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Merge pull request #11 from FoldingCommunity/master
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tematim authored Jul 15, 2020
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92 changes: 92 additions & 0 deletions Localization/en-US/covid-19.po
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msgid ""
msgstr ""
"FAH-Translate-Schema-Version: 1.0\n"
"URL: https://foldingathome.org/covid-19/\n"
"Content-Type: text/plain; charset=UTF-8\n"
"Source-Language: en-US\n"
"Source-Version: 1.0\n"
"Source-Last-Modified: 20200714\n"
"Target-Language: \n"
"Target-Version: \n"
"Target-Last-Modified: \n"

msgid "COVID-19"
msgstr ""

msgid "Coronavirus – What we’re doing and how you can help"
msgstr ""

msgid "Proteins are molecular machines that perform many functions we associate with life. They sense the environment (e.g. in taste and smell), perform work (e.g. muscle contraction and breaking down food), and play structural roles (e.g. your hair). They are made of a linear chain of chemicals called amino acids that, in many cases, spontaneously “fold” into compact, functional structures. Much like any other machine, it’s how a protein’s components are arranged and move that determine the protein’s function. In this case, the components are atoms."
msgstr ""

msgid "Viruses also have proteins that they use to suppress our immune systems and reproduce themselves."
msgstr ""

msgid "To help tackle coronavirus, we want to understand how these viral proteins work and how we can design therapeutics to stop them."
msgstr ""

msgid "There are many experimental methods for determining protein structures. While extremely powerful, they only reveal a single snapshot of a protein’s usual shape. But proteins have lots of moving parts, so we really want to see the protein in action. The structures we can’t see experimentally may be the key to discovering a new therapeutic."
msgstr ""

msgid "Using football as an analogy for the experimental situation, it’s as if you could only see the players lined up for the snap (the single arrangement the players spend the most time in) and were blind to the rest of the game."
msgstr ""

msgid "Seeing a single structure of a protein (left) is like seeing players lined up for the snap in football. Important information, but a lot missing too. The protein structure shows a sphere for each atom (blue) and red arrows highlighting the one drug binding site in this protein."
msgstr ""

msgid "Our specialty is in using computer simulations to understand proteins’ moving parts. Watching how the atoms in a protein move relative to one another is important because it captures valuable information that is inaccessible by any other means."
msgstr ""

msgid "Taking the experimental structures as starting points, we can simulate how all the atoms in the protein move, effectively filling in the rest of the game that experiments miss."
msgstr ""

msgid "A movie capturing how the protein shown before moves is like getting to watch the whole football game. In this case, we see a pocket form that was absent in the experimental structure."
msgstr ""

msgid "Doing so can reveal new therapeutic opportunities. For example, in our recent [paper](https://www.biorxiv.org/content/10.1101/2020.02.09.940510v1.abstract), we simulated a protein from Ebola virus that is typically considered ‘undruggable’ because the snapshots from experiments don’t have obvious druggable sites. But, our simulations uncovered an alternative structure that does have a druggable site. Importantly, we then performed experiments that confirmed our computational prediction, and are now searching for drugs that bind this newly discovered binding site."
msgstr ""

msgid "An experimental structure of an Ebola protein doesn’t have obvious druggable sites (no deep pockets among the atoms shown as spheres).Our simulations captured a motion that creates a potentially druggable site in this Ebola protein. Instead of showing spheres for each atom, this cartoon shows a ribbon tracing the linear chain of amino acids (chemicals) the protein is made of."
msgstr ""

msgid "We want to do the same thing with coronavirus."
msgstr ""

msgid "Spreading the knowledge, Opensource"
msgstr ""

msgid "When we are done with our analysis we upload the data here:"
msgstr ""

msgid "We also make all data publicly available, so that other people working in the field can check our analysis and anyone with new methods (e.g. the always growing machine learning data analysis) can look at them at any time: [https://osf.io/2h6p4/wiki/home/](https://osf.io/2h6p4/wiki/home/) and [https://osf.io/dp4cb/wiki/home/](https://osf.io/dp4cb/wiki/home/)"
msgstr ""

msgid "We are also collaborating with other labs and groups outside the Foldingathome Consortium to solve COVID-19 asap."
msgstr ""

msgid "What you can do"
msgstr ""

msgid "1. Donate computing power:"
msgstr ""

msgid "[Downloading Folding@home](/start-folding/) and helping us run simulations is the primary way to contribute. These calculations are enormous and every little bit helps! Each simulation you run is like buying a lottery ticket. The more tickets we buy, the better our chances of hitting the jackpot. Usually, your computer will never be idle, but we’ve had such an enthusiastic response to our COVID-19 work that you will see some intermittent downtime as we sprint to setup more simulations. Please be patient with us! There is a lot of valuable science to be done, and we’re getting it running as quickly as we can."
msgstr ""

msgid "Don’t miss our client FAQ. [HERE](https://foldingforum.org/viewtopic.php?f=24&t=32463)"
msgstr ""

