diff --git a/lib/galaxy/config/schemas/config_schema.yml b/lib/galaxy/config/schemas/config_schema.yml
index aa7f4891936d..624b08cb8e66 100644
--- a/lib/galaxy/config/schemas/config_schema.yml
+++ b/lib/galaxy/config/schemas/config_schema.yml
@@ -1529,6 +1529,14 @@ mapping:
         desc: |
           Prefix to use in the formation of the subdomain or path for interactive tools
 
+      interactivetools_verify_ssl:
+        type: bool
+        default: false
+        required: false
+        desc: |
+          Do not mark interactive tool endpoint as active until an HTTPS connection
+          can be established
+
       retry_interactivetool_metadata_internally:
         type: bool
         default: true
diff --git a/lib/galaxy/managers/interactivetool.py b/lib/galaxy/managers/interactivetool.py
index 8cec876ba561..ad04d610102a 100644
--- a/lib/galaxy/managers/interactivetool.py
+++ b/lib/galaxy/managers/interactivetool.py
@@ -6,6 +6,7 @@
     urlunsplit,
 )
 
+import requests
 from sqlalchemy import (
     or_,
     select,
@@ -296,6 +297,18 @@ def remove_entry_point(self, entry_point, flush=True):
                 self.sa_session.commit()
         self.propagator.remove_entry_point(entry_point)
 
+    def _ssl_check(self, url):
+        if self.app.config.interactivetools_verify_ssl:
+            try:
+                r = requests.get(url)
+            except requests.exceptions.SSLError:
+                return False
+            if r.status_code == 200:
+                return True
+            else:
+                return False
+        return True
+
     def target_if_active(self, trans, entry_point):
         if entry_point.active and not entry_point.deleted:
             use_it_proxy_host_cfg = (
@@ -315,7 +328,9 @@ def target_if_active(self, trans, entry_point):
                 if not use_it_proxy_host_cfg:
                     return url_path
 
-            return urlunsplit((url_parts.scheme, url_host, url_path, "", ""))
+            end_url = urlunsplit((url_parts.scheme, url_host, url_path, "", ""))
+            if self._ssl_check(end_url):
+                return end_url
 
     def _get_entry_point_url_elements(self, trans, entry_point):
         encoder = IdAsLowercaseAlphanumEncodingHelper(trans.security)