diff --git a/Formula/o/ola.rb b/Formula/o/ola.rb
index 859db0ae0ab2b..27ceb4d04cc05 100644
--- a/Formula/o/ola.rb
+++ b/Formula/o/ola.rb
@@ -1,11 +1,11 @@
 class Ola < Formula
   include Language::Python::Shebang
+  include Language::Python::Virtualenv
 
   desc "Open Lighting Architecture for lighting control information"
   homepage "https://www.openlighting.org/ola/"
   license all_of: ["GPL-2.0-or-later", "LGPL-2.1-or-later"]
   revision 1
-  head "https://github.com/OpenLightingProject/ola.git", branch: "master"
 
   stable do
     # TODO: Check if we can use unversioned `protobuf` at version bump
@@ -18,28 +18,47 @@ class Ola < Formula
       url "https://github.com/OpenLightingProject/ola/commit/e083653d2d18018fe6ef42f757bc06462de87f28.patch?full_index=1"
       sha256 "1276aded269497fab2e3fc95653b5b8203308a54c40fe2dcd2215a7f0d0369de"
     end
+
+    # Backport fix for protoc version detection
+    patch do
+      url "https://github.com/OpenLightingProject/ola/commit/aed518a81340a80765e258d1523b75c22a780052.patch?full_index=1"
+      sha256 "7e48c0027b79e129c1f25f29fae75568a418b99c5b789ba066a4253b7176b00a"
+    end
   end
 
   bottle do
-    rebuild 2
-    sha256 arm64_sequoia: "6756f75f71aeb38c7756dff6e090cfee952ca87692ca890a727d1b8dca4fdd30"
-    sha256 arm64_sonoma:  "c6fe0ecacc9a978798587d54d22eea826132e4400a4f9e76fc533591a526460c"
-    sha256 arm64_ventura: "344967cebfddd0b82cd24c29a65b7303798b65b9d93fd6977a1e62605b200ca9"
-    sha256 sonoma:        "ffdb1bc51a8dfdae5135c5c701932c600ee0b0c91424db61e6e4d713f553edfe"
-    sha256 ventura:       "ed977705d46715e70a8f882f979678e774ccdb8c083b0a85988c25d41c89032f"
-    sha256 x86_64_linux:  "7db8dc0961d2189f7a6ca03d96b028a1555ebda7fc69395addb98c11698d2cee"
+    rebuild 3
+    sha256                               arm64_sequoia: "98f3e8310711c1cf34244ef086e5a5c3650729c575ed5166d5412c4e72eb9605"
+    sha256                               arm64_sonoma:  "51c765b976627293c8892f0d8235d76da15042e478d49d89a1777643782b8bd3"
+    sha256                               arm64_ventura: "493dea963462b70d6e271702dd30a4398d3d70ce56f1a1e0f43dbb24a4931b40"
+    sha256                               sonoma:        "9def76b62762c9978d56bef0652e3571256ff07e2849082b34d437b09481cb41"
+    sha256                               ventura:       "1391ab8b7a5e462d8cbdcc273252dd37316a80539d19bdced603b02df9168188"
+    sha256 cellar: :any_skip_relocation, x86_64_linux:  "4879feff6a807b6340501b1dd117ced1a43dad368342e76172846c13beb7dfdf"
+  end
+
+  head do
+    url "https://github.com/OpenLightingProject/ola.git", branch: "master"
+
+    # Apply open PR to fix macOS HEAD build
+    # PR ref: https://github.com/OpenLightingProject/ola/pull/1983
+    patch do
+      url "https://github.com/OpenLightingProject/ola/commit/b8134b82e15f19266c79620b9c3c012bc515357d.patch?full_index=1"
+      sha256 "d168118436186f0a30f4f7f2fdfcde69a5d20a8dcbef61c586d89cfd8f513e33"
+    end
   end
 
   depends_on "autoconf" => :build
   depends_on "automake" => :build
+  depends_on "cppunit" => :build # TODO: remove once we no longer need to run tests
   depends_on "libtool" => :build
   depends_on "pkg-config" => :build
 
+  depends_on "abseil"
   depends_on "liblo"
   depends_on "libmicrohttpd"
   depends_on "libusb"
   depends_on "numpy"
-  depends_on "protobuf@21"
+  depends_on "protobuf"
   depends_on "python@3.13"
 
   uses_from_macos "bison" => :build
@@ -50,53 +69,74 @@ class Ola < Formula
     depends_on "util-linux"
   end
 
