.y;\n\n if (gpuAcceleration) {\n var _Object$assign;\n\n return Object.assign({}, commonStyles, (_Object$assign = {}, _Object$assign[sideY] = hasY ? '0' : '', _Object$assign[sideX] = hasX ? '0' : '', _Object$assign.transform = (win.devicePixelRatio || 1) <= 1 ? \"translate(\" + x + \"px, \" + y + \"px)\" : \"translate3d(\" + x + \"px, \" + y + \"px, 0)\", _Object$assign));\n }\n\n return Object.assign({}, commonStyles, (_Object$assign2 = {}, _Object$assign2[sideY] = hasY ? y + \"px\" : '', _Object$assign2[sideX] = hasX ? x + \"px\" : '', _Object$assign2.transform = '', _Object$assign2));\n}\n\nfunction computeStyles(_ref5) {\n var state = _ref5.state,\n options = _ref5.options;\n var _options$gpuAccelerat = options.gpuAcceleration,\n gpuAcceleration = _options$gpuAccelerat === void 0 ? true : _options$gpuAccelerat,\n _options$adaptive = options.adaptive,\n adaptive = _options$adaptive === void 0 ? true : _options$adaptive,\n _options$roundOffsets = options.roundOffsets,\n roundOffsets = _options$roundOffsets === void 0 ? true : _options$roundOffsets;\n\n if (process.env.NODE_ENV !== \"production\") {\n var transitionProperty = getComputedStyle(state.elements.popper).transitionProperty || '';\n\n if (adaptive && ['transform', 'top', 'right', 'bottom', 'left'].some(function (property) {\n return transitionProperty.indexOf(property) >= 0;\n })) {\n console.warn(['Popper: Detected CSS transitions on at least one of the following', 'CSS properties: \"transform\", \"top\", \"right\", \"bottom\", \"left\".', '\\n\\n', 'Disable the \"computeStyles\" modifier\\'s `adaptive` option to allow', 'for smooth transitions, or remove these properties from the CSS', 'transition declaration on the popper element if only transitioning', 'opacity or background-color for example.', '\\n\\n', 'We recommend using the popper element as a wrapper around an inner', 'element that can have any CSS property transitioned for animations.'].join(' '));\n }\n }\n\n var commonStyles = {\n placement: getBasePlacement(state.placement),\n variation: getVariation(state.placement),\n popper: state.elements.popper,\n popperRect: state.rects.popper,\n gpuAcceleration: gpuAcceleration,\n isFixed: state.options.strategy === 'fixed'\n };\n\n if (state.modifiersData.popperOffsets != null) {\n state.styles.popper = Object.assign({}, state.styles.popper, mapToStyles(Object.assign({}, commonStyles, {\n offsets: state.modifiersData.popperOffsets,\n position: state.options.strategy,\n adaptive: adaptive,\n roundOffsets: roundOffsets\n })));\n }\n\n if (state.modifiersData.arrow != null) {\n state.styles.arrow = Object.assign({}, state.styles.arrow, mapToStyles(Object.assign({}, commonStyles, {\n offsets: state.modifiersData.arrow,\n position: 'absolute',\n adaptive: false,\n roundOffsets: roundOffsets\n })));\n }\n\n state.attributes.popper = Object.assign({}, state.attributes.popper, {\n 'data-popper-placement': state.placement\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'computeStyles',\n enabled: true,\n phase: 'beforeWrite',\n fn: computeStyles,\n data: {}\n};","import getWindow from \"../dom-utils/getWindow.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar passive = {\n passive: true\n};\n\nfunction effect(_ref) {\n var state = _ref.state,\n instance = _ref.instance,\n options = _ref.options;\n var _options$scroll = options.scroll,\n scroll = _options$scroll === void 0 ? true : _options$scroll,\n _options$resize = options.resize,\n resize = _options$resize === void 0 ? true : _options$resize;\n var window = getWindow(state.elements.popper);\n var scrollParents = [].concat(state.scrollParents.reference, state.scrollParents.popper);\n\n if (scroll) {\n scrollParents.forEach(function (scrollParent) {\n scrollParent.addEventListener('scroll', instance.update, passive);\n });\n }\n\n if (resize) {\n window.addEventListener('resize', instance.update, passive);\n }\n\n return function () {\n if (scroll) {\n scrollParents.forEach(function (scrollParent) {\n scrollParent.removeEventListener('scroll', instance.update, passive);\n });\n }\n\n if (resize) {\n window.removeEventListener('resize', instance.update, passive);\n }\n };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'eventListeners',\n enabled: true,\n phase: 'write',\n fn: function fn() {},\n effect: effect,\n data: {}\n};","var hash = {\n left: 'right',\n right: 'left',\n bottom: 'top',\n top: 'bottom'\n};\nexport default function getOppositePlacement(placement) {\n return placement.replace(/left|right|bottom|top/g, function (matched) {\n return hash[matched];\n });\n}","var hash = {\n start: 'end',\n end: 'start'\n};\nexport default function getOppositeVariationPlacement(placement) {\n return placement.replace(/start|end/g, function (matched) {\n return hash[matched];\n });\n}","import getWindow from \"./getWindow.js\";\nexport default function getWindowScroll(node) {\n var win = getWindow(node);\n var scrollLeft = win.pageXOffset;\n var scrollTop = win.pageYOffset;\n return {\n scrollLeft: scrollLeft,\n scrollTop: scrollTop\n };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nexport default function getWindowScrollBarX(element) {\n // If has a CSS width greater than the viewport, then this will be\n // incorrect for RTL.\n // Popper 1 is broken in this case and never had a bug report so let's assume\n // it's not an issue. I don't think anyone ever specifies width on \n // anyway.\n // Browsers where the left scrollbar doesn't cause an issue report `0` for\n // this (e.g. Edge 2019, IE11, Safari)\n return getBoundingClientRect(getDocumentElement(element)).left + getWindowScroll(element).scrollLeft;\n}","import getComputedStyle from \"./getComputedStyle.js\";\nexport default function isScrollParent(element) {\n // Firefox wants us to check `-x` and `-y` variations as well\n var _getComputedStyle = getComputedStyle(element),\n overflow = _getComputedStyle.overflow,\n overflowX = _getComputedStyle.overflowX,\n overflowY = _getComputedStyle.overflowY;\n\n return /auto|scroll|overlay|hidden/.test(overflow + overflowY + overflowX);\n}","import getParentNode from \"./getParentNode.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nexport default function getScrollParent(node) {\n if (['html', 'body', '#document'].indexOf(getNodeName(node)) >= 0) {\n // $FlowFixMe[incompatible-return]: assume body is always available\n return node.ownerDocument.body;\n }\n\n if (isHTMLElement(node) && isScrollParent(node)) {\n return node;\n }\n\n return getScrollParent(getParentNode(node));\n}","import getScrollParent from \"./getScrollParent.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getWindow from \"./getWindow.js\";\nimport isScrollParent from \"./isScrollParent.js\";\n/*\ngiven a DOM element, return the list of all scroll parents, up the list of ancesors\nuntil we get to the top window object. This list is what we attach scroll listeners\nto, because if any of these parent elements scroll, we'll need to re-calculate the\nreference element's position.\n*/\n\nexport default function listScrollParents(element, list) {\n var _element$ownerDocumen;\n\n if (list === void 0) {\n list = [];\n }\n\n var scrollParent = getScrollParent(element);\n var isBody = scrollParent === ((_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body);\n var win = getWindow(scrollParent);\n var target = isBody ? [win].concat(win.visualViewport || [], isScrollParent(scrollParent) ? scrollParent : []) : scrollParent;\n var updatedList = list.concat(target);\n return isBody ? updatedList : // $FlowFixMe[incompatible-call]: isBody tells us target will be an HTMLElement here\n updatedList.concat(listScrollParents(getParentNode(target)));\n}","export default function rectToClientRect(rect) {\n return Object.assign({}, rect, {\n left: rect.x,\n top: rect.y,\n right: rect.x + rect.width,\n bottom: rect.y + rect.height\n });\n}","import { viewport } from \"../enums.js\";\nimport getViewportRect from \"./getViewportRect.js\";\nimport getDocumentRect from \"./getDocumentRect.js\";\nimport listScrollParents from \"./listScrollParents.js\";\nimport getOffsetParent from \"./getOffsetParent.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport contains from \"./contains.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport rectToClientRect from \"../utils/rectToClientRect.js\";\nimport { max, min } from \"../utils/math.js\";\n\nfunction getInnerBoundingClientRect(element, strategy) {\n var rect = getBoundingClientRect(element, false, strategy === 'fixed');\n rect.top = rect.top + element.clientTop;\n rect.left = rect.left + element.clientLeft;\n rect.bottom = rect.top + element.clientHeight;\n rect.right = rect.left + element.clientWidth;\n rect.width = element.clientWidth;\n rect.height = element.clientHeight;\n rect.x = rect.left;\n rect.y = rect.top;\n return rect;\n}\n\nfunction getClientRectFromMixedType(element, clippingParent, strategy) {\n return clippingParent === viewport ? rectToClientRect(getViewportRect(element, strategy)) : isElement(clippingParent) ? getInnerBoundingClientRect(clippingParent, strategy) : rectToClientRect(getDocumentRect(getDocumentElement(element)));\n} // A \"clipping parent\" is an overflowable container with the characteristic of\n// clipping (or hiding) overflowing elements with a position different from\n// `initial`\n\n\nfunction getClippingParents(element) {\n var clippingParents = listScrollParents(getParentNode(element));\n var canEscapeClipping = ['absolute', 'fixed'].indexOf(getComputedStyle(element).position) >= 0;\n var clipperElement = canEscapeClipping && isHTMLElement(element) ? getOffsetParent(element) : element;\n\n if (!isElement(clipperElement)) {\n return [];\n } // $FlowFixMe[incompatible-return]: https://github.com/facebook/flow/issues/1414\n\n\n return clippingParents.filter(function (clippingParent) {\n return isElement(clippingParent) && contains(clippingParent, clipperElement) && getNodeName(clippingParent) !== 'body';\n });\n} // Gets the maximum area that the element is visible in due to any number of\n// clipping parents\n\n\nexport default function getClippingRect(element, boundary, rootBoundary, strategy) {\n var mainClippingParents = boundary === 'clippingParents' ? getClippingParents(element) : [].concat(boundary);\n var clippingParents = [].concat(mainClippingParents, [rootBoundary]);\n var firstClippingParent = clippingParents[0];\n var clippingRect = clippingParents.reduce(function (accRect, clippingParent) {\n var rect = getClientRectFromMixedType(element, clippingParent, strategy);\n accRect.top = max(rect.top, accRect.top);\n accRect.right = min(rect.right, accRect.right);\n accRect.bottom = min(rect.bottom, accRect.bottom);\n accRect.left = max(rect.left, accRect.left);\n return accRect;\n }, getClientRectFromMixedType(element, firstClippingParent, strategy));\n clippingRect.width = clippingRect.right - clippingRect.left;\n clippingRect.height = clippingRect.bottom - clippingRect.top;\n clippingRect.x = clippingRect.left;\n clippingRect.y = clippingRect.top;\n return clippingRect;\n}","import getWindow from \"./getWindow.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport isLayoutViewport from \"./isLayoutViewport.js\";\nexport default function getViewportRect(element, strategy) {\n var win = getWindow(element);\n var html = getDocumentElement(element);\n var visualViewport = win.visualViewport;\n var width = html.clientWidth;\n var height = html.clientHeight;\n var x = 0;\n var y = 0;\n\n if (visualViewport) {\n width = visualViewport.width;\n height = visualViewport.height;\n var layoutViewport = isLayoutViewport();\n\n if (layoutViewport || !layoutViewport && strategy === 'fixed') {\n x = visualViewport.offsetLeft;\n y = visualViewport.offsetTop;\n }\n }\n\n return {\n width: width,\n height: height,\n x: x + getWindowScrollBarX(element),\n y: y\n };\n}","import getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nimport { max } from \"../utils/math.js\"; // Gets the entire size of the scrollable document area, even extending outside\n// of the `` and `` rect bounds if horizontally scrollable\n\nexport default function getDocumentRect(element) {\n var _element$ownerDocumen;\n\n var html = getDocumentElement(element);\n var winScroll = getWindowScroll(element);\n var body = (_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body;\n var width = max(html.scrollWidth, html.clientWidth, body ? body.scrollWidth : 0, body ? body.clientWidth : 0);\n var height = max(html.scrollHeight, html.clientHeight, body ? body.scrollHeight : 0, body ? body.clientHeight : 0);\n var x = -winScroll.scrollLeft + getWindowScrollBarX(element);\n var y = -winScroll.scrollTop;\n\n if (getComputedStyle(body || html).direction === 'rtl') {\n x += max(html.clientWidth, body ? body.clientWidth : 0) - width;\n }\n\n return {\n width: width,\n height: height,\n x: x,\n y: y\n };\n}","import getBasePlacement from \"./getBasePlacement.js\";\nimport getVariation from \"./getVariation.js\";\nimport getMainAxisFromPlacement from \"./getMainAxisFromPlacement.js\";\nimport { top, right, bottom, left, start, end } from \"../enums.js\";\nexport default function computeOffsets(_ref) {\n var reference = _ref.reference,\n element = _ref.element,\n placement = _ref.placement;\n var basePlacement = placement ? getBasePlacement(placement) : null;\n var variation = placement ? getVariation(placement) : null;\n var commonX = reference.x + reference.width / 2 - element.width / 2;\n var commonY = reference.y + reference.height / 2 - element.height / 2;\n var offsets;\n\n switch (basePlacement) {\n case top:\n offsets = {\n x: commonX,\n y: reference.y - element.height\n };\n break;\n\n case bottom:\n offsets = {\n x: commonX,\n y: reference.y + reference.height\n };\n break;\n\n case right:\n offsets = {\n x: reference.x + reference.width,\n y: commonY\n };\n break;\n\n case left:\n offsets = {\n x: reference.x - element.width,\n y: commonY\n };\n break;\n\n default:\n offsets = {\n x: reference.x,\n y: reference.y\n };\n }\n\n var mainAxis = basePlacement ? getMainAxisFromPlacement(basePlacement) : null;\n\n if (mainAxis != null) {\n var len = mainAxis === 'y' ? 