diff --git a/packages/e2e-test-utils-playwright/src/page-utils/keycodes.ts b/packages/e2e-test-utils-playwright/src/page-utils/keycodes.ts
index 3a848ac8fb7667..f2ae2d186c7a72 100644
--- a/packages/e2e-test-utils-playwright/src/page-utils/keycodes.ts
+++ b/packages/e2e-test-utils-playwright/src/page-utils/keycodes.ts
@@ -23,6 +23,11 @@ export const COMMAND = 'meta';
  */
 export const SHIFT = 'shift';
 
+/**
+ * Keycode for DELETE key.
+ */
+export const DELETE = 'delete';
+
 /**
  * Object that contains functions that return the available modifier
  * depending on platform.
@@ -44,5 +49,6 @@ export const modifiers: Record<
 	ctrlShift: () => [ CTRL, SHIFT ],
 	shift: () => [ SHIFT ],
 	shiftAlt: () => [ SHIFT, ALT ],
+	delete: () => [ DELETE ],
 	undefined: () => [],
 };
diff --git a/test/e2e/specs/editor/blocks/navigation.spec.js b/test/e2e/specs/editor/blocks/navigation.spec.js
index 83e95a08c0f6a2..7daab2f6ecc120 100644
--- a/test/e2e/specs/editor/blocks/navigation.spec.js
+++ b/test/e2e/specs/editor/blocks/navigation.spec.js
@@ -276,7 +276,7 @@ test.describe( 'Navigation block', () => {
 			await pageUtils.pressKeys( 'ArrowDown' );
 
 			// remove the child link
-			await pageUtils.pressKeys( 'access+z' );
+			await pageUtils.pressKeys( 'shift+delete' );
 
 			const submenuBlock2 = editor.canvas.getByRole( 'document', {
 				name: 'Block: Submenu',
@@ -494,7 +494,7 @@ test.describe( 'Navigation block', () => {
 		await pageUtils.pressKeys( 'ArrowDown', { times: 4 } );
 		await navigation.checkLabelFocus( 'wordpress.org' );
 		// Delete the nav link
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 		// Focus moved to sibling
 		await navigation.checkLabelFocus( 'Dog' );
 		// Add a link back so we can delete the first submenu link and see if focus returns to the parent submenu item
@@ -507,15 +507,15 @@ test.describe( 'Navigation block', () => {
 		await pageUtils.pressKeys( 'ArrowUp', { times: 2 } );
 		await navigation.checkLabelFocus( 'Dog' );
 		// Delete the nav link
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 		await pageUtils.pressKeys( 'ArrowDown' );
 		// Focus moved to parent submenu item
 		await navigation.checkLabelFocus( 'example.com' );
 		// Deleting this should move focus to the sibling item
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 		await navigation.checkLabelFocus( 'Cat' );
 		// Deleting with no more siblings should focus the navigation block again
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 		await expect( navBlock ).toBeFocused();
 		// Wait until the nav block inserter is visible before we continue.
 		await expect( navBlockInserter ).toBeVisible();
diff --git a/test/e2e/specs/editor/various/block-deletion.spec.js b/test/e2e/specs/editor/various/block-deletion.spec.js
index 9346412c46bcb2..fb7d898d1e5dee 100644
--- a/test/e2e/specs/editor/various/block-deletion.spec.js
+++ b/test/e2e/specs/editor/various/block-deletion.spec.js
@@ -134,7 +134,7 @@ test.describe( 'Block deletion', () => {
 		).toBeFocused();
 