msgid "To focus on Covid19 research set your category to any."
msgstr ""

msgid "2) If you don’t have computers to contribute or are feeling particularly generous, you can also [make donations](https://gifts.wustl.edu/med/index.html?other_designation_description=Folding@Home%20(Dr%20Greg%20Bowman,%20Dept%20of%20Biochemistry)&0_d_tr1=71&sc=NG) through Washington University in St. Louis. These funds are used for a number of purposes, including:"
msgstr ""

msgid "2.1) Supporting our software engineering and server-side hardware (particularly important right now as we scale up rapidly!)"
msgstr ""

msgid "2.2) Buying compounds to test experimentally based on insight from our simulations."
msgstr ""

msgid "Covid-19 collaborators"
msgstr ""
43 changes: 43 additions & 0 deletions Localization/es-MX/about.po
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msgid ""
msgstr ""
"FAH-Translate-Schema-Version: 1.0\n"
"URL: https://foldingathome.org/about/\n"
"Source-Language: en-US\n"
"Source-Version: 1.0\n"
"Source-Last-Modified: 20200705\n"
"Target-Language: es-MX\n"
"Target-Version: 1.0\n"
"Target-Last-Modified: 20200709 \n"
"Project-Id-Version: \n"
"POT-Creation-Date: \n"
"PO-Revision-Date: \n"
"Last-Translator: \n"
"Language-Team: \n"
"MIME-Version: 1.0\n"
"Content-Type: text/plain; charset=UTF-8\n"
"Content-Transfer-Encoding: 8bit\n"
"Language: es_MX\n"
"X-Generator: Poedit 2.3.1\n"

msgid "About"
msgstr "ACERCA DE"

msgid "Folding@home (FAH or F@h)"
msgstr "Folding@home (FAH o F@h)"

msgid ""
"is a distributed computing project for simulating protein dynamics, "
"including the process of protein folding and the movements of proteins "
"implicated in a variety of diseases. It brings together citizen scientists "
"who volunteer to run simulations of protein dynamics on their personal "
"computers. Insights from this data are helping scientists to better "
"understand biology, and providing new opportunities for developing "
"therapeutics."
msgstr ""
"es un proyecto de computación distribuida para simular la dinámica de las "
"proteínas, incluyendo el proceso de plegamiento de proteínas y los "
"movimientos de proteínas implicadas en diversas enfermedades. Reúne a "
"científicos ciudadanos que se ofrecen como voluntarios para ejecutar "
"simulaciones de dinámica de proteínas en sus computadoras personales. El "
"conocimiento de estos datos está ayudando a los científicos a comprender "
"mejor la biología y brindar nuevas oportunidades para desarrollar terapias."
11 changes: 0 additions & 11 deletions Localization/es-MX/about.yaml

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47 changes: 47 additions & 0 deletions Localization/es-MX/diseases.po
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msgid ""
msgstr ""
"FAH-Translate-Schema-Version: 1.0\n"
"URL: https://foldingathome.org/diseases/\n"
"Source-Language: en-US\n"
"Source-Version: 1.0\n"
"Source-Last-Modified: 20200705\n"
"Target-Language: es-MX\n"
"Target-Version: 1.0\n"
"Target-Last-Modified: 20200709 \n"
"Project-Id-Version: \n"
"POT-Creation-Date: \n"
"PO-Revision-Date: \n"
"Last-Translator: \n"
"Language-Team: \n"
"MIME-Version: 1.0\n"
"Content-Type: text/plain; charset=UTF-8\n"
"Content-Transfer-Encoding: 8bit\n"
"Language: es_MX\n"
"X-Generator: Poedit 2.3.1\n"

msgid "Diseases"
msgstr "Enfermedades"

msgid "The Folding@home project (FAH) is dedicated to understanding protein folding, the diseases that result from protein misfolding and aggregation, and novel computational ways to develop new drugs in general. Here, we briefly describe our goals, what we are doing, and some highlights so far."
msgstr "El proyecto de Folding@home (FAH) se dedica a comprender el plegamiento de las proteínas, las enfermedades resultantes del mal plegado y agregación proteica, y nuevas formas computacionales para desarrollar nuevos fármacos en general. Aquí, describimos brevemente nuestros objetivos, lo que estamos haciendo y algunos aspectos destacados hasta ahora."

msgid "A distributed computing project must not only run calculations on millions of PCs, but such projects must produce results, especially in the form of peer-reviewed publications, public lectures, and other ways that disseminate the results from FAH to the greater scientific community. In the sidebar, you will find links to our progress in different areas."
msgstr "Un proyecto de computación distribuida no solo debe realizar cálculos en millones de PC, sino que dichos proyectos deben producir resultados, especialmente en forma de publicaciones revisadas por pares, conferencias públicas y otras formas que difunden los resultados de FAH a la comunidad científica en general. En la barra lateral, encontrará enlaces a nuestro progreso en diferentes áreas."