'height' : 'width';\n\n switch (variation) {\n case start:\n offsets[mainAxis] = offsets[mainAxis] - (reference[len] / 2 - element[len] / 2);\n break;\n\n case end:\n offsets[mainAxis] = offsets[mainAxis] + (reference[len] / 2 - element[len] / 2);\n break;\n\n default:\n }\n }\n\n return offsets;\n}","import getClippingRect from \"../dom-utils/getClippingRect.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getBoundingClientRect from \"../dom-utils/getBoundingClientRect.js\";\nimport computeOffsets from \"./computeOffsets.js\";\nimport rectToClientRect from \"./rectToClientRect.js\";\nimport { clippingParents, reference, popper, bottom, top, right, basePlacements, viewport } from \"../enums.js\";\nimport { isElement } from \"../dom-utils/instanceOf.js\";\nimport mergePaddingObject from \"./mergePaddingObject.js\";\nimport expandToHashMap from \"./expandToHashMap.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport default function detectOverflow(state, options) {\n if (options === void 0) {\n options = {};\n }\n\n var _options = options,\n _options$placement = _options.placement,\n placement = _options$placement === void 0 ? state.placement : _options$placement,\n _options$strategy = _options.strategy,\n strategy = _options$strategy === void 0 ? state.strategy : _options$strategy,\n _options$boundary = _options.boundary,\n boundary = _options$boundary === void 0 ? clippingParents : _options$boundary,\n _options$rootBoundary = _options.rootBoundary,\n rootBoundary = _options$rootBoundary === void 0 ? viewport : _options$rootBoundary,\n _options$elementConte = _options.elementContext,\n elementContext = _options$elementConte === void 0 ? popper : _options$elementConte,\n _options$altBoundary = _options.altBoundary,\n altBoundary = _options$altBoundary === void 0 ? false : _options$altBoundary,\n _options$padding = _options.padding,\n padding = _options$padding === void 0 ? 0 : _options$padding;\n var paddingObject = mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n var altContext = elementContext === popper ? reference : popper;\n var popperRect = state.rects.popper;\n var element = state.elements[altBoundary ? altContext : elementContext];\n var clippingClientRect = getClippingRect(isElement(element) ? element : element.contextElement || getDocumentElement(state.elements.popper), boundary, rootBoundary, strategy);\n var referenceClientRect = getBoundingClientRect(state.elements.reference);\n var popperOffsets = computeOffsets({\n reference: referenceClientRect,\n element: popperRect,\n strategy: 'absolute',\n placement: placement\n });\n var popperClientRect = rectToClientRect(Object.assign({}, popperRect, popperOffsets));\n var elementClientRect = elementContext === popper ? popperClientRect : referenceClientRect; // positive = overflowing the clipping rect\n // 0 or negative = within the clipping rect\n\n var overflowOffsets = {\n top: clippingClientRect.top - elementClientRect.top + paddingObject.top,\n bottom: elementClientRect.bottom - clippingClientRect.bottom + paddingObject.bottom,\n left: clippingClientRect.left - elementClientRect.left + paddingObject.left,\n right: elementClientRect.right - clippingClientRect.right + paddingObject.right\n };\n var offsetData = state.modifiersData.offset; // Offsets can be applied only to the popper element\n\n if (elementContext === popper && offsetData) {\n var offset = offsetData[placement];\n Object.keys(overflowOffsets).forEach(function (key) {\n var multiply = [right, bottom].indexOf(key) >= 0 ? 1 : -1;\n var axis = [top, bottom].indexOf(key) >= 0 ? 'y' : 'x';\n overflowOffsets[key] += offset[axis] * multiply;\n });\n }\n\n return overflowOffsets;\n}","import getVariation from \"./getVariation.js\";\nimport { variationPlacements, basePlacements, placements as allPlacements } from \"../enums.js\";\nimport detectOverflow from \"./detectOverflow.js\";\nimport getBasePlacement from \"./getBasePlacement.js\";\nexport default function computeAutoPlacement(state, options) {\n if (options === void 0) {\n options = {};\n }\n\n var _options = options,\n placement = _options.placement,\n boundary = _options.boundary,\n rootBoundary = _options.rootBoundary,\n padding = _options.padding,\n flipVariations = _options.flipVariations,\n _options$allowedAutoP = _options.allowedAutoPlacements,\n allowedAutoPlacements = _options$allowedAutoP === void 0 ? allPlacements : _options$allowedAutoP;\n var variation = getVariation(placement);\n var placements = variation ? flipVariations ? variationPlacements : variationPlacements.filter(function (placement) {\n return getVariation(placement) === variation;\n }) : basePlacements;\n var allowedPlacements = placements.filter(function (placement) {\n return allowedAutoPlacements.indexOf(placement) >= 0;\n });\n\n if (allowedPlacements.length === 0) {\n allowedPlacements = placements;\n\n if (process.env.NODE_ENV !== \"production\") {\n console.error(['Popper: The `allowedAutoPlacements` option did not allow any', 'placements. Ensure the `placement` option matches the variation', 'of the allowed placements.', 'For example, \"auto\" cannot be used to allow \"bottom-start\".', 'Use \"auto-start\" instead.'].join(' '));\n }\n } // $FlowFixMe[incompatible-type]: Flow seems to have problems with two array unions...\n\n\n var overflows = allowedPlacements.reduce(function (acc, placement) {\n acc[placement] = detectOverflow(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding\n })[getBasePlacement(placement)];\n return acc;\n }, {});\n return Object.keys(overflows).sort(function (a, b) {\n return overflows[a] - overflows[b];\n });\n}","import getOppositePlacement from \"../utils/getOppositePlacement.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getOppositeVariationPlacement from \"../utils/getOppositeVariationPlacement.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport computeAutoPlacement from \"../utils/computeAutoPlacement.js\";\nimport { bottom, top, start, right, left, auto } from \"../enums.js\";\nimport getVariation from \"../utils/getVariation.js\"; // eslint-disable-next-line import/no-unused-modules\n\nfunction getExpandedFallbackPlacements(placement) {\n if (getBasePlacement(placement) === auto) {\n return [];\n }\n\n var oppositePlacement = getOppositePlacement(placement);\n return [getOppositeVariationPlacement(placement), oppositePlacement, getOppositeVariationPlacement(oppositePlacement)];\n}\n\nfunction flip(_ref) {\n var state = _ref.state,\n options = _ref.options,\n name = _ref.name;\n\n if (state.modifiersData[name]._skip) {\n return;\n }\n\n var _options$mainAxis = options.mainAxis,\n checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n _options$altAxis = options.altAxis,\n checkAltAxis = _options$altAxis === void 0 ? true : _options$altAxis,\n specifiedFallbackPlacements = options.fallbackPlacements,\n padding = options.padding,\n boundary = options.boundary,\n rootBoundary = options.rootBoundary,\n altBoundary = options.altBoundary,\n _options$flipVariatio = options.flipVariations,\n flipVariations = _options$flipVariatio === void 0 ? true : _options$flipVariatio,\n allowedAutoPlacements = options.allowedAutoPlacements;\n var preferredPlacement = state.options.placement;\n var basePlacement = getBasePlacement(preferredPlacement);\n var isBasePlacement = basePlacement === preferredPlacement;\n var fallbackPlacements = specifiedFallbackPlacements || (isBasePlacement || !flipVariations ? [getOppositePlacement(preferredPlacement)] : getExpandedFallbackPlacements(preferredPlacement));\n var placements = [preferredPlacement].concat(fallbackPlacements).reduce(function (acc, placement) {\n return acc.concat(getBasePlacement(placement) === auto ? computeAutoPlacement(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding,\n flipVariations: flipVariations,\n allowedAutoPlacements: allowedAutoPlacements\n }) : placement);\n }, []);\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var checksMap = new Map();\n var makeFallbackChecks = true;\n var firstFittingPlacement = placements[0];\n\n for (var i = 0; i < placements.length; i++) {\n var placement = placements[i];\n\n var _basePlacement = getBasePlacement(placement);\n\n var isStartVariation = getVariation(placement) === start;\n var isVertical = [top, bottom].indexOf(_basePlacement) >= 0;\n var len = isVertical ? 'width' : 'height';\n var overflow = detectOverflow(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n altBoundary: altBoundary,\n padding: padding\n });\n var mainVariationSide = isVertical ? isStartVariation ? right : left : isStartVariation ? bottom : top;\n\n if (referenceRect[len] > popperRect[len]) {\n mainVariationSide = getOppositePlacement(mainVariationSide);\n }\n\n var altVariationSide = getOppositePlacement(mainVariationSide);\n var checks = [];\n\n if (checkMainAxis) {\n checks.push(overflow[_basePlacement] <= 0);\n }\n\n if (checkAltAxis) {\n checks.push(overflow[mainVariationSide] <= 0, overflow[altVariationSide] <= 0);\n }\n\n if (checks.every(function (check) {\n return check;\n })) {\n firstFittingPlacement = placement;\n makeFallbackChecks = false;\n break;\n }\n\n checksMap.set(placement, checks);\n }\n\n if (makeFallbackChecks) {\n // `2` may be desired in some cases – research later\n var numberOfChecks = flipVariations ? 3 : 1;\n\n var _loop = function _loop(_i) {\n var fittingPlacement = placements.find(function (placement) {\n var checks = checksMap.get(placement);\n\n if (checks) {\n return checks.slice(0, _i).every(function (check) {\n return check;\n });\n }\n });\n\n if (fittingPlacement) {\n firstFittingPlacement = fittingPlacement;\n return \"break\";\n }\n };\n\n for (var _i = numberOfChecks; _i > 0; _i--) {\n var _ret = _loop(_i);\n\n if (_ret === \"break\") break;\n }\n }\n\n if (state.placement !== firstFittingPlacement) {\n state.modifiersData[name]._skip = true;\n state.placement = firstFittingPlacement;\n state.reset = true;\n }\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'flip',\n enabled: true,\n phase: 'main',\n fn: flip,\n requiresIfExists: ['offset'],\n data: {\n _skip: false\n }\n};","import { top, bottom, left, right } from \"../enums.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\n\nfunction getSideOffsets(overflow, rect, preventedOffsets) {\n if (preventedOffsets === void 0) {\n preventedOffsets = {\n x: 0,\n y: 0\n };\n }\n\n return {\n top: overflow.top - rect.height - preventedOffsets.y,\n right: overflow.right - rect.width + preventedOffsets.x,\n bottom: overflow.bottom - rect.height + preventedOffsets.y,\n left: overflow.left - rect.width - preventedOffsets.x\n };\n}\n\nfunction isAnySideFullyClipped(overflow) {\n return [top, right, bottom, left].some(function (side) {\n return overflow[side] >= 0;\n });\n}\n\nfunction hide(_ref) {\n var state = _ref.state,\n name = _ref.name;\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var preventedOffsets = state.modifiersData.preventOverflow;\n var referenceOverflow = detectOverflow(state, {\n elementContext: 'reference'\n });\n var popperAltOverflow = detectOverflow(state, {\n altBoundary: true\n });\n var referenceClippingOffsets = getSideOffsets(referenceOverflow, referenceRect);\n var popperEscapeOffsets = getSideOffsets(popperAltOverflow, popperRect, preventedOffsets);\n var isReferenceHidden = isAnySideFullyClipped(referenceClippingOffsets);\n var hasPopperEscaped = isAnySideFullyClipped(popperEscapeOffsets);\n state.modifiersData[name] = {\n referenceClippingOffsets: referenceClippingOffsets,\n popperEscapeOffsets: popperEscapeOffsets,\n isReferenceHidden: isReferenceHidden,\n hasPopperEscaped: hasPopperEscaped\n };\n state.attributes.popper = Object.assign({}, state.attributes.popper, {\n 'data-popper-reference-hidden': isReferenceHidden,\n 'data-popper-escaped': hasPopperEscaped\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'hide',\n enabled: true,\n phase: 'main',\n requiresIfExists: ['preventOverflow'],\n fn: hide\n};","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport { top, left, right, placements } from \"../enums.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport function distanceAndSkiddingToXY(placement, rects, offset) {\n var basePlacement = getBasePlacement(placement);\n var invertDistance = [left, top].indexOf(basePlacement) >= 0 ? -1 : 1;\n\n var _ref = typeof offset === 'function' ? offset(Object.assign({}, rects, {\n placement: placement\n })) : offset,\n skidding = _ref[0],\n distance = _ref[1];\n\n skidding = skidding || 0;\n distance = (distance || 0) * invertDistance;\n return [left, right].indexOf(basePlacement) >= 0 ? {\n x: distance,\n y: skidding\n } : {\n x: skidding,\n y: distance\n };\n}\n\nfunction offset(_ref2) {\n var state = _ref2.state,\n options = _ref2.options,\n name = _ref2.name;\n var _options$offset = options.offset,\n offset = _options$offset === void 0 ? [0, 0] : _options$offset;\n var data = placements.reduce(function (acc, placement) {\n acc[placement] = distanceAndSkiddingToXY(placement, state.rects, offset);\n return acc;\n }, {});\n var _data$state$placement = data[state.placement],\n x = _data$state$placement.x,\n y = _data$state$placement.y;\n\n if (state.modifiersData.popperOffsets != null) {\n state.modifiersData.popperOffsets.x += x;\n state.modifiersData.popperOffsets.y += y;\n }\n\n state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'offset',\n enabled: true,\n phase: 'main',\n requires: ['popperOffsets'],\n fn: offset\n};","import computeOffsets from \"../utils/computeOffsets.js\";\n\nfunction popperOffsets(_ref) {\n var state = _ref.state,\n name = _ref.name;\n // Offsets are the actual position the popper needs to have to be\n // properly positioned near its reference element\n // This is the most basic placement, and will be adjusted by\n // the modifiers in the next step\n state.modifiersData[name] = computeOffsets({\n reference: state.rects.reference,\n element: state.rects.popper,\n strategy: 'absolute',\n placement: state.placement\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'popperOffsets',\n enabled: true,\n phase: 'read',\n fn: popperOffsets,\n data: {}\n};","import { top, left, right, bottom, start } from \"../enums.