 		// Remove the current paragraph via dedicated keyboard shortcut.
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 
 		// Ensure the last block was removed.
 		await expect.poll( editor.getBlocks ).toMatchObject( [
diff --git a/test/e2e/specs/editor/various/block-locking.spec.js b/test/e2e/specs/editor/various/block-locking.spec.js
index a8895d282fb956..5b6e3e6946b565 100644
--- a/test/e2e/specs/editor/various/block-locking.spec.js
+++ b/test/e2e/specs/editor/various/block-locking.spec.js
@@ -133,7 +133,7 @@ test.describe( 'Block Locking', () => {
 		).toBeVisible();
 
 		await paragraph.click();
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 
 		await expect.poll( editor.getBlocks ).toMatchObject( [
 			{
diff --git a/test/e2e/specs/editor/various/list-view.spec.js b/test/e2e/specs/editor/various/list-view.spec.js
index 531faa8bea049d..52febba89ac398 100644
--- a/test/e2e/specs/editor/various/list-view.spec.js
+++ b/test/e2e/specs/editor/various/list-view.spec.js
@@ -809,8 +809,8 @@ test.describe( 'List View', () => {
 
 		// Delete remaining blocks.
 		// Keyboard shortcut should also work.
-		await pageUtils.pressKeys( 'access+z' );
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
+		await pageUtils.pressKeys( 'shift+delete' );
 		await expect
 			.poll(
 				listViewUtils.getBlocksWithA11yAttributes,
@@ -842,7 +842,7 @@ test.describe( 'List View', () => {
 				{ name: 'core/heading', selected: false },
 			] );
 
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 		await expect
 			.poll(
 				listViewUtils.getBlocksWithA11yAttributes,
@@ -865,7 +865,7 @@ test.describe( 'List View', () => {
 			.getByRole( 'gridcell', { name: 'File' } )
 			.getByRole( 'link' )
 			.focus();
-		for ( const keys of [ 'Delete', 'Backspace', 'access+z' ] ) {
+		for ( const keys of [ 'Delete', 'Backspace', 'shift+delete' ] ) {
 			await pageUtils.pressKeys( keys );
 			await expect
 				.poll(
@@ -1133,7 +1133,7 @@ test.describe( 'List View', () => {
 			optionsForFileMenu,
 			'Pressing Space should also open the menu dropdown'
 		).toBeVisible();
-		await pageUtils.pressKeys( 'access+z' ); // Keyboard shortcut for Delete.
+		await pageUtils.pressKeys( 'shift+delete' ); // Keyboard shortcut for Delete.
 		await expect
 			.poll(
 				listViewUtils.getBlocksWithA11yAttributes,
@@ -1153,7 +1153,7 @@ test.describe( 'List View', () => {
 			optionsForFileMenu.getByRole( 'menuitem', { name: 'Delete' } ),
 			'The delete menu item should be hidden for locked blocks'
 		).toBeHidden();
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 		await expect
 			.poll(
 				listViewUtils.getBlocksWithA11yAttributes,
diff --git a/test/e2e/specs/site-editor/template-part.spec.js b/test/e2e/specs/site-editor/template-part.spec.js
index d88273574bc4b0..abab6cf2210274 100644
--- a/test/e2e/specs/site-editor/template-part.spec.js
+++ b/test/e2e/specs/site-editor/template-part.spec.js
@@ -375,7 +375,7 @@ test.describe( 'Template Part', () => {
 		await editor.selectBlocks( siteTitle );
 
 		// Remove the default site title block.
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 
 		// Insert a group block with a Site Title block inside.
 		await editor.insertBlock( {
diff --git a/test/e2e/specs/widgets/editing-widgets.spec.js b/test/e2e/specs/widgets/editing-widgets.spec.js
index 019e07fe87daac..a287330a26a90c 100644
--- a/test/e2e/specs/widgets/editing-widgets.spec.js
+++ b/test/e2e/specs/widgets/editing-widgets.spec.js
@@ -573,7 +573,7 @@ test.describe( 'Widgets screen', () => {
 			.getByRole( 'document', { name: 'Block: Paragraph' } )
 			.filter( { hasText: 'Second Paragraph' } )
 			.focus();
-		await pageUtils.pressKeys( 'access+z' );
+		await pageUtils.pressKeys( 'shift+delete' );
 		await widgetsScreen.saveWidgets();
 
 		await expect.poll( widgetsScreen.getWidgetAreaBlocks ).toMatchObject( {