msgid "You will also find updates about our work, advancements and new projects in the main [Folding@home blog](https://foldingathome.org/news/)."
msgstr "También encontrarás actualizaciones sobre nuestro trabajo, avances y proyectos nuevos en la página principal [Folding@home blog](https://foldingathome.org/news/)."

msgid "What is protein folding and how is it related to disease?"
msgstr "¿Qué es el plegamiento de proteínas y cómo se relaciona con las enfermedades?"

msgid "Proteins are necklaces of amino acids, long chain molecules. They are the basis of how biology gets things done. As enzymes, they are the driving force behind all of the biochemical reactions that make biology work. As structural elements, they are the main constituent of our bones, muscles, hair, skin and blood vessels. As antibodies, they recognize invading elements and allow the immune system to get rid of the unwanted invaders. For these reasons, scientists have sequenced the human genome - the blueprint for all of the proteins in biology - but how can we understand what these proteins do and how they work?"
msgstr "Las proteínas son collares de aminoácidos, moléculas de cadena larga. Son la base de cómo la biología hace las cosas. Como enzimas, son la fuerza impulsora detrás de todas las reacciones bioquímicas que hacen que la biología funcione. Como elementos estructurales, son el componente principal de nuestros huesos, músculos, cabello, piel y vasos sanguíneos. Como anticuerpos, reconocen los elementos invasores y permiten que el sistema inmunitario elimine a los invasores no deseados. Por estas razones, los científicos han secuenciado el genoma humano, el modelo para todas las proteínas en biología, pero ¿cómo podemos entender qué hacen estas proteínas y cómo funcionan?"

msgid "However, only knowing this sequence tells us little about what the protein does and how it does it. In order to carry out their function (e.g. as enzymes or antibodies), they must take on a particular shape, also known as a \"fold\". Thus, proteins are truly amazing machines: before they do their work, they assemble themselves! This self-assembly is called \"folding\"."
msgstr "Sin embargo, solo conocer esta secuencia nos dice poco sobre lo que hace la proteína y cómo lo hace. Para llevar a cabo su función (por ejemplo, como enzimas o anticuerpos), deben adoptar una forma particular, también conocida como \"pliegue\". Por lo tanto, las proteínas son máquinas realmente sorprendentes: ¡Antes de hacer su trabajo, se ensamblan! Este autoensamblaje se llama \"plegado\"."

msgid "What happens if proteins don't fold correctly?"
msgstr "¿Qué ocurre si las proteínas no se pliegan correctamente?"

msgid "Diseases such as Alzheimer's disease, Huntington's disease, cystic fibrosis, BSE (Mad Cow disease), an inherited form of emphysema, and even many cancers are believed to result from protein misfolding. When proteins misfold, they can clump together (\"aggregate\"). These clumps can often gather in the brain, where they are believed to cause the symptoms of Mad Cow or Alzheimer's disease."
msgstr "Enfermedades el Alzheimer, la enfermedad de Huntington, la fibrosis quística, la EEB (enfermedad de las vacas locas), una forma hereditaria de enfisema, e incluso se cree que muchos cánceres son el resultado del mal plegamiento de proteínas. Cuando las proteínas se pliegan incorrectamente, pueden agruparse (\"agregado\"). Estos grupos a menudo pueden acumularse en el cerebro, donde se cree que causan los síntomas de la vaca loca o la enfermedad de Alzheimer."
34 changes: 0 additions & 34 deletions Localization/es-MX/diseases.yaml

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29 changes: 29 additions & 0 deletions Localization/es-MX/faq.po
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msgid ""
msgstr ""
"FAH-Translate-Schema-Version: 1.0\n"
"URL: https://foldingathome.org/support/faq/\n"
"Source-Language: en-US\n"
"Source-Version: 1.0\n"
"Source-Last-Modified: 20200705\n"
"Target-Language: es-MX\n"
"Target-Version: 1.0\n"
"Target-Last-Modified: 20200709 \n"
"Project-Id-Version: \n"
"POT-Creation-Date: \n"
"PO-Revision-Date: \n"
"Last-Translator: \n"
"Language-Team: \n"
"MIME-Version: 1.0\n"
"Content-Type: text/plain; charset=UTF-8\n"
"Content-Transfer-Encoding: 8bit\n"
"Language: es_MX\n"
"X-Generator: Poedit 2.3.1\n"

msgid "FAQ"
msgstr "PF"

msgid "You'll find a large library of frequently asked questions about all things connected to Folding@home."
msgstr "Encontrarás una gran biblioteca de preguntas frecuentes sobre todo lo relacionado con Folding@home."

msgid "This section contains everything from guides and information about how to install and use the Folding@home software to the science behind our research. Look through the sidebar and find the topic you want to know more about."
msgstr "Esta sección contiene todo desde guías e información sobre cómo instalar y usar el software Folding@home, hasta la ciencia detrás de nuestra investigación. Mire a través de la barra lateral y encuentre el tema sobre el que desea saber más."
11 changes: 0 additions & 11 deletions Localization/es-MX/faq.yaml

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