diff --git a/biolink-model.owl.ttl b/biolink-model.owl.ttl
index a3e3b45d5a..bbbb238a3b 100644
--- a/biolink-model.owl.ttl
+++ b/biolink-model.owl.ttl
@@ -10,10 +10,10 @@
     rdfs:label "Biolink-Model" ;
     dcterms:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
     skos:definition "Entity and association taxonomy and datamodel for life-sciences data" ;
-    meta:generation_date "2021-03-05 00:30" ;
+    meta:generation_date "2021-03-05 23:20" ;
     meta:metamodel_version "1.7.0" ;
     meta:source_file "biolink-model.yaml" ;
-    meta:source_file_date "Fri Mar  5 00:28:34 2021" ;
+    meta:source_file_date "Fri Mar  5 23:18:29 2021" ;
     meta:source_file_size 264767 .
 
 meta:SubsetDefinition a owl:Class ;
@@ -1356,20 +1356,20 @@ meta:variant_to_population_association_subject a owl:ObjectProperty,
     rdfs:label "disease to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/DiseaseToEntityAssociationMixin>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
@@ -1417,13 +1417,13 @@ meta:variant_to_population_association_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "exposure event to outcome association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_population_context> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/TimeType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_temporal_context> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_population_context> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToOutcomeAssociationMixin>,
         <https://w3id.org/biolink/vocab/ExposureEventToEntityAssociationMixin> ;
@@ -2691,10 +2691,6 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "cell line as a model of disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/CellLine> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
@@ -2702,6 +2698,10 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
@@ -2880,25 +2880,25 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "exposure event to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/ExposureEvent> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
     skos:definition "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype." .
@@ -2909,19 +2909,19 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_percentage> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/has_quotient> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_total> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_count> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_percentage> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_quotient> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_count> ],
         meta:mixin,
         <https://w3id.org/biolink/vocab/RelationshipQuantifier> .
 
@@ -2954,24 +2954,24 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
     rdfs:label "gene to gene coexpression association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeature> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/phenotypic_state> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/expression_site> ],
+            owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeature> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/phenotypic_state> ],
+            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/expression_site> ],
         <https://w3id.org/biolink/vocab/GeneExpressionMixin>,
         <https://w3id.org/biolink/vocab/GeneToGeneAssociation> ;
     skos:definition "Indicates that two genes are co-expressed, generally under the same conditions." .
@@ -2991,24 +2991,24 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
     rdfs:label "gene to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin>,
         <https://w3id.org/biolink/vocab/GeneToEntityAssociationMixin> .
@@ -3086,17 +3086,17 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/OrganismalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/OrganismalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToDiseaseAssociationMixin>,
         <https://w3id.org/biolink/vocab/ModelToDiseaseAssociationMixin> .
@@ -3124,16 +3124,16 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
 <https://w3id.org/biolink/vocab/SocioeconomicExposure> a owl:Class,
         meta:ClassDefinition ;
     rdfs:label "socioeconomic exposure" ;
-    rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/TimeType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/timepoint> ],
-        [ a owl:Class ;
+    rdfs:subClassOf [ a owl:Class ;
             owl:intersectionOf ( [ a owl:Restriction ;
                         owl:allValuesFrom <https://w3id.org/biolink/vocab/SocioeconomicAttribute> ;
                         owl:onProperty <https://w3id.org/biolink/vocab/has_attribute> ] [ a owl:Restriction ;
                         owl:onProperty <https://w3id.org/biolink/vocab/has_attribute> ;
                         owl:someValuesFrom <https://w3id.org/biolink/vocab/SocioeconomicAttribute> ] ) ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/TimeType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/timepoint> ],
         <https://w3id.org/biolink/vocab/Behavior>,
         <https://w3id.org/biolink/vocab/ExposureEvent> ;
     skos:definition "A socioeconomic exposure is a factor relating to social and financial status of an affected individual (e.g. poverty)." .
@@ -3172,20 +3172,20 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
     rdfs:label "variant to gene expression association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
+            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/expression_site> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/DiseaseOrPhenotypicFeature> ;
             owl:onProperty <https://w3id.org/biolink/vocab/phenotypic_state> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/expression_site> ],
+            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
@@ -3199,12 +3199,8 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
     rdfs:label "variant to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
@@ -3215,8 +3211,12 @@ meta:variant_to_gene_association_predicate a owl:ObjectProperty,
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin>,
         <https://w3id.org/biolink/vocab/VariantToEntityAssociationMixin> .
@@ -4033,11 +4033,11 @@ meta:publication_type a owl:ObjectProperty,
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/iso_abbreviation> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/issue> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/iso_abbreviation> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
             owl:onProperty <https://w3id.org/biolink/vocab/published_in> ;
@@ -4045,16 +4045,24 @@ meta:publication_type a owl:ObjectProperty,
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/issue> ],
         <https://w3id.org/biolink/vocab/Publication> .
 
