diff --git a/dev-requirements.txt b/dev-requirements.txt
index 4c6d6454..78facf93 100644
--- a/dev-requirements.txt
+++ b/dev-requirements.txt
@@ -48,7 +48,7 @@ click==8.1.7
     #   flask
 coverage==5.5
     # via pytest-cov
-cryptography==2.8
+cryptography==43.0.0
     # via
     #   -c requirements.txt
     #   moto
@@ -167,7 +167,6 @@ six==1.16.0
     #   -c requirements.txt
     #   aws-sam-translator
     #   cfn-lint
-    #   cryptography
     #   docker
     #   ecdsa
     #   mock
diff --git a/requirements.txt b/requirements.txt
index d98c232b..ba00e61f 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -10,7 +10,7 @@ cffi==1.15.1
     # via cryptography
 chardet==3.0.4
     # via requests
-cryptography==2.8
+cryptography==43.0.0
     # via
     #   gdc_client (setup.py)
     #   pyopenssl
@@ -46,7 +46,6 @@ requests==2.22.0
     # via gdc_client (setup.py)
 six==1.16.0
     # via
-    #   cryptography
     #   progressbar2
     #   pyopenssl
     #   python-utils
diff --git a/setup.py b/setup.py
index 642130f3..f55ac627 100644
--- a/setup.py
+++ b/setup.py
@@ -18,11 +18,11 @@
     package_data={},
     scripts=["bin/gdc-client"],
     install_requires=[
-        "cryptography~=2.8",
+        "cryptography",
         "jsonschema~=2.6.0",
         "lxml~=4.4.2",
         "ndg-httpsclient~=0.5.0",
-        "pyasn1~=0.4.3",
+        "pyasn1",
         "pyOpenSSL~=18.0.0",
         "PyYAML>=5.1",
         "intervaltree~=3.0.2",