diff --git a/.changeset/lucky-rockets-yawn.md b/.changeset/lucky-rockets-yawn.md
new file mode 100644
index 0000000000..5edfba135b
--- /dev/null
+++ b/.changeset/lucky-rockets-yawn.md
@@ -0,0 +1,5 @@
+---
+'@clerk/clerk-js': patch
+---
+
+Disable role selection for the last admin in OrganizationProfile
diff --git a/packages/clerk-js/src/ui/components/OrganizationProfile/ActiveMembersList.tsx b/packages/clerk-js/src/ui/components/OrganizationProfile/ActiveMembersList.tsx
index 98c1fbcaac..49c49f6bbc 100644
--- a/packages/clerk-js/src/ui/components/OrganizationProfile/ActiveMembersList.tsx
+++ b/packages/clerk-js/src/ui/components/OrganizationProfile/ActiveMembersList.tsx
@@ -15,9 +15,13 @@ export const ActiveMembersList = () => {
     organization,
     membershipList,
     membership: currentUserMembership,
+    memberships: adminMembers,
     ...rest
   } = useCoreOrganization({
     membershipList: { offset: (page - 1) * ITEMS_PER_PAGE, limit: ITEMS_PER_PAGE },
+    memberships: {
+      role: ['admin'],
+    },
   });
   const isAdmin = currentUserMembership?.role === 'admin';
 
@@ -32,14 +36,16 @@ export const ActiveMembersList = () => {
     return null;
   }
 
-  //TODO: calculate if user is the only admin
-  const canChangeOwnAdminRole = isAdmin && organization?.membersCount > 1;
-
   const handleRoleChange = (membership: OrganizationMembershipResource) => (newRole: MembershipRole) => {
     if (!isAdmin) {
       return;
     }
-    return card.runAsync(membership.update({ role: newRole })).catch(err => handleError(err, [], card.setError));
+    return card
+      .runAsync(async () => {
+        await membership.update({ role: newRole });
+        await (adminMembers as any).unstable__mutate?.();
+      })
+      .catch(err => handleError(err, [], card.setError));
   };
 
   const handleRemove = (membership: OrganizationMembershipResource) => () => {
@@ -47,7 +53,11 @@ export const ActiveMembersList = () => {
       return;
     }
     return card
-      .runAsync(membership.destroy())
+      .runAsync(async () => {
+        const destroyedMembership = membership.destroy();
+        await (adminMembers as any).unstable__mutate?.();
+        return destroyedMembership;
+      })
       .then(mutateSwrState)
       .catch(err => handleError(err, [], card.setError));
   };
@@ -70,8 +80,9 @@ export const ActiveMembersList = () => {
         <MemberRow
           key={m.id}
           membership={m}
-          onRoleChange={canChangeOwnAdminRole ? handleRoleChange(m) : undefined}
+          onRoleChange={handleRoleChange(m)}
           onRemove={handleRemove(m)}
+          adminCount={adminMembers?.count || 0}
         />
       ))}
     />
@@ -81,15 +92,17 @@ export const ActiveMembersList = () => {
 const MemberRow = (props: {
   membership: OrganizationMembershipResource;
   onRemove: () => unknown;
+  adminCount: number;
   onRoleChange?: (role: MembershipRole) => unknown;
 }) => {
-  const { membership, onRemove, onRoleChange } = props;
+  const { membership, onRemove, onRoleChange, adminCount } = props;
   const card = useCardState();
   const { membership: currentUserMembership } = useCoreOrganization();
   const user = useCoreUser();
 
   const isAdmin = currentUserMembership?.role === 'admin';
   const isCurrentUser = user.id === membership.publicUserData.userId;
+  const isLastAdmin = adminCount <= 1 && membership.role === 'admin';
 