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport getAltAxis from \"../utils/getAltAxis.js\";\nimport { within, withinMaxClamp } from \"../utils/within.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport getFreshSideObject from \"../utils/getFreshSideObject.js\";\nimport { min as mathMin, max as mathMax } from \"../utils/math.js\";\n\nfunction preventOverflow(_ref) {\n var state = _ref.state,\n options = _ref.options,\n name = _ref.name;\n var _options$mainAxis = options.mainAxis,\n checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n _options$altAxis = options.altAxis,\n checkAltAxis = _options$altAxis === void 0 ? false : _options$altAxis,\n boundary = options.boundary,\n rootBoundary = options.rootBoundary,\n altBoundary = options.altBoundary,\n padding = options.padding,\n _options$tether = options.tether,\n tether = _options$tether === void 0 ? true : _options$tether,\n _options$tetherOffset = options.tetherOffset,\n tetherOffset = _options$tetherOffset === void 0 ? 0 : _options$tetherOffset;\n var overflow = detectOverflow(state, {\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding,\n altBoundary: altBoundary\n });\n var basePlacement = getBasePlacement(state.placement);\n var variation = getVariation(state.placement);\n var isBasePlacement = !variation;\n var mainAxis = getMainAxisFromPlacement(basePlacement);\n var altAxis = getAltAxis(mainAxis);\n var popperOffsets = state.modifiersData.popperOffsets;\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var tetherOffsetValue = typeof tetherOffset === 'function' ? tetherOffset(Object.assign({}, state.rects, {\n placement: state.placement\n })) : tetherOffset;\n var normalizedTetherOffsetValue = typeof tetherOffsetValue === 'number' ? {\n mainAxis: tetherOffsetValue,\n altAxis: tetherOffsetValue\n } : Object.assign({\n mainAxis: 0,\n altAxis: 0\n }, tetherOffsetValue);\n var offsetModifierState = state.modifiersData.offset ? state.modifiersData.offset[state.placement] : null;\n var data = {\n x: 0,\n y: 0\n };\n\n if (!popperOffsets) {\n return;\n }\n\n if (checkMainAxis) {\n var _offsetModifierState$;\n\n var mainSide = mainAxis === 'y' ? top : left;\n var altSide = mainAxis === 'y' ? bottom : right;\n var len = mainAxis === 'y' ? 'height' : 'width';\n var offset = popperOffsets[mainAxis];\n var min = offset + overflow[mainSide];\n var max = offset - overflow[altSide];\n var additive = tether ? -popperRect[len] / 2 : 0;\n var minLen = variation === start ? referenceRect[len] : popperRect[len];\n var maxLen = variation === start ? -popperRect[len] : -referenceRect[len]; // We need to include the arrow in the calculation so the arrow doesn't go\n // outside the reference bounds\n\n var arrowElement = state.elements.arrow;\n var arrowRect = tether && arrowElement ? getLayoutRect(arrowElement) : {\n width: 0,\n height: 0\n };\n var arrowPaddingObject = state.modifiersData['arrow#persistent'] ? state.modifiersData['arrow#persistent'].padding : getFreshSideObject();\n var arrowPaddingMin = arrowPaddingObject[mainSide];\n var arrowPaddingMax = arrowPaddingObject[altSide]; // If the reference length is smaller than the arrow length, we don't want\n // to include its full size in the calculation. If the reference is small\n // and near the edge of a boundary, the popper can overflow even if the\n // reference is not overflowing as well (e.g. virtual elements with no\n // width or height)\n\n var arrowLen = within(0, referenceRect[len], arrowRect[len]);\n var minOffset = isBasePlacement ? referenceRect[len] / 2 - additive - arrowLen - arrowPaddingMin - normalizedTetherOffsetValue.mainAxis : minLen - arrowLen - arrowPaddingMin - normalizedTetherOffsetValue.mainAxis;\n var maxOffset = isBasePlacement ? -referenceRect[len] / 2 + additive + arrowLen + arrowPaddingMax + normalizedTetherOffsetValue.mainAxis : maxLen + arrowLen + arrowPaddingMax + normalizedTetherOffsetValue.mainAxis;\n var arrowOffsetParent = state.elements.arrow && getOffsetParent(state.elements.arrow);\n var clientOffset = arrowOffsetParent ? mainAxis === 'y' ? arrowOffsetParent.clientTop || 0 : arrowOffsetParent.clientLeft || 0 : 0;\n var offsetModifierValue = (_offsetModifierState$ = offsetModifierState == null ? void 0 : offsetModifierState[mainAxis]) != null ? _offsetModifierState$ : 0;\n var tetherMin = offset + minOffset - offsetModifierValue - clientOffset;\n var tetherMax = offset + maxOffset - offsetModifierValue;\n var preventedOffset = within(tether ? mathMin(min, tetherMin) : min, offset, tether ? mathMax(max, tetherMax) : max);\n popperOffsets[mainAxis] = preventedOffset;\n data[mainAxis] = preventedOffset - offset;\n }\n\n if (checkAltAxis) {\n var _offsetModifierState$2;\n\n var _mainSide = mainAxis === 'x' ? top : left;\n\n var _altSide = mainAxis === 'x' ? bottom : right;\n\n var _offset = popperOffsets[altAxis];\n\n var _len = altAxis === 'y' ? 'height' : 'width';\n\n var _min = _offset + overflow[_mainSide];\n\n var _max = _offset - overflow[_altSide];\n\n var isOriginSide = [top, left].indexOf(basePlacement) !== -1;\n\n var _offsetModifierValue = (_offsetModifierState$2 = offsetModifierState == null ? void 0 : offsetModifierState[altAxis]) != null ? _offsetModifierState$2 : 0;\n\n var _tetherMin = isOriginSide ? _min : _offset - referenceRect[_len] - popperRect[_len] - _offsetModifierValue + normalizedTetherOffsetValue.altAxis;\n\n var _tetherMax = isOriginSide ? _offset + referenceRect[_len] + popperRect[_len] - _offsetModifierValue - normalizedTetherOffsetValue.altAxis : _max;\n\n var _preventedOffset = tether && isOriginSide ? withinMaxClamp(_tetherMin, _offset, _tetherMax) : within(tether ? _tetherMin : _min, _offset, tether ? _tetherMax : _max);\n\n popperOffsets[altAxis] = _preventedOffset;\n data[altAxis] = _preventedOffset - _offset;\n }\n\n state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'preventOverflow',\n enabled: true,\n phase: 'main',\n fn: preventOverflow,\n requiresIfExists: ['offset']\n};","export default function getAltAxis(axis) {\n return axis === 'x' ? 'y' : 'x';\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getNodeScroll from \"./getNodeScroll.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport { round } from \"../utils/math.js\";\n\nfunction isElementScaled(element) {\n var rect = element.getBoundingClientRect();\n var scaleX = round(rect.width) / element.offsetWidth || 1;\n var scaleY = round(rect.height) / element.offsetHeight || 1;\n return scaleX !== 1 || scaleY !== 1;\n} // Returns the composite rect of an element relative to its offsetParent.\n// Composite means it takes into account transforms as well as layout.\n\n\nexport default function getCompositeRect(elementOrVirtualElement, offsetParent, isFixed) {\n if (isFixed === void 0) {\n isFixed = false;\n }\n\n var isOffsetParentAnElement = isHTMLElement(offsetParent);\n var offsetParentIsScaled = isHTMLElement(offsetParent) && isElementScaled(offsetParent);\n var documentElement = getDocumentElement(offsetParent);\n var rect = getBoundingClientRect(elementOrVirtualElement, offsetParentIsScaled, isFixed);\n var scroll = {\n scrollLeft: 0,\n scrollTop: 0\n };\n var offsets = {\n x: 0,\n y: 0\n };\n\n if (isOffsetParentAnElement || !isOffsetParentAnElement && !isFixed) {\n if (getNodeName(offsetParent) !== 'body' || // https://github.com/popperjs/popper-core/issues/1078\n isScrollParent(documentElement)) {\n scroll = getNodeScroll(offsetParent);\n }\n\n if (isHTMLElement(offsetParent)) {\n offsets = getBoundingClientRect(offsetParent, true);\n offsets.x += offsetParent.clientLeft;\n offsets.y += offsetParent.clientTop;\n } else if (documentElement) {\n offsets.x = getWindowScrollBarX(documentElement);\n }\n }\n\n return {\n x: rect.left + scroll.scrollLeft - offsets.x,\n y: rect.top + scroll.scrollTop - offsets.y,\n width: rect.width,\n height: rect.height\n };\n}","import getWindowScroll from \"./getWindowScroll.js\";\nimport getWindow from \"./getWindow.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getHTMLElementScroll from \"./getHTMLElementScroll.js\";\nexport default function getNodeScroll(node) {\n if (node === getWindow(node) || !isHTMLElement(node)) {\n return getWindowScroll(node);\n } else {\n return getHTMLElementScroll(node);\n }\n}","export default function getHTMLElementScroll(element) {\n return {\n scrollLeft: element.scrollLeft,\n scrollTop: element.scrollTop\n };\n}","import { modifierPhases } from \"../enums.js\"; // source: https://stackoverflow.com/questions/49875255\n\nfunction order(modifiers) {\n var map = new Map();\n var visited = new Set();\n var result = [];\n modifiers.forEach(function (modifier) {\n map.set(modifier.name, modifier);\n }); // On visiting object, check for its dependencies and visit them recursively\n\n function sort(modifier) {\n visited.add(modifier.name);\n var requires = [].concat(modifier.requires || [], modifier.requiresIfExists || []);\n requires.forEach(function (dep) {\n if (!visited.has(dep)) {\n var depModifier = map.get(dep);\n\n if (depModifier) {\n sort(depModifier);\n }\n }\n });\n result.push(modifier);\n }\n\n modifiers.forEach(function (modifier) {\n if (!visited.has(modifier.name)) {\n // check for visited object\n sort(modifier);\n }\n });\n return result;\n}\n\nexport default function orderModifiers(modifiers) {\n // order based on dependencies\n var orderedModifiers = order(modifiers); // order based on phase\n\n return modifierPhases.reduce(function (acc, phase) {\n return acc.concat(orderedModifiers.filter(function (modifier) {\n return modifier.phase === phase;\n }));\n }, []);\n}","import getCompositeRect from \"./dom-utils/getCompositeRect.js\";\nimport getLayoutRect from \"./dom-utils/getLayoutRect.js\";\nimport listScrollParents from \"./dom-utils/listScrollParents.js\";\nimport getOffsetParent from \"./dom-utils/getOffsetParent.js\";\nimport getComputedStyle from \"./dom-utils/getComputedStyle.js\";\nimport orderModifiers from \"./utils/orderModifiers.js\";\nimport debounce from \"./utils/debounce.js\";\nimport validateModifiers from \"./utils/validateModifiers.js\";\nimport uniqueBy from \"./utils/uniqueBy.js\";\nimport getBasePlacement from \"./utils/getBasePlacement.js\";\nimport mergeByName from \"./utils/mergeByName.js\";\nimport detectOverflow from \"./utils/detectOverflow.js\";\nimport { isElement } from \"./dom-utils/instanceOf.js\";\nimport { auto } from \"./enums.js\";\nvar INVALID_ELEMENT_ERROR = 'Popper: Invalid reference or popper argument provided. They must be either a DOM element or virtual element.';\nvar INFINITE_LOOP_ERROR = 'Popper: An infinite loop in the modifiers cycle has been detected! The cycle has been interrupted to prevent a browser crash.';\nvar DEFAULT_OPTIONS = {\n placement: 'bottom',\n modifiers: [],\n strategy: 'absolute'\n};\n\nfunction areValidElements() {\n for (var _len = arguments.length, args = new Array(_len), _key = 0; _key < _len; _key++) {\n args[_key] = arguments[_key];\n }\n\n return !args.some(function (element) {\n return !(element && typeof element.getBoundingClientRect === 'function');\n });\n}\n\nexport function popperGenerator(generatorOptions) {\n if (generatorOptions === void 0) {\n generatorOptions = {};\n }\n\n var _generatorOptions = generatorOptions,\n _generatorOptions$def = _generatorOptions.defaultModifiers,\n defaultModifiers = _generatorOptions$def === void 0 ? [] : _generatorOptions$def,\n _generatorOptions$def2 = _generatorOptions.defaultOptions,\n defaultOptions = _generatorOptions$def2 === void 0 ? DEFAULT_OPTIONS : _generatorOptions$def2;\n return function createPopper(reference, popper, options) {\n if (options === void 0) {\n options = defaultOptions;\n }\n\n var state = {\n placement: 'bottom',\n orderedModifiers: [],\n options: Object.assign({}, DEFAULT_OPTIONS, defaultOptions),\n modifiersData: {},\n elements: {\n reference: reference,\n popper: popper\n },\n attributes: {},\n styles: {}\n };\n var effectCleanupFns = [];\n var isDestroyed = false;\n var instance = {\n state: state,\n setOptions: function setOptions(setOptionsAction) {\n var options = typeof setOptionsAction === 'function' ? setOptionsAction(state.options) : setOptionsAction;\n cleanupModifierEffects();\n state.options = Object.assign({}, defaultOptions, state.options, options);\n state.scrollParents = {\n reference: isElement(reference) ? listScrollParents(reference) : reference.contextElement ? listScrollParents(reference.contextElement) : [],\n popper: listScrollParents(popper)\n }; // Orders the modifiers based on their dependencies and `phase`\n // properties\n\n var orderedModifiers = orderModifiers(mergeByName([].concat(defaultModifiers, state.options.modifiers))); // Strip out disabled modifiers\n\n state.orderedModifiers = orderedModifiers.filter(function (m) {\n return m.enabled;\n }); // Validate the provided modifiers so that the consumer will get warned\n // if one of the modifiers is invalid for any reason\n\n if (process.env.NODE_ENV !