diff --git a/guppy/cfg/builder.py b/guppy/cfg/builder.py
index 0c42207c..e67a5bf5 100644
--- a/guppy/cfg/builder.py
+++ b/guppy/cfg/builder.py
@@ -1,7 +1,7 @@
 import ast
 import itertools
 from collections.abc import Iterator
-from typing import NamedTuple, cast
+from typing import NamedTuple
 
 from guppy.ast_util import (
     AstVisitor,
@@ -258,9 +258,8 @@ def build(node: ast.expr, cfg: CFG, bb: BB) -> tuple[ast.expr, BB]:
     @classmethod
     def _tmp_assign(cls, tmp_name: str, value: ast.expr, bb: BB) -> None:
         """Adds a temporary variable assignment to a basic block."""
-        node = ast.Assign(targets=[make_var(tmp_name, value)], value=value)
-        set_location_from(node, value)
-        bb.statements.append(node)
+        lhs = make_var(tmp_name, value)
+        bb.statements.append(make_assign([lhs], value))
 
     def visit_Name(self, node: ast.Name) -> ast.Name:
         return node
@@ -309,31 +308,24 @@ def visit_ListComp(self, node: ast.ListComp) -> ast.AST:
             if g.is_async:
                 raise GuppyError("Async generators are not supported", g)
             g.iter = self.visit(g.iter)
-            gen = DesugaredGenerator()
-
-            template = """
-                it = make_iter
-                b, it = has_next
-                x, it = get_next
-            """
             it = make_var(next(tmp_vars), g.iter)
-            b = make_var(next(tmp_vars), g.iter)
-            [gen.iter_assign, gen.hasnext_assign, gen.next_assign] = cast(
-                list[ast.Assign],
-                template_replace(
-                    template,
-                    g.iter,
-                    it=it,
-                    b=b,
-                    x=g.target,
-                    make_iter=with_loc(it, MakeIter(value=g.iter, origin_node=node)),
-                    has_next=with_loc(it, IterHasNext(value=it)),
-                    get_next=with_loc(it, IterNext(value=it)),
+            hasnext = make_var(next(tmp_vars), g.iter)
+            desugared = DesugaredGenerator(
+                iter=it,
+                hasnext=hasnext,
+                iter_assign=make_assign(
+                    [it], with_loc(it, MakeIter(value=g.iter, origin_node=node))
+                ),
+                hasnext_assign=make_assign(
+                    [hasnext, it], with_loc(it, IterHasNext(value=it))
                 ),
+                next_assign=make_assign(
+                    [g.target, it], with_loc(it, IterNext(value=it))
+                ),
+                iterend=with_loc(it, IterEnd(value=it)),
+                ifs=g.ifs,
             )
-            gen.iterend = with_loc(it, IterEnd(value=it))
-            gen.iter, gen.hasnext, gen.ifs = it, b, g.ifs
-            gens.append(gen)
+            gens.append(desugared)
 
         node.elt = self.visit(node.elt)
         return with_loc(node, DesugaredListComp(elt=node.elt, generators=gens))
@@ -507,3 +499,13 @@ def make_var(name: str, loc: ast.AST | None = None) -> ast.Name:
     if loc is not None:
         set_location_from(node, loc)
     return node
+
+
+def make_assign(lhs: list[ast.AST], value: ast.expr) -> ast.Assign:
+    """Creates an `ast.Assign` node."""
+    assert len(lhs) > 0
+    if len(lhs) == 1:
+        target = lhs[0]
+    else:
+        target = with_loc(value, ast.Tuple(elts=lhs, ctx=ast.Store()))
+    return with_loc(value, ast.Assign(targets=[target], value=value))