diff --git a/src/mito2/src/region.rs b/src/mito2/src/region.rs
index 71006324d98d..b679365464f4 100644
--- a/src/mito2/src/region.rs
+++ b/src/mito2/src/region.rs
@@ -18,7 +18,7 @@ pub(crate) mod opener;
 pub mod options;
 pub(crate) mod version;
 
-use std::collections::HashMap;
+use std::collections::{HashMap, HashSet};
 use std::sync::atomic::{AtomicI64, Ordering};
 use std::sync::{Arc, RwLock};
 
@@ -471,6 +471,34 @@ impl RegionMap {
 
 pub(crate) type RegionMapRef = Arc<RegionMap>;
 
+/// Opening regions
+#[derive(Debug, Default)]
+pub(crate) struct OpeningRegions {
+    regions: RwLock<HashSet<RegionId>>,
+}
+
+impl OpeningRegions {
+    /// Returns true if the region exists.
+    pub(crate) fn is_region_exists(&self, region_id: RegionId) -> bool {
+        let regions = self.regions.read().unwrap();
+        regions.contains(&region_id)
+    }
+
+    /// Inserts a new region into the map.
+    pub(crate) fn insert_region(&self, region: RegionId) {
+        let mut regions = self.regions.write().unwrap();
+        regions.insert(region);
+    }
+
+    /// Remove region by id.
+    pub(crate) fn remove_region(&self, region_id: RegionId) {
+        let mut regions = self.regions.write().unwrap();
+        regions.remove(&region_id);
+    }
+}
+
+pub(crate) type OpeningRegionsRef = Arc<OpeningRegions>;
+
 #[cfg(test)]
 mod tests {
     use crossbeam_utils::atomic::AtomicCell;
diff --git a/src/mito2/src/worker.rs b/src/mito2/src/worker.rs
index fbd6656e2e6c..522b3acbbabf 100644
--- a/src/mito2/src/worker.rs
+++ b/src/mito2/src/worker.rs
@@ -51,7 +51,7 @@ use crate::error::{JoinSnafu, Result, WorkerStoppedSnafu};
 use crate::flush::{FlushScheduler, WriteBufferManagerImpl, WriteBufferManagerRef};
 use crate::memtable::MemtableBuilderProvider;
 use crate::metrics::WRITE_STALL_TOTAL;
-use crate::region::{MitoRegionRef, RegionMap, RegionMapRef};
+use crate::region::{MitoRegionRef, OpeningRegions, OpeningRegionsRef, RegionMap, RegionMapRef};
 use crate::request::{
     BackgroundNotify, DdlRequest, SenderDdlRequest, SenderWriteRequest, WorkerRequest,
 };
@@ -373,6 +373,7 @@ impl<S: LogStore> WorkerStarter<S> {
             config: self.config.clone(),
             regions: regions.clone(),
             dropping_regions: Arc::new(RegionMap::default()),
+            opening_regions: Arc::new(OpeningRegions::default()),
             sender: sender.clone(),
             receiver,
             wal: Wal::new(self.log_store),
@@ -531,6 +532,8 @@ struct RegionWorkerLoop<S> {
     regions: RegionMapRef,
     /// Regions that are not yet fully dropped.
     dropping_regions: RegionMapRef,
+    /// Regions that are opening.
+    opening_regions: OpeningRegionsRef,
     /// Request sender.
     sender: Sender<WorkerRequest>,
     /// Request receiver.
diff --git a/src/mito2/src/worker/handle_open.rs b/src/mito2/src/worker/handle_open.rs
index 6c26d7d8bdd1..b8b7119abde9 100644
--- a/src/mito2/src/worker/handle_open.rs
+++ b/src/mito2/src/worker/handle_open.rs
@@ -66,6 +66,10 @@ impl<S: LogStore> RegionWorkerLoop<S> {
         request: RegionOpenRequest,
         sender: OptionOutputTx,
     ) {
+        if self.opening_regions.is_region_exists(region_id) {
+            sender.send(Ok(0));
+            return;
+        };
         if self.regions.is_region_exists(region_id) {
             sender.send(Ok(0));
             return;
@@ -86,9 +90,10 @@ impl<S: LogStore> RegionWorkerLoop<S> {
             self.intermediate_manager.clone(),
         )
         .skip_wal_replay(request.skip_wal_replay)
+        .cache(Some(self.cache_manager.clone()))
         .parse_options(request.options)
         {
-            Ok(opener) => opener.cache(Some(self.cache_manager.clone())),
+            Ok(opener) => opener,
             Err(err) => {
                 sender.send(Err(err));
                 return;
@@ -98,6 +103,8 @@ impl<S: LogStore> RegionWorkerLoop<S> {
         let regions = self.regions.clone();
         let wal = self.wal.clone();
         let config = self.config.clone();
+        let opening_regions = self.opening_regions.clone();
+        opening_regions.insert_region(region_id);
         common_runtime::spawn_bg(async move {
             match opener.open(&config, &wal).await {
                 Ok(region) => {
@@ -113,6 +120,7 @@ impl<S: LogStore> RegionWorkerLoop<S> {
                     sender.send(Err(err));
                 }
             }
+            opening_regions.remove_region(region_id);
         });
     }
 }