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<title>Introduzione</title>
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<h1 class="title">Introduzione</h1>
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<p>La Figura @ref(fig:fig1) illustra una meta-analisi che mostra l’impatto delle statine ad alto dosaggio rispetto a quelle a dosaggio standard nella prevenzione della morte e dell’infarto miocardico (MI). Questa analisi è adattata da quella riportata da Cannon et al. e pubblicata sul Journalof the American College of Cardiology (2006). Il nostro obiettivo nel presentarla qui è quello di introdurre i vari elementi di una meta-analisi (la dimensione dell’effetto per ogni studio, il peso assegnato a ciascuna dimensione dell’effetto, la stima dell’effetto di sintesi e così via) e mostrare dove ciascuno si inserisce nello schema più ampio. Nei capitoli successivi, ognuno di questi elementi verrà esplorato in dettaglio.</p>
<div class="cell" data-rmd_chunk_options="fig1, echo= FALSE, out.width='100%', fig.cap='Dosaggio elevato rispetto al dosaggio standard di statine (adattato da [@Cannon2006Aug]).'" data-kernel="R" data-tags="["report_cell"]" data-vscode="{"languageId":"r"}" data-execution_count="1">
<div class="sourceCode cell-code" id="cb1"><pre class="sourceCode r code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1" aria-hidden="true" tabindex="-1"></a>knitr<span class="sc">::</span><span class="fu">include_graphics</span>(<span class="st">'Figures/Screenshot 2023-09-13 alle 10.55.41.png'</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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<pre><code>[1] "Figures/Screenshot 2023-09-13 alle 10.55.41.png"
attr(,"class")
[1] "knit_image_paths" "knit_asis" </code></pre>
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<p>L’obiettivo di questa presentazione è quello d’introdurre i vari elementi di una meta-analisi (la dimensione dell’effetto per ogni studio, il peso assegnato a ogni dimensione dell’effetto, la stima dell’effetto di sintesi e così via) e di mostrare dove ciascuno di essi si inserisce nello schema più ampio. Nei capitoli successivi, ognuno di questi elementi verrà esplorato in dettaglio.</p>
<section id="studi-individuali" class="level2">
<h2 class="anchored" data-anchor-id="studi-individuali">Studi individuali</h2>
<p>Le prime quattro righe di questo grafico rappresentano i quattro studi. Per ciascuno di essi, a sinistra è riportato il nome dello studio, seguito dalla dimensione dell’effetto, dal peso relativo assegnato allo studio per il calcolo dell’effetto sintetico e dal valore p. La dimensione dell’effetto e il peso sono mostrati anche in modo schematico.</p>
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