== \"production\") {\n var modifiers = uniqueBy([].concat(orderedModifiers, state.options.modifiers), function (_ref) {\n var name = _ref.name;\n return name;\n });\n validateModifiers(modifiers);\n\n if (getBasePlacement(state.options.placement) === auto) {\n var flipModifier = state.orderedModifiers.find(function (_ref2) {\n var name = _ref2.name;\n return name === 'flip';\n });\n\n if (!flipModifier) {\n console.error(['Popper: \"auto\" placements require the \"flip\" modifier be', 'present and enabled to work.'].join(' '));\n }\n }\n\n var _getComputedStyle = getComputedStyle(popper),\n marginTop = _getComputedStyle.marginTop,\n marginRight = _getComputedStyle.marginRight,\n marginBottom = _getComputedStyle.marginBottom,\n marginLeft = _getComputedStyle.marginLeft; // We no longer take into account `margins` on the popper, and it can\n // cause bugs with positioning, so we'll warn the consumer\n\n\n if ([marginTop, marginRight, marginBottom, marginLeft].some(function (margin) {\n return parseFloat(margin);\n })) {\n console.warn(['Popper: CSS \"margin\" styles cannot be used to apply padding', 'between the popper and its reference element or boundary.', 'To replicate margin, use the `offset` modifier, as well as', 'the `padding` option in the `preventOverflow` and `flip`', 'modifiers.'].join(' '));\n }\n }\n\n runModifierEffects();\n return instance.update();\n },\n // Sync update – it will always be executed, even if not necessary. This\n // is useful for low frequency updates where sync behavior simplifies the\n // logic.\n // For high frequency updates (e.g. `resize` and `scroll` events), always\n // prefer the async Popper#update method\n forceUpdate: function forceUpdate() {\n if (isDestroyed) {\n return;\n }\n\n var _state$elements = state.elements,\n reference = _state$elements.reference,\n popper = _state$elements.popper; // Don't proceed if `reference` or `popper` are not valid elements\n // anymore\n\n if (!areValidElements(reference, popper)) {\n if (process.env.NODE_ENV !== \"production\") {\n console.error(INVALID_ELEMENT_ERROR);\n }\n\n return;\n } // Store the reference and popper rects to be read by modifiers\n\n\n state.rects = {\n reference: getCompositeRect(reference, getOffsetParent(popper), state.options.strategy === 'fixed'),\n popper: getLayoutRect(popper)\n }; // Modifiers have the ability to reset the current update cycle. The\n // most common use case for this is the `flip` modifier changing the\n // placement, which then needs to re-run all the modifiers, because the\n // logic was previously ran for the previous placement and is therefore\n // stale/incorrect\n\n state.reset = false;\n state.placement = state.options.placement; // On each update cycle, the `modifiersData` property for each modifier\n // is filled with the initial data specified by the modifier. This means\n // it doesn't persist and is fresh on each update.\n // To ensure persistent data, use `${name}#persistent`\n\n state.orderedModifiers.forEach(function (modifier) {\n return state.modifiersData[modifier.name] = Object.assign({}, modifier.data);\n });\n var __debug_loops__ = 0;\n\n for (var index = 0; index < state.orderedModifiers.length; index++) {\n if (process.env.NODE_ENV !== \"production\") {\n __debug_loops__ += 1;\n\n if (__debug_loops__ > 100) {\n console.error(INFINITE_LOOP_ERROR);\n break;\n }\n }\n\n if (state.reset === true) {\n state.reset = false;\n index = -1;\n continue;\n }\n\n var _state$orderedModifie = state.orderedModifiers[index],\n fn = _state$orderedModifie.fn,\n _state$orderedModifie2 = _state$orderedModifie.options,\n _options = _state$orderedModifie2 === void 0 ? {} : _state$orderedModifie2,\n name = _state$orderedModifie.name;\n\n if (typeof fn === 'function') {\n state = fn({\n state: state,\n options: _options,\n name: name,\n instance: instance\n }) || state;\n }\n }\n },\n // Async and optimistically optimized update – it will not be executed if\n // not necessary (debounced to run at most once-per-tick)\n update: debounce(function () {\n return new Promise(function (resolve) {\n instance.forceUpdate();\n resolve(state);\n });\n }),\n destroy: function destroy() {\n cleanupModifierEffects();\n isDestroyed = true;\n }\n };\n\n if (!areValidElements(reference, popper)) {\n if (process.env.NODE_ENV !== \"production\") {\n console.error(INVALID_ELEMENT_ERROR);\n }\n\n return instance;\n }\n\n instance.setOptions(options).then(function (state) {\n if (!isDestroyed && options.onFirstUpdate) {\n options.onFirstUpdate(state);\n }\n }); // Modifiers have the ability to execute arbitrary code before the first\n // update cycle runs. They will be executed in the same order as the update\n // cycle. This is useful when a modifier adds some persistent data that\n // other modifiers need to use, but the modifier is run after the dependent\n // one.\n\n function runModifierEffects() {\n state.orderedModifiers.forEach(function (_ref3) {\n var name = _ref3.name,\n _ref3$options = _ref3.options,\n options = _ref3$options === void 0 ? {} : _ref3$options,\n effect = _ref3.effect;\n\n if (typeof effect === 'function') {\n var cleanupFn = effect({\n state: state,\n name: name,\n instance: instance,\n options: options\n });\n\n var noopFn = function noopFn() {};\n\n effectCleanupFns.push(cleanupFn || noopFn);\n }\n });\n }\n\n function cleanupModifierEffects() {\n effectCleanupFns.forEach(function (fn) {\n return fn();\n });\n effectCleanupFns = [];\n }\n\n return instance;\n };\n}\nexport var createPopper = /*#__PURE__*/popperGenerator(); // eslint-disable-next-line import/no-unused-modules\n\nexport { detectOverflow };","export default function debounce(fn) {\n var pending;\n return function () {\n if (!pending) {\n pending = new Promise(function (resolve) {\n Promise.resolve().then(function () {\n pending = undefined;\n resolve(fn());\n });\n });\n }\n\n return pending;\n };\n}","export default function mergeByName(modifiers) {\n var merged = modifiers.reduce(function (merged, current) {\n var existing = merged[current.name];\n merged[current.name] = existing ? Object.assign({}, existing, current, {\n options: Object.assign({}, existing.options, current.options),\n data: Object.assign({}, existing.data, current.data)\n }) : current;\n return merged;\n }, {}); // IE11 does not support Object.values\n\n return Object.keys(merged).map(function (key) {\n return merged[key];\n });\n}","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles];\nvar createPopper = /*#__PURE__*/popperGenerator({\n defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow };","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nimport offset from \"./modifiers/offset.js\";\nimport flip from \"./modifiers/flip.js\";\nimport preventOverflow from \"./modifiers/preventOverflow.js\";\nimport arrow from \"./modifiers/arrow.js\";\nimport hide from \"./modifiers/hide.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles, offset, flip, preventOverflow, arrow, hide];\nvar createPopper = /*#__PURE__*/popperGenerator({\n defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow }; // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper as createPopperLite } from \"./popper-lite.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport * from \"./modifiers/index.js\";","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): dropdown.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\nimport {\n defineJQueryPlugin,\n getElement,\n getNextActiveElement,\n isDisabled,\n isElement,\n isRTL,\n isVisible,\n noop\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * Constants\n */\n\nconst NAME = 'dropdown'\nconst DATA_KEY = 'bs.dropdown'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ESCAPE_KEY = 'Escape'\nconst TAB_KEY = 'Tab'\nconst ARROW_UP_KEY = 'ArrowUp'\nconst ARROW_DOWN_KEY = 'ArrowDown'\nconst RIGHT_MOUSE_BUTTON = 2 // MouseEvent.button value for the secondary button, usually the right button\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DATA_API = `keydown${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYUP_DATA_API = `keyup${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_DROPUP = 'dropup'\nconst CLASS_NAME_DROPEND = 'dropend'\nconst CLASS_NAME_DROPSTART = 'dropstart'\nconst CLASS_NAME_DROPUP_CENTER = 'dropup-center'\nconst CLASS_NAME_DROPDOWN_CENTER = 'dropdown-center'\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"dropdown\"]:not(.disabled):not(:disabled)'\nconst SELECTOR_DATA_TOGGLE_SHOWN = `${SELECTOR_DATA_TOGGLE}.${CLASS_NAME_SHOW}`\nconst SELECTOR_MENU = '.dropdown-menu'\nconst SELECTOR_NAVBAR = '.navbar'\nconst SELECTOR_NAVBAR_NAV = '.navbar-nav'\nconst SELECTOR_VISIBLE_ITEMS = '.dropdown-menu .dropdown-item:not(.disabled):not(:disabled)'\n\nconst PLACEMENT_TOP = isRTL() ? 'top-end' : 'top-start'\nconst PLACEMENT_TOPEND = isRTL() ? 'top-start' : 'top-end'\nconst PLACEMENT_BOTTOM = isRTL() ? 'bottom-end' : 'bottom-start'\nconst PLACEMENT_BOTTOMEND = isRTL() ? 'bottom-start' : 'bottom-end'\nconst PLACEMENT_RIGHT = isRTL() ? 'left-start' : 'right-start'\nconst PLACEMENT_LEFT = isRTL() ? 'right-start' : 'left-start'\nconst PLACEMENT_TOPCENTER = 'top'\nconst PLACEMENT_BOTTOMCENTER = 'bottom'\n\nconst Default = {\n autoClose: true,\n boundary: 'clippingParents',\n display: 'dynamic',\n offset: [0, 2],\n popperConfig: null,\n reference: 'toggle'\n}\n\nconst DefaultType = {\n autoClose: '(boolean|string)',\n boundary: '(string|element)',\n display: 'string',\n offset: '(array|string|function)',\n popperConfig: '(null|object|function)',\n reference: '(string|element|object)'\n}\n\n/**\n * Class definition\n */\n\nclass Dropdown extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._popper = null\n this._parent = this._element.parentNode // dropdown wrapper\n // todo: v6 revert #37011 & change markup https://getbootstrap.com/docs/5.2/forms/input-group/\n this._menu = SelectorEngine.next(this._element, SELECTOR_MENU)[0] ||\n SelectorEngine.prev(this._element, SELECTOR_MENU)[0] ||\n SelectorEngine.findOne(SELECTOR_MENU, this._parent)\n this._inNavbar = this._detectNavbar()\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle() {\n return this._isShown() ? this.hide() : this.show()\n }\n\n show() {\n if (isDisabled(this._element) || this._isShown()) {\n return\n }\n\n const relatedTarget = {\n relatedTarget: this._element\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, relatedTarget)\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n this._createPopper()\n\n // If this is a touch-enabled device we add extra\n // empty mouseover listeners to the body's immediate children;\n // only needed because of broken event delegation on iOS\n // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n if ('ontouchstart' in document.documentElement && !this._parent.closest(SELECTOR_NAVBAR_NAV)) {\n for (const element of [].concat(...document.body.children)) {\n EventHandler.on(element, 'mouseover', noop)\n }\n }\n\n this._element.focus()\n this._element.setAttribute('aria-expanded', true)\n\n this._menu.classList.add(CLASS_NAME_SHOW)\n this._element.classList.add(CLASS_NAME_SHOW)\n EventHandler.trigger(this._element, EVENT_SHOWN, relatedTarget)\n }\n\n hide() {\n if (isDisabled(this._element) || !this._isShown()) {\n return\n }\n\n const relatedTarget = {\n relatedTarget: this._element\n }\n\n this._completeHide(relatedTarget)\n }\n\n dispose() {\n if (this._popper) {\n this._popper.destroy()\n }\n\n super.dispose()\n }\n\n update() {\n this._inNavbar = this._detectNavbar()\n if (this._popper) {\n this._popper.update()\n }\n }\n\n // Private\n _completeHide(relatedTarget) {\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE, relatedTarget)\n if (hideEvent.defaultPrevented) {\n return\n }\n\n // If this is a touch-enabled device we remove the extra\n // empty mouseover listeners we added for iOS support\n if ('ontouchstart' in document.documentElement) {\n for (const element of [].concat(...document.body.children)) {\n EventHandler.off(element, 'mouseover', noop)\n }\n }\n\n if (this._popper) {\n this._popper.destroy()\n }\n\n this._menu.classList.remove(CLASS_NAME_SHOW)\n this._element.classList.remove(CLASS_NAME_SHOW)\n this._element.setAttribute('aria-expanded', 'false')\n Manipulator.removeDataAttribute(this._menu, 'popper')\n EventHandler.trigger(this._element, EVENT_HIDDEN, relatedTarget)\n }\n\n _getConfig(config) {\n config = super._getConfig(config)\n\n if (typeof config.reference === 'object' && !isElement(config.reference) &&\n typeof config.reference.getBoundingClientRect !== 'function'\n ) {\n // Popper virtual elements require a getBoundingClientRect method\n throw new TypeError(`${NAME.toUpperCase()}: Option \"reference\" provided type \"object\" without a required \"getBoundingClientRect\" method.`)\n }\n\n return config\n }\n\n _createPopper() {\n if (typeof Popper === 'undefined') {\n throw new TypeError('Bootstrap\\'s dropdowns require Popper (https://popper.js.org)')\n }\n\n let referenceElement = this._element\n\n if (this._config.reference === 'parent') {\n referenceElement = this._parent\n } else if (isElement(this._config.reference)) {\n referenceElement = getElement(this._config.reference)\n } else if (typeof this._config.reference === 'object') {\n referenceElement = this._config.reference\n }\n\n const popperConfig = this._getPopperConfig()\n this._popper = Popper.createPopper(referenceElement, this._menu, popperConfig)\n }\n\n _isShown() {\n return this._menu.classList.contains(CLASS_NAME_SHOW)\n }\n\n _getPlacement() {\n const parentDropdown = this._parent\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPEND)) {\n return PLACEMENT_RIGHT\n }\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPSTART)) {\n return PLACEMENT_LEFT\n }\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPUP_CENTER)) {\n return PLACEMENT_TOPCENTER\n }\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPDOWN_CENTER)) {\n return PLACEMENT_BOTTOMCENTER\n }\n\n // We need to trim the value because custom properties can also include spaces\n const isEnd = getComputedStyle(this._menu).getPropertyValue('--bs-position').trim() === 'end'\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPUP)) {\n return isEnd ? PLACEMENT_TOPEND : PLACEMENT_TOP\n }\n\n return isEnd ? PLACEMENT_BOTTOMEND : PLACEMENT_BOTTOM\n }\n\n _detectNavbar() {\n return this._element.closest(SELECTOR_NAVBAR) !