From f4e514188893bfc773f9531c001524952d9e8e57 Mon Sep 17 00:00:00 2001 From: adelbke Date: Thu, 12 Dec 2024 16:36:56 +0100 Subject: [PATCH] published disprot release 2024_12 --- _posts/2024-12-12-release_2024_12.markdown | 23 ++++++++++++++++++++++ 1 file changed, 23 insertions(+) create mode 100644 _posts/2024-12-12-release_2024_12.markdown diff --git a/_posts/2024-12-12-release_2024_12.markdown b/_posts/2024-12-12-release_2024_12.markdown new file mode 100644 index 0000000..e7a6dd4 --- /dev/null +++ b/_posts/2024-12-12-release_2024_12.markdown @@ -0,0 +1,23 @@ +--- +layout: post +title: 'DisProt 2024_12 - New thematic dataset of Age-related disorders proteins' +date: 2024-12-12 16:40:00 +0200 +author: "Maria Cristina Aspromonte" +headline: 'With this last DisProt thematic dataset, we explore the role of intrinsically disordered proteins (IDPs) in Age-related diseases.' +topic: "disprot" +--- + + + +# **New thematic dataset for discovering the role of IDPs/IDRs on Age-diseases** + +Age-related diseases are common worldwide conditions affecting adults and are often caused by the dysregulation of proteins associated with multiple biological systems. Here, we introduce a new thematic dataset: **Age-related Disorders Proteins**. + +Our dataset currently focuses on **intrinsically disordered proteins (IDPs)** that are well-known for their involvement in neurodegenerative diseases (NDDs). Proteins were extracted from a curated database [NDDvarbase](http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0), which includes entries related to 37 different NDDs. This dataset highlights some of the most notable proteins, including: + +* [**DP00070**](https://disprot.org/DP00070) **\- Alpha-synuclein**, encoded by the gene SNCA, with a disorder content of 99.3%. This protein is crucial for amyloid fibril formation and is responsible for Lewy body dementia. + +* [**DP01248**](https://disprot.org/DP01248) **\- Vesicle-associated membrane protein-associated protein B/C**, an endoplasmic reticulum (ER)-anchored protein primarily involved in Amyotrophic Lateral Sclerosis (OMIM#608627) and Spinal Muscular Atrophy, late-onset Finkel type (OMIM#182980). + + +Thanks to the dedicated efforts of expert DisProt biocurators—**Victoria M. Nugnes**, **Federica Quaglia**, and the DisProt Consortium —the dataset now features **45 proteins** supported by over **306 pieces of evidence** extracted from **115 scientific publications**. \ No newline at end of file