Copy Number Variation analysis

[melconrad]

Related Problem

Solution Requested

We would like to detect increased copy number for plasmepsin 1/2 (PM1/PM2), mdr1, gch1.

As a starting point, it seems appropriate to count UMIs from genes that we know have a single copy number, and then if the UMIs from our gene that we suspect has copy number variation, a 2 fold increase in UMIs in that gene would be called as having 2 (copies.

A more complex solution that uses Hardy Weinberg would be useful for future builds.