+  resource "protobuf" do
+    url "https://files.pythonhosted.org/packages/74/6e/e69eb906fddcb38f8530a12f4b410699972ab7ced4e21524ece9d546ac27/protobuf-5.28.3.tar.gz"
+    sha256 "64badbc49180a5e401f373f9ce7ab1d18b63f7dd4a9cdc43c92b9f0b481cef7b"
+  end
+
+  # Apply open PR to support Protobuf 22+ API
+  # PR ref: https://github.com/OpenLightingProject/ola/pull/1984
+  patch do
+    url "https://github.com/OpenLightingProject/ola/commit/4924c9908ea879b36dc9132768fca25f6f21a677.patch?full_index=1"
+    sha256 "4d3ed12a41d4c2717cfbb3fa790ddf115b084c1d3566a4d2f0e52a8ab25053ef"
+  end
+
   def python3
     "python3.13"
   end
 
-  # Remove when we use unversioned protobuf
   def extra_python_path
-    Formula["protobuf@21"].opt_prefix/Language::Python.site_packages(python3)
+    opt_libexec/Language::Python.site_packages(python3)
   end
 
   def install
-    # https://github.com/Homebrew/homebrew-core/pull/123791
-    # remove when the above PR is merged
-    ENV.append_to_cflags "-DNDEBUG"
+    # Workaround to build with newer Protobuf due to Abseil C++ standard
+    # Issue ref: https://github.com/OpenLightingProject/ola/issues/1879
+    inreplace "configure.ac", "-std=gnu++11", "-std=gnu++17"
+    if ENV.compiler == :clang
+      # Workaround until https://github.com/OpenLightingProject/ola/pull/1889
+      ENV.append "CXXFLAGS", "-D_LIBCPP_ENABLE_CXX17_REMOVED_AUTO_PTR"
+      # Workaround until https://github.com/OpenLightingProject/ola/pull/1890
+      ENV.append "CXXFLAGS", "-D_LIBCPP_ENABLE_CXX17_REMOVED_BINDERS"
+      ENV.append "CXXFLAGS", "-D_LIBCPP_ENABLE_CXX17_REMOVED_UNARY_BINARY_FUNCTION"
+    end
 
-    # protobuf@21 is keg-only.
-    # Remove when we use unversioned protobuf
-    ENV.prepend_path "PYTHONPATH", extra_python_path
+    # Skip flaky python tests. Remove when no longer running tests
+    inreplace "python/ola/Makefile.mk", /^test_scripts \+= \\$/, "skipped_test_scripts = \\"
+
+    venv = virtualenv_create(libexec, python3)
+    venv.pip_install resources
 
     args = %W[
       --disable-fatal-warnings
       --disable-silent-rules
-      --disable-unittests
+      --enable-unittests
       --enable-python-libs
       --enable-rdm-tests
-      --with-python_prefix=#{prefix}
-      --with-python_exec_prefix=#{prefix}
+      --with-python_prefix=#{libexec}
+      --with-python_exec_prefix=#{libexec}
     ]
 
-    ENV["PYTHON"] = python3
+    ENV["PYTHON"] = venv.root/"bin/python"
     system "autoreconf", "--force", "--install", "--verbose"
-    system "./configure", *std_configure_args, *args
+    system "./configure", *args, *std_configure_args
+    system "make"
+    # Run tests to check the workarounds applied haven't broken basic functionality.
+    # TODO: Remove and revert to `--disable-unittests` when workarounds can be dropped.
+    system "make", "check"
     system "make", "install"
 
-    rewrite_shebang detected_python_shebang, *bin.children
+    rewrite_shebang python_shebang_rewrite_info(venv.root/"bin/python"), *bin.children
   end
 
-  # Remove when we use unversioned protobuf
   def caveats
     <<~EOS
       To use the bundled Python libraries:
-        export PYTHONPATH=#{extra_python_path}
+        #{Utils::Shell.export_value("PYTHONPATH", extra_python_path)}
     EOS
   end
 
   test do
-    # `protobuf@21` is keg-only.
-    # Remove when we use unversioned protobuf
     ENV.prepend_path "PYTHONPATH", extra_python_path
     system bin/"ola_plugin_state", "-h"
     system python3, "-c", "from ola.ClientWrapper import ClientWrapper"