diff --git a/src/python/ensembl/io/genomio/gff3/extract_annotation.py b/src/python/ensembl/io/genomio/gff3/extract_annotation.py
index 414e41314..79d802cc1 100644
--- a/src/python/ensembl/io/genomio/gff3/extract_annotation.py
+++ b/src/python/ensembl/io/genomio/gff3/extract_annotation.py
@@ -230,6 +230,7 @@ def _transfer_description_up(self, child_feature: str) -> None:
         for child_id, child in children_features.items():
             child_description = child.get("description")
             if child_description is not None:
+                child_description = self._clean_description(child_description)
                 # Check parent
                 parent_id = self.get_parent(parent_type, child_id)
                 parent = parent_features[parent_id]
@@ -237,6 +238,13 @@ def _transfer_description_up(self, child_feature: str) -> None:
                 if parent_description is None:
                     parent["description"] = child_description
 
+    @staticmethod
+    def _clean_description(description: str) -> str:
+        """Returns the description without "transcript variant" information."""
+        variant_re = re.compile(r", transcript variant [A-Z][0-9]+$", re.IGNORECASE)
+        description = re.sub(variant_re, "", description)
+        return description
+
     @staticmethod
     def product_is_informative(product: str, feat_ids: Optional[List[str]] = None) -> bool:
         """Returns True if the product name contains informative words, False otherwise.
diff --git a/src/python/tests/gff3/test_extract_annotation.py b/src/python/tests/gff3/test_extract_annotation.py
index f169bb55a..47d8ba164 100644
--- a/src/python/tests/gff3/test_extract_annotation.py
+++ b/src/python/tests/gff3/test_extract_annotation.py
@@ -312,14 +312,22 @@ def test_get_features(feat_type: str, expected_number: int, expected: ContextMan
 @pytest.mark.parametrize(
     "gene_desc, transc_desc, transl_desc, out_gene_desc, out_transc_desc",
     [
-        (None, None, None, None, None),
-        ("Foobar", None, None, "Foobar", None),  # Only gene descriptions
-        ("gene A", "transc B", "prod C", "gene A", "transc B"),  # All descriptions set
-        (None, None, "Foobar", "Foobar", "Foobar"),  # Transfer from transl
-        (None, "Foobar", None, "Foobar", "Foobar"),  # Transfer from transc
-        (None, "Foobar", "Lorem", "Foobar", "Foobar"),  # Transfer from transc, transl also set
-        ("Hypothetical gene", "Predicted function", "Foobar", "Foobar", "Foobar"),  # Non informative
-        (None, None, "Unknown product", None, None),  # Non informative source
+        param(None, None, None, None, None, id="Nothing provided"),
+        param("Foobar", None, None, "Foobar", None, id="Only gene description"),
+        param("gene A", "transc B", "prod C", "gene A", "transc B", id="All descriptions set"),
+        param(None, None, "Foobar", "Foobar", "Foobar", id="Transfer from transl"),
+        param(None, "Foobar", None, "Foobar", "Foobar", id="Transfer from transc"),
+        param(
+            None,
+            "Foobar, transcript variant X1",
+            None,
+            "Foobar",
+            "Foobar, transcript variant X1",
+            id="transcr with variant",
+        ),
+        param(None, "Foobar", "Lorem", "Foobar", "Foobar", id="Transfer from transc, transl also set"),
+        param("Hypothetical gene", "Predicted function", "Foobar", "Foobar", "Foobar", id="Non informative"),
+        param(None, None, "Unknown product", None, None, id="Non informative source"),
     ],
 )
 @pytest.mark.dependency(depends=["get_features"])