diff --git a/CHANGELOG.md b/CHANGELOG.md
index fe7bada73..be248fd9a 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -11,6 +11,7 @@
 
 ## Changed
 * Subroutines that take ABI type of Transaction now allow any Transaction type to be passed. ([#531](https://github.com/algorand/pyteal/pull/531))
+* Relaxing exact type check in `InnerTxnFieldExpr.MethodCall` by applying `abi.type_spec_is_assignable_to`. ([#561](https://github.com/algorand/pyteal/pull/561))
 
 # 0.18.1
 
diff --git a/pyteal/ast/abi/__init__.py b/pyteal/ast/abi/__init__.py
index c137110de..f13a59b60 100644
--- a/pyteal/ast/abi/__init__.py
+++ b/pyteal/ast/abi/__init__.py
@@ -82,6 +82,7 @@
     make,
     size_of,
     type_spec_from_annotation,
+    type_spec_from_algosdk,
     type_specs_from_signature,
     contains_type_spec,
     type_spec_is_assignable_to,
@@ -162,6 +163,7 @@
     "KeyRegisterTransactionTypeSpec",
     "TransactionTypeSpecs",
     "type_spec_from_annotation",
+    "type_spec_from_algosdk",
     "type_specs_from_signature",
     "make",
     "size_of",
diff --git a/pyteal/ast/itxn.py b/pyteal/ast/itxn.py
index d38eb55d5..71b39445c 100644
--- a/pyteal/ast/itxn.py
+++ b/pyteal/ast/itxn.py
@@ -387,9 +387,10 @@ def MethodCall(
 
                 txntype = cast(EnumInt, arg[TxnField.type_enum]).name
                 # If the arg is an unspecified transaction, no need to check the type_enum
-                if not type(
-                    method_arg_ts
-                ) is abi.TransactionTypeSpec and txntype != str(method_arg_ts):
+
+                if not abi.type_spec_is_assignable_to(
+                    abi.type_spec_from_algosdk(txntype), method_arg_ts
+                ):
                     raise TealInputError(
                         f"Expected Transaction at arg {idx} to be {method_arg_ts}, got {txntype}"
                     )
@@ -459,7 +460,9 @@ def MethodCall(
                     require_type(arg, TealType.bytes)
                     app_args.append(arg)
                 elif isinstance(arg, abi.BaseType):
-                    if arg.type_spec() != method_arg_ts:
+                    if not abi.type_spec_is_assignable_to(
+                        arg.type_spec(), method_arg_ts
+                    ):
                         raise TealTypeError(arg.type_spec(), method_arg_ts)
                     app_args.append(arg.encode())
                 else:
diff --git a/pyteal/ast/itxn_test.py b/pyteal/ast/itxn_test.py
index f6ee455ef..d4f111215 100644
--- a/pyteal/ast/itxn_test.py
+++ b/pyteal/ast/itxn_test.py
@@ -309,6 +309,27 @@ def test_InnerTxnBuilder_Execute():
         ),
         None,
     ),
+    (
+        pt.Int(1),
+        "query(byte[],uint64)void",
+        [t6_1 := pt.abi.DynamicBytes(), t6_2 := pt.abi.Uint64()],
+        {TxnField.fee: pt.Int(0)},
+        pt.Seq(
+            pt.InnerTxnBuilder.SetFields(
+                {
+                    pt.TxnField.type_enum: TxnType.ApplicationCall,
+                    pt.TxnField.application_id: pt.Int(1),
+                    pt.TxnField.application_args: [
+                        pt.MethodSignature("query(byte[],uint64)void"),
+                        t6_1.encode(),
+                        t6_2.encode(),
+                    ],
+                    pt.TxnField.fee: pt.Int(0),
+                }
+            ),
+        ),
+        None,
+    ),
     # Error cases
     (
         pt.Int(1),