 <https://w3id.org/biolink/vocab/BehaviorToBehavioralFeatureAssociation> a owl:Class,
         meta:ClassDefinition ;
     rdfs:label "behavior to behavioral feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/BehavioralFeature> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
             owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Behavior> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
@@ -4067,14 +4075,6 @@ meta:publication_type a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/BehavioralFeature> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
     skos:definition "An association between an aggregate behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior." .
@@ -4106,14 +4106,14 @@ meta:publication_type a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/chapter> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/published_in> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/published_in> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Publication> .
 
 <https://w3id.org/biolink/vocab/Case> a owl:Class,
@@ -4210,13 +4210,13 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "entity to feature or disease qualifiers mixin" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         meta:mixin,
         <https://w3id.org/biolink/vocab/FrequencyQualifierMixin> ;
     skos:definition "Qualifiers for entity to disease or phenotype associations." .
@@ -4282,13 +4282,13 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "gene to go term association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOntologyClass> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/FunctionalAssociation> ;
     skos:altLabel "functional association" .
 
@@ -4296,21 +4296,17 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "genotype to phenotypic feature association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+            owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
@@ -4319,6 +4315,10 @@ meta:publication_type a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin>,
         <https://w3id.org/biolink/vocab/GenotypeToEntityAssociationMixin> ;
@@ -4330,11 +4330,11 @@ meta:publication_type a owl:ObjectProperty,
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Float> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/latitude> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/longitude> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Float> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/longitude> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/latitude> ],
         <https://w3id.org/biolink/vocab/PlanetaryEntity> ;
     skos:definition "a location that can be described in lat/long coordinates" .
 
@@ -4395,11 +4395,11 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "RNA product" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/synonym> ],
-        [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/synonym> ],
         <https://w3id.org/biolink/vocab/GeneProductMixin>,
         <https://w3id.org/biolink/vocab/Transcript> .
 
@@ -4407,13 +4407,13 @@ meta:publication_type a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "sequence variant modulates treatment association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/Treatment> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/Treatment> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a sequence variant and a treatment or health intervention. The treatment object itself encompasses both the disease and the drug used." ;
     skos:note "An alternate way to model the same information could be via a qualifier" .
@@ -4428,19 +4428,19 @@ meta:publication_type a owl:ObjectProperty,
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/iso_abbreviation> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/type> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
-            owl:qualifiedCardinality 1 ],
+            owl:onProperty <https://w3id.org/biolink/vocab/volume> ],
         [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/iso_abbreviation> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Publication> ;
     skos:altLabel "journal" ;
     skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." .
@@ -4807,14 +4807,14 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/AnatomicalEntityToAnatomicalEntityAssociation> ;
     skos:definition "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms" .
 
@@ -4834,11 +4834,11 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
     rdfs:subClassOf [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/source_logo> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/source_web_page> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/source_web_page> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/source_logo> ],
         <https://w3id.org/biolink/vocab/InformationContentEntity> ;
     skos:definition "an item that holds summary level information about a dataset." .
 
@@ -4864,6 +4864,10 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "gene expression mixin" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
             owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
@@ -4875,10 +4879,6 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/expression_site> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
         meta:mixin ;
     skos:definition "Observed gene expression intensity, context (site, stage) and associated phenotypic status within which the expression occurs." .
 