== null\n }\n\n _getOffset() {\n const { offset } = this._config\n\n if (typeof offset === 'string') {\n return offset.split(',').map(value => Number.parseInt(value, 10))\n }\n\n if (typeof offset === 'function') {\n return popperData => offset(popperData, this._element)\n }\n\n return offset\n }\n\n _getPopperConfig() {\n const defaultBsPopperConfig = {\n placement: this._getPlacement(),\n modifiers: [{\n name: 'preventOverflow',\n options: {\n boundary: this._config.boundary\n }\n },\n {\n name: 'offset',\n options: {\n offset: this._getOffset()\n }\n }]\n }\n\n // Disable Popper if we have a static display or Dropdown is in Navbar\n if (this._inNavbar || this._config.display === 'static') {\n Manipulator.setDataAttribute(this._menu, 'popper', 'static') // todo:v6 remove\n defaultBsPopperConfig.modifiers = [{\n name: 'applyStyles',\n enabled: false\n }]\n }\n\n return {\n ...defaultBsPopperConfig,\n ...(typeof this._config.popperConfig === 'function' ? this._config.popperConfig(defaultBsPopperConfig) : this._config.popperConfig)\n }\n }\n\n _selectMenuItem({ key, target }) {\n const items = SelectorEngine.find(SELECTOR_VISIBLE_ITEMS, this._menu).filter(element => isVisible(element))\n\n if (!items.length) {\n return\n }\n\n // if target isn't included in items (e.g. when expanding the dropdown)\n // allow cycling to get the last item in case key equals ARROW_UP_KEY\n getNextActiveElement(items, target, key === ARROW_DOWN_KEY, !items.includes(target)).focus()\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Dropdown.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n })\n }\n\n static clearMenus(event) {\n if (event.button === RIGHT_MOUSE_BUTTON || (event.type === 'keyup' && event.key !== TAB_KEY)) {\n return\n }\n\n const openToggles = SelectorEngine.find(SELECTOR_DATA_TOGGLE_SHOWN)\n\n for (const toggle of openToggles) {\n const context = Dropdown.getInstance(toggle)\n if (!context || context._config.autoClose === false) {\n continue\n }\n\n const composedPath = event.composedPath()\n const isMenuTarget = composedPath.includes(context._menu)\n if (\n composedPath.includes(context._element) ||\n (context._config.autoClose === 'inside' && !isMenuTarget) ||\n (context._config.autoClose === 'outside' && isMenuTarget)\n ) {\n continue\n }\n\n // Tab navigation through the dropdown menu or events from contained inputs shouldn't close the menu\n if (context._menu.contains(event.target) && ((event.type === 'keyup' && event.key === TAB_KEY) || /input|select|option|textarea|form/i.test(event.target.tagName))) {\n continue\n }\n\n const relatedTarget = { relatedTarget: context._element }\n\n if (event.type === 'click') {\n relatedTarget.clickEvent = event\n }\n\n context._completeHide(relatedTarget)\n }\n }\n\n static dataApiKeydownHandler(event) {\n // If not an UP | DOWN | ESCAPE key => not a dropdown command\n // If input/textarea && if key is other than ESCAPE => not a dropdown command\n\n const isInput = /input|textarea/i.test(event.target.tagName)\n const isEscapeEvent = event.key === ESCAPE_KEY\n const isUpOrDownEvent = [ARROW_UP_KEY, ARROW_DOWN_KEY].includes(event.key)\n\n if (!isUpOrDownEvent && !isEscapeEvent) {\n return\n }\n\n if (isInput && !isEscapeEvent) {\n return\n }\n\n event.preventDefault()\n\n // todo: v6 revert #37011 & change markup https://getbootstrap.com/docs/5.2/forms/input-group/\n const getToggleButton = this.matches(SELECTOR_DATA_TOGGLE) ?\n this :\n (SelectorEngine.prev(this, SELECTOR_DATA_TOGGLE)[0] ||\n SelectorEngine.next(this, SELECTOR_DATA_TOGGLE)[0] ||\n SelectorEngine.findOne(SELECTOR_DATA_TOGGLE, event.delegateTarget.parentNode))\n\n const instance = Dropdown.getOrCreateInstance(getToggleButton)\n\n if (isUpOrDownEvent) {\n event.stopPropagation()\n instance.show()\n instance._selectMenuItem(event)\n return\n }\n\n if (instance._isShown()) { // else is escape and we check if it is shown\n event.stopPropagation()\n instance.hide()\n getToggleButton.focus()\n }\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_DATA_TOGGLE, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_MENU, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_CLICK_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_KEYUP_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n event.preventDefault()\n Dropdown.getOrCreateInstance(this).toggle()\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Dropdown)\n\nexport default Dropdown\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): util/scrollBar.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport SelectorEngine from '../dom/selector-engine'\nimport Manipulator from '../dom/manipulator'\nimport { isElement } from './index'\n\n/**\n * Constants\n */\n\nconst SELECTOR_FIXED_CONTENT = '.fixed-top, .fixed-bottom, .is-fixed, .sticky-top'\nconst SELECTOR_STICKY_CONTENT = '.sticky-top'\nconst PROPERTY_PADDING = 'padding-right'\nconst PROPERTY_MARGIN = 'margin-right'\n\n/**\n * Class definition\n */\n\nclass ScrollBarHelper {\n constructor() {\n this._element = document.body\n }\n\n // Public\n getWidth() {\n // https://developer.mozilla.org/en-US/docs/Web/API/Window/innerWidth#usage_notes\n const documentWidth = document.documentElement.clientWidth\n return Math.abs(window.innerWidth - documentWidth)\n }\n\n hide() {\n const width = this.getWidth()\n this._disableOverFlow()\n // give padding to element to balance the hidden scrollbar width\n this._setElementAttributes(this._element, PROPERTY_PADDING, calculatedValue => calculatedValue + width)\n // trick: We adjust positive paddingRight and negative marginRight to sticky-top elements to keep showing fullwidth\n this._setElementAttributes(SELECTOR_FIXED_CONTENT, PROPERTY_PADDING, calculatedValue => calculatedValue + width)\n this._setElementAttributes(SELECTOR_STICKY_CONTENT, PROPERTY_MARGIN, calculatedValue => calculatedValue - width)\n }\n\n reset() {\n this._resetElementAttributes(this._element, 'overflow')\n this._resetElementAttributes(this._element, PROPERTY_PADDING)\n this._resetElementAttributes(SELECTOR_FIXED_CONTENT, PROPERTY_PADDING)\n this._resetElementAttributes(SELECTOR_STICKY_CONTENT, PROPERTY_MARGIN)\n }\n\n isOverflowing() {\n return this.getWidth() > 0\n }\n\n // Private\n _disableOverFlow() {\n this._saveInitialAttribute(this._element, 'overflow')\n this._element.style.overflow = 'hidden'\n }\n\n _setElementAttributes(selector, styleProperty, callback) {\n const scrollbarWidth = this.getWidth()\n const manipulationCallBack = element => {\n if (element !== this._element && window.innerWidth > element.clientWidth + scrollbarWidth) {\n return\n }\n\n this._saveInitialAttribute(element, styleProperty)\n const calculatedValue = window.getComputedStyle(element).getPropertyValue(styleProperty)\n element.style.setProperty(styleProperty, `${callback(Number.parseFloat(calculatedValue))}px`)\n }\n\n this._applyManipulationCallback(selector, manipulationCallBack)\n }\n\n _saveInitialAttribute(element, styleProperty) {\n const actualValue = element.style.getPropertyValue(styleProperty)\n if (actualValue) {\n Manipulator.setDataAttribute(element, styleProperty, actualValue)\n }\n }\n\n _resetElementAttributes(selector, styleProperty) {\n const manipulationCallBack = element => {\n const value = Manipulator.getDataAttribute(element, styleProperty)\n // We only want to remove the property if the value is `null`; the value can also be zero\n if (value === null) {\n element.style.removeProperty(styleProperty)\n return\n }\n\n Manipulator.removeDataAttribute(element, styleProperty)\n element.style.setProperty(styleProperty, value)\n }\n\n this._applyManipulationCallback(selector, manipulationCallBack)\n }\n\n _applyManipulationCallback(selector, callBack) {\n if (isElement(selector)) {\n callBack(selector)\n return\n }\n\n for (const sel of SelectorEngine.find(selector, this._element)) {\n callBack(sel)\n }\n }\n}\n\nexport default ScrollBarHelper\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): util/backdrop.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport { execute, executeAfterTransition, getElement, reflow } from './index'\nimport Config from './config'\n\n/**\n * Constants\n */\n\nconst NAME = 'backdrop'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst EVENT_MOUSEDOWN = `mousedown.bs.${NAME}`\n\nconst Default = {\n className: 'modal-backdrop',\n clickCallback: null,\n isAnimated: false,\n isVisible: true, // if false, we use the backdrop helper without adding any element to the dom\n rootElement: 'body' // give the choice to place backdrop under different elements\n}\n\nconst DefaultType = {\n className: 'string',\n clickCallback: '(function|null)',\n isAnimated: 'boolean',\n isVisible: 'boolean',\n rootElement: '(element|string)'\n}\n\n/**\n * Class definition\n */\n\nclass Backdrop extends Config {\n constructor(config) {\n super()\n this._config = this._getConfig(config)\n this._isAppended = false\n this._element = null\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n show(callback) {\n if (!this._config.isVisible) {\n execute(callback)\n return\n }\n\n this._append()\n\n const element = this._getElement()\n if (this._config.isAnimated) {\n reflow(element)\n }\n\n element.classList.add(CLASS_NAME_SHOW)\n\n this._emulateAnimation(() => {\n execute(callback)\n })\n }\n\n hide(callback) {\n if (!this._config.isVisible) {\n execute(callback)\n return\n }\n\n this._getElement().classList.remove(CLASS_NAME_SHOW)\n\n this._emulateAnimation(() => {\n this.dispose()\n execute(callback)\n })\n }\n\n dispose() {\n if (!this._isAppended) {\n return\n }\n\n EventHandler.off(this._element, EVENT_MOUSEDOWN)\n\n this._element.remove()\n this._isAppended = false\n }\n\n // Private\n _getElement() {\n if (!this._element) {\n const backdrop = document.createElement('div')\n backdrop.className = this._config.className\n if (this._config.isAnimated) {\n backdrop.classList.add(CLASS_NAME_FADE)\n }\n\n this._element = backdrop\n }\n\n return this._element\n }\n\n _configAfterMerge(config) {\n // use getElement() with the default \"body\" to get a fresh Element on each instantiation\n config.rootElement = getElement(config.rootElement)\n return config\n }\n\n _append() {\n if (this._isAppended) {\n return\n }\n\n const element = this._getElement()\n this._config.rootElement.append(element)\n\n EventHandler.on(element, EVENT_MOUSEDOWN, () => {\n execute(this._config.clickCallback)\n })\n\n this._isAppended = true\n }\n\n _emulateAnimation(callback) {\n executeAfterTransition(callback, this._getElement(), this._config.isAnimated)\n }\n}\n\nexport default Backdrop\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): util/focustrap.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport SelectorEngine from '../dom/selector-engine'\nimport Config from './config'\n\n/**\n * Constants\n */\n\nconst NAME = 'focustrap'\nconst DATA_KEY = 'bs.focustrap'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_KEYDOWN_TAB = `keydown.tab${EVENT_KEY}`\n\nconst TAB_KEY = 'Tab'\nconst TAB_NAV_FORWARD = 'forward'\nconst TAB_NAV_BACKWARD = 'backward'\n\nconst Default = {\n autofocus: true,\n trapElement: null // The element to trap focus inside of\n}\n\nconst DefaultType = {\n autofocus: 'boolean',\n trapElement: 'element'\n}\n\n/**\n * Class definition\n */\n\nclass FocusTrap extends Config {\n constructor(config) {\n super()\n this._config = this._getConfig(config)\n this._isActive = false\n this._lastTabNavDirection = null\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n activate() {\n if (this._isActive) {\n return\n }\n\n if (this._config.autofocus) {\n this._config.trapElement.focus()\n }\n\n EventHandler.off(document, EVENT_KEY) // guard against infinite focus loop\n EventHandler.on(document, EVENT_FOCUSIN, event => this._handleFocusin(event))\n EventHandler.on(document, EVENT_KEYDOWN_TAB, event => this._handleKeydown(event))\n\n this._isActive = true\n }\n\n deactivate() {\n if (!this._isActive) {\n return\n }\n\n this._isActive = false\n EventHandler.off(document, EVENT_KEY)\n }\n\n // Private\n _handleFocusin(event) {\n const { trapElement } = this._config\n\n if (event.target === document || event.target === trapElement || trapElement.contains(event.target)) {\n return\n }\n\n const elements = SelectorEngine.focusableChildren(trapElement)\n\n if (elements.length === 0) {\n trapElement.focus()\n } else if (this._lastTabNavDirection === TAB_NAV_BACKWARD) {\n elements[elements.length - 1].focus()\n } else {\n elements[0].focus()\n }\n }\n\n _handleKeydown(event) {\n if (event.key !== TAB_KEY) {\n return\n }\n\n this._lastTabNavDirection = event.shiftKey ? TAB_NAV_BACKWARD : TAB_NAV_FORWARD\n }\n}\n\nexport default FocusTrap\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): modal.