diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
new file mode 100644
index 0000000..da899de
--- /dev/null
+++ b/.github/workflows/ci.yml
@@ -0,0 +1,48 @@
+name: CI
+
+on:
+  push:
+    branches: [ main ]
+
+  workflow_dispatch:
+
+jobs:
+  cancel-previous:
+    runs-on: ubuntu-latest
+    if: github.ref != 'refs/heads/main'
+    steps:
+      - uses: khan/pull-request-workflow-cancel@1.0.0
+        with:
+          workflows: "ci.yml"
+        env:
+          GITHUB_TOKEN: '${{ secrets.GITHUB_TOKEN }}'
+
+  testing:
+    runs-on: ubuntu-latest
+    strategy:
+      matrix:
+        python-version:
+          - "3.8"
+          - "3.9"
+          - "3.10"
+          - "3.11"
+
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v2
+
+      - name: Install Python
+        uses: actions/setup-python@v2
+        with:
+          python-version: ${{ matrix.python-version }}
+
+      - name: Install system dependencies
+        run: |
+          sudo apt install libhts-dev libhts3 libhtscodecs-dev libhtscodecs2 tabix
+          pip install -U pip setuptools
+          pip install -U pytest pytest-cov pytest-vcr
+          pip install -e .
+
+      - name: Run tests
+        run: |
+          pytest
diff --git a/.github/workflows/conventional-prs.yml b/.github/workflows/conventional-prs.yml
new file mode 100644
index 0000000..3f3e53c
--- /dev/null
+++ b/.github/workflows/conventional-prs.yml
@@ -0,0 +1,19 @@
+name: PR
+
+on:
+  pull_request_target:
+    types:
+      - opened
+      - reopened
+      - edited
+      - synchronize
+
+jobs:
+  title-format:
+    runs-on: ubuntu-latest
+    steps:
+      - uses: amannn/action-semantic-pull-request@v3.4.0
+        env:
+          GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
+        with:
+          validateSingleCommit: true
diff --git a/.github/workflows/cqa.yml b/.github/workflows/cqa.yml
deleted file mode 100644
index 9c7df6d..0000000
--- a/.github/workflows/cqa.yml
+++ /dev/null
@@ -1,39 +0,0 @@
-name: Test & Upload
-
-on:
-  push:
-    branches: [ main ]
-
-  workflow_dispatch:
-
-jobs:
-  test_and_publish:
-    runs-on: ubuntu-latest
-
-    steps:
-      - uses: actions/checkout@v2
-
-      - uses: actions/setup-python@v2
-        with:
-          python-version: 3.9
-
-      - name: install
-        run: |
-          sudo apt install libhts-dev libhts3 libhtscodecs-dev libhtscodecs2 tabix
-          pip install -U pip setuptools
-          pip install -U pytest pytest-cov twine
-          pip install .
-
-      - name: Test
-        run: |
-          pytest
-          
-      - name: Build and Upload
-        run: |
-          python3 -m build
-          python3 -m twine upload dist/*
-        env:
-          TWINE_USERNAME: __token__
-          TWINE_PASSWORD: ${{ secrets.TWINE_TEST_TOKEN }}
-          TWINE_REPOSITORY: testpypi
-  
diff --git a/.github/workflows/release-please.yml b/.github/workflows/release-please.yml
new file mode 100644
index 0000000..d2aaeb0
--- /dev/null
+++ b/.github/workflows/release-please.yml
@@ -0,0 +1,41 @@
+name: release-please
+
+on:
+  push:
+    branches:
+      - main
+
+jobs:
+  release-please:
+    runs-on: ubuntu-latest
+    steps:
+
+      - uses: GoogleCloudPlatform/release-please-action@v2
+        id: release
+        with:
+          release-type: python
+          package-name: biocommons.seqrepo
+
+      - uses: actions/checkout@v2
+        if: ${{ steps.release.outputs.release_created }}
+        with:
+          fetch-depth: 0
+
+      - name: Set up Python
+        if: ${{ steps.release.outputs.release_created }}
+        uses: actions/setup-python@v2
+        with:
+          python-version: '3.x'
+
+      - name: Build package
+        if: ${{ steps.release.outputs.release_created }}
+        run: |
+          python -m pip install --upgrade pip
+          python setup.py sdist
+
+      - name: Publish to PyPI
+        if: ${{ steps.release.outputs.release_created }}
+        uses: pypa/gh-action-pypi-publish@master
+        with:
+          user: __token__
+          password: ${{ secrets.PYPI_TOKEN }}
diff --git a/CHANGELOG.md b/CHANGELOG.md
new file mode 100644
index 0000000..825c32f
--- /dev/null
+++ b/CHANGELOG.md
@@ -0,0 +1 @@
+# Changelog