@@ -4913,21 +4913,21 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "gene to disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToDiseaseAssociationMixin>,
         <https://w3id.org/biolink/vocab/GeneToEntityAssociationMixin> ;
@@ -4976,14 +4976,14 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/Gene> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/Gene> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "Any association between a genotype and a gene. The genotype have have multiple variants in that gene or a single one. There is no assumption of cardinality" .
 
@@ -4991,10 +4991,6 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "genotype to genotype part association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
@@ -5002,6 +4998,10 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "Any association between one genotype and a genotypic entity that is a sub-component of it" .
 
@@ -5009,6 +5009,10 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "genotype to variant association" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
@@ -5016,10 +5020,6 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/Genotype> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "Any association between a genotype and a sequence variant." .
 
@@ -5027,16 +5027,16 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "material sample derivation association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/MaterialSample> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a material sample and the material entity from which it is derived." .
@@ -5058,14 +5058,14 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/OrganismTaxonToOrganismTaxonAssociation> ;
     skos:definition "An interaction relationship between two taxa. This may be a symbiotic relationship (encompassing mutualism and parasitism), or it may be non-symbiotic. Example: plague transmitted_by flea; cattle domesticated_by Homo sapiens; plague infects Homo sapiens" .
 
@@ -5124,16 +5124,16 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "population to population association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a two populations" .
@@ -5160,13 +5160,13 @@ meta:sequence_feature_relationship_subject a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "variant to gene association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Gene> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/VariantToEntityAssociationMixin> ;
     skos:definition "An association between a variant and a gene, where the variant has a genetic association with the gene (i.e. is in linkage disequilibrium)" .
@@ -5423,11 +5423,11 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "biological process or activity" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_input> ],
-        [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/PhysicalEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/enabled_by> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/NamedThing> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_input> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/NamedThing> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_output> ],
@@ -5450,20 +5450,20 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "chemical to chemical derivation association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/MacromolecularMachineMixin> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/catalyst_qualifier> ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/ChemicalSubstance> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/ChemicalSubstance> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/MacromolecularMachineMixin> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/catalyst_qualifier> ],
         <https://w3id.org/biolink/vocab/ChemicalToChemicalAssociation> ;
     skos:definition """A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction:
   IF
@@ -5478,20 +5478,20 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "contributor association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/OntologyClass> ;
             owl:onProperty <https://w3id.org/biolink/vocab/qualifiers> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/InformationContentEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/Agent> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/InformationContentEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "Any association between an entity (such as a publication) and various agents that contribute to its realisation" .
 
@@ -5502,14 +5502,14 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/DatasetDistribution> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_distribution> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Dataset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_dataset> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/ingest_date> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Dataset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_dataset> ],
         <https://w3id.org/biolink/vocab/InformationContentEntity> ;
     skos:definition "an item that holds version level information about a dataset." .
 
@@ -5517,19 +5517,11 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "entity" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/CategoryType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/category> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
-        [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/Agent> ;
             owl:onProperty <https://w3id.org/biolink/vocab/provided_by> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
-            owl:qualifiedCardinality 1 ],
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/Attribute> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_attribute> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/NarrativeText> ;
@@ -5537,18 +5529,26 @@ meta:functional_association_object a owl:ObjectProperty,
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/source> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
         [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/Attribute> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_attribute> ],
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/type> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/IriType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/iri> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/type> ] ;
+            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/source> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/CategoryType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/category> ] ;
     skos:definition "Root Biolink Model class for all things and informational relationships, real or imagined." .
 
 <https://w3id.org/biolink/vocab/EntityToDiseaseOrPhenotypicFeatureAssociationMixin> a owl:Class,
@@ -5571,29 +5571,29 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "genotype to disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToDiseaseAssociationMixin>,
         <https://w3id.org/biolink/vocab/GenotypeToEntityAssociationMixin> ;
@@ -5640,11 +5640,11 @@ meta:functional_association_object a owl:ObjectProperty,
     rdfs:label "organism taxon to organism taxon association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/OrganismTaxon> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "A relationship between two organism taxon nodes" .
@@ -5660,13 +5660,13 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "quantity value" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/Unit> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_unit> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_numeric_value> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/Unit> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_unit> ],
         <https://w3id.org/biolink/vocab/Annotation> ;
     skos:definition "A value of an attribute that is quantitative and measurable, expressed as a combination of a unit and a numeric value" .
 
