diff --git a/ants/label/label_overlap_measures.py b/ants/label/label_overlap_measures.py
index 815c4fc0..4b7e7280 100644
--- a/ants/label/label_overlap_measures.py
+++ b/ants/label/label_overlap_measures.py
@@ -40,5 +40,7 @@ def label_overlap_measures(source_image, target_image):
     libfn = get_lib_fn("labelOverlapMeasures%iD" % source_image_int.dimension)
     df = libfn(source_image_int.pointer, target_image_int.pointer)
     df = pd.DataFrame(df)
+    # Set Label column to object type as it can contain strings
+    df['Label'] = df['Label'].astype(object)
     df.loc[0, 'Label'] = 'All'
     return df