diff --git a/CMakeLists.txt b/CMakeLists.txt
index b152fe01d2e77..80113e21b2b0b 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -173,6 +173,7 @@ if(NOT EXISTS "${NUTTX_APPS_DIR}")
   message(FATAL_ERROR "Application directory ${NUTTX_APPS_DIR} is not found")
 endif()
 
+get_filename_component(NUTTX_APPS_DIR ${NUTTX_APPS_DIR} ABSOLUTE)
 get_filename_component(apps_dir ${NUTTX_APPS_DIR} NAME)
 set(NUTTX_APPS_BINDIR "${CMAKE_BINARY_DIR}/${apps_dir}")
 
@@ -513,6 +514,21 @@ if(CONFIG_NDEBUG)
   add_compile_options(-DNDEBUG)
 endif()
 
+# Cmake build provide absolute paths to compile files. If __FILE__ macros are
+# used in the source code(ASSERT), the binary will be occupied by many invalid
+# paths. If the compiler support preprocessing files and expand the "__FILE__"
+# and "__BASE_FILE__" macros as if the files resided in directory new instead.
+# This saves some memory, stops leaking user locations in binaries, makes
+# failure logs more deterministic and most importantly makes builds more
+# deterministic. Debuggers usually have a path mapping feature to ensure the
+# files are still found.
+if(CONFIG_OUTPUT_STRIP_PATHS)
+  add_compile_options(-fmacro-prefix-map=${NUTTX_DIR}=)
+  add_compile_options(-fmacro-prefix-map=${NUTTX_APPS_DIR}=)
+  add_compile_options(-fmacro-prefix-map=${NUTTX_BOARD_ABS_DIR}=)
+  add_compile_options(-fmacro-prefix-map=${NUTTX_CHIP_ABS_DIR}=)
+endif()
+
 add_definitions(-D__NuttX__)
 
 set_property(
diff --git a/Kconfig b/Kconfig
index 0550e05c99e26..4463a7ff87dcc 100644
--- a/Kconfig
+++ b/Kconfig
@@ -447,6 +447,23 @@ config DFU_PID
 	hex "PID to use for DFU image"
 
 endif # DFU_BINARY
+
+config OUTPUT_STRIP_PATHS
+	bool "Strip absolute paths from binaries"
+	default y
+	depends on ARCH_TOOLCHAIN_GNU
+	---help---
+	  Cmake build provide absolute paths to compile files. If __FILE__
+	  macros are used in the source code(ASSERT), the binary will be occupied
+	  by many invalid paths.
+	  If the compiler support preprocessing files and expand the "__FILE__"
+	  and "__BASE_FILE__" macros as if the files resided in directory new instead.
+	  This saves some memory, stops leaking user locations in binaries, makes
+	  failure logs more deterministic and most importantly makes builds more
+	  deterministic.
+	  Debuggers usually have a path mapping feature to ensure the files are
+	  still found.
+
 endmenu # Binary Output Formats
 
 menu "Customize Header Files"