@@ -5674,28 +5674,28 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "variant to disease association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/Onset> ;
             owl:onProperty <https://w3id.org/biolink/vocab/onset_qualifier> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/SeverityValue> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/severity_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/EntityToDiseaseAssociationMixin>,
@@ -5830,25 +5830,25 @@ meta:functional_association_object a owl:ObjectProperty,
     rdfs:label "gene to expression site association" ;
     rdfs:seeAlso "https://github.com/monarch-initiative/ingest-artifacts/tree/master/sources/BGee" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
             owl:onProperty <https://w3id.org/biolink/vocab/quantifier_qualifier> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/LifeStage> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/stage_qualifier> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/AnatomicalEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a gene and an expression site, possibly qualified by stage/timing info." ;
     skos:editorialNote "TBD: introduce subclasses for distinction between wild-type and experimental conditions?" .
@@ -5858,11 +5858,11 @@ meta:functional_association_object a owl:ObjectProperty,
     rdfs:label "gene to gene association" ;
     rdfs:subClassOf [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GeneOrGeneProduct> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:altLabel "molecular or genetic interaction" ;
@@ -5892,6 +5892,14 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "pairwise molecular interaction" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/interacting_molecules_category> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/relation> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/id> ;
             owl:qualifiedCardinality 1 ],
@@ -5899,21 +5907,13 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/interacting_molecules_category> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/relation> ;
+            owl:onClass <https://w3id.org/biolink/vocab/MolecularEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/PairwiseGeneToGeneInteraction> ;
     skos:definition "An interaction at the molecular level between two physical entities" .
@@ -5958,30 +5958,30 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/FrequencyValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/frequency_qualifier> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_percentage> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/has_quotient> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_total> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/has_count> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PopulationOfIndividualOrganisms> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_quotient> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_count> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/has_total> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/SequenceVariant> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Double> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_percentage> ],
         <https://w3id.org/biolink/vocab/Association>,
         <https://w3id.org/biolink/vocab/FrequencyQualifierMixin>,
         <https://w3id.org/biolink/vocab/FrequencyQuantifier>,
@@ -6072,13 +6072,13 @@ meta:functional_association_object a owl:ObjectProperty,
         meta:ClassDefinition ;
     rdfs:label "functional association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/GeneOntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/MacromolecularMachineMixin> ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/GeneOntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Association> ;
     skos:definition "An association between a macromolecular machine mixin (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed." .
 
@@ -6112,12 +6112,12 @@ meta:functional_association_object a owl:ObjectProperty,
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/TimeType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/timepoint> ],
-        [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/Procedure> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_procedure> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/Device> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_device> ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/Procedure> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_procedure> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/Drug> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_drug> ],
@@ -6240,6 +6240,10 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
         meta:ClassDefinition ;
     rdfs:label "entity to phenotypic feature association mixin" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/NarrativeText> ;
             owl:onProperty <https://w3id.org/biolink/vocab/description> ],
@@ -6247,10 +6251,6 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
             owl:onClass <https://w3id.org/biolink/vocab/PhenotypicFeature> ;
             owl:onProperty <https://w3id.org/biolink/vocab/object> ;
             owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/BiologicalSex> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/sex_qualifier> ],
         meta:mixin,
         <https://w3id.org/biolink/vocab/EntityToFeatureOrDiseaseQualifiersMixin> .
 
@@ -6263,32 +6263,32 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
             owl:onProperty <https://w3id.org/biolink/vocab/strand> ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/GenomicEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/start_interbase_coordinate> ],
+            owl:onClass <https://w3id.org/biolink/vocab/GenomicEntity> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/object> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/genome_build> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/phase> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/phase> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/start_interbase_coordinate> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Integer> ;
             owl:onProperty <https://w3id.org/biolink/vocab/end_interbase_coordinate> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/GenomicEntity> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/genome_build> ],
         <https://w3id.org/biolink/vocab/SequenceAssociation> ;
     skos:definition "A relationship between a sequence feature and a genomic entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig." .
 
