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DESCRIPTION
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DESCRIPTION
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Package: singleseqgset
Title: Single-cell Gene Set Enrichment Analysis
Version: 0.1.2.9000
Authors@R:
person(given = "Anthony",
family = "Cillo",
role = c("aut", "cre"),
email = "[email protected]",
comment = c(ORCID = "0000-0002-3213-3129"))
Description: This package takes single-cell gene expression data and lists of gene sets, and tests whether specific clusters have enrichment for the given gene sets compared to other clusters. To accomplish this, we implement a Wilcoxon Mann Whitney correlated-corrected statistic inspired by CAMERA to compare genes within the gene set versus genes outside of the gene set (see Camera: a competitive gene set test accounting for inter-gene correlation by Wu and Smyth, Nucleic Acids Research 2012 for more information).
Depends:
R (>= 3.4.0),
Matrix (>= 1.2.0),
msigdbr (>= 6.2.0)
Suggests:
Seurat (>= 2.3.0),
heatmap3 (>= 1.1.0),
knitr (>= 1.20),
rmarkdown (>= 1.10)
VignetteBuilder: knitr
License: CCO
Encoding: UTF-8
LazyData: true
RoxygenNote: 6.1.1