   return (
     <RowContainer>
@@ -112,7 +125,7 @@ const MemberRow = (props: {
       <Td>
         {isAdmin ? (
           <RoleSelect
-            isDisabled={card.isLoading || !onRoleChange}
+            isDisabled={card.isLoading || !onRoleChange || isLastAdmin}
             value={membership.role}
             onChange={onRoleChange}
           />
diff --git a/packages/clerk-js/src/ui/components/OrganizationProfile/__tests__/OrganizationMembers.test.tsx b/packages/clerk-js/src/ui/components/OrganizationProfile/__tests__/OrganizationMembers.test.tsx
index 1030acc862..b4ee975f7a 100644
--- a/packages/clerk-js/src/ui/components/OrganizationProfile/__tests__/OrganizationMembers.test.tsx
+++ b/packages/clerk-js/src/ui/components/OrganizationProfile/__tests__/OrganizationMembers.test.tsx
@@ -111,6 +111,15 @@ describe('OrganizationMembers', () => {
         lastName: 'Last2',
         createdAt: new Date('2022-01-01'),
       }),
+      createFakeMember({
+        id: '3',
+        orgId: '1',
+        role: 'admin',
+        identifier: 'test_user3',
+        firstName: 'First3',
+        lastName: 'Last3',
+        createdAt: new Date('2022-01-01'),
+      }),
     ];
     const { wrapper, fixtures } = await createFixtures(f => {
       f.withOrganizations();
@@ -120,17 +129,74 @@ describe('OrganizationMembers', () => {
       });
     });
 
-    fixtures.clerk.organization?.getMemberships.mockReturnValue(Promise.resolve(membersList));
-    const { queryByText } = render(<OrganizationMembers />, { wrapper });
-    expect(fixtures.clerk.organization?.getMemberships).toHaveBeenCalled();
-    expect(fixtures.clerk.organization?.getPendingInvitations).not.toHaveBeenCalled();
-    expect(fixtures.clerk.organization?.getMembershipRequests).not.toHaveBeenCalled();
-    expect(queryByText('test_user1')).toBeDefined();
-    expect(queryByText('First1 Last1')).toBeDefined();
-    expect(queryByText('Admin')).toBeDefined();
-    expect(queryByText('test_user2')).toBeDefined();
-    expect(queryByText('First2 Last2')).toBeDefined();
-    expect(queryByText('Member')).toBeDefined();
+    fixtures.clerk.organization?.getMemberships.mockReturnValueOnce(
+      Promise.resolve({
+        data: [],
+        total_count: 2,
+      }),
+    );
+
+    fixtures.clerk.organization?.getMemberships.mockReturnValueOnce(Promise.resolve(membersList));
+
+    const { queryByText, queryAllByRole } = render(<OrganizationMembers />, { wrapper });
+
+    await waitFor(() => {
+      expect(fixtures.clerk.organization?.getMemberships).toHaveBeenCalled();
+      expect(fixtures.clerk.organization?.getPendingInvitations).not.toHaveBeenCalled();
+      expect(fixtures.clerk.organization?.getMembershipRequests).not.toHaveBeenCalled();
+      expect(queryByText('test_user1')).toBeInTheDocument();
+      expect(queryByText('First1 Last1')).toBeInTheDocument();
+      const buttons = queryAllByRole('button', { name: 'Admin' });
+      buttons.forEach(button => expect(button).not.toBeDisabled());
+      expect(queryByText('test_user2')).toBeInTheDocument();
+      expect(queryByText('First2 Last2')).toBeInTheDocument();
+      expect(queryByText('Member')).toBeInTheDocument();
+    });
+  });
+
+  it('Last admin cannot change to member', async () => {
+    const membersList: OrganizationMembershipResource[] = [
+      createFakeMember({
+        id: '1',
+        orgId: '1',
+        role: 'admin',
+        identifier: 'test_user1',
+        firstName: 'First1',
+        lastName: 'Last1',
+        createdAt: new Date('2022-01-01'),
+      }),
+      createFakeMember({
+        id: '2',
+        orgId: '1',
+        role: 'basic_member',
+        identifier: 'test_user2',
+        firstName: 'First2',
+        lastName: 'Last2',
+        createdAt: new Date('2022-01-01'),
+      }),
+    ];
+    const { wrapper, fixtures } = await createFixtures(f => {
+      f.withOrganizations();
+      f.withUser({
+        email_addresses: ['test@clerk.dev'],
+        organization_memberships: [{ name: 'Org1', id: '1', role: 'admin' }],
+      });
+    });
+
+    fixtures.clerk.organization?.getMemberships.mockReturnValueOnce(
+      Promise.resolve({
+        data: [],
+        total_count: 0,
+      }),
+    );
+
+    fixtures.clerk.organization?.getMemberships.mockReturnValueOnce(Promise.resolve(membersList));
+
+    const { queryByRole } = render(<OrganizationMembers />, { wrapper });
+
+    await waitFor(() => {
+      expect(queryByRole('button', { name: 'Admin' })).toBeDisabled();
+    });
   });
 
   it('displays counter in requests tab', async () => {