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin, getElementFromSelector, isRTL, isVisible, reflow } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport SelectorEngine from './dom/selector-engine'\nimport ScrollBarHelper from './util/scrollbar'\nimport BaseComponent from './base-component'\nimport Backdrop from './util/backdrop'\nimport FocusTrap from './util/focustrap'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * Constants\n */\n\nconst NAME = 'modal'\nconst DATA_KEY = 'bs.modal'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst ESCAPE_KEY = 'Escape'\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DISMISS = `click.dismiss${EVENT_KEY}`\nconst EVENT_MOUSEDOWN_DISMISS = `mousedown.dismiss${EVENT_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_OPEN = 'modal-open'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_STATIC = 'modal-static'\n\nconst OPEN_SELECTOR = '.modal.show'\nconst SELECTOR_DIALOG = '.modal-dialog'\nconst SELECTOR_MODAL_BODY = '.modal-body'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"modal\"]'\n\nconst Default = {\n backdrop: true,\n focus: true,\n keyboard: true\n}\n\nconst DefaultType = {\n backdrop: '(boolean|string)',\n focus: 'boolean',\n keyboard: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Modal extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._dialog = SelectorEngine.findOne(SELECTOR_DIALOG, this._element)\n this._backdrop = this._initializeBackDrop()\n this._focustrap = this._initializeFocusTrap()\n this._isShown = false\n this._isTransitioning = false\n this._scrollBar = new ScrollBarHelper()\n\n this._addEventListeners()\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle(relatedTarget) {\n return this._isShown ? this.hide() : this.show(relatedTarget)\n }\n\n show(relatedTarget) {\n if (this._isShown || this._isTransitioning) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, {\n relatedTarget\n })\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n this._isShown = true\n this._isTransitioning = true\n\n this._scrollBar.hide()\n\n document.body.classList.add(CLASS_NAME_OPEN)\n\n this._adjustDialog()\n\n this._backdrop.show(() => this._showElement(relatedTarget))\n }\n\n hide() {\n if (!this._isShown || this._isTransitioning) {\n return\n }\n\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n if (hideEvent.defaultPrevented) {\n return\n }\n\n this._isShown = false\n this._isTransitioning = true\n this._focustrap.deactivate()\n\n this._element.classList.remove(CLASS_NAME_SHOW)\n\n this._queueCallback(() => this._hideModal(), this._element, this._isAnimated())\n }\n\n dispose() {\n for (const htmlElement of [window, this._dialog]) {\n EventHandler.off(htmlElement, EVENT_KEY)\n }\n\n this._backdrop.dispose()\n this._focustrap.deactivate()\n super.dispose()\n }\n\n handleUpdate() {\n this._adjustDialog()\n }\n\n // Private\n _initializeBackDrop() {\n return new Backdrop({\n isVisible: Boolean(this._config.backdrop), // 'static' option will be translated to true, and booleans will keep their value,\n isAnimated: this._isAnimated()\n })\n }\n\n _initializeFocusTrap() {\n return new FocusTrap({\n trapElement: this._element\n })\n }\n\n _showElement(relatedTarget) {\n // try to append dynamic modal\n if (!document.body.contains(this._element)) {\n document.body.append(this._element)\n }\n\n this._element.style.display = 'block'\n this._element.removeAttribute('aria-hidden')\n this._element.setAttribute('aria-modal', true)\n this._element.setAttribute('role', 'dialog')\n this._element.scrollTop = 0\n\n const modalBody = SelectorEngine.findOne(SELECTOR_MODAL_BODY, this._dialog)\n if (modalBody) {\n modalBody.scrollTop = 0\n }\n\n reflow(this._element)\n\n this._element.classList.add(CLASS_NAME_SHOW)\n\n const transitionComplete = () => {\n if (this._config.focus) {\n this._focustrap.activate()\n }\n\n this._isTransitioning = false\n EventHandler.trigger(this._element, EVENT_SHOWN, {\n relatedTarget\n })\n }\n\n this._queueCallback(transitionComplete, this._dialog, this._isAnimated())\n }\n\n _addEventListeners() {\n EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n if (event.key !== ESCAPE_KEY) {\n return\n }\n\n if (this._config.keyboard) {\n event.preventDefault()\n this.hide()\n return\n }\n\n this._triggerBackdropTransition()\n })\n\n EventHandler.on(window, EVENT_RESIZE, () => {\n if (this._isShown && !this._isTransitioning) {\n this._adjustDialog()\n }\n })\n\n EventHandler.on(this._element, EVENT_MOUSEDOWN_DISMISS, event => {\n // a bad trick to segregate clicks that may start inside dialog but end outside, and avoid listen to scrollbar clicks\n EventHandler.one(this._element, EVENT_CLICK_DISMISS, event2 => {\n if (this._element !== event.target || this._element !== event2.target) {\n return\n }\n\n if (this._config.backdrop === 'static') {\n this._triggerBackdropTransition()\n return\n }\n\n if (this._config.backdrop) {\n this.hide()\n }\n })\n })\n }\n\n _hideModal() {\n this._element.style.display = 'none'\n this._element.setAttribute('aria-hidden', true)\n this._element.removeAttribute('aria-modal')\n this._element.removeAttribute('role')\n this._isTransitioning = false\n\n this._backdrop.hide(() => {\n document.body.classList.remove(CLASS_NAME_OPEN)\n this._resetAdjustments()\n this._scrollBar.reset()\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n })\n }\n\n _isAnimated() {\n return this._element.classList.contains(CLASS_NAME_FADE)\n }\n\n _triggerBackdropTransition() {\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n if (hideEvent.defaultPrevented) {\n return\n }\n\n const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n const initialOverflowY = this._element.style.overflowY\n // return if the following background transition hasn't yet completed\n if (initialOverflowY === 'hidden' || this._element.classList.contains(CLASS_NAME_STATIC)) {\n return\n }\n\n if (!isModalOverflowing) {\n this._element.style.overflowY = 'hidden'\n }\n\n this._element.classList.add(CLASS_NAME_STATIC)\n this._queueCallback(() => {\n this._element.classList.remove(CLASS_NAME_STATIC)\n this._queueCallback(() => {\n this._element.style.overflowY = initialOverflowY\n }, this._dialog)\n }, this._dialog)\n\n this._element.focus()\n }\n\n /**\n * The following methods are used to handle overflowing modals\n */\n\n _adjustDialog() {\n const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n const scrollbarWidth = this._scrollBar.getWidth()\n const isBodyOverflowing = scrollbarWidth > 0\n\n if (isBodyOverflowing && !isModalOverflowing) {\n const property = isRTL() ? 'paddingLeft' : 'paddingRight'\n this._element.style[property] = `${scrollbarWidth}px`\n }\n\n if (!isBodyOverflowing && isModalOverflowing) {\n const property = isRTL() ? 'paddingRight' : 'paddingLeft'\n this._element.style[property] = `${scrollbarWidth}px`\n }\n }\n\n _resetAdjustments() {\n this._element.style.paddingLeft = ''\n this._element.style.paddingRight = ''\n }\n\n // Static\n static jQueryInterface(config, relatedTarget) {\n return this.each(function () {\n const data = Modal.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](relatedTarget)\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n const target = getElementFromSelector(this)\n\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n EventHandler.one(target, EVENT_SHOW, showEvent => {\n if (showEvent.defaultPrevented) {\n // only register focus restorer if modal will actually get shown\n return\n }\n\n EventHandler.one(target, EVENT_HIDDEN, () => {\n if (isVisible(this)) {\n this.focus()\n }\n })\n })\n\n // avoid conflict when clicking modal toggler while another one is open\n const alreadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n if (alreadyOpen) {\n Modal.getInstance(alreadyOpen).hide()\n }\n\n const data = Modal.getOrCreateInstance(target)\n\n data.toggle(this)\n})\n\nenableDismissTrigger(Modal)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Modal)\n\nexport default Modal\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): offcanvas.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n defineJQueryPlugin,\n getElementFromSelector,\n isDisabled,\n isVisible\n} from './util/index'\nimport ScrollBarHelper from './util/scrollbar'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\nimport SelectorEngine from './dom/selector-engine'\nimport Backdrop from './util/backdrop'\nimport FocusTrap from './util/focustrap'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * Constants\n */\n\nconst NAME = 'offcanvas'\nconst DATA_KEY = 'bs.offcanvas'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst ESCAPE_KEY = 'Escape'\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_SHOWING = 'showing'\nconst CLASS_NAME_HIDING = 'hiding'\nconst CLASS_NAME_BACKDROP = 'offcanvas-backdrop'\nconst OPEN_SELECTOR = '.offcanvas.show'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"offcanvas\"]'\n\nconst Default = {\n backdrop: true,\n keyboard: true,\n scroll: false\n}\n\nconst DefaultType = {\n backdrop: '(boolean|string)',\n keyboard: 'boolean',\n scroll: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Offcanvas extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n this._isShown = false\n this._backdrop = this._initializeBackDrop()\n this._focustrap = this._initializeFocusTrap()\n this._addEventListeners()\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n toggle(relatedTarget) {\n return this._isShown ? this.hide() : this.show(relatedTarget)\n }\n\n show(relatedTarget) {\n if (this._isShown) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, { relatedTarget })\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n this._isShown = true\n this._backdrop.show()\n\n if (!this._config.scroll) {\n new ScrollBarHelper().hide()\n }\n\n this._element.setAttribute('aria-modal', true)\n this._element.setAttribute('role', 'dialog')\n this._element.classList.add(CLASS_NAME_SHOWING)\n\n const completeCallBack = () => {\n if (!this._config.scroll || this._config.backdrop) {\n this._focustrap.activate()\n }\n\n this._element.classList.add(CLASS_NAME_SHOW)\n this._element.classList.remove(CLASS_NAME_SHOWING)\n EventHandler.trigger(this._element, EVENT_SHOWN, { relatedTarget })\n }\n\n this._queueCallback(completeCallBack, this._element, true)\n }\n\n hide() {\n if (!this._isShown) {\n return\n }\n\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n if (hideEvent.defaultPrevented) {\n return\n }\n\n this._focustrap.deactivate()\n this._element.blur()\n this._isShown = false\n this._element.classList.add(CLASS_NAME_HIDING)\n this._backdrop.hide()\n\n const completeCallback = () => {\n this._element.classList.remove(CLASS_NAME_SHOW, CLASS_NAME_HIDING)\n this._element.removeAttribute('aria-modal')\n this._element.removeAttribute('role')\n\n if (!this._config.scroll) {\n new ScrollBarHelper().reset()\n }\n\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n }\n\n this._queueCallback(completeCallback, this._element, true)\n }\n\n dispose() {\n this._backdrop.dispose()\n this._focustrap.deactivate()\n super.dispose()\n }\n\n // Private\n _initializeBackDrop() {\n const clickCallback = () => {\n if (this._config.backdrop === 'static') {\n EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n return\n }\n\n this.hide()\n }\n\n // 'static' option will be translated to true, and booleans will keep their value\n const isVisible = Boolean(this._config.backdrop)\n\n return new Backdrop({\n className: CLASS_NAME_BACKDROP,\n isVisible,\n isAnimated: true,\n rootElement: this._element.parentNode,\n clickCallback: isVisible ? clickCallback : null\n })\n }\n\n _initializeFocusTrap() {\n return new FocusTrap({\n trapElement: this._element\n })\n }\n\n _addEventListeners() {\n EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n if (event.key !== ESCAPE_KEY) {\n return\n }\n\n if (!this._config.keyboard) {\n EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n return\n }\n\n this.hide()\n })\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Offcanvas.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](this)\n })\n }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n const target = getElementFromSelector(this)\n\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n if (isDisabled(this)) {\n return\n }\n\n EventHandler.one(target, EVENT_HIDDEN, () => {\n // focus on trigger when it is closed\n if (isVisible(this)) {\n this.focus()\n }\n })\n\n // avoid conflict when clicking a toggler of an offcanvas, while another is open\n const alreadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n if (alreadyOpen && alreadyOpen !== target) {\n Offcanvas.getInstance(alreadyOpen).hide()\n }\n\n const data = Offcanvas.getOrCreateInstance(target)\n data.toggle(this)\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n for (const selector of SelectorEngine.find(OPEN_SELECTOR)) {\n Offcanvas.getOrCreateInstance(selector).show()\n }\n})\n\nEventHandler.on(window, EVENT_RESIZE, () => {\n for (const element of SelectorEngine.find('[aria-modal][class*=show][class*=offcanvas-]')) {\n if (getComputedStyle(element).position !== 'fixed') {\n Offcanvas.getOrCreateInstance(element).hide()\n }\n }\n})\n\nenableDismissTrigger(Offcanvas)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Offcanvas)\n\nexport default Offcanvas\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): util/sanitizer.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nconst uriAttributes = new Set([\n 'background',\n 'cite',\n 'href',\n 'itemtype',\n 'longdesc',\n 'poster',\n 'src',\n 'xlink:href'\n])\n\nconst ARIA_ATTRIBUTE_PATTERN = /^aria-[\\w-]*$/i\n\n/**\n * A pattern that recognizes a commonly useful subset of URLs that are safe.\n *\n * Shout-out to Angular https://github.com/angular/angular/blob/12.2.x/packages/core/src/sanitization/url_sanitizer.ts\n */\nconst SAFE_URL_PATTERN = /^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i\n\n/**\n * A pattern that matches safe data URLs. Only matches image, video and audio types.