diff --git a/tensorflow/lite/core/c/BUILD b/tensorflow/lite/core/c/BUILD
index 35fcea37f9d62d..70999f0b24cf7a 100644
--- a/tensorflow/lite/core/c/BUILD
+++ b/tensorflow/lite/core/c/BUILD
@@ -190,6 +190,33 @@ cc_test(
     ],
 )
 
+cc_test(
+    name = "c_api_test_with_opaque_delegate",
+    size = "small",
+    srcs = ["c_api_test.cc"],
+    copts = tflite_copts(),
+    data = [
+        "//tensorflow/lite:testdata/2_subgraphs.bin",
+        "//tensorflow/lite:testdata/add.bin",
+        "//tensorflow/lite:testdata/add_quantized.bin",
+        "//tensorflow/lite:testdata/custom_sinh.bin",
+    ],
+    local_defines = ["TFLITE_USE_OPAQUE_DELEGATE"],
+    deps = [
+        ":c_api",
+        ":c_api_experimental",
+        ":c_api_types",
+        ":common",
+        "//tensorflow/lite:string_util",
+        "//tensorflow/lite/c:c_api_internal",
+        "//tensorflow/lite/core:subgraph",
+        "//tensorflow/lite/delegates:delegate_test_util",
+        "//tensorflow/lite/schema:schema_fbs",
+        "//tensorflow/lite/testing:util",
+        "@com_google_googletest//:gtest_main",
+    ],
+)
+
 cc_test(
     name = "selectively_built_c_api_test",
     size = "small",
diff --git a/tensorflow/lite/core/c/c_api_test.cc b/tensorflow/lite/core/c/c_api_test.cc
index abb0083e12578c..189cd9815f8ebf 100644
--- a/tensorflow/lite/core/c/c_api_test.cc
+++ b/tensorflow/lite/core/c/c_api_test.cc
@@ -291,6 +291,7 @@ TEST(CApiSimple, TfLiteInterpreterGetTensor) {
   TfLiteInterpreterDelete(interpreter);
 }
 
+#if !TFLITE_USE_OPAQUE_DELEGATE
 TEST(CApiSimple, Delegate) {
   TfLiteModel* model =
       TfLiteModelCreateFromFile("tensorflow/lite/testdata/add.bin");
@@ -316,6 +317,7 @@ TEST(CApiSimple, Delegate) {
   EXPECT_EQ(TfLiteInterpreterInvoke(interpreter), kTfLiteOk);
   TfLiteInterpreterDelete(interpreter);
 }
+#endif
 
 TEST(CApiSimple, DelegateExternal_GetExecutionPlan) {
   TfLiteModel* model =
@@ -409,6 +411,7 @@ TEST(CApiSimple, DelegateExternal_MarkSubgraphAsDelegationSkippable) {
   TfLiteOpaqueDelegateDelete(opaque_delegate);
 }
 
+#if !TFLITE_USE_OPAQUE_DELEGATE
 TEST(CApiSimple, DelegateFails) {
   TfLiteModel* model =
       TfLiteModelCreateFromFile("tensorflow/lite/testdata/add.bin");
@@ -428,6 +431,7 @@ TEST(CApiSimple, DelegateFails) {
   TfLiteInterpreterOptionsDelete(options);
   TfLiteModelDelete(model);
 }
+#endif
 
 struct DelegateState {
   bool delegate_prepared;
diff --git a/tensorflow/lite/core/interpreter.h b/tensorflow/lite/core/interpreter.h
index 334de115286d93..ed9d798f34753b 100644
--- a/tensorflow/lite/core/interpreter.h
+++ b/tensorflow/lite/core/interpreter.h
@@ -580,6 +580,7 @@ class Interpreter {
   /// 5. kTfLiteError: Unexpected/runtime failure. \n
   /// \warning This is an experimental API and subject to change. \n
   TfLiteStatus ModifyGraphWithDelegate(TfLiteDelegate* delegate);
+  TfLiteStatus ModifyGraphWithDelegate(TfLiteOpaqueDelegateStruct* delegate);
 
   // Owning handle to a TfLiteDelegate instance.
   using TfLiteDelegatePtr =
diff --git a/tensorflow/lite/core/interpreter_experimental.cc b/tensorflow/lite/core/interpreter_experimental.cc
index e04b1d3e7c675d..016d45df977955 100644
--- a/tensorflow/lite/core/interpreter_experimental.cc
+++ b/tensorflow/lite/core/interpreter_experimental.cc
@@ -84,6 +84,12 @@ TfLiteStatus Interpreter::ModifyGraphWithDelegate(TfLiteDelegate* delegate) {
   return ModifyGraphWithDelegateImpl(delegate);
 }
 
+TfLiteStatus Interpreter::ModifyGraphWithDelegate(
+    TfLiteOpaqueDelegateStruct* delegate) {
+  return ModifyGraphWithDelegateImpl(
+      reinterpret_cast<TfLiteDelegate*>(delegate));
+}
+
 bool Interpreter::HasDelegates() { return primary_subgraph().HasDelegates(); }
 
 TfLiteStatus Interpreter::SetBufferHandle(int tensor_index,
diff --git a/tensorflow/lite/delegates/delegate_test.cc b/tensorflow/lite/delegates/delegate_test.cc
index dbfb3de9f4cfb7..560b2b4c65b940 100644
--- a/tensorflow/lite/delegates/delegate_test.cc
+++ b/tensorflow/lite/delegates/delegate_test.cc
@@ -51,7 +51,8 @@ using test_utils::TestTwoDelegates;
 namespace {
 
 TEST_F(TestDelegate, NullDelegate) {
-  EXPECT_EQ(interpreter_->ModifyGraphWithDelegate(nullptr),
+  TfLiteOpaqueDelegate* delegate = nullptr;
+  EXPECT_EQ(interpreter_->ModifyGraphWithDelegate(delegate),
             kTfLiteDelegateError);
 }
 
@@ -1488,7 +1489,8 @@ TEST_P(TestFP16Delegation, NonDelegatedInterpreterWorks) {
 }
 
 TEST_F(TestFP16Delegation, NullDelegate) {
-  EXPECT_EQ(interpreter_->ModifyGraphWithDelegate(nullptr),
+  TfLiteOpaqueDelegate* delegate = nullptr;
+  EXPECT_EQ(interpreter_->ModifyGraphWithDelegate(delegate),
             kTfLiteDelegateError);
   // Verify that resulting interpreter still works, despite null delegate.
   ASSERT_EQ(interpreter_->AllocateTensors(), kTfLiteOk);