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Handling of X-linked variants in males #7

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dconrad opened this issue Feb 13, 2017 · 0 comments
Open

Handling of X-linked variants in males #7

dconrad opened this issue Feb 13, 2017 · 0 comments

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@dconrad
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dconrad commented Feb 13, 2017

We currently model the ploidy of variants in the pseudoautosomal regions of the X chromosome the same as the non-PAR regions in males. Specifically, we treat all genotypes as homozygous. So if the male is het in the VCF (as may be the case in PAR, or due to mapping error of reads coming from the Y or elsewhere) we force the genotype to be homozygous for the alternate allele.

@dconrad dconrad changed the title Handling of X-linked variants in males Handling of X-linked variants in males and females Aug 3, 2017
@dconrad dconrad changed the title Handling of X-linked variants in males and females Handling of X-linked variants in males Aug 3, 2017
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