diff --git a/pathwaysutils/__init__.py b/pathwaysutils/__init__.py
index 3af7ad9..84e6e19 100644
--- a/pathwaysutils/__init__.py
+++ b/pathwaysutils/__init__.py
@@ -60,6 +60,11 @@ def _is_persistence_enabled():
     pathways_orbax_handler.register_pathways_handlers(
         datetime.timedelta(minutes=10)
     )
+
+  # Turn off JAX compilation cache because Pathways handles its own compilation
+  # cache.
+  jax.config.update("jax_enable_compilation_cache", False)
+
   try:
     cloud_logging.setup()
   except OSError as e: