diff --git a/workflow/rules/somatic.smk b/workflow/rules/somatic.smk index 02c69b2..eda5f93 100644 --- a/workflow/rules/somatic.smk +++ b/workflow/rules/somatic.smk @@ -609,12 +609,14 @@ rule gatk_filter_mutect2: config['tools']['gatk4'], config['tools']['vcftools'], shell: """ - # Mutect2 orien bias filter + # Mutect2 orien bias filter, + # removing the contamination filter + # option due to causing low recall + # with SEQC2 truth set gatk FilterMutectCalls \\ -R {params.genome} \\ -V {input.vcf} \\ --ob-priors {input.orien} \\ - --contamination-table {input.summary} \\ -O {output.vcf} \\ --stats {input.stats} """