\n *\n * Shout-out to Angular https://github.com/angular/angular/blob/12.2.x/packages/core/src/sanitization/url_sanitizer.ts\n */\nconst DATA_URL_PATTERN = /^data:(?:image\\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\\/(?:mpeg|mp4|ogg|webm)|audio\\/(?:mp3|oga|ogg|opus));base64,[\\d+/a-z]+=*$/i\n\nconst allowedAttribute = (attribute, allowedAttributeList) => {\n const attributeName = attribute.nodeName.toLowerCase()\n\n if (allowedAttributeList.includes(attributeName)) {\n if (uriAttributes.has(attributeName)) {\n return Boolean(SAFE_URL_PATTERN.test(attribute.nodeValue) || DATA_URL_PATTERN.test(attribute.nodeValue))\n }\n\n return true\n }\n\n // Check if a regular expression validates the attribute.\n return allowedAttributeList.filter(attributeRegex => attributeRegex instanceof RegExp)\n .some(regex => regex.test(attributeName))\n}\n\nexport const DefaultAllowlist = {\n // Global attributes allowed on any supplied element below.\n '*': ['class', 'dir', 'id', 'lang', 'role', ARIA_ATTRIBUTE_PATTERN],\n a: ['target', 'href', 'title', 'rel'],\n area: [],\n b: [],\n br: [],\n col: [],\n code: [],\n div: [],\n em: [],\n hr: [],\n h1: [],\n h2: [],\n h3: [],\n h4: [],\n h5: [],\n h6: [],\n i: [],\n img: ['src', 'srcset', 'alt', 'title', 'width', 'height'],\n li: [],\n ol: [],\n p: [],\n pre: [],\n s: [],\n small: [],\n span: [],\n sub: [],\n sup: [],\n strong: [],\n u: [],\n ul: []\n}\n\nexport function sanitizeHtml(unsafeHtml, allowList, sanitizeFunction) {\n if (!unsafeHtml.length) {\n return unsafeHtml\n }\n\n if (sanitizeFunction && typeof sanitizeFunction === 'function') {\n return sanitizeFunction(unsafeHtml)\n }\n\n const domParser = new window.DOMParser()\n const createdDocument = domParser.parseFromString(unsafeHtml, 'text/html')\n const elements = [].concat(...createdDocument.body.querySelectorAll('*'))\n\n for (const element of elements) {\n const elementName = element.nodeName.toLowerCase()\n\n if (!Object.keys(allowList).includes(elementName)) {\n element.remove()\n\n continue\n }\n\n const attributeList = [].concat(...element.attributes)\n const allowedAttributes = [].concat(allowList['*'] || [], allowList[elementName] || [])\n\n for (const attribute of attributeList) {\n if (!allowedAttribute(attribute, allowedAttributes)) {\n element.removeAttribute(attribute.nodeName)\n }\n }\n }\n\n return createdDocument.body.innerHTML\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): util/template-factory.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { DefaultAllowlist, sanitizeHtml } from './sanitizer'\nimport { getElement, isElement } from '../util/index'\nimport SelectorEngine from '../dom/selector-engine'\nimport Config from './config'\n\n/**\n * Constants\n */\n\nconst NAME = 'TemplateFactory'\n\nconst Default = {\n allowList: DefaultAllowlist,\n content: {}, // { selector : text , selector2 : text2 , }\n extraClass: '',\n html: false,\n sanitize: true,\n sanitizeFn: null,\n template: '
    '\n}\n\nconst DefaultType = {\n allowList: 'object',\n content: 'object',\n extraClass: '(string|function)',\n html: 'boolean',\n sanitize: 'boolean',\n sanitizeFn: '(null|function)',\n template: 'string'\n}\n\nconst DefaultContentType = {\n entry: '(string|element|function|null)',\n selector: '(string|element)'\n}\n\n/**\n * Class definition\n */\n\nclass TemplateFactory extends Config {\n constructor(config) {\n super()\n this._config = this._getConfig(config)\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n getContent() {\n return Object.values(this._config.content)\n .map(config => this._resolvePossibleFunction(config))\n .filter(Boolean)\n }\n\n hasContent() {\n return this.getContent().length > 0\n }\n\n changeContent(content) {\n this._checkContent(content)\n this._config.content = { ...this._config.content, ...content }\n return this\n }\n\n toHtml() {\n const templateWrapper = document.createElement('div')\n templateWrapper.innerHTML = this._maybeSanitize(this._config.template)\n\n for (const [selector, text] of Object.entries(this._config.content)) {\n this._setContent(templateWrapper, text, selector)\n }\n\n const template = templateWrapper.children[0]\n const extraClass = this._resolvePossibleFunction(this._config.extraClass)\n\n if (extraClass) {\n template.classList.add(...extraClass.split(' '))\n }\n\n return template\n }\n\n // Private\n _typeCheckConfig(config) {\n super._typeCheckConfig(config)\n this._checkContent(config.content)\n }\n\n _checkContent(arg) {\n for (const [selector, content] of Object.entries(arg)) {\n super._typeCheckConfig({ selector, entry: content }, DefaultContentType)\n }\n }\n\n _setContent(template, content, selector) {\n const templateElement = SelectorEngine.findOne(selector, template)\n\n if (!templateElement) {\n return\n }\n\n content = this._resolvePossibleFunction(content)\n\n if (!content) {\n templateElement.remove()\n return\n }\n\n if (isElement(content)) {\n this._putElementInTemplate(getElement(content), templateElement)\n return\n }\n\n if (this._config.html) {\n templateElement.innerHTML = this._maybeSanitize(content)\n return\n }\n\n templateElement.textContent = content\n }\n\n _maybeSanitize(arg) {\n return this._config.sanitize ? sanitizeHtml(arg, this._config.allowList, this._config.sanitizeFn) : arg\n }\n\n _resolvePossibleFunction(arg) {\n return typeof arg === 'function' ? arg(this) : arg\n }\n\n _putElementInTemplate(element, templateElement) {\n if (this._config.html) {\n templateElement.innerHTML = ''\n templateElement.append(element)\n return\n }\n\n templateElement.textContent = element.textContent\n }\n}\n\nexport default TemplateFactory\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): tooltip.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\nimport { defineJQueryPlugin, findShadowRoot, getElement, getUID, isRTL, noop } from './util/index'\nimport { DefaultAllowlist } from './util/sanitizer'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport BaseComponent from './base-component'\nimport TemplateFactory from './util/template-factory'\n\n/**\n * Constants\n */\n\nconst NAME = 'tooltip'\nconst DISALLOWED_ATTRIBUTES = new Set(['sanitize', 'allowList', 'sanitizeFn'])\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_MODAL = 'modal'\nconst CLASS_NAME_SHOW = 'show'\n\nconst SELECTOR_TOOLTIP_INNER = '.tooltip-inner'\nconst SELECTOR_MODAL = `.${CLASS_NAME_MODAL}`\n\nconst EVENT_MODAL_HIDE = 'hide.bs.modal'\n\nconst TRIGGER_HOVER = 'hover'\nconst TRIGGER_FOCUS = 'focus'\nconst TRIGGER_CLICK = 'click'\nconst TRIGGER_MANUAL = 'manual'\n\nconst EVENT_HIDE = 'hide'\nconst EVENT_HIDDEN = 'hidden'\nconst EVENT_SHOW = 'show'\nconst EVENT_SHOWN = 'shown'\nconst EVENT_INSERTED = 'inserted'\nconst EVENT_CLICK = 'click'\nconst EVENT_FOCUSIN = 'focusin'\nconst EVENT_FOCUSOUT = 'focusout'\nconst EVENT_MOUSEENTER = 'mouseenter'\nconst EVENT_MOUSELEAVE = 'mouseleave'\n\nconst AttachmentMap = {\n AUTO: 'auto',\n TOP: 'top',\n RIGHT: isRTL() ? 'left' : 'right',\n BOTTOM: 'bottom',\n LEFT: isRTL() ? 'right' : 'left'\n}\n\nconst Default = {\n allowList: DefaultAllowlist,\n animation: true,\n boundary: 'clippingParents',\n container: false,\n customClass: '',\n delay: 0,\n fallbackPlacements: ['top', 'right', 'bottom', 'left'],\n html: false,\n offset: [0, 0],\n placement: 'top',\n popperConfig: null,\n sanitize: true,\n sanitizeFn: null,\n selector: false,\n template: '
    ' +\n '
    ' +\n '
    ' +\n '
    ',\n title: '',\n trigger: 'hover focus'\n}\n\nconst DefaultType = {\n allowList: 'object',\n animation: 'boolean',\n boundary: '(string|element)',\n container: '(string|element|boolean)',\n customClass: '(string|function)',\n delay: '(number|object)',\n fallbackPlacements: 'array',\n html: 'boolean',\n offset: '(array|string|function)',\n placement: '(string|function)',\n popperConfig: '(null|object|function)',\n sanitize: 'boolean',\n sanitizeFn: '(null|function)',\n selector: '(string|boolean)',\n template: 'string',\n title: '(string|element|function)',\n trigger: 'string'\n}\n\n/**\n * Class definition\n */\n\nclass Tooltip extends BaseComponent {\n constructor(element, config) {\n if (typeof Popper === 'undefined') {\n throw new TypeError('Bootstrap\\'s tooltips require Popper (https://popper.js.org)')\n }\n\n super(element, config)\n\n // Private\n this._isEnabled = true\n this._timeout = 0\n this._isHovered = null\n this._activeTrigger = {}\n this._popper = null\n this._templateFactory = null\n this._newContent = null\n\n // Protected\n this.tip = null\n\n this._setListeners()\n\n if (!this._config.selector) {\n this._fixTitle()\n }\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n enable() {\n this._isEnabled = true\n }\n\n disable() {\n this._isEnabled = false\n }\n\n toggleEnabled() {\n this._isEnabled = !this._isEnabled\n }\n\n toggle() {\n if (!this._isEnabled) {\n return\n }\n\n this._activeTrigger.click = !this._activeTrigger.click\n if (this._isShown()) {\n this._leave()\n return\n }\n\n this._enter()\n }\n\n dispose() {\n clearTimeout(this._timeout)\n\n EventHandler.off(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n\n if (this.tip) {\n this.tip.remove()\n }\n\n if (this._element.getAttribute('data-bs-original-title')) {\n this._element.setAttribute('title', this._element.getAttribute('data-bs-original-title'))\n }\n\n this._disposePopper()\n super.dispose()\n }\n\n show() {\n if (this._element.style.display === 'none') {\n throw new Error('Please use show on visible elements')\n }\n\n if (!(this._isWithContent() && this._isEnabled)) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, this.constructor.eventName(EVENT_SHOW))\n const shadowRoot = findShadowRoot(this._element)\n const isInTheDom = (shadowRoot || this._element.ownerDocument.documentElement).contains(this._element)\n\n if (showEvent.defaultPrevented || !isInTheDom) {\n return\n }\n\n // todo v6 remove this OR make it optional\n if (this.tip) {\n this.tip.remove()\n this.tip = null\n }\n\n const tip = this._getTipElement()\n\n this._element.setAttribute('aria-describedby', tip.getAttribute('id'))\n\n const { container } = this._config\n\n if (!this._element.ownerDocument.documentElement.contains(this.tip)) {\n container.append(tip)\n EventHandler.trigger(this._element, this.constructor.eventName(EVENT_INSERTED))\n }\n\n if (this._popper) {\n this._popper.update()\n } else {\n this._popper = this._createPopper(tip)\n }\n\n tip.classList.add(CLASS_NAME_SHOW)\n\n // If this is a touch-enabled device we add extra\n // empty mouseover listeners to the body's immediate children;\n // only needed because of broken event delegation on iOS\n // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n if ('ontouchstart' in document.documentElement) {\n for (const element of [].concat(...document.body.children)) {\n EventHandler.on(element, 'mouseover', noop)\n }\n }\n\n const complete = () => {\n EventHandler.trigger(this._element, this.constructor.eventName(EVENT_SHOWN))\n\n if (this._isHovered === false) {\n this._leave()\n }\n\n this._isHovered = false\n }\n\n this._queueCallback(complete, this.tip, this._isAnimated())\n }\n\n hide() {\n if (!this._isShown()) {\n return\n }\n\n const hideEvent = EventHandler.trigger(this._element, this.constructor.eventName(EVENT_HIDE))\n if (hideEvent.defaultPrevented) {\n return\n }\n\n const tip = this._getTipElement()\n tip.classList.remove(CLASS_NAME_SHOW)\n\n // If this is a touch-enabled device we remove the extra\n // empty mouseover listeners we added for iOS support\n if ('ontouchstart' in document.documentElement) {\n for (const element of [].concat(...document.body.children)) {\n EventHandler.off(element, 'mouseover', noop)\n }\n }\n\n this._activeTrigger[TRIGGER_CLICK] = false\n this._activeTrigger[TRIGGER_FOCUS] = false\n this._activeTrigger[TRIGGER_HOVER] = false\n this._isHovered = null // it is a trick to support manual triggering\n\n const complete = () => {\n if (this._isWithActiveTrigger()) {\n return\n }\n\n if (!this._isHovered) {\n tip.remove()\n }\n\n this._element.removeAttribute('aria-describedby')\n EventHandler.trigger(this._element, this.constructor.eventName(EVENT_HIDDEN))\n\n this._disposePopper()\n }\n\n this._queueCallback(complete, this.tip, this._isAnimated())\n }\n\n update() {\n if (this._popper) {\n this._popper.update()\n }\n }\n\n // Protected\n _isWithContent() {\n return Boolean(this._getTitle())\n }\n\n _getTipElement() {\n if (!this.tip) {\n this.tip = this._createTipElement(this._newContent || this._getContentForTemplate())\n }\n\n return this.tip\n }\n\n _createTipElement(content) {\n const tip = this._getTemplateFactory(content).toHtml()\n\n // todo: remove this check on v6\n if (!tip) {\n return null\n }\n\n tip.classList.remove(CLASS_NAME_FADE, CLASS_NAME_SHOW)\n // todo: on v6 the following can be achieved with CSS only\n tip.classList.add(`bs-${this.constructor.NAME}-auto`)\n\n const tipId = getUID(this.constructor.NAME).toString()\n\n tip.setAttribute('id', tipId)\n\n if (this._isAnimated()) {\n tip.classList.add(CLASS_NAME_FADE)\n }\n\n return tip\n }\n\n setContent(content) {\n this._newContent = content\n if (this._isShown()) {\n this._disposePopper()\n this.show()\n }\n }\n\n _getTemplateFactory(content) {\n if (this._templateFactory) {\n this._templateFactory.changeContent(content)\n } else {\n this._templateFactory = new TemplateFactory({\n ...this._config,\n // the `content` var has to be after `this._config`\n // to override config.content in case of popover\n content,\n extraClass: this._resolvePossibleFunction(this._config.customClass)\n })\n }\n\n return this._templateFactory\n }\n\n _getContentForTemplate() {\n return {\n [SELECTOR_TOOLTIP_INNER]: this._getTitle()\n }\n }\n\n _getTitle() {\n return this._resolvePossibleFunction(this._config.title) || this._element.getAttribute('data-bs-original-title')\n }\n\n // Private\n _initializeOnDelegatedTarget(event) {\n return this.constructor.getOrCreateInstance(event.delegateTarget, this._getDelegateConfig())\n }\n\n _isAnimated() {\n return this._config.animation || (this.tip && this.tip.classList.contains(CLASS_NAME_FADE))\n }\n\n _isShown() {\n return this.tip && this.tip.classList.contains(CLASS_NAME_SHOW)\n }\n\n _createPopper(tip) {\n const placement = typeof this._config.placement === 'function' ?