diff --git a/cadet/cadet.py b/cadet/cadet.py
index 7644d88..957a994 100644
--- a/cadet/cadet.py
+++ b/cadet/cadet.py
@@ -216,9 +216,14 @@ def __init__(self, install_path: Optional[Path] = None, use_dll: bool = False, *
             self.use_dll = use_dll
 
         if hasattr(self, "cadet_dll_path") and self.cadet_dll_path is not None:
-            self._cadet_dll_runner: Optional[CadetDLLRunner] = CadetDLLRunner(
-                self.cadet_dll_path
-            )
+            try:
+                self._cadet_dll_runner: Optional[CadetDLLRunner] = CadetDLLRunner(
+                    self.cadet_dll_path
+                )
+            except ValueError:
+                self.cadet_dll_path = None
+                self._cadet_dll_runner: Optional[CadetCLIRunner] = None
+                self.use_dll = False
         else:
             self._cadet_dll_runner: Optional[CadetCLIRunner] = None
             self.use_dll = use_dll
@@ -263,15 +268,18 @@ def install_path(self, install_path: Optional[os.PathLike]) -> None:
         root_path, cadet_cli_path, cadet_dll_path, create_lwe_path = install_path_to_cadet_paths(install_path)
 
         self._install_path = root_path
-        self.cadet_cli_path = cadet_cli_path
-        self.cadet_dll_path = cadet_dll_path
         self.cadet_create_lwe_path = create_lwe_path
 
-        if self.cadet_cli_path is not None:
-            self._cadet_cli_runner = CadetCLIRunner(self.cadet_cli_path)
-        if self.cadet_dll_path is not None:
-            self._cadet_dll_runner = CadetDLLRunner(self.cadet_dll_path)
+        if cadet_cli_path is not None:
+            self._cadet_cli_runner = CadetCLIRunner(cadet_cli_path)
+            self.cadet_cli_path = cadet_cli_path
 
+        if cadet_dll_path is not None:
+            try:
+                self._cadet_dll_runner = CadetDLLRunner(cadet_dll_path)
+                self.cadet_dll_path = cadet_dll_path
+            except ValueError:
+                pass
 
     @property
     def cadet_path(self) -> Optional[Path]:
diff --git a/cadet/cadet_dll.py b/cadet/cadet_dll.py
index 69ca98f..a93005d 100644
--- a/cadet/cadet_dll.py
+++ b/cadet/cadet_dll.py
@@ -1668,12 +1668,22 @@ def __init__(self, dll_path: os.PathLike | str) -> None:
         self._default_log_level = 2
 
         # Query API
-        cdtGetAPIv010000 = self._lib.cdtGetAPIv010000
-        cdtGetAPIv010000.argtypes = [ctypes.POINTER(CADETAPIV010000)]
-        cdtGetAPIv010000.restype = c_cadet_result
-
-        self._api = CADETAPIV010000()
-        cdtGetAPIv010000(ctypes.byref(self._api))
+        cdtGetLatestCAPIVersion = self._lib.cdtGetLatestCAPIVersion
+        cdtGetLatestCAPIVersion.restype = ctypes.c_char_p
+        self._cadet_capi_version = cdtGetLatestCAPIVersion().decode('utf-8')
+
+        # Check which C-API is provided by CADET (given the current install path)
+        if self._cadet_capi_version == "1.0.0":
+            cdtGetAPIv010000 = self._lib.cdtGetAPIv010000
+            cdtGetAPIv010000.argtypes = [ctypes.POINTER(CADETAPIV010000)]
+            cdtGetAPIv010000.restype = c_cadet_result
+            self._api = CADETAPIV010000()
+            cdtGetAPIv010000(ctypes.byref(self._api))
+        else:
+            raise ValueError(
+                "CADET-Python does not support CADET-CAPI version "
+                f"({self._cadet_capi_version})."
+            )
 
         self._driver = self._api.createDriver()
         self.res: Optional[SimulationResult] = None