@@ -6375,12 +6375,12 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
         meta:ClassDefinition ;
     rdfs:label "agent" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/affiliation> ],
-        [ a owl:Restriction ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/id> ;
             owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/affiliation> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
@@ -6424,6 +6424,10 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
     rdfs:subClassOf [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/QuantityValue> ;
             owl:onProperty <https://w3id.org/biolink/vocab/has_quantitative_value> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/NamedThing> ;
@@ -6432,18 +6436,14 @@ In an RDF database, nodes will typically have an rdf:type triples. This can be t
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/IriType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/iri> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/has_attribute_type> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/source> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/OntologyClass> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/has_attribute_type> ;
+            owl:qualifiedCardinality 1 ],
         <https://w3id.org/biolink/vocab/Annotation>,
         <https://w3id.org/biolink/vocab/OntologyClass> ;
     skos:definition "A property or characteristic of an entity. For example, an apple may have properties such as color, shape, age, crispiness. An environmental sample may have attributes such as depth, lat, long, material." .
@@ -6505,10 +6505,6 @@ meta:topValue a owl:DatatypeProperty ;
         meta:ClassDefinition ;
     rdfs:label "information content entity" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/rights> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Date> ;
             owl:onProperty <https://w3id.org/biolink/vocab/creation_date> ],
@@ -6516,6 +6512,10 @@ meta:topValue a owl:DatatypeProperty ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/format> ],
+        [ a owl:Restriction ;
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/rights> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
@@ -6562,18 +6562,23 @@ meta:topValue a owl:DatatypeProperty ;
         meta:ClassDefinition ;
     rdfs:label "publication" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/authors> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
         [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/keywords> ],
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/type> ;
+            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/mesh_terms> ],
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/name> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
@@ -6582,16 +6587,11 @@ meta:topValue a owl:DatatypeProperty ;
             owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/pages> ],
         [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/type> ;
-            owl:qualifiedCardinality 1 ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/id> ;
-            owl:qualifiedCardinality 1 ],
+            owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/mesh_terms> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/authors> ],
+            owl:onProperty <https://w3id.org/biolink/vocab/keywords> ],
         <https://w3id.org/biolink/vocab/InformationContentEntity> ;
     skos:definition "Any published piece of information. Can refer to a whole publication, its encompassing publication (i.e. journal or book) or to a part of a publication, if of significant knowledge scope (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web, as well as printed materials, either directly or in one of the Publication Biolink category subclasses." .
 