\n this._config.placement.call(this, tip, this._element) :\n this._config.placement\n const attachment = AttachmentMap[placement.toUpperCase()]\n return Popper.createPopper(this._element, tip, this._getPopperConfig(attachment))\n }\n\n _getOffset() {\n const { offset } = this._config\n\n if (typeof offset === 'string') {\n return offset.split(',').map(value => Number.parseInt(value, 10))\n }\n\n if (typeof offset === 'function') {\n return popperData => offset(popperData, this._element)\n }\n\n return offset\n }\n\n _resolvePossibleFunction(arg) {\n return typeof arg === 'function' ? arg.call(this._element) : arg\n }\n\n _getPopperConfig(attachment) {\n const defaultBsPopperConfig = {\n placement: attachment,\n modifiers: [\n {\n name: 'flip',\n options: {\n fallbackPlacements: this._config.fallbackPlacements\n }\n },\n {\n name: 'offset',\n options: {\n offset: this._getOffset()\n }\n },\n {\n name: 'preventOverflow',\n options: {\n boundary: this._config.boundary\n }\n },\n {\n name: 'arrow',\n options: {\n element: `.${this.constructor.NAME}-arrow`\n }\n },\n {\n name: 'preSetPlacement',\n enabled: true,\n phase: 'beforeMain',\n fn: data => {\n // Pre-set Popper's placement attribute in order to read the arrow sizes properly.\n // Otherwise, Popper mixes up the width and height dimensions since the initial arrow style is for top placement\n this._getTipElement().setAttribute('data-popper-placement', data.state.placement)\n }\n }\n ]\n }\n\n return {\n ...defaultBsPopperConfig,\n ...(typeof this._config.popperConfig === 'function' ? this._config.popperConfig(defaultBsPopperConfig) : this._config.popperConfig)\n }\n }\n\n _setListeners() {\n const triggers = this._config.trigger.split(' ')\n\n for (const trigger of triggers) {\n if (trigger === 'click') {\n EventHandler.on(this._element, this.constructor.eventName(EVENT_CLICK), this._config.selector, event => {\n const context = this._initializeOnDelegatedTarget(event)\n context.toggle()\n })\n } else if (trigger !== TRIGGER_MANUAL) {\n const eventIn = trigger === TRIGGER_HOVER ?\n this.constructor.eventName(EVENT_MOUSEENTER) :\n this.constructor.eventName(EVENT_FOCUSIN)\n const eventOut = trigger === TRIGGER_HOVER ?\n this.constructor.eventName(EVENT_MOUSELEAVE) :\n this.constructor.eventName(EVENT_FOCUSOUT)\n\n EventHandler.on(this._element, eventIn, this._config.selector, event => {\n const context = this._initializeOnDelegatedTarget(event)\n context._activeTrigger[event.type === 'focusin' ? TRIGGER_FOCUS : TRIGGER_HOVER] = true\n context._enter()\n })\n EventHandler.on(this._element, eventOut, this._config.selector, event => {\n const context = this._initializeOnDelegatedTarget(event)\n context._activeTrigger[event.type === 'focusout' ? TRIGGER_FOCUS : TRIGGER_HOVER] =\n context._element.contains(event.relatedTarget)\n\n context._leave()\n })\n }\n }\n\n this._hideModalHandler = () => {\n if (this._element) {\n this.hide()\n }\n }\n\n EventHandler.on(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n }\n\n _fixTitle() {\n const title = this._element.getAttribute('title')\n\n if (!title) {\n return\n }\n\n if (!this._element.getAttribute('aria-label') && !this._element.textContent.trim()) {\n this._element.setAttribute('aria-label', title)\n }\n\n this._element.setAttribute('data-bs-original-title', title) // DO NOT USE IT. Is only for backwards compatibility\n this._element.removeAttribute('title')\n }\n\n _enter() {\n if (this._isShown() || this._isHovered) {\n this._isHovered = true\n return\n }\n\n this._isHovered = true\n\n this._setTimeout(() => {\n if (this._isHovered) {\n this.show()\n }\n }, this._config.delay.show)\n }\n\n _leave() {\n if (this._isWithActiveTrigger()) {\n return\n }\n\n this._isHovered = false\n\n this._setTimeout(() => {\n if (!this._isHovered) {\n this.hide()\n }\n }, this._config.delay.hide)\n }\n\n _setTimeout(handler, timeout) {\n clearTimeout(this._timeout)\n this._timeout = setTimeout(handler, timeout)\n }\n\n _isWithActiveTrigger() {\n return Object.values(this._activeTrigger).includes(true)\n }\n\n _getConfig(config) {\n const dataAttributes = Manipulator.getDataAttributes(this._element)\n\n for (const dataAttribute of Object.keys(dataAttributes)) {\n if (DISALLOWED_ATTRIBUTES.has(dataAttribute)) {\n delete dataAttributes[dataAttribute]\n }\n }\n\n config = {\n ...dataAttributes,\n ...(typeof config === 'object' && config ? config : {})\n }\n config = this._mergeConfigObj(config)\n config = this._configAfterMerge(config)\n this._typeCheckConfig(config)\n return config\n }\n\n _configAfterMerge(config) {\n config.container = config.container === false ? document.body : getElement(config.container)\n\n if (typeof config.delay === 'number') {\n config.delay = {\n show: config.delay,\n hide: config.delay\n }\n }\n\n if (typeof config.title === 'number') {\n config.title = config.title.toString()\n }\n\n if (typeof config.content === 'number') {\n config.content = config.content.toString()\n }\n\n return config\n }\n\n _getDelegateConfig() {\n const config = {}\n\n for (const key in this._config) {\n if (this.constructor.Default[key] !== this._config[key]) {\n config[key] = this._config[key]\n }\n }\n\n config.selector = false\n config.trigger = 'manual'\n\n // In the future can be replaced with:\n // const keysWithDifferentValues = Object.entries(this._config).filter(entry => this.constructor.Default[entry[0]] !== this._config[entry[0]])\n // `Object.fromEntries(keysWithDifferentValues)`\n return config\n }\n\n _disposePopper() {\n if (this._popper) {\n this._popper.destroy()\n this._popper = null\n }\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Tooltip.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n })\n }\n}\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Tooltip)\n\nexport default Tooltip\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): popover.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport Tooltip from './tooltip'\n\n/**\n * Constants\n */\n\nconst NAME = 'popover'\n\nconst SELECTOR_TITLE = '.popover-header'\nconst SELECTOR_CONTENT = '.popover-body'\n\nconst Default = {\n ...Tooltip.Default,\n content: '',\n offset: [0, 8],\n placement: 'right',\n template: '
    ' +\n '
    ' +\n '

    ' +\n '
    ' +\n '
    ',\n trigger: 'click'\n}\n\nconst DefaultType = {\n ...Tooltip.DefaultType,\n content: '(null|string|element|function)'\n}\n\n/**\n * Class definition\n */\n\nclass Popover extends Tooltip {\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Overrides\n _isWithContent() {\n return this._getTitle() || this._getContent()\n }\n\n // Private\n _getContentForTemplate() {\n return {\n [SELECTOR_TITLE]: this._getTitle(),\n [SELECTOR_CONTENT]: this._getContent()\n }\n }\n\n _getContent() {\n return this._resolvePossibleFunction(this._config.content)\n }\n\n // Static\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Popover.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n })\n }\n}\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Popover)\n\nexport default Popover\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.2.2): scrollspy.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin, getElement, isDisabled, isVisible } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * Constants\n */\n\nconst NAME = 'scrollspy'\nconst DATA_KEY = 'bs.scrollspy'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_ACTIVATE = `activate${EVENT_KEY}`\nconst EVENT_CLICK = `click${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_DROPDOWN_ITEM = 'dropdown-item'\nconst CLASS_NAME_ACTIVE = 'active'\n\nconst SELECTOR_DATA_SPY = '[data-bs-spy=\"scroll\"]'\nconst SELECTOR_TARGET_LINKS = '[href]'\nconst SELECTOR_NAV_LIST_GROUP = '.nav, .list-group'\nconst SELECTOR_NAV_LINKS = '.nav-link'\nconst SELECTOR_NAV_ITEMS = '.nav-item'\nconst SELECTOR_LIST_ITEMS = '.list-group-item'\nconst SELECTOR_LINK_ITEMS = `${SELECTOR_NAV_LINKS}, ${SELECTOR_NAV_ITEMS} > ${SELECTOR_NAV_LINKS}, ${SELECTOR_LIST_ITEMS}`\nconst SELECTOR_DROPDOWN = '.dropdown'\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\n\nconst Default = {\n offset: null, // TODO: v6 @deprecated, keep it for backwards compatibility reasons\n rootMargin: '0px 0px -25%',\n smoothScroll: false,\n target: null,\n threshold: [0.1, 0.5, 1]\n}\n\nconst DefaultType = {\n offset: '(number|null)', // TODO v6 @deprecated, keep it for backwards compatibility reasons\n rootMargin: 'string',\n smoothScroll: 'boolean',\n target: 'element',\n threshold: 'array'\n}\n\n/**\n * Class definition\n */\n\nclass ScrollSpy extends BaseComponent {\n constructor(element, config) {\n super(element, config)\n\n // this._element is the observablesContainer and config.target the menu links wrapper\n this._targetLinks = new Map()\n this._observableSections = new Map()\n this._rootElement = getComputedStyle(this._element).overflowY === 'visible' ? null : this._element\n this._activeTarget = null\n this._observer = null\n this._previousScrollData = {\n visibleEntryTop: 0,\n parentScrollTop: 0\n }\n this.refresh() // initialize\n }\n\n // Getters\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n refresh() {\n this._initializeTargetsAndObservables()\n this._maybeEnableSmoothScroll()\n\n if (this._observer) {\n this._observer.disconnect()\n } else {\n this._observer = this._getNewObserver()\n }\n\n for (const section of this._observableSections.values()) {\n this._observer.observe(section)\n }\n }\n\n dispose() {\n this._observer.disconnect()\n super.dispose()\n }\n\n // Private\n _configAfterMerge(config) {\n // TODO: on v6 target should be given explicitly & remove the {target: 'ss-target'} case\n config.target = getElement(config.target) || document.body\n\n // TODO: v6 Only for backwards compatibility reasons. Use rootMargin only\n config.rootMargin = config.offset ? `${config.offset}px 0px -30%` : config.rootMargin\n\n if (typeof config.threshold === 'string') {\n config.threshold = config.threshold.split(',').map(value => Number.parseFloat(value))\n }\n\n return config\n }\n\n _maybeEnableSmoothScroll() {\n if (!this._config.smoothScroll) {\n return\n }\n\n // unregister any previous listeners\n EventHandler.off(this._config.target, EVENT_CLICK)\n\n EventHandler.on(this._config.target, EVENT_CLICK, SELECTOR_TARGET_LINKS, event => {\n const observableSection = this._observableSections.get(event.target.hash)\n if (observableSection) {\n event.preventDefault()\n const root = this._rootElement || window\n const height = observableSection.offsetTop - this._element.offsetTop\n if (root.scrollTo) {\n root.scrollTo({ top: height, behavior: 'smooth' })\n return\n }\n\n // Chrome 60 doesn't support `scrollTo`\n root.scrollTop = height\n }\n })\n }\n\n _getNewObserver() {\n const options = {\n root: this._rootElement,\n threshold: this._config.threshold,\n rootMargin: this._config.rootMargin\n }\n\n return new IntersectionObserver(entries => this._observerCallback(entries), options)\n }\n\n // The logic of selection\n _observerCallback(entries) {\n const targetElement = entry => this._targetLinks.get(`#${entry.target.id}`)\n const activate = entry => {\n this._previousScrollData.visibleEntryTop = entry.target.offsetTop\n this._process(targetElement(entry))\n }\n\n const parentScrollTop = (this._rootElement || document.documentElement).scrollTop\n const userScrollsDown = parentScrollTop >= this._previousScrollData.parentScrollTop\n this._previousScrollData.parentScrollTop = parentScrollTop\n\n for (const entry of entries) {\n if (!entry.isIntersecting) {\n this._activeTarget = null\n this._clearActiveClass(targetElement(entry))\n\n continue\n }\n\n const entryIsLowerThanPrevious = entry.target.offsetTop >= this._previousScrollData.visibleEntryTop\n // if we are scrolling down, pick the bigger offsetTop\n if (userScrollsDown && entryIsLowerThanPrevious) {\n activate(entry)\n // if parent isn't scrolled, let's keep the first visible item, breaking the iteration\n if (!parentScrollTop) {\n return\n }\n\n continue\n }\n\n // if we are scrolling up, pick the smallest offsetTop\n if (!userScrollsDown && !entryIsLowerThanPrevious) {\n activate(entry)\n }\n }\n }\n\n _initializeTargetsAndObservables() {\n this._targetLinks = new Map()\n this._observableSections = new Map()\n\n const targetLinks = SelectorEngine.find(SELECTOR_TARGET_LINKS, this._config.target)\n\n for (const anchor of targetLinks) {\n // ensure that the anchor has an id and is not disabled\n if (!anchor.hash || isDisabled(anchor)) {\n continue\n }\n\n const observableSection = SelectorEngine.findOne(anchor.hash, this._element)\n\n // ensure that the observableSection exists & is visible\n if (isVisible(observableSection)) {\n this._targetLinks.set(anchor.hash, anchor)\n this._observableSections.set(anchor.hash, observableSection)\n }\n }\n }\n\n _process(target) {\n if (this._activeTarget === target) {\n return\n }\n\n this._clearActiveClass(this._config.target)\n this._activeTarget = target\n target.classList.add(CLASS_NAME_ACTIVE)\n this._activateParents(target)\n\n EventHandler.trigger(this._element, EVENT_ACTIVATE, { relatedTarget: target })\n }\n\n _activateParents(target) {\n // Activate dropdown parents\n if (target.classList.contains(CLASS_NAME_DROPDOWN_ITEM)) {\n SelectorEngine.findOne(SELECTOR_DROPDOWN_TOGGLE, target.closest(SELECTOR_DROPDOWN))\n .classList.add(CLASS_NAME_ACTIVE)\n return\n }\n\n for (const listGroup of SelectorEngine.parents(target, SELECTOR_NAV_LIST_GROUP)) {\n // Set triggered links parents as active\n // With both

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