diff --git a/test/e2e/__snapshots__/test_missing_core/test_missing_core_422.json b/test/e2e/__snapshots__/test_missing_core/test_missing_core_422.json
new file mode 100644
index 000000000..e7f74b496
--- /dev/null
+++ b/test/e2e/__snapshots__/test_missing_core/test_missing_core_422.json
@@ -0,0 +1,3 @@
+{
+  "message": "バージョン 4.0.4 のコアが見つかりません"
+}
diff --git a/test/e2e/test_missing_core.py b/test/e2e/test_missing_core.py
new file mode 100644
index 000000000..39e241fa2
--- /dev/null
+++ b/test/e2e/test_missing_core.py
@@ -0,0 +1,11 @@
+"""コア取得失敗のテスト"""
+
+from fastapi.testclient import TestClient
+from syrupy.assertion import SnapshotAssertion
+
+
+def test_missing_core_422(client: TestClient, snapshot_json: SnapshotAssertion) -> None:
+    """存在しないコアを指定するとエラーを返す。"""
+    response = client.get("/supported_devices", params={"core_version": "4.0.4"})
+    assert response.status_code == 422
+    assert snapshot_json == response.json()
diff --git a/test/test_core_initializer.py b/test/test_core_initializer.py
index 6e8ff7056..954c5ac1e 100644
--- a/test/test_core_initializer.py
+++ b/test/test_core_initializer.py
@@ -3,10 +3,13 @@
 from unittest.mock import patch
 
 import pytest
-from fastapi import HTTPException
 
 from voicevox_engine.core.core_adapter import CoreAdapter
-from voicevox_engine.core.core_initializer import CoreManager, get_half_logical_cores
+from voicevox_engine.core.core_initializer import (
+    CoreManager,
+    CoreNotFound,
+    get_half_logical_cores,
+)
 from voicevox_engine.dev.core.mock import MockCoreWrapper
 
 
@@ -93,7 +96,7 @@ def test_cores_get_core_missing() -> None:
     core_manager.register_core(core2, "0.0.2")
 
     # Test
-    with pytest.raises(HTTPException) as _:
+    with pytest.raises(CoreNotFound):
         core_manager.get_core("0.0.3")
 
 
diff --git a/voicevox_engine/app/application.py b/voicevox_engine/app/application.py
index bbe435f1d..d49c2d1b0 100644
--- a/voicevox_engine/app/application.py
+++ b/voicevox_engine/app/application.py
@@ -4,6 +4,7 @@
 
 from voicevox_engine import __version__
 from voicevox_engine.app.dependencies import deprecated_mutable_api
+from voicevox_engine.app.global_exceptions import configure_global_exception_handlers
 from voicevox_engine.app.middlewares import configure_middlewares
 from voicevox_engine.app.openapi_schema import configure_openapi_schema
 from voicevox_engine.app.routers.engine_info import generate_engine_info_router
@@ -51,6 +52,7 @@ def generate_app(
         version=__version__,
     )
     app = configure_middlewares(app, cors_policy_mode, allow_origin)
+    app = configure_global_exception_handlers(app)
 
     if disable_mutable_api:
         deprecated_mutable_api.enable = False
diff --git a/voicevox_engine/app/global_exceptions.py b/voicevox_engine/app/global_exceptions.py
new file mode 100644
index 000000000..81a00bfd1
--- /dev/null
+++ b/voicevox_engine/app/global_exceptions.py
@@ -0,0 +1,17 @@
+"""グローバルな例外ハンドラの定義と登録"""
+
+from fastapi import FastAPI, Request
+from fastapi.responses import JSONResponse
+
+from voicevox_engine.core.core_initializer import CoreNotFound
+
+
+def configure_global_exception_handlers(app: FastAPI) -> FastAPI:
+    """グローバルな例外ハンドラを app へ設定する。"""
+
+    # 指定されたコアが見つからないエラー
+    @app.exception_handler(CoreNotFound)
+    async def cnf_exception_handler(request: Request, e: CoreNotFound) -> JSONResponse:
+        return JSONResponse(status_code=422, content={"message": f"{str(e)}"})
+
+    return app
diff --git a/voicevox_engine/core/core_initializer.py b/voicevox_engine/core/core_initializer.py
index 14b3eef1d..b8a4bc5d1 100644
--- a/voicevox_engine/core/core_initializer.py
+++ b/voicevox_engine/core/core_initializer.py
@@ -3,8 +3,6 @@
 import sys
 from pathlib import Path
 
-from fastapi import HTTPException
-
 from ..utility.core_version_utility import get_latest_version
 from ..utility.path_utility import engine_root, get_save_dir
 from .core_adapter import CoreAdapter
@@ -20,6 +18,12 @@ def get_half_logical_cores() -> int:
     return logical_cores // 2
 
 
+class CoreNotFound(Exception):
+    """コアが見つからないエラー"""
+
+    pass
+
+
 class CoreManager:
     """コアの集まりを一括管理するマネージャー"""
 
@@ -44,9 +48,7 @@ def get_core(self, version: str | None = None) -> CoreAdapter:
             return self._cores[self.latest_version()]
         elif version in self._cores:
             return self._cores[version]
-
-        # FIXME: ドメインがずれているのでこのエラーは routers へ持っていく
-        raise HTTPException(status_code=422, detail="不明なバージョンです")
+        raise CoreNotFound(f"バージョン {version} のコアが見つかりません")
 
     def has_core(self, version: str) -> bool:
         """指定バージョンのコアが登録されているか否かを返す。"""