@@ -6608,12 +6608,12 @@ meta:topValue a owl:DatatypeProperty ;
         meta:ClassDefinition ;
     rdfs:label "organism taxon" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/OrganismTaxon> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/subclass_of> ],
-        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/vocab/TaxonomicRank> ;
             owl:onProperty meta:has_taxonomic_rank ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/OrganismTaxon> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/subclass_of> ],
         <https://w3id.org/biolink/vocab/OntologyClass> ;
     skos:altLabel "taxon",
         "taxonomic classification" ;
@@ -6668,15 +6668,15 @@ meta:TypeDefinition a owl:Class ;
         meta:ClassDefinition ;
     rdfs:label "gene" ;
     rdfs:subClassOf [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/LabelType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/synonym> ],
+        [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
             owl:onProperty <https://w3id.org/biolink/vocab/symbol> ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/IriType> ;
             owl:onProperty <https://w3id.org/biolink/vocab/xref> ],
-        [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/LabelType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/synonym> ],
         <https://w3id.org/biolink/vocab/GeneOrGeneProduct>,
         <https://w3id.org/biolink/vocab/GenomicEntity> ;
     skos:altLabel "locus" ;
@@ -6769,24 +6769,12 @@ meta:TypeDefinition a owl:Class ;
         meta:ClassDefinition ;
     rdfs:label "association" ;
     rdfs:subClassOf [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/CategoryType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/category> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/relation> ;
-            owl:qualifiedCardinality 1 ],
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/Publication> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/publications> ],
         [ a owl:Restriction ;
             owl:maxQualifiedCardinality 1 ;
             owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Boolean> ;
             owl:onProperty <https://w3id.org/biolink/vocab/negated> ],
-        [ a owl:Restriction ;
-            owl:maxQualifiedCardinality 1 ;
-            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/type> ],
-        [ a owl:Restriction ;
-            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
-            owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
             owl:allValuesFrom <https://w3id.org/biolink/vocab/OntologyClass> ;
             owl:onProperty <https://w3id.org/biolink/vocab/qualifiers> ],
@@ -6799,8 +6787,20 @@ meta:TypeDefinition a owl:Class ;
             owl:onProperty <https://w3id.org/biolink/vocab/subject> ;
             owl:qualifiedCardinality 1 ],
         [ a owl:Restriction ;
-            owl:allValuesFrom <https://w3id.org/biolink/vocab/Publication> ;
-            owl:onProperty <https://w3id.org/biolink/vocab/publications> ],
+            owl:maxQualifiedCardinality 1 ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/String> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/type> ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/vocab/PredicateType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/predicate> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:onClass <https://w3id.org/biolink/biolinkml/meta/types/Uriorcurie> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/relation> ;
+            owl:qualifiedCardinality 1 ],
+        [ a owl:Restriction ;
+            owl:allValuesFrom <https://w3id.org/biolink/vocab/CategoryType> ;
+            owl:onProperty <https://w3id.org/biolink/vocab/category> ],
         <https://w3id.org/biolink/vocab/Entity> ;
     skos:definition "A typed association between two entities, supported by evidence" ;
     skos:note "This is roughly the model used by biolink and ontobio at the moment" .
diff --git a/biolink-model.ttl b/biolink-model.ttl
index bc14c3de30..178e8e614a 100644
--- a/biolink-model.ttl
+++ b/biolink-model.ttl
@@ -15,7 +15,7 @@
 
