diff --git a/pkgs/development/python-modules/mygene/default.nix b/pkgs/development/python-modules/mygene/default.nix
new file mode 100644
index 0000000000000..42da424254956
--- /dev/null
+++ b/pkgs/development/python-modules/mygene/default.nix
@@ -0,0 +1,43 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  setuptools,
+  pytestCheckHook,
+
+  # Dependencies
+  biothings-client,
+  pandas,
+  requests,
+}:
+buildPythonPackage rec {
+  pname = "mygene";
+  version = "3.2.2";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "biothings";
+    repo = "mygene.py";
+    rev = "v${version}";
+    hash = "sha256-/KxlzOTbZTN5BA0PrJyivVFh4cLtW90/EFwczda61Tg=";
+  };
+
+  optional-dependencies = {
+    complete = [ pandas ];
+  };
+
+  build-system = [ setuptools ];
+  dependencies = [
+    biothings-client
+    requests
+  ];
+  pythonImportsCheck = [ "mygene" ];
+
+  meta = {
+    changelog = "https://github.com/biothings/mygene.py/blob/v${version}/CHANGES.txt";
+    description = "REST web services to query/retrieve gene annotation data";
+    homepage = "https://github.com/biothings/mygene.py";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ rayhem ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 197698ccf8d3e..02b18c2abbbf1 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8569,6 +8569,8 @@ self: super: with self; {
 
   myfitnesspal = callPackage ../development/python-modules/myfitnesspal { };
 
+  mygene = callPackage ../development/python-modules/mygene { };
+
   mygpoclient = callPackage ../development/python-modules/mygpoclient { };
 
   myhdl = callPackage ../development/python-modules/myhdl {