 <https://w3id.org/biolink/vocab/Biolink-Model> a metatype:SchemaDefinition ;
     dcterms:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
-    pav:version "1.4.0" ;
+    pav:version "1.6.0" ;
     skos:definition "Entity and association taxonomy and datamodel for life-sciences data" ;
     meta:classes <https://w3id.org/biolink/vocab/Activity>,
         <https://w3id.org/biolink/vocab/ActivityAndBehavior>,
@@ -260,199 +260,199 @@
         <https://w3id.org/biolink/vocab/Vitamin>,
         <https://w3id.org/biolink/vocab/Zygosity> ;
     meta:default_range <https://w3id.org/biolink/vocab/string> ;
-    meta:generation_date "2021-03-05 00:30"^^xsd:dateTime ;
+    meta:generation_date "2021-03-05 23:20"^^xsd:dateTime ;
     meta:id <https://w3id.org/biolink/biolink-model> ;
     meta:imports biolinkml:types ;
-    meta:prefixes [ meta:prefix_reference <http://translator.ncats.nih.gov/Aeolus_> ;
-            metatype:prefix_prefix "Aeolus" ],
-        [ meta:prefix_reference <http://pharos.nih.gov/> ;
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     meta:domain <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
     meta:domain_of <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
-    meta:examples [ skos:definition "Hyperkinesis" ;
+    meta:examples [ skos:definition "abnormal circulating bilirubin level" ;
+            skos:example "MP:0001569" ],
+        [ skos:definition "Hyperkinesis" ;
             skos:example "HP:0002487" ],
         [ skos:definition "axon morphology variant" ;
-            skos:example "WBPhenotype:0000180" ],
-        [ skos:definition "abnormal circulating bilirubin level" ;
-            skos:example "MP:0001569" ] ;
+            skos:example "WBPhenotype:0000180" ] ;
     meta:is_a <https://w3id.org/biolink/vocab/object> ;
     meta:is_usage_slot true ;
     meta:owner <https://w3id.org/biolink/vocab/EntityToPhenotypicFeatureAssociationMixin> ;
@@ -2816,10 +2816,10 @@
     skos:inScheme <https://w3id.org/biolink/biolink-model> ;
     meta:domain <https://w3id.org/biolink/vocab/VariantToEntityAssociationMixin> ;
     meta:domain_of <https://w3id.org/biolink/vocab/VariantToEntityAssociationMixin> ;
-    meta:examples [ skos:definition "chr13:g.32921033G>C (hg19) in ClinGen" ;
-            skos:example "ClinGen:CA024716" ],
-        [ skos:definition "ClinVar representation of NM_000059.3(BRCA2):c.7007G>A (p.Arg2336His)" ;
-            skos:example "ClinVar:38077" ] ;
+    meta:examples [ skos:definition "ClinVar representation of NM_000059.3(BRCA2):c.7007G>A (p.Arg2336His)" ;
+            skos:example "ClinVar:38077" ],
+        [ skos:definition "chr13:g.32921033G>C (hg19) in ClinGen" ;
+            skos:example "ClinGen:CA024716" ] ;
     meta:is_a <https://w3id.org/biolink/vocab/subject> ;
     meta:is_usage_slot true ;
     meta:owner <https://w3id.org/biolink/vocab/VariantToEntityAssociationMixin> ;
@@ -4237,11 +4237,11 @@
     meta:domain <https://w3id.org/biolink/vocab/Association> ;
     meta:is_a <https://w3id.org/biolink/vocab/association_slot> ;
     meta:local_names [ a metatype:LocalName ;
-            skos:altLabel "predicate" ;
-            metatype:local_name_source "translator" ],
-        [ a metatype:LocalName ;
             skos:altLabel "annotation predicate" ;
-            metatype:local_name_source "ga4gh" ] ;
+            metatype:local_name_source "ga4gh" ],
+        [ a metatype:LocalName ;
+            skos:altLabel "predicate" ;
+            metatype:local_name_source "translator" ] ;
     meta:owner <https://w3id.org/biolink/vocab/edge_label> ;
     meta:range <https://w3id.org/biolink/vocab/predicate_type> ;
     meta:required true ;
@@ -4435,10 +4435,10 @@
     skos:inScheme <https://w3id.org/biolink/biolink-model> ;
     meta:domain <https://w3id.org/biolink/vocab/SequenceVariant> ;
     meta:domain_of <https://w3id.org/biolink/vocab/SequenceVariant> ;
-    meta:examples [ skos:definition "ti282a allele from ZFIN" ;
-            skos:example "ZFIN:ZDB-ALT-980203-1091" ],
-        [ skos:definition "NM_007294.3(BRCA1):c.2521C>T (p.Arg841Trp)" ;
-            skos:example "ClinVarVariant:17681" ] ;
+    meta:examples [ skos:definition "NM_007294.3(BRCA1):c.2521C>T (p.Arg841Trp)" ;
+            skos:example "ClinVarVariant:17681" ],
+        [ skos:definition "ti282a allele from ZFIN" ;
+            skos:example "ZFIN:ZDB-ALT-980203-1091" ] ;
     meta:identifier true ;
     meta:is_a <https://w3id.org/biolink/vocab/id> ;
     meta:is_usage_slot true ;
@@ -7568,11 +7568,11 @@
     meta:inherited true ;
     meta:is_a <https://w3id.org/biolink/vocab/entity_regulates_entity> ;
     meta:local_names [ a metatype:LocalName ;
-            skos:altLabel "positively regulates" ;
-            metatype:local_name_source "translator" ],
-        [ a metatype:LocalName ;
             skos:altLabel "activity directly positively regulates activity of" ;
-            metatype:local_name_source "ro" ] ;
+            metatype:local_name_source "ro" ],
+        [ a metatype:LocalName ;
+            skos:altLabel "positively regulates" ;
+            metatype:local_name_source "translator" ] ;
     meta:mixins <https://w3id.org/biolink/vocab/positively_regulates> ;
     meta:multivalued true ;
     meta:owner <https://w3id.org/biolink/vocab/entity_positively_regulates_entity> ;
@@ -9357,10 +9357,10 @@
     skos:inScheme <https://w3id.org/biolink/biolink-model> ;
     meta:domain <https://w3id.org/biolink/vocab/FunctionalAssociation> ;
     meta:domain_of <https://w3id.org/biolink/vocab/FunctionalAssociation> ;
-    meta:examples [ skos:definition "postsynaptic membrane" ;
-            skos:example "GO:0045211" ],
-        [ skos:definition "kinase activity" ;
-            skos:example "GO:0016301" ] ;
+    meta:examples [ skos:definition "kinase activity" ;
+            skos:example "GO:0016301" ],
+        [ skos:definition "postsynaptic membrane" ;
+            skos:example "GO:0045211" ] ;
     meta:inlined true ;
     meta:is_a <https://w3id.org/biolink/vocab/object> ;
     meta:is_usage_slot true ;
@@ -10058,11 +10058,11 @@
     meta:inherited true ;
     meta:is_a <https://w3id.org/biolink/vocab/affects> ;
     meta:local_names [ a metatype:LocalName ;
-            skos:altLabel "activity directly regulates activity of" ;
-            metatype:local_name_source "ro" ],
-        [ a metatype:LocalName ;
             skos:altLabel "regulates" ;
-            metatype:local_name_source "translator" ] ;
+            metatype:local_name_source "translator" ],
+        [ a metatype:LocalName ;
+            skos:altLabel "activity directly regulates activity of" ;
+            metatype:local_name_source "ro" ] ;
     meta:mixins <https://w3id.org/biolink/vocab/regulates> ;
     meta:multivalued true ;
     meta:owner <https://w3id.org/biolink/vocab/entity_regulates_entity> ;
diff --git a/biolink/model.py b/biolink/model.py
index 2b633dddc5..8a16f200d5 100644
--- a/biolink/model.py
+++ b/biolink/model.py
@@ -1,5 +1,5 @@
 # Auto generated from biolink-model.yaml by pythongen.py version: 0.9.0
-# Generation date: 2021-03-05 00:30
+# Generation date: 2021-03-05 23:20
 # Schema: Biolink-Model
 #
 # id: https://w3id.org/biolink/biolink-model
diff --git a/context.jsonld b/context.jsonld
index 7053595cfe..59d30663f6 100644
--- a/context.jsonld
+++ b/context.jsonld
@@ -1,5 +1,5 @@
 {
-   "_comments": "Auto generated from biolink-model.yaml by jsonldcontextgen.py version: 0.1.1\nGeneration date: 2021-03-05 00:30\nSchema: Biolink-Model\n\nid: https://w3id.org/biolink/biolink-model\ndescription: Entity and association taxonomy and datamodel for life-sciences data\nlicense: https://creativecommons.org/publicdomain/zero/1.0/\n",
+   "_comments": "Auto generated from biolink-model.yaml by jsonldcontextgen.py version: 0.1.1\nGeneration date: 2021-03-05 23:19\nSchema: Biolink-Model\n\nid: https://w3id.org/biolink/biolink-model\ndescription: Entity and association taxonomy and datamodel for life-sciences data\nlicense: https://creativecommons.org/publicdomain/zero/1.0/\n",
    "@context": {
       "type": {
          "@id": "rdf:type"
diff --git a/contextn.jsonld b/contextn.jsonld
index b339998078..a1993d7c47 100644
--- a/contextn.jsonld
+++ b/contextn.jsonld
@@ -1,5 +1,5 @@
 {
-   "_comments": "Auto generated from biolink-model.yaml by jsonldcontextgen.py version: 0.1.1\nGeneration date: 2021-03-05 00:30\nSchema: Biolink-Model\n\nid: https://w3id.org/biolink/biolink-model\ndescription: Entity and association taxonomy and datamodel for life-sciences data\nlicense: https://creativecommons.org/publicdomain/zero/1.0/\n",
+   "_comments": "Auto generated from biolink-model.yaml by jsonldcontextgen.py version: 0.1.1\nGeneration date: 2021-03-05 23:20\nSchema: Biolink-Model\n\nid: https://w3id.org/biolink/biolink-model\ndescription: Entity and association taxonomy and datamodel for life-sciences data\nlicense: https://creativecommons.org/publicdomain/zero/1.0/\n",
    "@context": {
       "type": "@type",
       "APO": "http://purl.obolibrary.org/obo/APO_",